Commercial and Pipeline Perspectives: Obesity - Super-sized Epidemic
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Cardiovascular pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Scope of the analysis - page 3
- Datamonitor insight into the anti-obesity drug market - page 4
- Summary - page 10
- Key metrics - page 12
- CHAPTER 2 PATIENT POTENTIAL - page 21
- Definition of obesity - page 21
- Causes of obesity - page 21
- Obesity prevalence - page 23
- Obesity prevalence - page 23
- Obesity forecasts - page 26
- Obesity prevalence methodology - page 31
- US - page 31
- Japan - page 31
- France - page 32
- Germany - page 32
- Italy - page 32
- Spain - page 32
- UK - page 33
- Forecast methodology - page 33
- Prevalence of obesity in juveniles - page 33
- Segmentation of obesity - page 34
- Overview of guidelines - page 37
- Unmet needs in obesity - page 40
- More cost-effective care - page 40
- Increased patient knowledge and physician awareness - page 41
- Safe and tolerable drugs - page 41
- Drugs with greater efficacy - page 41
- Improved patient compliance - page 42
- CHAPTER 3 GLOBAL MARKET OVERVIEW - page 44
- Overview of the global anti-obesity drug market - page 44
- US - page 46
- National organizations - page 48
- Awareness campaigns - page 49
- Japan - page 52
- Takeda - page 52
- Europe - page 53
- European initiatives - page 53
- UK - page 59
- Awareness campaigns - page 59
- Global market forecast - page 63
- US - page 46
- Overview of the global anti-obesity drug market - page 44
- CHAPTER 4 DRUG ANALYSIS - page 66
- Xenical analysis - page 66
- Drug overview - page 66
- Marketing strategies - page 72
- Xenical forecasts to 2012 - page 75
- Meridia analysis - page 78
- Drug overview - page 78
- Marketing strategies - page 84
- Meridia forecasts to 2012 - page 85
- Xenical analysis - page 66
- CHAPTER 5 R&D APPROACH - page 88
- Classification of pipeline products - page 88
- Cannabinoid (CB1) antagonists - page 88
- SNRIs - page 89
- Beta-3 adrenergic agonists - page 89
- Cholecystokinin agonists - page 90
- Carboxypeptidase inhibitors - page 90
- Ciliary neurotrophic factor (CNTF) agonists - page 90
- Lipase inhibitors - page 90
- Leptin agonists - page 91
- Lipid metabolism modulators - page 92
- Clinical trial design - page 92
- Clinical endpoints - page 95
- Insulin sensitivity and prevention of type 2 diabetes - page 97
- HDL and LDL cholesterol levels - page 97
- Critique of clinical trial design in obesity - page 98
- Classification of pipeline products - page 88
- CHAPTER 6 OBESITY PIPELINE ANALYSIS - page 99
- Pipeline overview - page 99
- Key companies involved in the anti-obesity drug market - page 100
- Sanofi-Aventis - page 102
- Breakdown by type of therapy - page 102
- Key marketing opportunities - page 103
- Axokine - page 105
- AOD9604 - page 105
- Pipeline overview - page 99
- CHAPTER 7 DRUGS IN DEVELOPMENT - page 107
- Phase III - page 107
- Pipeline summary - page 107
- Definition of current comparator therapy - page 107
- Acomplia (rimonabant) - page 107
- Drug overview - page 107
- Clinical trial data - page 108
- Patient potential - page 111
- Marketing factors - page 111
- Satisfaction of unmet needs - page 112
- Forecasts to 2012 - page 113
- Axokine - page 116
- Drug overview - page 116
- Clinical trial data - page 116
- Satisfaction of unmet needs - page 123
- Forecasts to 2012 - page 125
- Phase II drugs - page 127
- ATL-962 - page 127
- Drug overview - page 127
- Clinical trial data - page 127
- Patient potential - page 129
- Marketing factors - page 129
- Satisfaction of unmet needs - page 129
- Forecasts to 2012 - page 131
- 1426 - page 133
- Drug overview - page 133
- Clinical trial background - page 133
- Satisfaction of unmet needs - page 134
- Forecasts to 2012 - page 135
- AOD9604 - page 137
- Drug overview - page 137
- Clinical trial data - page 137
- Satisfaction of unmet needs - page 139
- Forecast to 2012 - page 141
- GI181771 - page 142
- A137 - page 143
- ATL-962 - page 127
- Comparison of key compounds - page 143
- 10% and 5% weight loss - page 144
- Side effects - page 144
- Patient potential - page 145
- Marketing strength - page 145
- Overall performance - page 145
- Comparative forecasts - page 146
- Innovative early-stage projects - page 148
- 1954 - page 148
- C2624 - page 148
- C5093 - page 149
- LY377604 - page 149
- Peptide YY [3-36] - page 149
- SLV319 - page 149
- T71 - page 149
- APD356 - page 150
- S2367 - page 150
- Peg Axokine - page 150
- CP 331684 - page 150
- Discontinued anti-obesity agents - page 151
- Phase III - page 107
- APPENDIX A - page 152
- Contributing experts - page 152
- Bibliography - page 152
- Epidemiology sources - page 152
- US - page 152
- Japan - page 153
- France - page 153
- Germany - page 153
- Italy - page 153
- Spain - page 154
- UK - page 154
- Epidemiology sources - page 152
- Report methodology - page 157
- Japanese market data - page 157
- APPENDIX B - page 158
- About Datamonitor - page 158
- About Datamonitor Healthcare - page 158
- Datamonitor Healthcare's research and analysis methodologies - page 159
- Datamonitor Healthcare's therapy area capabilities - page 159
- About the Cardiovascular analysis team - page 160
- Key therapy team members - page 161
- Dr Allison Fleetwood - page 161
- Disclaimer - page 162
- About Datamonitor - page 158
- List of Tables
- Table 1: Prevalence of obesity in the seven major markets by age (000s), 2003 - page 12
- Table 2: Forecast of key pipeline products in the anti-obesity drug market in 2012 - page 13
- Table 3: Prevalence of obesity in the seven major markets by age (000s), 2003 - page 25
- Table 4: Prevalence of overweight in the seven major markets by age (000s), 2003 - page 26
- Table 5: Forecast prevalence of obesity in the US (000s), 2003-12 - page 27
- Table 6: Forecast prevalence of overweight in the US (000s), 2003-12 - page 28
- Table 7: Forecast prevalence of obesity in the UK (000s), 2003-12 - page 29
- Table 8: Forecast prevalence of overweight in the UK (000s), 2003-12 - page 30
- Table 9: Classification of overweight, obesity by BMI, waist circumference and associated disease risk - page 36
- Table 10: A guide to treatment selection - page 39
- Table 11: Global anti-obesity drug sales 1999-2003, across the seven major markets - page 44
- Table 12: US anti-obesity drug sales from 1999-2003 - page 46
- Table 13: Anti-obesity drug sales in Japan, 1999-03 - page 52
- Table 14: French anti-obesity drug sales, 1999-2003 - page 55
- Table 15: German anti-obesity drug sales, 1999-2003 - page 56
- Table 16: Italian anti-obesity drug sales, 1999-2003 - page 57
- Table 17: Spanish anti-obesity drug sales, 1999-2003 - page 58
- Table 18: UK anti-obesity drug sales, 1999-2003 - page 59
- Table 19: Global anti-obesity drug forecast, 2003-12 - page 64
- Table 20: Xenical: key characteristics - page 66
- Table 21: Xenical events, 2003-04 - page 68
- Table 22: Impacting factors on the sales of Xenical, 2003-12 - page 76
- Table 23: Meridia: key characteristics - page 78
- Table 24: Meridia events, 2003-04 - page 79
- Table 25: Impacting factors on the revenues of Meridia, 2003-12 - page 86
- Table 26: Clinical trial designs - page 94
- Table 27: Clinical trial endpoints - page 96
- Table 28: Anti-obesity R&D pipeline, June 2004 - page 100
- Table 29: Companies with anti-obesity drugs in Phase I or above - page 101
- Table 30: Breakdown of the anti-obesity pipeline by type of therapy, 2004 - page 103
- Table 31: Marketing position of companies with anti-obesity R&D products - page 104
- Table 32: Key products in late-stage R&D pipeline for obesity, June 2004 - page 107
- Table 33: Results of the Phase III RIO-Lipids study - page 109
- Table 34: Impacting factors on the revenues of Acomplia, 2003-12 - page 114
- Table 35: Phase III Axokine trial results - page 118
- Table 36: Comparison of Axokine trial results according to patients developing antibodies and those who did not - page 118
- Table 37: Average weight loss in pounds in Phase II of Axokine trial from baseline weight - page 121
- Table 38: Percentage of patients losing at least 5% of body weight - page 121
- Table 39: Impacting factors on the revenues of Axokine, 2006-12 - page 126
- Table 40: Impacting factors on the revenues of ATL-962, 2008-12 - page 132
- Table 41: Impacting factors on the revenues of 1426, 2009-12 - page 136
- Table 42: Impacting factors on the revenues of AOD9604, 2009-12 - page 142
- Table 43: Global sales forecasts for anti-obesity drugs, 2003-12 - page 147
- Table 44: Anti-obesity agents in Phase I of development, June 2004 - page 148
- Table 45: Discontinued R&D anti-obesity agents - page 151
- List of Figures
- Figure 1: Impacts on the global anti-obesity market to 2012 - page 11
- Figure 2: Classification of overweight and obesity - page 35
- Figure 3: Overview of obesity treatment guidelines from the NHLBI - page 38
- Figure 4: Growth and market share of anti-obesity drugs, 2002-03 - page 45
- Figure 5: Xenical SWOT analysis - page 72
- Figure 6: Global sales forecasts for Xenical, 2003-12 - page 75
- Figure 7: Meridia SWOT analysis - page 84
- Figure 8: Global sales forecasts for Meridia, 2003-12 - page 86
- Figure 9: Rimonabant's satisfaction of unmet needs - page 112
- Figure 10: Global sales forecasts for Acomplia, 2003-12 - page 114
- Figure 11: Phase III Axokine trial design - page 117
- Figure 12: Axokine Phase II trial design - page 120
- Figure 13: Axokine's satisfaction of unmet needs - page 123
- Figure 14: Global sales forecasts for Axokine, 2006-12 - page 125
- Figure 15: ATL-962 Phase II trial designs - page 128
- Figure 16: ATL-962's satisfaction of unmet needs - page 130
- Figure 17: Global sales forecasts for ATL-962, 2008-12 - page 132
- Figure 18: 1426's satisfaction of unmet needs - page 134
- Figure 19: Global sales forecasts for 1426, 2003-12 - page 136
- Figure 20: AOD9604's satisfaction of unmet needs - page 140
- Figure 21: Global sales forecasts for AOD9604, 2003-12 - page 141
- Figure 22: Comparison of key R&D products in anti-obesity pipeline - page 143
- Figure 23: Comparative sales forecasts for the key therapies in the anti-obesity drug market, 2003-12 - page 146
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