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• Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle.
• Application of small interfering RNA (siRNA) for modulation of airway epithelial gene expression.
• High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID).
• Nonionic amphiphilic block copolymers promote gene transfer to the lung.
• High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse.
• The specific delivery of proteins to human liver cells by engineered bio-nanocapsules.
• Serum albumin enhances polyethylenimine-mediated gene delivery to human respiratory epithelial cells.
• PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice.
• A peptide carrier with a built-in vaccine adjuvant: construction of immunogenic conjugates.
• The proteasome metabolizes peptide-mediated nonviral gene delivery systems.
• Exploration of peptide motifs for potent non-viral gene delivery highly selective for dividing cells.
• A novel insulin delivery algorithm in rats with type 1 diabetes: the fading memory proportional-derivative method.
• Peptide nucleic acid antisense oligomer as a therapeutic strategy against bacterial infection: proof of principle using mouse intraperitoneal infection.
• A new direction for gene therapy: intrathymic T cell-specific lentiviral gene transfer.
• Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms.
• A rapid computational filter for cytochrome P450 1A2 inhibition potential of compound libraries.
• Intracellular trafficking of nonviral vectors.
• A high-density screen for linkage in multiple sclerosis.
• Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR.
• A collagen IV matrix is required for guinea pig gastric epithelial cell monolayers to provide an optimal model of the stomach surface for biopharmaceutical screening.
• Targeted delivery of therapeutic oligonucleotides to pulmonary circulation.
• Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis.
• Novel detection system for biomolecules using nano-sized bacterial magnetic particles and magnetic force microscopy.
• Cationic liposomes containing mycobacterial lipids: a new powerful Th1 adjuvant system.
• Granulocyte-colony stimulating factor augments neovascularization induced by bone marrow transplantation in rat hindlimb ischemia.
• Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.
• A network-based analysis of systemic inflammation in humans.
• The transcriptional landscape of the mammalian genome.
• Antisense transcription in the mammalian transcriptome.
• Elucidation of the small RNA component of the transcriptome.
• A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.
• Comparing antigenicity and immunogenicity of engineered gp120.
• Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain.
• Toward high-resolution de novo structure prediction for small proteins.
• Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells.
• Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies.
• Coronaviruses as vectors: stability of foreign gene expression.
• Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults.
• Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein.
• Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.
• Towards a proteome-scale map of the human protein-protein interaction network.
• Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence.
• Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia.
• Application of high amplitude alternating magnetic fields for heat induction of nanoparticles localized in cancer.
• Targeted virus replication plus immunotherapy eradicates primary and distant pancreatic tumors in nude mice.
• Prediction of regulatory modules comprising microRNAs and target genes.
• An attempt to define allergen-specific molecular surface features: a bioinformatic approach.
• A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
• Generation and characterization of novel stromal specific antibodies.
• Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells.
• A fine-scale map of recombination rates and hotspots across the human genome.
• Liver-directed gamma interferon gene delivery in chronic hepatitis C.
• Combinations of polyclonal or monoclonal antibodies to proteins of the outer membranes of the two infectious forms of vaccinia virus protect mice against a lethal respiratory challenge.
• Prophylactic alpha interferon treatment increases the therapeutic index of oncolytic vesicular stomatitis virus virotherapy for advanced hepatocellular carcinoma in immune-competent rats.
• An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction.
• Natural selection on protein-coding genes in the human genome.
• Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling.
• Oncogenic pathway signatures in human cancers as a guide to targeted therapies.
• A quantitative protein interaction network for the ErbB receptors using protein microarrays.
• Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus.
• Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial.
• Generation of adenosine A3 receptor functionally humanized mice for the evaluation of the human antagonists.
• Inhibition of atherogenesis in LDLR knockout mice by systemic delivery of adeno-associated virus type 2-hIL-10.
• A new vector for controllable expression of an anti-HER2/neu mini-antibody-barnase fusion protein in HEK 293T cells.
• A novel mucosal vaccine based on live Lactococci expressing E7 antigen and IL-12 induces systemic and mucosal immune responses and protects mice against human papillomavirus type 16-induced tumors.
• Enhancement of adenovirus-mediated gene delivery to rheumatoid arthritis synoviocytes and synovium by fiber modifications: role of arginine-glycine-aspartic acid (RGD)- and non-RGD-binding integrins.
• Efficacy of immuno-cell therapy in patients with advanced pancreatic cancer.
• Re-targeting of cytotoxic T lymphocytes and/or natural killer cells to CEA-expressing tumor cells with anti-CEA antibody activity.
• Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
• Spatially controlled electro-stimulated DNA adsorption and desorption for biochip applications.
• IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.
• High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery.
• Human immunodeficiency virus type 1 latency model for high-throughput screening.
• Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis.
• On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes.
• Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing Gag.
• Effect of paclitaxel and mesenchymal stem cells seeding on ex vivo vascular endothelial repair and smooth muscle cells growth.
• Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening.
• Patient-reported outcomes of psoriasis improvement with etanercept therapy: results of a randomized phase III trial.
• Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice.
• Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch micro-fabricated micro-needles.
• Polypropylenimine dendrimer-induced gene expression changes: the effect of complexation with DNA, dendrimer generation and cell type.
• Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year extended study.
• CD4+ T cell-independent DNA vaccination against opportunistic infections.
• Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
• The inhibition of angiogenesis by antisense oligonucleotides to clusterin.
• A novel human monoclonal antibody derived from tumor-infiltrating lymphocytes in lung cancer inhibits cancer cell growth with morphological changes.
• Humanized monoclonal antibody against parathyroid hormone-related protein suppresses osteolytic bone metastasis of human breast cancer cells derived from MDA-MB-231.
• Assessment of anti-estrogenic activity of tamoxifen in transgenic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element.
• p53 protein transduction therapy: successful targeting and inhibition of the growth of the bladder cancer cells.
• Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated.
• Lentiviral vector expression of tumour antigens in dendritic cells as an immunotherapeutic strategy.
• Growth inhibition of breast cancer cell lines overexpressing Her2/neu by a novel internalized fully human Fab antibody fragment.
• Sustained and therapeutic levels of human factor IX in hemophilia B mice implanted with microcapsules: key role of encapsulated cells.
• Characterization of prostate-specific antigen binding peptides selected by phage display technology.
• Do bone marrow stromal cells proliferate after transplantation into mice cerebral infarct?--a double labeling study.
• Identification and characterization of high affinity antisense PNAs for the human unr (upstream of N-ras) mRNA which is uniquely overexpressed in MCF-7 breast cancer cells.
• Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection.
• Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.
• Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent.
• Phase I study of the sequential combination of interleukin-12 and interferon alfa-2b in advanced cancer: evidence for modulation of interferon signaling pathways by interleukin-12.
• Anti-CD2 monoclonal antibody and tacrolimus in adult liver transplantation.
• Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics.
• Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells.
• Induction of anti-tumor immunity by vaccination with dendritic cells pulsed with anti-CD44 IgG opsonized tumor cells.
• Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin.
• Target ability and therapy efficacy of immunoliposomes using a humanized antihepatoma disulfide-stabilized Fv fragment on tumor cells.
• Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis.
• Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling.
• Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver.
• In vitro uptake of gelatin nanoparticles by murine dendritic cells and their intracellular localisation.
• Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4.
• Inhibition of nitric oxide and caspase-3 mediated apoptosis by a tetrapeptide derivative (PEP1261) in cultured synovial fibroblasts from collagen-induced arthritis.
• Oral adeno-associated virus-sTRAIL gene therapy suppresses human hepatocellular carcinoma growth in mice.
• A novel system for efficient gene transfer into primary human hepatocytes via cell-permeable hepatitis B virus-like particle.
• Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels.
• Generation of antigen-presenting cells using cultured dendritic cells and amplified autologous tumor mRNA.
• Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo.
• Administration-route and gender-independent long-term therapeutic correction of phenylketonuria (PKU) in a mouse model by recombinant adeno-associated virus 8 pseudotyped vector-mediated gene transfer.
• Progress and prospects: cell based regenerative therapy for cardiovascular disease.
• Chimpanzee-origin adenovirus vectors as vaccine carriers.
• In silico fragment-based discovery of DPP-IV S1 pocket binders.
• Immunohistochemical detection of CD 95 (Fas) & Fas ligand (Fas-L) in plasma cells of multiple myeloma and its correlation with survival.
• Triple gene-deleted oncolytic herpes simplex virus vector double-armed with interleukin 18 and soluble B7-1 constructed by bacterial artificial chromosome-mediated system.
• Prospective identification of tumorigenic prostate cancer stem cells.
• Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance.
• RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation.
• Short hairpin RNA-mediated inhibition of matrix metalloproteinase-1 in MDA-231 cells: effects on matrix destruction and tumor growth.
• Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck.
• Antibody microarray profiling reveals individual and combined serum proteins associated with pancreatic cancer.
• Genome-wide screening of genomic alterations and their clinicopathologic implications in non-small cell lung cancers.
• Site-specific drug delivery by photochemical internalization enhances the antitumor effect of bleomycin.
• Combination B7-Fc fusion protein treatment and Treg cell depletion therapy.
• Targeted cytotoxic bombesin analog AN-215 effectively inhibits experimental human breast cancers with a low induction of multi-drug resistance proteins.
• Protection of erythrocytes from human complement-mediated lysis by membrane-targeted recombinant soluble CD59: a new approach to PNH therapy.
• Supernatural T cells: genetic modification of T cells for cancer therapy.
• Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays.
• cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance.
• Carbon nanohorns as anticancer drug carriers.
• A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation.
• Pegylated liposomal doxorubicin (Lipo-Dox) for platinum-resistant or refractory epithelial ovarian carcinoma: a Taiwanese gynecologic oncology group study with long-term follow-up.
• In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin.
• Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.
• Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence.
• Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation.
• A peptide aptamer to antagonize BCL-6 function.
• Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells.
• Are there clinical benefits with early erythropoietic intervention for chemotherapy-induced anemia? A systematic review.
• A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: implication in tumor angiogenesis.
• A phase 2 dose-finding study of PEGylated recombinant methionyl human soluble tumor necrosis factor type I in patients with rheumatoid arthritis.
• Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.
• Oral delivery of lipid-encapsulated Mycobacterium bovis BCG extends survival of the bacillus in vivo and induces a long-term protective immune response against tuberculosis.
• CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia.
• Comparative virtual and experimental high-throughput screening for glycogen synthase kinase-3beta inhibitors.
• Genomic and proteomic analysis of mammary tumors arising in transgenic mice.
• Dual expression system suitable for high-throughput fluorescence-based screening and production of soluble proteins.
• Expression profiling of herpesvirus and vaccinia virus proteins using a high-throughput baculovirus screening system.
• Development and evaluation of a micro- and nanoscale proteomic sample preparation method.
• In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures.
• Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion.
• siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo.
• Estrogen, neuroinflammation and neuroprotection in Parkinson's disease: glia dictates resistance versus vulnerability to neurodegeneration.
• Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma.
• Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution.
• Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.
• Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes.
• Erythropoietin attenuates cachectic events and decreases production of interleukin-6, a cachexia-inducing cytokine.
• Intratracheal gene transfer of tissue factor pathway inhibitor attenuates pulmonary fibrosis.
• Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters.
• Screening for selective small molecule inhibitors of the proteasome using activity-based probes.
• In vitro SCFbeta-Trcp1-mediated IkappaBalpha ubiquitination assay for high-throughput screen.
• Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice.
• Herpesviral protein networks and their interaction with the human proteome.
• A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.
• Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets.
• Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement.
• Elevated T regulatory cells in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin.
• Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection.
• Microwave-assisted protein preparation and enzymatic digestion in proteomics.
• A plasmid-encoded VEGF siRNA reduces glioblastoma angiogenesis and its combination with interleukin-4 blocks tumor growth in a xenograft mouse model.
• Injection of skeletal muscle-derived cells into the penis improves erectile function.
• Genospheres: self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery.
• Ring-Sp1 decoy oligonucleotide effectively suppresses extracellular matrix gene expression and fibrosis of rat kidney induced by unilateral ureteral obstruction.
• Selective replication of E1B55K-deleted adenoviruses depends on enhanced E1A expression in cancer cells.
• Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival.
• Th2-dominated antitumor immunity induced by DNA immunization with the genes coding for a basal core peptide PDTRP and GM-CSF.
• Lipid microarrays identify key mediators of autoimmune brain inflammation.
• The in vitro antitumor effect and in vivo tumor-specificity distribution of human-mouse chimeric antibody against transferrin receptor.
• Transfer of siRNA against XIAP induces apoptosis and reduces tumor cells growth potential in human breast cancer in vitro and in vivo.
• Outcome of patients with active ankylosing spondylitis after two years of therapy with etanercept: clinical and magnetic resonance imaging data.
• A pilot phase 2 study of oregovomab murine monoclonal antibody to CA125 as an immunotherapeutic agent for recurrent ovarian cancer.
• Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo.
• In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.
• A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes.
• In vivo electrogene transfer of interleukin-12 inhibits tumor growth and lymph node and lung metastases in mouse mammary carcinomas.
• Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia.
• "UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection.
• Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells.
• A simple method to predict protein-binding from aligned sequences--application to MHC superfamily and beta2-microglobulin.
• Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura.
• Painless electroporation with a new needle-free microelectrode array to enhance transdermal drug delivery.
• Immunization by particle bombardment of antigen-loaded poly-(DL-lactide-co-glycolide) microspheres in mice.
• High-throughput screening of enzyme libraries: thiolactonases evolved by fluorescence-activated sorting of single cells in emulsion compartments.
• SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations.
• Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus.
• Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-1alpha oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor.
• Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
• Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma.
• Tumor-targeted therapy with a conditionally replicating mutant of HSV-1 induces regression of xenografted human hepatomas.
• Paclitaxel encapsulated in cationic lipid complexes (MBT-0206) impairs functional tumor vascular properties as detected by dynamic contrast enhanced magnetic resonance imaging.
• Treatment of NSCLC patients with an EGF-based cancer vaccine: report of a Phase I trial.
• Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia.
• Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers.
• Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1.
• Patient, disease, and therapy-related factors that influence discontinuation of disease-modifying antirheumatic drugs: a population-based incidence cohort of patients with rheumatoid arthritis.
• Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.
• Encapsulation of the immune potentiators MPL and RC529 in PLG microparticles enhances their potency.
• Gene therapy strategies for Duchenne muscular dystrophy utilizing recombinant adeno-associated virus vectors.
• Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.
• A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells.
• AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model.
• Dual promoter-controlled oncolytic adenovirus CG5757 has strong tumor selectivity and significant antitumor efficacy in preclinical models.
• Efficacy and safety analysis of epoetin alfa in patients with small-cell lung cancer: a randomized, double-blind, placebo-controlled trial.
• Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen.
• Investigation of early protein changes in the urinary bladder following partial bladder outlet obstruction by proteomic approach.
• In vivo delivery of small interfering RNA targeting brain capillary endothelial cells.
• Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood.
• Phase I study of radioimmunotherapy with an anti-CD20 murine radioimmunoconjugate ((90)Y-ibritumomab tiuxetan) in relapsed or refractory indolent B-cell lymphoma.
• Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.
• A novel strategy to compensate the disadvantages of live vaccine using suicide-gene system and provide better antitumor immunity.
• An iontophoretic fentanyl patient-activated analgesic delivery system for postoperative pain: a double-blind, placebo-controlled trial.
• Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs.
• Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases.
• Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium.
• Inhibition of host signal transducer and activator of transcription factor 6 results in cure with cyclophosphamide and interleukin 12 immunotherapy.
• Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
• Tumor vascular targeting therapy with viral vectors.
• Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
• Human tumor membrane vesicles modified to express glycolipid-anchored IL-12 by protein transfer induce T cell proliferation in vitro: a potential approach for local delivery of cytokines during vaccination.
• Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848).
• Phase I study of CT-2103, a polymer-conjugated paclitaxel, and carboplatin in patients with advanced solid tumors.
• Developments in the apheresis procedure for the treatment of inflammatory bowel disease.
• Preliminary data on the use of apheresis in inflammatory bowel disease.
• Rituximab (chimeric anti-CD20 antibody) for posttransplant lymphoproliferative disorder after solid organ transplantation in adults: long-term experience from a single center.
• In vitro cardiomyogenic potential of human umbilical vein-derived mesenchymal stem cells.
• pH triggered release of protective poly(ethylene glycol)-b-polycation copolymers from liposomes.
• Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse.
• Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.
• Proteomics in tumor progression and metastasis.
• Morphogenics as a tool for target discovery and drug development.
• Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage.
• The effectiveness of anti-tumor necrosis factor therapy in preventing progressive radiographic joint damage in rheumatoid arthritis: a population-based study.
• Applications of support vector machines to cancer classification with microarray data.
• Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apolipoprotein E-null mice.
• Design, synthesis and preliminary biological evaluations of novel amphiphilic drug carriers.
• Delivering PD-1 inhibitory signal concomitant with blocking ICOS co-stimulation suppresses lupus-like syndrome in autoimmune BXSB mice.
• Use of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury.
• Transfection of CD40Ig into liver prevents acute rejection in rat liver transplantation.
• The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease.
• Aberrant T helper cell response in tumor-bearing mice limits the efficacy of dendritic cell vaccine.
• Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western Kenya.
• Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector.
• Elimination of innate immune responses and liver inflammation by PEGylation of adenoviral vectors and methylprednisolone.
• Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954.
• A phase I trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer.
• Characterisation of CD8 monoclonal antibody-induced protection from diabetes in NOD mice.
• Randomized trial of a nonpolymer-based rapamycin-eluting stent versus a polymer-based paclitaxel-eluting stent for the reduction of late lumen loss.
• Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.
• Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.
• Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice.
• Molecular detection of circulating cancer cells in the peripheral blood of patients with colorectal cancer by using membrane array with a multiple mRNA marker panel.
• Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo.
• Delivery of the bacterial nitroreductase gene into endothelial cells prolongs the survival of tumour-bearing mice by bystander mechanisms.
• GTI-2501, an antisense agent targeting R1, the large subunit of human ribonucleotide reductase, shows potent anti-tumor activity against a variety of tumors.
• mHFE7A, a newly identified monoclonal antibody to Fas, induces apoptosis in human melanoma cells in vitro and delays the growth of melanoma xenotransplants.
• FR177391, a new anti-hyperlipidemic agent from Serratia. III. Microbial conversion of FR177391 and synthesis of FR177391 derivatives for its target protein screening by chemical genetic approaches.
• Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis.
• Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model.
• In vivo studies of dialkynoyl analogues of DOTAP demonstrate improved gene transfer efficiency of cationic liposomes in mouse lung.
• Effects of oral bacterial immunotherapy in children with atopic eczema/dermatitis syndrome : a pilot study.
• Therapeutic potential of oligonucleotides expressing immunosuppressive TTAGGG motifs.
• Breaking tolerance to tumors with dendritic cell-based immunotherapy.
• Development of resistance to RNAi in mammalian cells.
• Application of expression genomics for predicting treatment response in cancer.
• Vaccine efficacy of fusogenic liposomes containing tumor cell-lysate against murine B16BL6 melanoma.
• Non-methylated CpG motif packaged into fusogenic liposomes enhance antigen-specific immunity in mice.
• Anti-infliximab antibodies in patients with rheumatoid arthritis who require higher doses of infliximab to achieve or maintain a clinical response.
• A multicenter, double-blind, randomized, placebo controlled trial of infliximab combined with low dose methotrexate in Japanese patients with rheumatoid arthritis.
• Safety of extended treatment with anakinra in patients with rheumatoid arthritis.
• Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer.
• Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model.
• Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.
• Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells.
• Lentiviral-mediated delivery of siRNAs for antiviral therapy.
• Using anti-VEGF McAb and magnetic nanoparticles as double-targeting vector for the radioimmunotherapy of liver cancer.
• The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling.
• Efficient nonviral gene delivery into primary lymphocytes from rats and mice.
• cDNA array reveals increased expression of glucose-dependent insulinotropic polypeptide following chronic clozapine treatment: role in atypical antipsychotic drug-induced adverse metabolic effects.
• Biological treatment in rheumatic diseases: results from a longitudinal surveillance: adverse events.
• The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo.
• Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma.
• PDGF gene therapy enhances expression of VEGF and bFGF genes and activates the NF-kappaB gene in signal pathways in ischemic flaps.
• Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries.
• Glycoprotein A34, a novel target for antibody-based cancer immunotherapy.
• Characterization of two polyclonal peptide antibodies that recognize the carboxy terminus of angiotensin II AT1A and AT1B receptors.
• Nanodecoy system: a novel approach to design hepatitis B vaccine for immunopotentiation.
• A clinical trial with chimeric monoclonal antibody WX-G250 and low dose interleukin-2 pulsing scheme for advanced renal cell carcinoma.
• Erythropoietin plus granulocyte colony-stimulating factor is better than erythropoietin alone to treat anemia in low-risk myelodysplastic syndromes: results from a randomized single-centre study.
• The anti-tumor efficacy of a GM-CSF-secreting tumor cell vaccine is not inhibited by docetaxel administration.
• Targeting the NF-kappaB pathway in estrogen receptor negative MDA-MB-231 breast cancer cells using small inhibitory RNAs.
• Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery.
• Bioluminescence imaging of systemic tumor targeting using a prostate-specific lentiviral vector.
• Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity.
• Expression Analysis Systematic Explorer (EASE) analysis reveals differential gene expression in permanent and transient focal stroke rat models.
• Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer.
• Inhibition of Bcl-2 expression by a novel tumor-specific RNA interference system increases chemosensitivity to 5-fluorouracil in Hela cells.
• In silico identification of novel EGFR inhibitors with antiproliferative activity against cancer cells.
• Rab4GTPase modulates CFTR function by impairing channel expression at plasma membrane.
• Near-infrared spectroscopy: promising diagnostic tool for viral infections.
• Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
• Regulation of antisense RNA expression during cardiac MHC gene switching in response to pressure overload.
• Thromboembolic adverse events after use of recombinant human coagulation factor VIIa.
• Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
• An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice.
• Effect of adenovirus-mediated heat shock protein expression and oncolysis in combination with low-dose cyclophosphamide treatment on antitumor immune responses.
• Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.
• The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells.
• The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.
• Efficient induction of tumor antigen-specific CD8+ memory T cells by recombinant lentivectors.
• Vaccine with beta-defensin 2-transduced leukemic cells activates innate and adaptive immunity to elicit potent antileukemia responses.
• Sepsis in European intensive care units: results of the SOAP study.
• Discovery and analysis of pancreatic adenocarcinoma genes using cDNA microarrays.
• Post-marketing experience with an opioid nasal spray for migraine: lessons for the future.
• The effect of CD3-specific monoclonal antibody on treating experimental autoimmune myasthenia gravis.
• RNA interference in immune cells by use of osmotic delivery of siRNA.
• Prediction of hERG potassium channel affinity by the CODESSA approach.
• Antimalarial activity: a QSAR modeling using CODESSA PRO software.
• SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development.
• HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.
• Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.
• Antitumor efficacy of CD137 ligation is maximized by the use of a CD137 single-chain Fv-expressing whole-cell tumor vaccine compared with CD137-specific monoclonal antibody infusion.
• Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells.
• A unique role of the DNA fragmentation factor in maintaining genomic stability.
• Synergistic effects of combined therapy using paclitaxel and [90Y-DOTA]776.1 on growth of OVCAR-3 ovarian carcinoma xenografts.
• Intranasal lipopeptide primes lung-resident memory CD8+ T cells for long-term pulmonary protection against influenza.
• Cleavage of intracellular hepatitis C RNA in the virus core protein coding region by deoxyribozymes.
• Selective migration of neuralized embryonic stem cells to stem cell factor and media conditioned by glioma cell lines.
• Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control.
• Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-throughput format.
• Lentiviral gene transfer of the chemokine antagonist RANTES 9-68 prolongs heart graft survival.
• CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS.
• Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines.
• Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
• A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that overcomes preexisting anti-ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques.
• Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection.
• Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines.
• Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells.
• Design and evolution of new catalytic activity with an existing protein scaffold.
• RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells.
• A microplate assay for the screening of ADAMTS-4 inhibitors.
• In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI.
• Phase 1 trial of a CpG oligodeoxynucleotide for patients with recurrent glioblastoma.
• A novel dendritic cell subset involved in tumor immunosurveillance.
• Phase II study of the combination of pegylated liposomal doxorubicin and topotecan in platinum-resistant ovarian cancer.
• Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally.
• Targeting cancer cells: magnetic nanoparticles as drug carriers.
• Isolation of cell specific peptide ligands using fluorescent bacterial display libraries.
• Quantitative comparison of the HSV-1 and HSV-2 transcriptomes using DNA microarray analysis.
• Partial reconstitution of virus-specific memory CD8+ T cells following whole body gamma-irradiation.
• pDNAVACCultra vector family: high throughput intracellular targeting DNA vaccine plasmids.
• Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus.
• Probabilistic neural network model for the in silico evaluation of anti-HIV activity and mechanism of action.
• Development of the PANVAC-VF vaccine for pancreatic cancer.
• Protein chip discovery of secreted proteins regulated by the phosphatidylinositol 3-kinase pathway in ovarian cancer cell lines.
• Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors.
• An integrated computational/experimental model of tumor invasion.
• Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vector.
• Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.
• Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors.
• The anti-human leukocyte antigen-DR monoclonal antibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient mice.
• Therapeutic short hairpin RNA expression in the liver: viral targets and vectors.
• High-throughput multi-antigen microfluidic fluorescence immunoassays.
• Purified human bone marrow multipotent mesenchymal stem cells regenerate infarcted myocardium in experimental rats.
• Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial.
• Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus.
• Local delivery of vaccinia virus expressing multiple costimulatory molecules for the treatment of established tumors.
• Development of a novel high-throughput assay for the investigation of GlyT-1b neurotransmitter transporter function.
• Intranasal immunization with human papillomavirus type 16 capsomeres in the presence of non-toxic cholera toxin-based adjuvants elicits increased vaginal immunoglobulin levels.
• Optimal organization of a polypeptide-based candidate cancer vaccine composed of cryptic tumor peptides with enhanced immunogenicity.
• Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate.
• Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens.
• OX40 ligation of CD4+ T cells enhances virus-specific CD8+ T cell memory responses independently of IL-2 and CD4+ T regulatory cell inhibition.
• Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors.
• Regression of papilloma high-grade lesions (CIN 2 and CIN 3) is stimulated by therapeutic vaccination with MVA E2 recombinant vaccine.
• Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice.
• Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system.
• Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery.
• Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential.
• Intestinal uptake and biodistribution of novel polymeric micelles after oral administration.
• T lymphocytes as potential therapeutic drug carrier for cancer treatment.
• Fully automated quantitation of hepatitis B virus (HBV) DNA in human plasma by the COBAS AmpliPrep/COBAS TaqMan system.
• Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery.
• A microRNA expression signature of human solid tumors defines cancer gene targets.
• An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport.
• The challenge of analyzing the proteome in humans with autoimmune diseases.
• A transgenic approach for RNA interference-based genetic screening in mice.
• Induction of apoptosis by hybrid liposomes for human breast tumor cells along with activation of caspases.
• A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees.
• Gene expression analysis of human hepatocellular carcinoma by using full-length cDNA library.
• Continued inhibition of radiographic progression in patients with psoriatic arthritis following 2 years of treatment with etanercept.
• Anti-tumor effect and mechanism of SEA-Fab' coupled protein on gastric tumor.
• The use of microarray technologies in clinical oncology.
• Role of anti-IgE monoclonal antibody (omalizumab) in the treatment of bronchial asthma and allergic respiratory diseases.
• High speed detection of circulating tumor cells.
• Disruption of T cell regulatory pathways is necessary for immunotherapeutic cure of T cell acute lymphoblastic leukemia in mice.
• Screening for peptide drugs from the natural repertoire of biodiverse protein folds.
• Treatment of bone metastasis induced by MDA-MB-231 breast cancer cells with an antibody against bone sialoprotein.
• A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice.
• Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin.
• Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.
• Selective intratumoral amplification of an antiangiogenic vector by an oncolytic virus produces enhanced antivascular and anti-tumor efficacy.
• Novel polymeric prodrug with multivalent components for cancer therapy.
• PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality.
• Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial.
• Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens.
• Lentiviral delivery of RNAi in hippocampal neurons.
• Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis.
• Sequence-specific interference by small RNAs derived from adenovirus VAI RNA.
• Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases.
• Point-of-care biosensor systems for cancer diagnostics/prognostics.
• Measurement of cytokine release at the single cell level using the ELISPOT assay.
• An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses.
• Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction.
• Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors.
• Cytidine-phosphate-guanosine oligodeoxynucleotides and interferon-alpha-expressing tumor cells effectively induce dendritic cell maturation in vitro.
• Comparative evaluation of linear and cyclic 99mTc-RGD peptides for targeting of integrins in tumor angiogenesis.
• Peptide phage display: opportunities for development of personalized anti-cancer strategies.
• Prolonged survival of mice with acute liver failure with transplantation of monkey hepatocytes cultured with an antiapoptotic pentapeptide V5.
• CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, for steroid-dependent Crohn's disease: a randomized, double-blind, placebo-controlled trial.
• Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation.
• Biodistribution and localization of iodine-131-labeled metuximab in patients with hepatocellular carcinoma.
• Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs.
• Vaccination of hormone-refractory prostate cancer patients with peptide cocktail-loaded dendritic cells: results of a phase I clinical trial.
• A human cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM overexpressing tumor cells.
• Oncolysis and suppression of tumor growth by a GFP-expressing oncolytic adenovirus controlled by an hTERT and CMV hybrid promoter.
• Pharmacokinetics of darbepoetin alfa after intravenous or subcutaneous administration in patients with non-myeloid malignancies undergoing chemotherapy.
• Intranasal IFNgamma extends passive IgA antibody protection of mice against Mycobacterium tuberculosis lung infection.
• Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development.
• Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model.
• Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates.
• Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.
• A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.
• Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.
• Antitumor effects of systemic and local immunization with a CTL-directed peptide in combination with a local injection of OK-432.
• Paclitaxel-loaded microparticles and implants for the treatment of brain cancer: preparation and physicochemical characterization.
• A robust screen for inhibitors and enhancers of phosphoinositide-3 kinase (PI3K) activities by ratiometric fluorescence superquenching.
• Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates.
• Effective gene therapy with nonintegrating lentiviral vectors.
• Human tissue-engineered blood vessels for adult arterial revascularization.
• Electrical and thermal characterization of nanochannels between a cell and a silicon based micro-pore.
• Elucidating in vitro cell-cell interaction using a microfluidic coculture system.
• Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer.
• Adenovirus-mediated CD40 ligand therapy induces tumor cell apoptosis and systemic immunity in the TRAMP-C2 mouse prostate cancer model.
• Quantitative angiogenesis in breast cancer.
• Detection of aberrant glycosylation in breast cancer using lectin histochemistry.
• SDS-PAGE and Western blotting to detect proteins and glycoproteins of interest in breast cancer research.
• Breast cancer proteomics using two-dimensional electrophoresis: studying the breast cancer proteome.
• Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates.
• Are shorter courses of filgrastim prophylaxis associated with increased risk of hospitalization?
• Vaccine-induced memory CD8+ T cells cannot prevent central nervous system virus reactivation.
• Therapeutic neovascularization by transplantation of mobilized peripheral blood mononuclear cells for limb ischemia. A comparison between CD34+ and CD34- mononuclear cells.
• Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity.
• Targeted delivery of ribavirin improves outcome of murine viral fulminant hepatitis via enhanced anti-viral activity.
• Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay.
• A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature.
• Magnetic force microscopy analysis of apoptosis of HL-60 cells induced by complex of antisense oligonucleotides and magnetic nanoparticles.
• Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice.
• Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn's disease.
• Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive heart failure.
• Soft trapping and manipulation of cells using a disposable nanoliter biochamber.
• Intranasal vaccination with recombinant adeno-associated virus type 5 against human papillomavirus type 16 L1.
• Preclinical evaluation of two neutralizing human monoclonal antibodies against hepatitis C virus (HCV): a potential treatment to prevent HCV reinfection in liver transplant patients.
• Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice.
• Viral nanoparticles as tools for intravital vascular imaging.
• Stem cell therapy in postinfarction chronic coronary heart disease.
• Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes.
• Bone marrow cell transfer in acute myocardial infarction.
• Effects of granulocyte-colony-stimulating factor on mobilization of bone-marrow-derived stem cells after myocardial infarction in humans.
• Derivation of a cardiopoietic population from human mesenchymal stem cells yields cardiac progeny.
• Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration.
• Intramyocardial injection of skeletal myoblasts: long-term follow-up with pressure-volume loops.
• Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study.
• Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer.
• Gene expression profiling of ovarian tissues for determination of molecular pathways reflective of tumorigenesis.
• Functional screening for proapoptotic genes by reverse transfection cell array technology.
• HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain.
• PhosphoregDB: the tissue and sub-cellular distribution of mammalian protein kinases and phosphatases.
• CARAT: a novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays.
• Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein.
• In silico ADME modelling 2: computational models to predict human serum albumin binding affinity using ant colony systems.
• Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer.
• Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery.
• An oncolytic adenovirus expressing soluble transforming growth factor-beta type II receptor for targeting breast cancer: in vitro evaluation.
• Restriction of adenoviral replication to the transcriptional intersection of two different promoters for colorectal and pancreatic cancer treatment.
• Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine.
• Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to intercellular adhesion molecule 1.
• Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction.
• Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.
• The colorectal microRNAome.
• Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer.
• Development and validation of HTS flux assay for endogenously expressed chloride channels in a CHO-K1 cell line.
• Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer.
• Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease.
• A comprehensive SAGE database for the analysis of gammadelta T cells.
• Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial.
• Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis.
• Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.
• Lack of efficacy of a third tumour necrosis factor alpha antagonist after failure of a soluble receptor and a monoclonal antibody.
• Gene therapy as a therapeutic approach for the treatment of rheumatoid arthritis: innovative vectors and therapeutic genes.
• Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
• Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma.
• Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2.
• Natalizumab plus interferon beta-1a for relapsing multiple sclerosis.
• Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy.
• Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis.
• A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1.
• Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA.
• Gene therapy of ovarian cancer with IFN-alpha-producing fibroblasts: comparison of constitutive and inducible vectors.
• Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer.
• In vitro investigation of lipid implants as a controlled release system for interleukin-18.
• Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells.
• Current progress in the development of HIV vaccines.
• Immunotherapy for prostate cancer.
• A phase II study of pegylated liposomal doxorubicin oxaliplatin and cyclophosphamide as second-line treatment in relapsed ovarian carcinoma.
• Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
• Development and characterization of interleukin-18-loaded biodegradable microspheres.
• A novel stealth liposomal topotecan with amlodipine: apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia.
• Single dose and multiple dose studies of itraconazole nanoparticles.
• Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease.
• F0F1-ATPase as biosensor to detect single virus.
• Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres.
• A fast and robust 19F NMR-based method for finding new HIV-1 protease inhibitors.
• Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon.
• Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells.
• Epitope enhancement of a CD4 HIV epitope toward the development of the next generation HIV vaccine.
• Gene therapy for breast cancer. --Review of clinical gene therapy trials for breast cancer and MDR1 gene therapy trial in Cancer Institute Hospital.
• Anti-infective monoclonal antibodies: perils and promise of development.
• Marked decrease of plasma VEGF after implantation of autologous bone marrow mononuclear cells in a patient with critical limb ischemia--a case report.
• Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
• Prediction of renal allograft rejection by urinary protein analysis using ProteinChip Arrays (surface-enhanced laser desorption/ionization time-of-flight mass spectrometry).
• In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.
• Synergistic antitumor effects of immune cell-viral biotherapy.
• Augmenting the immunogenicity of DNA vaccines: role of plasmid-encoded Flt-3 ligand, as a molecular adjuvant in genetic vaccination.
• In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis.
• Characterization of the recombinant adenovirus vector AdYB-1: implications for oncolytic vector development.
• Hepatitis B surface antigen vector delivers protective cytotoxic T-lymphocyte responses to disease-relevant foreign epitopes.
• A loss-of-function RNA interference screen for molecular targets in cancer.
• G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice.
• A single nucleotide polymorphism chip-based method for combined genetic and epigenetic profiling: validation in decitabine therapy and tumor/normal comparisons.
• Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers.
• Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth.
• Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma.
• Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.
• Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer.
• Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine.
• Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes.
• Immunosensitization of tumor cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade).
• PEGylated glucagon-like peptide-1 displays preserved effects on insulin release in isolated pancreatic islets and improved biological activity in db/db mice.
• Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke.
• Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: a phase I-II study.
• Construction and characterization of a novel fusion protein consisting of anti-CD3 antibody fused to recombinant interleukin-2.
• Development of a "reverse capture" autoantibody microarray for studies of antigen-autoantibody profiling.
• Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction.
• Use of semiconductor-based oligonucleotide microarrays for influenza a virus subtype identification and sequencing.
• Evaluation of the COBAS AmpliPrep-total nucleic acid isolation-COBAS TaqMan hepatitis B virus (HBV) quantitative test and comparison to the VERSANT HBV DNA 3.0 assay.
• In vitro panning of a targeting peptide to hepatocarcinoma from a phage display peptide library.
• Suppression of angiogenesis, tumor growth, and metastasis by adenovirus-mediated gene transfer of human angiotensinogen.
• Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes.
• Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition.
• Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation.
• Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
• Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer.
• Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs.
• Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas.
• Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug.
• Monoclonal and polyclonal antibody therapy for treating acute rejection in kidney transplant recipients: a systematic review of randomized trial data.
• Transplanted neonatal cardiomyocytes as a potential biological pacemaker in pigs with complete atrioventricular block.
• Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy.
• Darbepoetin alfa administered every three weeks is effective for the treatment of chemotherapy-induced anemia.
• An antibody-based microarray assay for small RNA detection.
• Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma.
• A live, attenuated recombinant West Nile virus vaccine.
• Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein.
• Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine.
• The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis.
• ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a single center experience.
• Pinpoint targeted immunosuppression: anti-CD20/MMF desensitization with anti-CD25 in successful ABO-incompatible kidney transplantation without splenectomy.
• DNA vaccines expressing the duck hepatitis B virus surface proteins lead to reduced numbers of infected hepatocytes and protect ducks against the development of chronic infection in a virus dose-dependent manner.
• Pharmaco-metabonomic phenotyping and personalized drug treatment.
• Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.
• Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
• Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.
• Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles.
• Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.
• Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.
• Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes.
• Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers.
• Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model.
• Long-term multiple-dose pharmacokinetics of human monoclonal antibodies (MAbs) against human immunodeficiency virus type 1 envelope gp120 (MAb 2G12) and gp41 (MAbs 4E10 and 2F5).
• Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines.
• Reduced incidence of severe palmar-plantar erythrodysesthesia and mucositis in a prospective multicenter phase II trial with pegylated liposomal doxorubicin at 40 mg/m2 every 4 weeks in previously treated patients with metastatic breast cancer.
• In vitro and in vivo evaluation of WK-X-34, a novel inhibitor of P-glycoprotein and BCRP, using radio imaging techniques.
• Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.
• Detection of circulating tumor cells in peripheral blood of breast cancer patients during or after therapy using a multigene real-time RT-PCR assay.
• Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.
• Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.
• Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer.
• Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway.
• Targeted chemotherapy against intraperitoneally disseminated colon carcinoma using a cationized gelatin-conjugated HVJ envelope vector.
• Application of Micro- and Nano-Electromechanical Devices to Drug Delivery.
• Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade.
• Selective gene transfer to T lymphocytes using coreceptor-specific [MLV(HIV)] pseudotype vectors in a transgenic mouse model.
• In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency.
• Noninvasive bioluminescence imaging of normal and spontaneously transformed prostate tissue in mice.
• Combination of a fusogenic glycoprotein, prodrug activation, and oncolytic herpes simplex virus for enhanced local tumor control.
• Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity.
• Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors.
• Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras.
• Inhibition of experimental metastasis by targeting the HUIV26 cryptic epitope in collagen.
• Low-molecular-weight heparin (enoxaparin) as adjuvant therapy in the treatment of active ulcerative colitis: a randomized, controlled, comparative study.
• Atypical lymphoproliferation progressing into B-cell lymphoma in rheumatoid arthritis treated with different biological agents: clinical course and molecular characterization.
• CD64-directed immunotoxin inhibits arthritis in a novel CD64 transgenic rat model.
• Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects.
• Induction of primary human T cell responses against hepatitis C virus-derived antigens NS3 or core by autologous dendritic cells expressing hepatitis C virus antigens: potential for vaccine and immunotherapy.
• IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy.
• Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus.
• Comparison between sirolimus- and Paclitaxel-eluting stents for the treatment of chronic total occlusions.
• Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.
• Development and optimization of high-throughput methods to measure Plasmodium falciparum-specific growth inhibitory antibodies.
• Multilaboratory comparison of hepatitis C virus viral load assays.
• Comparative evaluation of the performance of the Abbott real-time human immunodeficiency virus type 1 (HIV-1) assay for measurement of HIV-1 plasma viral load following automated specimen preparation.
• Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.
• A small-molecule screen in C. elegans yields a new calcium channel antagonist.
• Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice.
• Eradication of established HPV 16-expressing tumors by a single administration of a vaccine composed of a liposome-encapsulated CTL-T helper fusion peptide in a water-in-oil emulsion.
• Cell-based assays for profiling activity and safety properties of cancer drugs.
• Antisense oligonucleotide inhibition of tumor necrosis factor receptor 1 protects the liver from radiation-induced apoptosis.
• Enhanced gene transfer and oncolysis of head and neck cancer and melanoma cells by fiber chimeric oncolytic adenoviruses.
• Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.
• Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent.
• Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats.
• Immune enhancement and anti-tumour activity of IL-23.
• DC-based vaccine loaded with acid-eluted peptides in acute myeloid leukemia: the importance of choosing the best elution method.
• Inhibition of injury-induced arterial remodelling and carotid atherosclerosis by recombinant human antibodies against aldehyde-modified apoB-100.
• Cancer immunomics: using autoantibody signatures in the early detection of prostate cancer.
• PEGylated albumin-heme as an oxygen-carrying plasma expander: Exchange transfusion into acute anemia rat model.
• Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2.
• Intracarotid injection of granulocyte-macrophage colony-stimulating factor induces neuroprotection in a rat transient middle cerebral artery occlusion model.
• Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles.
• Eradication of established tumors in mice by a combination antibody-based therapy.
• Direct transfer of membrane proteins from bacteria to planar bilayers for rapid screening by single-channel recording.
• A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.
• Arsenic trioxide-loaded, microemulsion-enhanced cytotoxicity on MDAH 2774 ovarian carcinoma cell line.
• Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo.
• Potent neutralization of VEGF biological activities with a fully human antibody Fab fragment directed against VEGF receptor 2.
• Small-molecule microarrays: development of novel linkers and an efficient detection method for bound proteins.
• Production of an anti-severe acute respiratory syndrome (SARS) coronavirus human monoclonal antibody Fab fragment by using a combinatorial immunoglobulin gene library derived from patients who recovered from SARS.
• Modulation of CD4(+)CD28null T lymphocytes by tumor necrosis factor-alpha blockade in patients with unstable angina.
• Cost-effectiveness of adding granulocyte colony-stimulating factor to primary prophylaxis with antibiotics in small-cell lung cancer.
• Pegylated liposomal doxorubicin and trastuzumab in HER-2 overexpressing metastatic breast cancer: a multicenter phase II trial.
• Technology insight: pharmacoproteomics for cancer--promises of patient-tailored medicine using protein microarrays.
• Phase I trial of thalidomide and interleukin-2 in patients with metastatic renal cell carcinoma.
• Development of an Advanced Hyperspectral Imaging (HSI) System with Applications for Cancer Detection.
• A phase I safety and dose escalation trial of docetaxel combined with GEM231, a second generation antisense oligonucleotide targeting protein kinase A R1alpha in patients with advanced solid cancers.
• Probing a protein-protein interaction by in vitro evolution.
• Long-term complete responses after 131I-tositumomab therapy for relapsed or refractory indolent non-Hodgkin's lymphoma.
• The clinical benefit of pegylated liposomal doxorubicin in patients with metastatic breast cancer previously treated with conventional anthracyclines: a multicentre phase II trial.
• Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine.
• Estrogen enhances the efficacy of an oncolytic HSV-1 mutant in the treatment of estrogen receptor-positive breast cancer.
• Effective therapy of experimental human malignant melanomas with a targeted cytotoxic somatostatin analogue without induction of multi-drug resistance proteins.
• Robust ligand-based modeling of the biological targets of known drugs.
• Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl-2 and Bcl-xL genes.
• Neutralization of interleukin-2 retards the growth of mouse renal cancer.
• Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.
• Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
• Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases.
• Antibody to E1 peptide of hepatitis C virus genotype 4 inhibits virus binding and entry to HepG2 cells in vitro.
• Antisense angiopoietin-1 inhibits tumorigenesis and angiogenesis of gastric cancer.
• A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)(HXB2) Rev/Env or codon-optimized HIV-1(JR-FL) gp120 generates durable immune responses in mice.
• Virology- and immunology-based gene therapy for cancer.
• Synthesis of [11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase.
• A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors.
• A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication.
• A recombinant probiotic for treatment and prevention of cholera.
• Screening and evaluation of human single-chain fragment variable antibody against hepatitis B virus surface antigen.
• Effects of adenovirus-mediated gene transfer of ICOSIg and CTLA4Ig fusion protein on experimental autoimmune myocarditis.
• Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses.
• Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 protein.
• High-efficiency system for the construction of adenovirus vectors and its application to the generation of representative adenovirus-based cDNA expression libraries.
• A herpes simplex virus recombinant that exhibits a single-chain antibody to HER2/neu enters cells through the mammary tumor receptor, independently of the gD receptors.
• Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection.
• Silencing of hepatitis A virus infection by small interfering RNAs.
• Enhanced immunity to breast cancer in mice immunized with fibroblasts transfected with a complementary DNA expression library from breast cancer cells: Enrichment of the vaccine for immunotherapeutic cells.
• In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging.
• Phase II study of MTX-HSA in combination with cisplatin as first line treatment in patients with advanced or metastatic transitional cell carcinoma.
• Improved anti-tumor response rate with decreased cardiotoxicity of non-pegylated liposomal doxorubicin compared with conventional doxorubicin in first-line treatment of metastatic breast cancer in patients who had received prior adjuvant doxorubicin: results of a retrospective analysis.
• Differentiation of hippocampal stem cells into functional neurons: evolving our understanding of monoamine oxidase-A inhibition.
• Moclobemide upregulated Bcl-2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular-regulated kinase pathway.
• Single-drug multiligand conjugates: synthesis and preliminary cytotoxicity evaluation of a paclitaxel-dipeptide "scorpion" molecule.
• Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells.
• Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living mice.
• Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines.
• Folate immobilized and PEGylated adenovirus for retargeting to tumor cells.
• A rapid and efficient in vivo method for determining the biologic efficacy of monoclonal antibodies in animal models of cancer.
• Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis.
• Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register.
• Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials.
• Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients.
• Evaluation of 10 commercial diagnostic kits for in vitro expressed hepatitis B virus (HBV) surface antigens encoded by HBV of genotypes A to H.
• The analytic sensitivity and mutant detection capability of six hepatitis B surface antigen assays.
• Doxorubicin plus interleukin-2 chemoimmunotherapy against breast cancer in mice.
• Therapeutic efficacy of antigen-specific vaccination and toll-like receptor stimulation against established transplanted and autochthonous melanoma in mice.
• Vaccination with human HER-2/neu (435-443) CTL peptide induces effective antitumor immunity against HER-2/neu-expressing tumor cells in vivo.
• Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer.
• Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer.
• Adenovirus-mediated tBid overexpression results in therapeutic effects on p53-resistant hepatocellular carcinoma.
• Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versa.
• Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.
• Randomized comparison of every-2-week darbepoetin alfa and weekly epoetin alfa for the treatment of chemotherapy-induced anemia: the 20030125 Study Group Trial.
• Molecular basis for temperature sensing by an RNA thermometer.
• Oncolytic adenoviral vector carrying the cytosine deaminase gene for melanoma gene therapy.
• Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA.
• The use of high-content screening for the discovery and characterization of compounds that modulate mitotic index and cell cycle progression by differing mechanisms of action.
• Selection and characterization of an HIV-1 gp120-binding affibody ligand.
• Development of hepatitis B oral vaccine using B-cell epitope loaded PLG microparticles.
• PEGylated J591 mAb loaded in PLGA-PEG-PLGA tri-block copolymer for targeted delivery: in vitro evaluation in human prostate cancer cells.
• Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux.
• Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles.
• Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapy.
• Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules.
• Human recombinant antibodies against Plasmodium falciparum merozoite surface protein 3 cloned from peripheral blood leukocytes of individuals with immunity to malaria demonstrate antiparasitic properties.
• Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells.
• Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis.
• Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep.
• Antitumor therapeutic effects of e7 subunit and DNA vaccines in an animal cervical cancer model: antitumor efficacy of e7 therapeutic vaccines is dependent on tumor sizes, vaccine doses, and vaccine delivery routes.
• Construction, purification, and characterization of a chimeric TH1 antagonist.
• Paclitaxel nanoparticle inhibits growth of ovarian cancer xenografts and enhances lymphatic targeting.
• Pegylated liposomal doxorubicin in combination with vinorelbine as salvage treatment in pretreated patients with advanced breast cancer: a multicentre phase II study.
• Immune therapy including dendritic cell based therapy in chronic hepatitis B virus infection.
• An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
• Soluble multimer of recombinant endostatin expressed in E. coli has anti-angiogenesis activity.
• Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ibalpha promoter: in vivo model for platelet-targeting gene therapy.
• Mechanism of enhanced activity of liposome-entrapped aminoglycosides against resistant strains of Pseudomonas aeruginosa.
• Targeting antibacterial agents by using drug-carrying filamentous bacteriophages.
• Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma.
• In vitro and in vivo evaluation of 111In-labeled E. coli heat-stable enterotoxin analogs for specific targeting of human breast cancers.
• Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen.
• SiRNA targeting SHP-1 accelerates angiogenesis in a rat model of hindlimb ischemia.
• Oncolytic measles virus targets high CD46 expression on multiple myeloma cells.
• Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritis.
• Development of a high-throughput screen for soluble epoxide hydrolase inhibition.
• Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors.
• 8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs).
• Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.
• Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.
• An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea.
• Reversing multidrug resistance by RNA interference through the suppression of MDR1 gene in human hepatoma cells.
• Computational redesign of endonuclease DNA binding and cleavage specificity.
• A pilot study of the liposomal MUC1 vaccine BLP25 in prostate specific antigen failures after radical prostatectomy.
• Phase II trial of idiotype vaccination in previously treated patients with indolent non-Hodgkin's lymphoma resulting in durable clinical responses.
• High-throughput screening for the discovery of inhibitors of fatty acid amide hydrolase using a microsome-based fluorescent assay.
• Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects: a pilot study.
• Enhanced baculovirus-mediated transduction of human cancer cells by tumor-homing peptides.
• Efficacy and safety of adalimumab in patients with ankylosing spondylitis: results of a multicenter, randomized, double-blind, placebo-controlled trial.
• Antisense oligonucleotide inhibition of hepatitis C virus genotype 4 replication in HepG2 cells.
• Double-blind, placebo-controlled, randomized trial of granulocyte-colony stimulating factor during postoperative radiotherapy for squamous head and neck cancer.
• Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis.
• Development of first photoresponsive prodrug of paclitaxel.
• Fluorogenic ester substrates to assess proteolytic activity.
• Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties.
• Antibody arrays: technical considerations and clinical applications in cancer.
• The ALIAS Pilot Trial: a dose-escal