Commercial Insight: Antipsychotics - From Blockbuster Brands to Billion Dollar Generics
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the CNS pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the antipsychotics market - page 3
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 11
- Market definition for this report - page 11
- Current market situation - page 11
- Zyprexa - the gold-standard antipsychotic - page 14
- Strategic scoping and focus - page 19
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 21
- Current and future opportunities and threats in the antipsychotic market - page 21
- Global opportunities and threats - page 21
- Opportunities - page 21
- Threats - page 36
- US - page 42
- Market overview - page 42
- Opportunity - page 43
- Threats - page 46
- Japan - page 51
- Opportunities - page 52
- Threats - page 56
- France - page 58
- Market overview - page 58
- Opportunity - page 59
- Threats - page 60
- Germany - page 63
- Market overview - page 63
- Opportunities - page 64
- Threats - page 68
- Italy - page 72
- Market overview - page 72
- Opportunities - page 73
- Threats - page 75
- Spain - page 77
- Market overview - page 77
- Opportunities - page 78
- Threats - page 79
- UK - page 82
- Market overview - page 82
- Opportunities - page 83
- Threats - page 87
- Global opportunities and threats - page 21
- Current and future opportunities and threats in the antipsychotic market - page 21
- CHAPTER 4 FORECAST ANALYSIS - page 93
- Assumptions and events - page 93
- 2004 - page 93
- Patent genericization of Solian - page 93
- Launch of IM Zyprexa - page 94
- Zyprexa approval for bipolar disorders - page 94
- Risperdal receives approvable letter for autism - page 95
- Risperdal approval for bipolar disorders - page 96
- Risperdal Consta launch - page 96
- Seroquel approval for bipolar mania - page 96
- Geodon approved for bipolar mania - page 97
- Abilify launch in the EU and FDA approval for bipolar mania in the US - page 97
- Poor 2004 performance for Zyprexa - page 98
- 2005 - page 99
- Re-launch of Serdolect - page 99
- Launch of Seroquel in France - page 100
- Abilify lifecycle management - page 100
- 2006 - page 101
- Launch of Asenapine - page 101
- Launch of paliperidone ER - page 101
- Serdolect patent expiry - page 102
- 2007 - page 103
- Zomaril launch - page 103
- Geodon US patent expiry - page 103
- Seroquel patent expiry - page 104
- Launch of Bifeprunox - page 104
- 2008 - page 105
- Seroquel line extension - page 105
- Risperdal patent expiry - page 106
- Launch of ORG-24448 - page 107
- Launch of PNU170413 - page 108
- 2009 - page 108
- Launch of blonanserin - page 108
- Abilify global patent expiry - page 109
- Zomaril patent expiry - page 109
- 2011 - page 110
- Seroquel US patent expiry - page 110
- Zyprexa patent expiry - page 111
- 2004 - page 93
- Limitations of data - page 111
- Forecasts - page 111
- Assumptions and events - page 93
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 112
- Achieving and maintaining market leadership - page 112
- Different strategies leading to differing definitions of market leader - page 112
- Indication expansion - page 112
- Reformulations - page 113
- Specialization or generalization - Zyprexa versus Risperdal - page 114
- Risperdal lifecycle strategies - page 115
- Zyprexa lifecycle strategies - page 129
- Strategies employed by Zyprexa and Risperdal - page 133
- Lifecycle strategies - the pros, the cons and the implications - page 134
- Choice, implementation and outcome of lifecycle strategies - page 136
- BMS outlines future lifecycle strategies for Abilify - page 136
- Different strategies leading to differing definitions of market leader - page 112
- Generic threat to Zyprexa - page 139
- Zyprexa patent challenge - page 139
- Anticipation - page 140
- Obviousness - page 140
- Inequitable conduct - page 140
- Double-patenting - page 141
- Public use - page 141
- Trial outcome - page 141
- The worst case scenario - approval of generic olanzapine - page 142
- The impact of generic olanzapine - page 142
- Zyprexa patent challenge - page 139
- Achieving and maintaining market leadership - page 112
- APPENDIX A - page 146
- Global antipsychotics market data - page 146
- SGA market data - page 147
- Global antipsychotics market data - page 146
- APPENDIX B - page 162
- Key Opinion Leaders - page 162
- Bibliography - page 162
- Journals and abstracts - page 162
- Websites - page 165
- Report methodology - page 169
- Standard units - page 169
- Japanese market data - page 169
- Regional launch dates for new products - page 170
- Additional information - page 170
- About Datamonitor - page 171
- About Datamonitor Healthcare - page 171
- About the CNS analysis team - page 172
- Key therapy team members - page 173
- Lynda Lynch, Director CNS - page 173
- David Abramson, Therapeutic Lead Consultant - page 173
- Disclaimer - page 174
- List of Tables
- Table 1: key players in the SGA market - page 18
- Table 2: Prescriptions (m) of antipsychotics in the US, 2000-03 - page 24
- Table 3: Prescriptions (m) of antipsychotics in the EU, 2000-03 - page 25
- Table 4: Prescriptions (m) of antipsychotics in Japan, 2000-03 - page 25
- Table 5: On and off-label prescription breakdown of the key SGAs in the US market (000s), 2003 - page 31
- Table 6: US antipsychotic market revenues ($m), 2002-03 - page 42
- Table 7: Japanese antipsychotic market revenues ($m), 2002-03 - page 51
- Table 8: French antipsychotic market revenues ($m), 2002-03 - page 58
- Table 9: German antipsychotic market revenues ($m), 2002-03 - page 63
- Table 10: Italian antipsychotic market revenues ($m), 2002-03 - page 72
- Table 11: Spanish antipsychotic market revenues ($m), 2002-03 - page 77
- Table 12: UK antipsychotic market revenues ($m), 2002-03 - page 82
- Table 13: Forecast for Zyprexa revenues ($m) if the patent challenge is up held and alternatively if generic incursion occurs in 2005 - page 144
- Table 14: Historical sales in the antipsychotics market, 2000-2003 (m) - page 146
- Table 15: Zyprexa key facts - page 147
- Table 16: Key Zyprexa events, 2003-2004 - page 148
- Table 17: Risperdal key facts - page 149
- Table 18: Key Risperdal events, 2003-2004 - page 150
- Table 19: Seroquel key facts - page 151
- Table 20: Key Seroquel events, 2003-2004 - page 152
- Table 21: Geodon key facts - page 153
- Table 22: Key Geodon events, 2003-2004 - page 154
- Table 23: Abilify key facts - page 155
- Table 24: Key Abilify, 2003-2004 - page 156
- Table 25: Solian key facts - page 157
- Table 26: Key Solian, 2003-2004 - page 157
- Table 27: Leponex key facts - page 158
- Table 28: Zoleptil key facts - page 159
- Table 29: Serdolect key facts - page 160
- Table 30: The late stage R&D pipeline for new antipsychotic agents, 2004 - page 161
- List of Figures
- Figure 1: Revenue growth, market share and revenues of leading antipsychotics, 2002-03 - page 13
- Figure 2: Market share of the modern SGAs, 1999-2004 - page 14
- Figure 3: Global sales of Zyprexa and key lifecycle events, 1996-2003 - page 17
- Figure 4: Prescriptions rate of antipsychotics in the US, EU and Japan, 2000-03 - page 26
- Figure 5: On and off-label prescription breakdown of the US SGA market by indication, 2000-2003 - page 28
- Figure 6: On and off-label prescription breakdown of the key SGAs in the US market (000s), 2003 - page 32
- Figure 7: Summary of opportunities for the global antipsychotic market and examples of strengths and weaknesses - page 35
- Figure 8: Non-compliance due to fear of antipsychotic side effects, 2004 - page 37
- Figure 9: Summary of threats for the global antipsychotic market and examples of strengths and weaknesses - page 41
- Figure 10: Summary of opportunities for the US antipsychotic market and examples of strengths and weaknesses - page 46
- Figure 11: Summary of threats for the US antipsychotic market and examples of strengths and weaknesses - page 51
- Figure 12: Summary of opportunities for the Japanese antipsychotic market and examples of strengths and weaknesses - page 55
- Figure 13: Summary of threats for the Japanese antipsychotic market and examples of strengths and weaknesses - page 57
- Figure 14: Summary of opportunities for the French antipsychotic market and examples of strengths and weaknesses - page 60
- Figure 15: Summary of threats for the French antipsychotic market and examples of strengths and weaknesses - page 62
- Figure 16: Summary of opportunities for the German antipsychotic market and examples of strengths and weaknesses - page 67
- Figure 17: Summary of threats for the German antipsychotic market and examples of strengths and weaknesses - page 71
- Figure 18: Summary of opportunities for the Italian antipsychotic market and examples of strengths and weaknesses - page 74
- Figure 19: Summary of threats for the Italian antipsychotic market and examples of strengths and weaknesses - page 76
- Figure 20: Summary of opportunities for the Spanish antipsychotic market and examples of strengths and weaknesses - page 79
- Figure 21: Summary of threats for the Spanish antipsychotic market and examples of strengths and weaknesses - page 81
- Figure 22: Summary of opportunities for the UK antipsychotic market and examples of strengths and weaknesses - page 87
- Figure 23: Summary of threats for the UK antipsychotic market and examples of strengths and weaknesses - page 92
- Figure 24: Revenues of Risperdal formulations (US), 1999-2003 - page 121
- Figure 25: Revenues of oral antipsychotic solutions (US), 1999-2003 - page 123
- Figure 26: JNJ's new Risperdal Consta website - page 124
- Figure 27: How well drug formulations could improve patient compliance in schizophrenia, 2004 - page 126
- Figure 28: Revenues of Risperdal Consta since launch (US, EU and Japan) - page 127
- Figure 29: Promotional spend versus revenues for Risperdal, 1999-2004 - page 128
- Figure 30: Global sales of Risperdal and key lifecycle events, 1993-2003 - page 129
- Figure 31: US revenues of rapid-acting IM injectables, 2000-04 - page 131
- Figure 32: Revenues of Zyprexa formulations (US), 1999-2003 - page 132
- Figure 33: Revenues of dissolvable SGA tablets, 2000-2004 - page 134
- Figure 34: Alternate SGA forecast, 2004-2014 - page 145
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