Commercial Insight: Parkinson's Disease - Increased Focus on Earlier Treatment and Managing Levodopa
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the CNS pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the Parkinson's disease market - page 3
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 10
- Market definition for this report - page 10
- Current market situation - page 10
- Levodopa still the gold standard in Parkinson's disease - page 11
- Key players - page 14
- Strategic scoping and focus - page 15
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 16
- Current and future opportunities and threats in the Parkinson's disease market - page 16
- Global opportunities and threats - page 16
- Opportunities - page 16
- Threats - page 19
- US: opportunities and threats - page 21
- Opportunities - page 21
- Threats - page 24
- Japan: opportunities and threats - page 27
- Opportunities - page 27
- Threats - page 29
- France: opportunities and threats - page 30
- Opportunities - page 30
- Threats - page 32
- Germany: opportunities and threats - page 35
- Opportunities - page 35
- Threats - page 37
- Italy: opportunities and threats - page 40
- Opportunities - page 40
- Threats - page 42
- Spain: opportunities and threats - page 45
- Opportunities - page 45
- Threats - page 46
- UK: opportunities and threats - page 49
- Opportunities - page 49
- Threats - page 52
- Global opportunities and threats - page 16
- Current and future opportunities and threats in the Parkinson's disease market - page 16
- CHAPTER 4 FORECAST ANALYSIS - page 56
- Assumptions and events - page 56
- 2004 - page 56
- Continuing decline in sales of Tasmar (tolcapone) - page 56
- Declining sales of branded dopaminergics - page 56
- Growth in sales of entacapone compounds due to roll out of Stalevo - page 57
- Declining sales of Permax (pergolide) due to generic competition - page 58
- Ongoing safety concerns with pergolide negatively impact sales of ergot-derived dopamine agonists - page 58
- Pramipexole launched in Japan and France - page 59
- Approval of Apokyn - page 60
- Rasagiline launched - page 60
- 2005 - page 62
- Rotigotine CDS launched - page 62
- Requip CR launched - page 63
- 2006 - page 64
- Cabaser faces generic competition - page 64
- 2007 - page 65
- Launch of istradefylline (KW-6002) - page 65
- TCH-346 launched - page 65
- Comtan patent expiry - page 66
- 2008 - page 67
- Generic versions of ropinirole immediate release launched in US - page 67
- Launch of CEP-1347 - page 67
- 2009 - page 68
- Sarizotan launched - page 68
- 2010 - page 68
- Stalevo patent expires - page 68
- Availability of generic pramipexole - page 69
- 2004 - page 56
- Limitations of data - page 70
- Forecasts - page 70
- Assumptions and events - page 56
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 71
- Market penetration and brand positioning - page 71
- Case study: GSK and Pfizer target early-stage patients - page 72
- Case study: Novartis and Bertek target patients with advanced PD - page 74
- Lifecycle management and revenue protection strategies - page 76
- Case study: GSK focuses on reformulation and additional indications - page 77
- Case study: Novartis launches Comtan combination therapy - page 78
- Stakeholder product positioning - page 78
- Case study: Novartis educates patients - page 79
- Market penetration and brand positioning - page 71
- APPENDIX A - MARKET DATA AND MAJOR BRAND KEY FACTS - page 82
- Global Parkinson's disease market data - page 82
- Dopaminergic market data - page 83
- Dopamine agonist market data - page 86
- Catechol-O-methyltransferase (COMT)-inhibitors - page 94
- R&D drugs - page 98
- APPENDIX B - page 99
- Contributing experts - page 99
- Bibliography - page 100
- Market definition and overview - page 100
- Country market assessments - page 100
- Forecast analysis - page 101
- Commercial impact and lifecycle management - page 102
- Websites - page 102
- Report methodology - page 105
- Standard units - page 105
- Japanese market data - page 105
- Indications - page 106
- Regional launch dates for new products - page 106
- Additional information - page 106
- About Datamonitor - page 107
- About Datamonitor Healthcare - page 107
- About the CNS analysis team - page 108
- Key therapy team members - page 109
- Lynda Lynch, Director CNS - page 109
- Disclaimer - page 110
- List of Tables
- Table 1: Key players in the Parkinson's disease market - page 14
- Table 2: Historical sales in the Parkinson's disease market, 2000-03 - page 82
- Table 3: Madopar: key facts - page 83
- Table 4: Sinemet: key facts - page 84
- Table 5: Key Sinemet events, 2003-04 - page 85
- Table 6: Requip: key facts - page 86
- Table 7: Key ropinirole events, 2003-04 - page 87
- Table 8: Mirapex: key facts - page 88
- Table 9: Key pramipexole events, 2003-04 - page 89
- Table 10: Parlodel: key facts - page 90
- Table 11: Permax: key facts - page 91
- Table 12: Key pergolide events, 2003-04 - page 92
- Table 13: Cabaser: key facts - page 93
- Table 14: Tasmar: key facts - page 94
- Table 15: Comtan: key facts - page 95
- Table 16: Key entacapone events, 2003-04 - page 95
- Table 17: Stalevo: key facts - page 96
- Table 18: Key Stalevo events, 2003-04 - page 97
- Table 19: Key compounds in development for Parkinson's disease, 2004 - page 98
- List of Figures
- Figure 1: Development of the Parkinson's disease classes and leading drugs within each class, 1960-2004 - page 11
- Figure 2: Current recommendations for management of Parkinson's disease - page 12
- Figure 3: Sales of Parkinson's disease drug classes across seven major markets, 2002-03 - page 13
- Figure 4: Summary of global opportunities for PD market and examples of influencing strengths/weaknesses - page 18
- Figure 5: Summary of global threats for PD market and examples of influencing strengths/weaknesses - page 21
- Figure 6: Summary of US opportunities for PD market and examples of influencing strengths/weaknesses - page 24
- Figure 7: Summary of US threats for PD market and examples of influencing strengths/weaknesses - page 27
- Figure 8: Summary of Japan opportunities for PD market and examples of influencing strengths/weaknesses - page 28
- Figure 9: Summary of Japan threats for PD market and examples of influencing strengths/weaknesses - page 30
- Figure 10: Summary of France opportunities for PD market and examples of influencing strengths/weaknesses - page 32
- Figure 11: Summary of France threats for PD market and examples of influencing strengths/weaknesses - page 35
- Figure 12: Summary of Germany opportunities for PD market and examples of influencing strengths/weaknesses - page 37
- Figure 13: Summary of Germany threats for PD market and examples of influencing strengths/weaknesses - page 40
- Figure 14: Summary of Italy opportunities for PD market and examples of influencing strengths/weaknesses - page 42
- Figure 15: Summary of Italy threats for PD market and examples of influencing strengths/weaknesses - page 45
- Figure 16: Summary of Spain opportunities for PD market and examples of influencing strengths/weaknesses - page 46
- Figure 17: Summary of Spain threats for PD market and examples of influencing strengths/weaknesses - page 48
- Figure 18: Summary of UK opportunities for PD market and examples of influencing strengths/weaknesses - page 52
- Figure 19: Summary of UK threats for PD market and examples of influencing strengths/weaknesses - page 55
- Figure 20: US sales of Comtan versus Tasmar, 1999-2000 - page 75
- Figure 21: Novartis's patient education website - page 80
- Figure 22: Parkinsonpoly website - page 81
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