Commercial Insight: Migraine - A Painful Future for the Triptans?
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the CNS pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the migraine market - page 3
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 11
- Market definition for this report - page 11
- Disease overview - page 11
- Etiology - page 11
- Epidemiology - page 12
- Segmentation of migraine - page 13
- Current market situation - page 15
- Key players - page 16
- Strategic scoping and focus - page 17
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 18
- Current and future opportunities and threats in the migraine market - page 18
- Global opportunities and threats - page 18
- Opportunities - page 18
- Threats - page 21
- US: opportunities and threats - page 28
- Market overview - page 28
- Opportunities - page 29
- Threats - page 32
- Japan: opportunities and threats - page 35
- Market overview - page 35
- Opportunities - page 37
- Threats - page 39
- France: opportunities and threats - page 41
- Market overview - page 41
- Opportunities - page 41
- Threats - page 42
- Germany: opportunities and threats - page 45
- Market overview - page 45
- Opportunities - page 45
- Threats - page 46
- Italy: opportunities and threats - page 51
- Market overview - page 51
- Opportunities - page 52
- Threats - page 53
- Spain: opportunities and threats - page 58
- Market overview - page 58
- Opportunities - page 58
- Threats - page 60
- UK: opportunities and threats - page 64
- Market overview - page 64
- Opportunities - page 64
- Threats - page 67
- Global opportunities and threats - page 18
- Current and future opportunities and threats in the migraine market - page 18
- CHAPTER 4 FORECAST ANALYSIS - page 73
- Factors affecting the market - page 73
- Topamax approved for migraine prophylaxis in the US - page 73
- Generic Topamax enters US market - page 74
- Forecasting assumptions and events - page 74
- 2004 - page 74
- Frovatriptan launched in Italy - page 74
- 2005 - page 75
- Zolmitriptan nasal spray launch in Japan - page 75
- 2006 - page 75
- Frovatriptan gains approval for MAM - page 75
- MT-400 (Trexima) launched - page 76
- 2007 - page 77
- Launch of donitriptan - page 77
- GSK/Aradigm's needleless formulation of sumatriptan launched - page 78
- 2008 - page 79
- Naratriptan launched in Japan - page 79
- Nimodipine launched - page 79
- Olcegepant launched in first market - page 80
- 2009 - page 81
- Launch of almotriptan in Japan - page 81
- Generic sumatriptan enters US market - page 81
- Arius/Atrix's transmucosal formulation of sumatriptan launched - page 82
- 2010 - page 82
- Naratriptan US patent expiry - page 82
- NovaDel's sublingual sumatriptan formulation launched - page 83
- 2012 - page 83
- Rizatriptan and frovatriptan US patent expiries - page 83
- 2013 - page 83
- Zolmitriptan and eletriptan US patent expiries - page 83
- 2004 - page 74
- Limitations of data - page 84
- Forecasts - page 84
- Factors affecting the market - page 73
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 85
- Case study: Sumatriptan patent expiry-GSK's strategic options - page 85
- Introduction - page 85
- GSK's current position in the migraine market - page 85
- Sumatriptan - page 85
- Naratriptan - page 87
- The strategic challenge-facing the threat of patent expiry - page 88
- Patent expiry is not a new challenge for GSK - page 88
- Augmentin - page 89
- Wellbutrin - page 89
- Paxil - page 90
- Summary of GSK's previous patent expiry management strategies - page 92
- GSK's current and future activities to manage the threat of sumatriptan generic erosion - page 92
- Imitrex reformulation - page 93
- Novel indication for Imitrex - page 94
- Launching a replacement drug - page 94
- Refocus on alternative oral triptan for migraine - page 94
- Inhalation delivery-a potential additional opportunity for GSK? - page 95
- Summary - page 95
- Case study: Promoting migraine prophylaxis - page 96
- Current treatments - page 96
- Anticonvulsants - page 96
- Antidepressants - page 97
- Beta-blockers - page 97
- Serotonergic agents - page 97
- Others - page 97
- Unmet needs - page 98
- Greater efficacy - page 98
- Fewer side effects - page 98
- Migraine-specific drug - page 98
- Use of triptans for prophylaxis - page 98
- Datamonitor recommendations - page 100
- Current treatments - page 96
- Case study: Sumatriptan patent expiry-GSK's strategic options - page 85
- APPENDIX A-MARKET DATA AND MAJOR BRAND KEY FACTS - page 102
- Global migraine market data - page 102
- Triptans market data - page 103
- APPENDIX B - page 107
- Contributing experts - page 107
- Bibliography - page 107
- Epidemiology - page 109
- Clinical trial data - page 109
- Websites - page 110
- Report methodology - page 111
- Standard units - page 111
- Japanese market data - page 111
- Regional launch dates for new products - page 112
- Additional information - page 112
- About Datamonitor - page 113
- About Datamonitor Healthcare - page 113
- About the CNS analysis team - page 114
- Key therapy team members - page 115
- Lynda Lynch, Director CNS - page 115
- David Abramson, Therapeutic Lead Consultant - page 115
- Disclaimer - page 116
- List of Tables
- Table 1: Prevalence of migraine in the seven major markets - page 13
- Table 2: Key triptan brands - page 16
- Table 3: Other acute migraine drugs - page 17
- Table 4: Key brands in migraine prophylaxis - page 17
- Table 5: The US migraine market sales and share - page 28
- Table 6: The Japanese migraine market sales and share - page 35
- Table 7: The French migraine market sales and share - page 41
- Table 8: The German migraine market sales and share - page 45
- Table 9: The Italian migraine market sales and shares - page 51
- Table 10: The Spanish migraine market sales and share - page 58
- Table 11: The UK migraine market sales and share - page 64
- Table 12: Comparative action across triptan brands - page 87
- Table 13: Historical sales of the leading migraine drugs ($m), 2000-03* - page 102
- Table 14: Sumatriptan: key facts - page 103
- Table 15: Naratriptan: key facts - page 103
- Table 16: Zolmitriptan: key facts - page 104
- Table 17: Rizatriptan: key facts - page 104
- Table 18: Almotriptan: key facts - page 105
- Table 19: Eletriptan: key facts - page 105
- Table 20: Frovatriptan: key facts - page 106
- List of Figures
- Figure 1: Summary of global opportunities for the migraine market and examples of influencing strengths/weaknesses - page 21
- Figure 2: Summary of global threats for the migraine market and examples of influencing strengths/weaknesses - page 27
- Figure 3: Summary of opportunities in the US migraine market and examples of influencing strengths/weaknesses - page 31
- Figure 4: Summary of threats in the US migraine market and examples of influencing strengths/weaknesses - page 34
- Figure 5: Summary of opportunities in the Japanese migraine market and examples of influencing strengths/weaknesses - page 39
- Figure 6: Summary of threats in the Japanese migraine market and examples of influencing strengths/weaknesses - page 40
- Figure 7: Summary of opportunities in the French migraine market and examples of influencing strengths/weaknesses - page 42
- Figure 8: Summary of threats in the French migraine market and examples of influencing strengths/weaknesses - page 44
- Figure 9: Summary of opportunities in the German migraine market and examples of influencing strengths/weaknesses - page 46
- Figure 10: Summary of threats in the German migraine market and examples of influencing strengths/weaknesses - page 50
- Figure 11: Summary of opportunities in the Italian migraine market and examples of influencing strengths/weaknesses - page 53
- Figure 12: Summary of threats in the Italian migraine market and examples of influencing strengths/weaknesses - page 57
- Figure 13: Summary of opportunities in the Spanish migraine market and examples of influencing strengths/weaknesses - page 60
- Figure 14: Summary of threats in the Spanish migraine market and examples of influencing strengths/weaknesses - page 63
- Figure 15: Summary of opportunities in the UK migraine market and examples of influencing strengths/weaknesses - page 67
- Figure 16: Summary of threats in the UK migraine market and examples of influencing strengths/weaknesses - page 72
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