Translational Medicine in Biopharmaceutical Research and Development
As the pharma industry continues to experience rising research costs, drug failures and low returns on investment, companies who are increasingly facing major patent expiries and scarcely populated late-stage pipelines have accelerated efforts to enhance the speed and efficiency of drug research. Translational science has emerged as a concept that is set to revolutionise the traditional R&D paradigm by integrating drug discovery and development, areas with previously limited interaction. The primary goals of this approach are to terminate unsuccessful compounds earlier in their development, improve confidence in human drug targets and enhance cost-effective decision-making. Translational Medicine in Biopharmaceutical R&D examines how translational medicine can positively influence the impact of biomarkers, innovations in clinical trial designs and the IT systems that support these functions. The report will identify how data generated from pre-clinical studies and clinical trials can be used synergistically between lab and clinic to enhance success rates and improve go/no-go decision making. The strategies adopted by pharma companies to incorporate such initiatives are evaluated and potential cost-savings are assessed. This report will also highlight recent regulatory shifts in biomarker development and application, in addition to investigating the development of adaptive and seamless trial designs and micro-dosing. Discover the benefits of translational medicine, evaluate the strategies used by R&D organisations to implement translational methods and identify the innovative technologies central to efficiency gains with this report
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