Adult ADHD - Therapeutic Opportunities
With the recent medical classification of adult ADHD and potentially twice the number of patients compared to pediatric ADHD, manufacturers are seeking new indications in this expanding and lucrative market. Lilly�s Strattera was the first drug to exploit this, and is forecast to reach blockbuster status by 2006. Consequently, manufacturers will need to differentiate their products from Strattera.
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- TABLE OF CONTENTS - page 3
- EXECUTIVE SUMMARY - page 5
- Introduction - page 5
- Scope and coverage of the Brief - page 5
- Key findings about the the topic - page 6
- Strattera was the first drug approved for the treatment of adult ADHD in November 2002. Since launch, Strattera sales have steadily increased from $55m in Q1 2003 to $133m in Q4 2003, and Datamonitor expects Strattera to reach blockbuster status by 2006. - page 6
- Shire's Adderall XR recently received an approvable letter from the FDA for an indication in adult ADHD and J&J's Concerta is currently in Phase III with an expected launch in 2005. Datamonitor forecasts that both drugs will see an increase in sales from gaining an indication for this market although both will also experience a decline in revenues post 2005. - page 7
- It is currently estimated that approximately 75% of adults with ADHD present with a comorbid condition, of which anxiety and depressive disorders predominate. Datamonitor has highlighted two drug classes that may benefit from further investigation of the treatment of such comorbidities in order to increase their market share in the adult ADHD market. - page 8
- DISEASE OVERVIEW - page 10
- Disease definition - page 10
- Etiology of ADHD - page 10
- Structural abnormalities - page 11
- Genetic predisposition - page 11
- Neurotransmitter dysfunction - page 11
- Dopaminergic genes - page 11
- DSM-IV diagnostic criteria of ADHD - page 12
- Progression of symptoms from pediatric to adult ADHD - page 13
- Etiology of ADHD - page 10
- Epidemiology - page 14
- Prevalence of adult ADHD - page 14
- Segmentation of adult ADHD - page 16
- Gender - page 16
- Comorbidities - page 16
- Anxiety and mood comorbidities - page 17
- Substance abuse - page 18
- Disease definition - page 10
- DIAGNOSIS - page 19
- Diagnostic guidelines - page 19
- History of symptoms - page 20
- Diagnostic rate - page 22
- Diagnostic guidelines - page 19
- TREATMENT - page 25
- Treatment guidelines - page 25
- Pharmacological treatment - page 26
- Stimulants - page 27
- Stimulants for adult ADHD - page 28
- Adderall XR - page 28
- The clinical data supporting Adderall for the treatment of adult ADHD - page 29
- Adderall XR forecast - page 30
- Opportunities for Shire and Adderall XR - page 32
- Concerta - page 32
- Concerta forecast - page 34
- Opportunities for J&J and Concerta - page 35
- Non-stimulants - page 35
- Strattera - page 36
- The clinical data supporting Strattera for the treatment of adult ADHD - page 36
- Strattera forecast - page 37
- Opportunuities for Lilly and Strattera - page 40
- Strattera - page 36
- Antidepressants - page 40
- Off-label prescribing - page 41
- PIPELINE ANALYSIS - page 43
- Unmet needs - page 43
- Pipeline drugs - page 43
- Methypatch - page 44
- SPD-503 - page 45
- Backlash to adult ADHD? - page 45
- APPENDIX - page 48
- Bibliography - page 48
- Websites - page 51
- Research methodology - page 51
- Disclaimer - page 51
- List of Tables
- Table 1: Symptoms of ADHD in children and adults. - page 14
- Table 2: Comorbid disorders with ADHD - page 17
- Table 3: ADHD diagnostic tools - page 21
- Table 4: Stimulants for ADHD - page 27
- Table 5: Adderall sales forecast to 2008 - page 31
- Table 6: Concerta sales forecast to 2008 - page 35
- Table 7: Non-stimulants for ADHD - page 36
- Table 8: Strattera sales forecast to 2008 - page 39
- Table 9: Forecast sales for ADHD drugs approved for both child and adult markets, 2002-08 - page 42
- Table 10: Late stage pipeline ADHD drugs, 2004 - page 43
- List of Figures
- Figure 1: Prevalence of adults with ADHD in the general population across the seven major markets, 2004 - page 15
- Figure 2: Assessment of adults presenting with symptoms of ADHD - page 19
- Figure 3: Diagnosis rate of ADHD across the seven major markets, 2004 - page 22
- Figure 4: ADHD pharmacological treatment algorithm - page 25
- Figure 5: ADHD patients receiving pharmacological treatment, 2004 - page 26
- Figure 6: Adderall study for adult ADHD - page 29
- Figure 7: Adderall XR study in adult ADHD - page 30
- Figure 8: Adderall sales forecast to 2008 - page 31
- Figure 9: Release rate of Concerta and resulting serum levels - page 33
- Figure 10: Concerta sales forecast to 2008 - page 34
- Figure 11: Strattera sales forecast to 2008 - page 39
- Figure 12: Sales of ADHD drugs ($m), Q3 2000(Q2 2003 - page 42
- Figure 13: Methypatch sales forecast to 2008 - page 45
- Figure 14: Lilly's Adult Self-Report Scale - page 47
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