Restless Legs Syndrome - Recognition Lacking Still
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the CNS pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 5
- Introduction - page 5
- Scope and coverage of the Brief - page 5
- Key findings about restless legs syndrome - page 5
- Despite affecting an estimated 66.6 million individuals, less than 10% of RLS sufferers receive treatment. If pharmaceutical companies are to see a return on their investment in this market, they must be willing to invest in raising awareness amongst the public and physicians. - page 6
- There is currently no treatment approved for RLS in the US and therapy typically involves 'off-label' use of a variety of drug classes. However, with GSK's Requip anticipated to become the first drug to gain approval for RLS in 2005, companies wishing to enter the market at a later date may have to implement more innovative strategies, such as targeting specific symptoms and patient cohorts. - page 8
- CHAPTER 2 EPIDEMIOLOGY - page 10
- Definition of disorder - page 10
- Impact of the disorder - page 10
- Etiology - page 11
- Comorbidities - page 12
- Prevalence - page 12
- Who is at greatest risk? - page 12
- Prevalence rate - page 12
- US - page 13
- EU - page 14
- Japan - page 15
- Summary - page 16
- CHAPTER 3 CLINICAL PRACTICE - page 17
- Presentation - page 17
- Who are patients presenting to? - page 17
- Diagnosis - page 18
- Diagnosis rate - page 18
- Treatment rate - page 20
- Summary - page 21
- Presentation - page 17
- CHAPTER 4 CURRENT THERAPY - page 22
- Guidelines - page 22
- Non-pharmacological management - page 25
- Pharmacological management - page 25
- Dopaminergic agents - page 25
- Levodopa - page 25
- Dopamine agonists - page 26
- Ergot derivatives - page 26
- Market potential - page 28
- Non-ergot derivatives - page 29
- Dopaminergic agents - page 25
- Other drugs - page 29
- Benzodiazepines - page 29
- Opioids - page 30
- Anticonvulsants - page 30
- Gabapentin - page 31
- CHAPTER 5 FUTURE THERAPY - page 33
- Pipeline 'marketed' products - page 33
- Requip (ropinirole) - page 34
- Mirapex (pramipexole) - page 38
- Stalevo (carbidopa/levodopa/entacapone) - page 40
- Pipeline 'premarket' products - page 41
- Neupro (rotigotine) - page 41
- GW-353162 - page 43
- SEP-226330 - page 43
- XP-13512 - page 43
- Pipeline 'marketed' products - page 33
- CHAPTER 6 MARKET OPPORTUNITIES - page 44
- Unmet needs - page 44
- Addressing the unmet needs - page 44
- Patient education - page 44
- Physician education - page 46
- Improved treatment guidelines/strategy - page 48
- Broadening treatment options - page 49
- APPENDIX - page 51
- Bibliography - page 51
- Websites - page 56
- Disclaimer - page 57
- List of Tables
- Table 1: Prevalence of RLS across the seven major markets, 2004 - page 16
- Table 2: Diagnosis rate of RLS among US adults, 2003 - page 19
- Table 3: Treatment rate of RLS among US adults, 2003 - page 20
- Table 4: Patients diagnosed and treated for RLS across seven major markets, 2004 - page 21
- Table 5: Recommended practice for RLS according to the American Academy of Sleep Medicine - page 23
- Table 6: Key products in development for RLS, 2004 - page 33
- Table 7: Key ropinirole studies - page 37
- List of Figures
- Figure 1: Algorithm for the management of RLS - page 24
- Figure 2: Summary of unmet needs in RLS market - page 44
- Figure 3: Restless Legs Syndrome Foundation website - page 45
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