Commercial Perspectives: Multiple Sclerosis - How to Find Opportunities in an Unremitting Market
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- CHAPTER 1 EXECUTIVE SUMMARY - page 5
- Scope of the analysis - page 5
- Datamonitor insight into the multiple sclerosis market - page 6
- The MS market has continued to grow, with revenues increasing by 23.4% in 2003, in a market valued at $2.8 billion. Biogen-IDEC's Avonex remains market leader, although with the continued, rapid uptake of Rebif in the US, Avonex's days at the top are numbered. Furthermore, the MS market is set to undergo considerable change over the forecast period, with the launch of novel MS drugs and the potential threat of generics. Manufacturers will therefore have to adopt novel lifecycle initiatives if they wish to survive. - page 7
- Increasingly, manufacturers are seeking co-development and marketing agreements in order to increase the marketing strength of their products and to penetrate new markets. Elan/Biogen-IDEC's anticipated launch of Antegren in 2005, and Serono's acquisition of Novantrone in the US market, indicates the future role of combination therapies in MS. However, manufacturers will have to provide clear efficacy data and affordable pricing strategies for such combinations to become widely used. - page 8
- Efficacy remains the primary unmet need of MS treatment. As yet, no drug has been approved for the treatment of primary progressive MS (PPMS), the most aggressive form of MS, with a number of drugs having previously failed clinical trials. Datamonitor has highlighted potential strategies to increase the chance of drug approval for PPMS; although it does not believe any of the currently marketed drugs will gain an indication in this niche market. - page 10
- Summary - page 12
- TABLE OF CONTENTS - page 22
- CHAPTER 2 MARKET SEGMENTATION & DEFINITION - page 23
- Strategic scoping and focus - page 24
- Market definition - page 25
- Diagnostic definitions - page 25
- Marketed drugs - page 27
- The gold standard in MS - page 28
- Comparison of key brands - page 28
- CHAPTER 3 GLOBAL MARKET OVERVIEW - page 34
- Multiple sclerosis market analysis - page 35
- Seven major market forecast - page 38
- R&D MS drugs - page 41
- Rebif - page 46
- Drug overview - page 47
- Rebif strategic analysis - page 48
- Rebif revenues to date - page 53
- Rebif forecast to 2012 - page 56
- Avonex - page 61
- Drug overview - page 63
- Avonex strategic analysis - page 63
- Avonex revenues to date - page 66
- Forecast to 2012 - page 71
- Betaseron/Betaferon - page 74
- Drug overview - page 75
- Betaseron strategic analysis - page 77
- Betaseron revenues to date - page 82
- Forecast to 2012 - page 86
- Copaxone - page 88
- Drug overview - page 89
- Copaxone strategic analysis - page 91
- Copaxone revenues to date - page 95
- Forecast to 2012 - page 98
- Novantrone - page 100
- Drug overview - page 101
- Novantrone strategic analysis - page 102
- Novantrone revenues to date - page 105
- Forecast to 2012 - page 107
- Alfaferone - page 109
- Multiple sclerosis market analysis - page 35
- CHAPTER 4 PORTFOLIO AND LIFECYCLE MANAGEMENT - page 110
- Portfolio management - page 111
- Market attractiveness - page 111
- Positioning of the major MS market players - page 118
- Portfolio analysis - page 122
- Lifecycle management - page 129
- MS product lifecycle - page 129
- Optimizing peak sales and revenue protection strategies - page 134
- Threatening generic penetration - page 138
- Portfolio management - page 111
- CHAPTER 5 STRATEGIC PRODUCT POSITIONING - page 144
- Physician-focused product positioning - page 145
- Physician definition - page 145
- Brand imaging - page 146
- Product-specific websites and promotional literature - page 147
- Company health information websites - page 153
- Independent MS websites - page 155
- Treatment guidelines - page 159
- The cannabis debate - page 160
- Pricing and reimbursement - page 164
- Reimbursement - page 166
- Pricing data for key products across the seven major markets - page 170
- List of tables - page 174
- List of figures - page 175
- Key Opinion Leaders - page 176
- Bibliography - page 176
- Conference abstracts - page 176
- Journal articles - page 176
- Websites - page 178
- Report methodology - page 180
- Date of research completion - page 180
- About Datamonitor - page 181
- About Datamonitor Healthcare - page 181
- Datamonitor Healthcare's research and analysis methodologies - page 182
- Datamonitor Healthcare's therapy area capabilities - page 182
- About the CNS analysis team - page 183
- Key therapy team members - page 183
- Disclaimer - page 185
- Physician-focused product positioning - page 145
- List of Tables
- Table 1: Drug revenues, 2003 - page 3
- Table 2: Key parameters of the MS market to 2012 - page 12
- Table 3: Market forecast for currently marketed MS products to 2012 - page 13
- Table 4: Classification of MS - page 25
- Figure 3: Timeline: the launch dates of MS therapies, 1993-2002 - page 28
- Table 5: Comparison of marketed MS brands - page 29
- Table 6: MS market forecast, 2003-12 - page 40
- Table 7: R&D drugs, 2004 - page 41
- Table 8: Rebif: key facts - page 46
- Table 9: Key Rebif events, 2003-04 - page 47
- Table 10: Avonex: key facts - page 61
- Table 11: Key Avonex events, 2003-04 - page 62
- Table 12: Betaseron: key facts - page 74
- Table 13: Key Betaseron events, 2003-04 - page 75
- Table 14: Copaxone: key facts - page 88
- Table 15: Key Copaxone events, 2003-04 - page 89
- Table 16: Novantrone: key facts - page 100
- Table 17: Key Novantrone events, 2003-04 - page 101
- Table 18: Total CNS and MS drug performance of the MS manufacturers, 2003 - page 118
- Table 19: Growth in ethical, CNS and MS drug revenues for the MS manufacturers, 2002-03 - page 119
- Table 20: Overview of multiple sclerosis pipeline and key players' marketed drugs - page 122
- Table 21: Biogen-IDEC's MS portfolio to 2012 - page 123
- Table 22: Serono's MS portfolio to 2012 - page 125
- Table 23: Oral formulations in the late-stage MS pipeline, 2004 - page 136
- Table 24: Future biogeneric threats - page 139
- Table 25: Health information websites - page 154
- Table 26: Key themes pursued by major MS manufacturers at the AAN, 2004 - page 164
- Table 27: Selected market pricing data for MS drugs - page 171
- List of Figures
- Figure 1: Key drivers in the MS market to 2012 - page 12
- Figure 2: Types of MS - page 26
- Figure 4: Comparison of MS brands - page 30
- Figure 5: Annual comparative class contribution to the MS market growth, 1999-2003 - page 36
- Figure 6: Revenue growth of MS drugs, 1999-2003 - page 37
- Figure 7: MS market forecast, 2003-12 - page 39
- Figure 8: SWOT analysis of Rebif, 2004 - page 48
- Figure 9: Rebif revenues and growth, 1999-2003 - page 54
- Figure 10: Rebif forecast, 2004-12 - page 56
- Figure 11: SWOT analysis of Avonex, 2004 - page 63
- Figure 12: Avonex revenues and growth, 1999-2003 - page 67
- Figure 13: Avonex forecast, 2004-12 - page 71
- Figure 14: SWOT analysis of Betaseron, 2004 - page 77
- Figure 15: Betaseron revenues and growth, 1999-2003 - page 82
- Figure 16: Betaseron forecast, 2004-12 - page 86
- Figure 17: SWOT analysis of Copaxone, 2003 - page 91
- Figure 18: Copaxone revenues and growth (1999-2003) - page 95
- Figure 19: Copaxone forecast, 2004-12 - page 98
- Figure 20: SWOT analysis of Novantrone, 2003 - page 102
- Figure 21: US Novantrone revenues and growth, 1999-2003 - page 105
- Figure 22: US Novantrone forecast, 2004-12 - page 108
- Figure 23: Competitive attractiveness of the MS market, 2003-12 - page 111
- Figure 24: Comparative attractiveness of beta-interferons versus other drug classes, 2003-12 - page 117
- Figure 25: Positioning of MS drug manufacturer portfolios, 2002-03 - page 121
- Figure 26: Global sales of Betaseron, 1993-2003 - page 129
- Figure 27: Medical professionals diagnosing MS - page 145
- Figure 28: Medical professionals treating MS - page 146
- Figure 29: Avonex: Strong all week long - page 147
- Figure 30: Rebif: promotion of efficacy - page 149
- Figure 31: Betaseron: BETA Nurses - page 150
- Figure 32: Copaxone's leading message - page 151
- Figure 33: Novantrone: Patient Resources - page 152
- Figure 34: MultipleSclerosis.com homepage - page 156
- Figure 35: MSIF website sponsors - page 158
- Figure 36: Pricing strategies in the MS market - page 170
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