The World Market for Vaccines
This report covers pediatric and adult preventive vaccine products and provides an analysis of therapeutic vaccines for cancer treatment. In assessing the market for vaccine products, Kalorama Information provides sales data for the 2001-2003 historical years, the 2004 base year, and the 2001 through 2010 forecast years. Revenues are expressed in terms of manufacturers’ annual sales and in current U.S. dollars.
The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and e-mail correspondence were the primary method of gathering information. For the purpose of this study, Kalorama Information conducted interviews with key industry officials, consultants, health care providers, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company representatives included marketing directors, division managers, and product representatives.
Pediatric vaccines include the following:
- Combination vaccines
- Diphtheria-tetanus-pertussis (DTP) and diphtheria-tetanus-acellular pertussis (DTaP)
- Hepatits A; Hepatitis B
- Measles-mumps-rubella (MMR)
- Pneumococcal
- Poliovirus
- Varicella
- Others
Adult vaccines include the following:
- Hepatitis A; Hepatitis B
- Influenza
- Pneunomoccal
- Travel; DT; others
In addition to preventive vaccines, the emerging area of therapeutic vaccines for the treatment of cancer is covered, including current revenues from the handful of products now on the market, plus a forecast of revenues for products likely to see approval through 2008.
Table of Contents
Chapter One: Executive Summary
Scope and Methodology
Size and Growth of the Market
Market Trends
Industry Structure and Leading Competitors
Chapter Two: Introduction to Vaccines
A Brief History: The Development of Vaccines
The Immune Response
Mechanism of Action
Types of Vaccines
Attenuated (Weakened) Live Viruses
Killed Whole Vaccines
Toxoid Vaccines
Genetically Engineered/Modified Vaccines
Subunit Vaccines
Conjugate Vaccines
Vaccine Approval Process
DNA Vaccines
Mechanism of Action of DNA Vaccines
Advantages of DNA Vaccines
Therapeutic Vaccines to Treat Cancer
Chapter Three: Pediatric Preventive Vaccines
Overview
Childhood Immunization in the United States
Childhood Immunization Rates
Challenges to the Vaccine Delivery System
Recommended Childhood Immunization Schedule
Pediatric Vaccine Products
BCG Vaccines
Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio Vaccines
Diphtheria
Pertussis
Tetanus
Hepatitis B
Poliomyelitis
Haemophilus Influenzae Type B Vaccines
Hepatitis A Vaccines
Measles, Mumps and Rubella Vaccines
Measles
Mumps
Rubella
Pneumococcal Conjugate Vaccine
Rotavirus Vaccines
Varicella Vaccines
Cost of Vaccines in the United States
Pediatric Vaccines in Development
Global Initiatives for Vaccine Research
Diarrhea-Related Diseases
Rotavirus
Rotavirus Vaccines
Rotavirus Vaccines in Clinical Trials
Enterotoxigenic Escherichia coli
ETEC Vaccines in Clinical Trials
Acute Respiratory Infections
Streptococcus Pneumoniae
Pneumococcal Vaccines
Respiratory Syncytial Virus
RSV Vaccines in Clinical Trials
Parainfluenza Virus Type 3
PIV-3 Vaccines in Clinical Trials
The World Market for Pediatric Preventive Vaccines
Total Market Size and Forecast
DTP and DTaP Vaccine Market
Market Analysis
Leading Products and Competitors
Hepatitis Vaccine Market
Market Analysis
Leading Products and Competitors
Haemophilus Influenzae Type B Vaccine Market
Market Analysis
Leading Products and Competitors
Measles, Mumps and Rubella Vaccines
Market Analysis
Leading Products and Competitors
Combination Vaccines Market
Market Analysis
Leading Products and Competitors
Pneumococcal Vaccine
Market Analysis
Poliovirus Vaccine
Market Analysis
Leading Products and Competitors
Varicella Vaccines
Market Analysis
Leading Products and Competitors
Other Vaccines Market
Market Analysis
Leading Products and Competitors
Chapter Four: Adult Preventive Vaccines
Introduction
Adult Vaccine-Preventable Diseases: Facts and Figures
Global Virological Surveillance Program
Recommendations for Adult Immunizations
Vaccine Recommendations for International Travel
CDC’s Revised Recommendations for Influenza Vaccination for 2004-05 Flu Season
Priority Groups for Influenza Vaccination
Other Vaccination Recommendations
Vaccination of Persons in Nonpriority Groups
Persons Who Should Not Receive Influenza Vaccine
CDC’s Recommendations for Yellow Fever Vaccination
WHO International Health Regulations
Adult Vaccine Products
BCG Vaccines
Cholera Vaccines
Diphtheria-Tetanus Vaccines
Hepatitis Vaccines
Hepatitis A
Hepatitis B
Influenza Vaccines
Japanese Encephalitis Vaccine
Pneumococcal Disease Vaccines
Rabies Vaccine
Typhoid Vaccines
Yellow Fever Vaccines
Adult Vaccines in Development
Global Initiatives for Vaccine Research
Cholera Vaccines
Dengue Fever Vaccines
Epstein-Barr Virus Vaccines
HIV/AIDS
AIDS Vaccines
Helicobacter Pylori Vaccines
Hepatitis Vaccines
Hepatitis C
Hepatitis E
Herpesvirus Vaccines
Leishmaniasis
Severe Acute Respiratory Syndrome
Shigella Vaccine
West Nile Virus
The World Market for Adult Preventive Vaccines
Total Market Size and Forecast
Hepatitis Market
Market Analysis
Leading Products and Competitors
Influenza Vaccine Market
Market Analysis
Leading Products and Competitors
Pneumococcal Vaccine Market
Market Analysis
Leading Products and Competitors
Travel; DT; Miscellaneous Market
Market Analysis
Leading Products and Competitors
Chapter Five: Preventive Vaccines Market Summary
Trends Driving the Preventive Vaccines Market
Market Size and Forecast
Vaccine Market Competitors
Pediatric Vaccines
Major Manufacturer’s Market Share
Adult Vaccines
Major Manufacturer’s Market Share
Chapter Six: Therapeutic Cancer Vaccines
Cancer Vaccine Technology
Cancer Statistics
Available Cancer Vaccines
Bladder Cancer
Colorectal Cancer
Melanoma
Types of Cancers Susceptible to Vaccines
Breast Cancer
Cervical Cancer
Colorectal Cancer
Gastrointestinal Cancer
Stomach
Liver
Pancreas
Kidney
Leukemia
Lung Cancer
Lymphoma
Melanoma
Multiple Myeloma
Neuroblastoma
Ovarian Cancer
Prostate Cancer
Sarcoma
Cancer Vaccine Pipeline
Vaccine Candidates in Phase III
Vaccine Candidates in Phase II
Vaccine Candidates in Phase I
The Emerging Cancer Vaccine Market
Total Market Size and Forecast
Competitor Analysis
Chapter Seven: Issues and Trends
Vaccine Safety
Pre-licensure Evaluation
Post-Licensure Surveillance
Vaccine Adverse Event Reporting System
The Vaccine Safety Datalink Project
The Vaccine Injury Compensation Program
The Future of Vaccine Safety
Vaccine Shortages
Preventing Future Shortages in the U.S.
Financial incentives
Equitable pricing
Utilizing vaccine stockpiles
Impact of Product Divergence on Vaccine Supply in Developing Countries
Vaccines and Bioterrorism
Overview
Project Bioshield Act of 2004
Anthrax
Smallpox
Plague
Botulism
Tularemia
Viral Hemorrhagic Fevers
Innovations in Vaccine Delivery Systems
Edible Vaccines
Mucosal Delivery
Intranasal Delivery
Oral Vaccines
Vaccine Patches
Chapter Eight: Company Profiles
Acambis plc
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
AlphaVax, Inc.
History and Lines of Business
Strategic Alliances
Vaccine Products
Avant Immunotherapeutics
History and Lines of Business
Strategic Alliances
Vaccine Products
Aventis Pasteur
History and Lines of Business
Strategic Alliances
Vaccine products
Financial Information
Bavarian Nordic A/S
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Baxter Healthcare
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Berna Biotech AG
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
BioPort Corporation
History and Lines of Business
Strategic Acquisition and Alliance
Vaccine Products
Chiron Corporation
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Corixa Corporation
History and Lines of Business
Strategic Alliances
Vaccine Products
Epimmune, Inc.
History and Development
Corporate Contract with NIH
Vaccine Products
GlaxoSmithKline
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
ID Biomedical Corporation
History and Lines of Business
Vaccine Products
MedImmune, Inc.
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Merck & Co Inc
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Nabi Biopharmaceuticals
History and Lines of Business
Strategic Alliance
Vaccine Products
Financial Information
Vical Incorporated
History and Lines of Business
Strategic Alliances
Technology Platform
Therapeutic Cancer Vaccine Products in Clinical Trials
Financial Information
Wyeth
History and Lines of Business
Vaccine Products
Financial Information
Appendix A: Vaccine Products
Appendix B: Company Directory
Chapter One: Executive Summary
Table 1-1: Impact of Vaccines in the 20th Century
Table 1-2: The World Vaccines Market by Vaccine Target 2001-2005
Figure 1-1: World Market for Vaccines, by Type, 2001-2010
Figure 1-2: World Market for Vaccines, by Type, 2001, 2005 and 2010
Table 1-3: Major Manufacturer’s Shares of the World Vaccine Market 2003
Figure 1-3: World Vaccines Market Share by Leading Competitors 2003
Chapter Two: Introduction to Vaccines
Table 2-1: Impact of Vaccines in the 20th Century
Table 2-2: Vaccine-Preventable Diseases
Chapter Three: Pediatric Preventive Vaccines
Table 3-1: Global Immunization Score Card: Percentage of Countries and Population Left to Reach by WHO Objective
Table 3-2: Immunization Profile of the United States
Table 3-3: U.S. Recommended Childhood Immunization Schedule, July through December 2004
Table 3-4: Cost of Vaccines: Private Sector Versus Public Sector: Prices Last Reviewed/Updated, August 2004
Table 3-5: Selected Pediatric Vaccines in Development
Table 3-6: World Market for Pediatric Vaccines by Type 2001-2010
Figure 3-1: Market Share of Pediatric Vaccines by Type 2004
Figure 3-2: Market Share of Pediatric Vaccines by Type 2010new FieldsetController( 'Order Online Now_details' );
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