Stakeholder Insight: HIV Related Neuropathic Pain - Useful Niche for Peripheral Companies
Fueled by the growing interest in neuropathic pain but keen to avoid competition with larger players, small companies recognize the commercial opportunity of the HIV-related neuropathic pain (HIVNP) market. Not only does HIVNP offer a well-served patient base and good awareness, it is also a useful stepping-stone to larger more prevalent neuropathic pain types and thus greater commercial gains.
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- 1.1 Scope of the Analysis - page 3
- 1.2 Datamonitor insight into HIV-related neuropathic pain - page 3
- Neuropathic pain affects over 480,000 people with HIV across the seven major pharmaceutical markets. In countries such as the US and the UK there is a strong therapeutic relationship between HIVNP patients and HIV specialists. Although patients tend to be well served and treatment initiated reasonably early, there is still a need to educate HIV physicians on HIVNP management. - page 4
- The tricyclic antidepressant amitriptyline is a popular treatment of neuropathic pain across the seven markets, although its side effects are intolerable to many HIVNP patients. The newer SNRI class of antidepressants, however, appears to offer a cleaner side effect profile with equivalent analgesic ability. A key advantage of these drugs is that, given the high prevalence of comorbid depression among HIV sufferers, they possess a dual therapeutic action thus reducing the all important pill burden. - page 5
- In the long-term, the future HIVNP market will see the launch of pathogenesis-based therapies, such as nerve growth factor agonists. However, while the search for effective neurotrophic compounds that can halt or ideally reverse nerve damage causing HIVNP continues, analgesics will remain an important part of pain management. - page 6
- Summary - page 7
- 1.3 HIV-related neuropathic pain Insight: methodology - page 8
- TABLE OF CONTENTS - page 10
- CHAPTER 2 INTRODUCTION - page 16
- CHAPTER 3 PATIENT POTENTIAL - page 17
- 3.1 Definition and classification of HIV related neuropathy - page 17
- 3.2 Epidemiology across the seven major markets - page 18
- Prevalence - page 18
- Breakdown by severity - page 19
- CHAPTER 4 ASSESSMENT AND TREATMENT - page 22
- 4.1 Referral patterns - page 22
- Overview - page 22
- US - page 23
- France - page 24
- Germany - page 24
- Italy - page 25
- UK - page 25
- 4.2 Importance of therapeutic endpoints on prescribing decisions - page 27
- Overview - page 27
- US - page 28
- France - page 28
- Germany - page 29
- Italy - page 30
- UK - page 30
- 4.3 Pharmacotherapy - page 31
- Introduction - page 31
- 4.4 Treatment of HIV-related neuropathic pain in five major markets - page 32
- Profiles of commonly used drugs - page 32
- US - page 38
- France - page 41
- Germany - page 45
- Italy - page 49
- UK - page 52
- 4.5 R&D drugs - page 57
- Pipeline overview - page 57
- NGX-4010 - page 58
- Prosaptide - page 59
- 4.6 Unmet needs - page 59
- Improved pain relief and reduced pill burden - page 59
- Improved diagnosis and early intervention - page 60
- Improved HIVNP drug efficacy measures - page 60
- Minimal drug interactions - page 61
- 4.1 Referral patterns - page 22
- CHAPTER 5 APPENDIX A - page 62
- 5.1 Bibliography - page 62
- References - page 62
- Websites - page 65
- 5.2 Contributing experts - page 65
- 5.3 Physician research methodology - page 68
- Introduction - page 68
- Our research partners - page 70
- Research objectives - page 71
- Questionnaire development - page 73
- Research methodology - page 74
- Data processing - page 76
- Quality control - page 76
- 5.4 Neuropathic Pain Insight Questionnaire - page 76
- 5.1 Bibliography - page 62
- CHAPTER 6 APPENDIX B - page 83
- 6.1 About Datamonitor - page 83
- About Datamonitor Healthcare - page 83
- Datamonitor Healthcare's research and analysis methodologies - page 84
- 6.2 Datamonitor Healthcare's therapy area capabilities - page 84
- About the CNS analysis team - page 85
- Datamonitor Healthcare's Consulting expertise - page 86
- Key therapy team members - page 87
- About the Author - page 88
- Disclaimer - page 90
- 6.1 About Datamonitor - page 83
- List of Tables
- Table 1: Sample size of the HIV-related neuropathic pain Insight study - page 8
- Table 2: Rate of peripheral neuropathy associated with key antiretroviral drugs - page 17
- Table 3: The HIVNP patient population across the seven major markets, 2003 - page 19
- Table 4: HIVNP referral patterns across five major markets, 2003 - page 22
- Table 5: Referral patterns of HIVNP patients in the US, 2003 - page 23
- Table 6: Referral patterns of HIVNP patients in France, 2003 - page 24
- Table 7: Referral patterns of HIVNP patients in Germany, 2003 - page 25
- Table 8: Referral patterns of HIVNP patients in Italy, 2003 - page 25
- Table 9: Referral patterns of HIVNP patients in the UK, 2003 - page 26
- Table 10: Importance of key therapeutic endpoints in HIVNP according to US physicians, 2003 - page 28
- Table 11: Importance of key therapeutic endpoints in HIVNP according to physicians in France, 2003 - page 29
- Table 12: Importance of key therapeutic endpoints in HIVNP according to physicians in Germany, 2003 - page 29
- Table 13: Importance of key therapeutic endpoints in HIVNP according to physicians in Italy, 2003 - page 30
- Table 14: Importance of key therapeutic endpoints in HIVNP according to physicians in the UK, 2003 - page 31
- Table 15: Top ten first-line treatments of HIVNP in the US, 2003 - page 39
- Table 16: Progression of HIVNP patients to second-line therapy in the US, 2003 - page 40
- Table 17: Top ten most widely adopted second-line treatments of HIVNP in the US, 2003 - page 40
- Table 18: Progression of HIVNP patients to third-line therapy in the US, 2003 - page 41
- Table 19: Top ten most widely adopted third-line treatments of HIVNP in the US, 2003 - page 41
- Table 20: Top ten first-line treatments of HIVNP in France, 2003 - page 43
- Table 21: Progression of HIVNP patients to second-line therapy in France, 2003 - page 43
- Table 22: Top ten most widely adopted second-line treatments of HIVNP in France, 2003 - page 44
- Table 23: Progression of HIVNP patients to third-line therapy in France, 2003 - page 44
- Table 24: Top ten most widely adopted third-line treatments of HIVNP in France, 2003 - page 45
- Table 25: Top ten first-line treatments of HIVNP in Germany, 2003 - page 46
- Table 26: Progression of HIVNP patients to second-line therapy in Germany, 2003 - page 47
- Table 27: Top ten most widely adopted second-line treatments of HIVNP in Germany, 2003 - page 47
- Table 28: Progression of HIVNP patients to third-line therapy in Germany, 2003 - page 48
- Table 29: Top ten most widely adopted third-line treatments of HIVNP in Germany, 2003 - page 49
- Table 30: Top first-line treatments of HIVNP in Italy, 2003 - page 50
- Table 31: Progression of HIVNP patients to second-line therapy in Italy, 2003 - page 51
- Table 32: Top ten most widely adopted second-line treatments of HIVNP in Italy, 2003 - page 51
- Table 33: Progression of HIVNP patients to third-line therapy in Italy, 2003 - page 52
- Table 34: Top ten most widely adopted third-line treatments of HIVNP in Italy, 2003 - page 52
- Table 35: Top first-line treatments of HIVNP in the UK, 2003 - page 54
- Table 36: Progression of HIVNP patients to second-line therapy in the UK, 2003 - page 55
- Table 37: Top most widely adopted second-line treatments of HIVNP in the UK, 2003 - page 55
- Table 38: Progression of HIVNP patients to third-line therapy in the UK, 2003 - page 56
- Table 39: Top ten most widely adopted third-line treatments of HIVNP in the UK, 2003 - page 56
- Table 40: R&D compounds for HIVNP, 2004 - page 57
- Table 41: Stakeholder and Multiclient Insight Studies by Therapy Area, 2003 - page 69
- List of Figures
- Figure 1: Breakdown of HIVNP patients by pain severity in the US, 2003 - page 19
- Figure 2: Breakdown of HIVNP patients by pain severity in France, 2003 - page 20
- Figure 3: Breakdown of HIVNP patients by pain severity in Germany, 2003 - page 20
- Figure 4: Breakdown of HIVNP patients by pain severity in Italy, 2003 - page 21
- Figure 5: Breakdown of HIVNP patients by pain severity in the UK, 2003 - page 21
- Figure 6: Importance of key therapeutic endpoints in HIVNP, 2003 - page 27
- Figure 7: Top three most widely adopted first-line treatments across five major markets, 2003 - page 33
- Figure 8: Summary of HIVNP treatment in the US, 2003 - page 38
- Figure 9: Summary of HIVNP treatment in France, 2003 - page 42
- Figure 10: Summary of HIVNP treatment in Germany, 2003 - page 45
- Figure 11: Summary of HIVNP treatment in Italy, 2003 - page 50
- Figure 12: Summary of HIVNP treatment in the UK, 2003 - page 53
- Figure 13: Primary Research Process - page 70
- Figure 14: Datamonitor's Healthcare Consultancy - page 86
- Figure 15: Datamonitor Healthcare's Therapeutic Consulting capabilities - page 87
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