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- Effect of methylthiouracil on the colloidopexic capacity of hepatosplenic macrophages through thyroid function depression.
- Efficacy and safety of delavirdine mesylate with zidovudine and didanosine compared with two-drug combinations of these agents in persons with HIV disease with CD4 counts of 100 to 500 cells/mm3 (ACTG 261). ACTG 261 Team.
- Clinical safety and tolerability of montelukast, a leukotriene receptor antagonist, in controlled clinical trials in patients aged > or = 6 years.
- Clinical benefit of very-low-dose perindopril-indapamide combination in hypertension.
- Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients.
- Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind, placebo-controlled, randomized cross-over trial [ISRCTN08745124].
- A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and design.
- Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
- Inhibitor of p42/44 mitogen-activated protein kinase, but not p38 MAPK, attenuated antigen challenge of guinea pig airways in vitro.
- Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria.
- RDP58, a novel immunomodulatory peptide, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalomyelitis.
- Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain.
- ORP150 ameliorates ischemia/reperfusion injury from middle cerebral artery occlusion in mouse brain.
- Is diabetes an independent risk factor for mortality after myocardial infarction? The ARIC (Atherosclerosis Risk in Communities) Surveillance Study.
- Serine protease inhibitor 2A inhibits caspase-independent cell death.
- Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor.
- 4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors.
- Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors.
- Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
- Oxamides as novel NR2B selective NMDA receptor antagonists.
- 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
- Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His-D-Phe-Arg-Trp-NH2]. An additional binding site within the human melanocortin receptor 1?
- Aptamer selection for the inhibition of cell adhesion with fibronectin as target.
- Parallel synthesis and structure-activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors.
- Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
- Randomized phase II trial of docetaxel plus thalidomide in androgen-independent prostate cancer.
- Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial.
- Sodium 4-phenylbutyrate protects against cerebral ischemic injury.
- Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route.
- Excess risk of cancer in patients with primary venous thromboembolism: a national, population-based cohort study.
- Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity.
- Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports.
- Inhibition of papilloma progression by antisense oligonucleotides targeted to HPV11 E6/E7 RNA.
- Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension.
- Risk-benefit profile for raloxifene: 4-year data From the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial.
- Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.
- Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists.
- Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis.
- Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies.
- Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
- BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
- Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.
- Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.
- A central role for inflammation in the pathogenesis of diabetic retinopathy.
- Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.
- Duloxetine in the treatment of depression: a double-blind placebo-controlled comparison with paroxetine.
- Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer.
- Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors.
- Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
- Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.
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