Commercial and Pipeline Insight: Infertility
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Women's Health pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Scope of the analysis - page 3
- Contributing experts - page 4
- Datamonitor insight into the infertility market - page 6
- Key metrics - page 8
- Datamonitor pipeline assessment summary - page 9
- CHAPTER 2 DISEASE OVERVIEW - page 12
- Definition of infertility - page 13
- Unassisted reproduction - page 13
- Etiology of infertility - page 14
- The causes of female infertility - page 14
- Polycystic ovary syndrome - page 15
- Endometriosis - page 17
- Uterine fibroids - page 18
- The causes of male infertility - page 19
- Correctable conditions in the male - page 20
- Combined infertility - page 21
- Unexplained infertility - page 22
- The causes of female infertility - page 14
- Definition of infertility - page 13
- CHAPTER 3 EPIDEMIOLOGY AND PATIENT BASED MARKET FORECASTS - page 23
- Epidemiologically-derived infertility market size - page 24
- Epidemiologic methodology of sizing the US and 5EU patient population - page 24
- Female population eligible for infertility treatment (1) - page 25
- Relationship status: marriage assumed necessary (2) - page 25
- Prevalence of infertility (3) - page 26
- Presentation rates (4) - page 27
- Diagnosis rates of a specialist physician (5) - page 28
- Treatment initiation (6) - page 29
- Epidemiologic methodology of sizing the Japanese patient population - page 30
- Epidemiologic methodology of sizing the US and 5EU patient population - page 24
- Patient derived infertility market forecasts - page 30
- Patient derived forecast methodology - page 32
- Trending the treatment seeking rate - page 32
- Trending the marriage rate - page 32
- Segmentation of the patient population by treatment cycles - page 33
- Cost per treatment cycle - page 34
- Market value - page 34
- Patient derived forecast methodology - page 32
- Epidemiological trends - page 35
- The ageing population will prevent dramatic market growth - page 35
- The prevalence of infertility by etiology - page 37
- Almost 20% of couples seeking treatment require therapy for multiple-factor infertility - page 38
- Epidemiologically-derived infertility market size - page 24
- CHAPTER 4 TREATMENT OPTIONS AND TRENDS - page 40
- Segmentation of infertility treatment - page 41
- ART treatment options - page 41
- Ovulation induction - page 41
- Intrauterine insemination - page 42
- In vitro fertilization - page 43
- Intracytoplasmic sperm injection - page 44
- Gamete intrafallopian transfer - page 44
- Zygote intrafallopian transfer - page 44
- ART treatment options - page 41
- Classification of infertility products - page 44
- Follicle stimulating hormones-follitropins (FSH) - page 46
- Luteinizing hormone (LH) - page 47
- Human menopausal gonadotrophins-menotropins (hMG) - page 47
- Human chorionic gonadotrophin (hCG) - page 48
- Gonadotrophin releasing hormone (GnRH) analogs - page 49
- Pharmaceutical treatment pathways - page 50
- Over 193,000 treatment cycles occurred in the 5EU in 2001 - page 52
- Future treatment trends - page 52
- IVF more frequently chosen as first-line therapy - page 53
- GnRH agonists versus GnRH antagonists - page 54
- The advantages of antagonists - page 55
- Efficacy studies fail to identify superior analog - page 55
- Physician choice will divide future market share equally - page 56
- Volume reduction as mild stimulation protocols strive to reduce multiple births - page 57
- Urinary and recombinant products must fulfill different niches - page 59
- r-FSH versus menotropins - page 61
- Unmet need in the infertility market - page 62
- Education of non-specialist physicians will aid diagnosis and referral - page 63
- Complicated treatment cycles detract from success rates - page 64
- Patient-friendly delivery devices help to prevent discontinuation - page 64
- Simplified treatment regimens ease patient stress levels - page 66
- Neutrality in clinical trials to avoid bias - page 67
- Segmentation of infertility treatment - page 41
- CHAPTER 5 MARKET DYNAMICS - page 69
- Market sizing using prescription data - page 70
- Dynamics of the current infertility market - page 71
- Slow growth recoups market value to 2003 level - page 71
- Gonadotrophins are the integral part of infertility treatment - page 72
- GnRH antagonists gain on agonists in 2006 but still have some way to go - page 74
- Regional sales are influenced by country-specific legislation - page 74
- Follitropin products lead the market - page 77
- Product use is not exclusive to infertility - page 79
- Slow growth recoups market value to 2003 level - page 71
- Key companies involved in the infertility market - page 80
- Three companies hold 84.6% share of the total infertility market - page 80
- Change at the top means competition will be fierce - page 81
- Smaller portfolios suit current market climate - page 82
- Successful companies generate strong relationships with physicians - page 82
- Organon capitalizes on Puregon to become 2006 market leader - page 83
- Merck Serono loses share despite extensive portfolio - page 85
- Innovation allows Ferring greatest growth - page 88
- IBSA's geographical experience is a threat to 7MM players - page 90
- Three companies hold 84.6% share of the total infertility market - page 80
- SWOT analysis of the infertility market - page 91
- Opportunities - page 92
- Trend towards later parenthood will increase demand for fertility services - page 92
- New embryological techniques expand treatable population - page 93
- Infertility support websites can increase brand awareness among patients - page 96
- Threats - page 99
- Restrictive guidelines are unlikely to slacken in the near future - page 99
- Influx of low-priced alternatives will increase price competition - page 100
- Opportunities - page 92
- CHAPTER 6 R&D PIPELINE OVERVIEW AND CLINICAL TRIAL DESIGN - page 104
- Pipeline overview: limited pipeline dominated by existing market players - page 105
- Infertility pipeline lacks direction and innovation - page 106
- Development needs to diversify - page 107
- Pergoveris is the initial threat to marketed products - page 108
- Top three market players overwhelm pipeline - page 108
- Merck Serono's pipeline structure optimizes timing of market entry - page 109
- Organon's pipeline indicates long-term focus - page 109
- Small companies should capitalize on outlicensing - page 109
- Infertility pipeline lacks direction and innovation - page 106
- Clinical trial design in infertility and subfertility research - page 110
- Code of best practice - page 110
- Analysis must stem from 'intention to treat' patient numbers - page 111
- Controversial crossover trials may inflate results - page 112
- First-cycle enrolment avoids carry-over effects - page 113
- Sample size estimation to be derived from patient number - page 113
- Lack of superiority is not the same as equivalence - page 114
- Should singleton live birth rate replace live birth rate as primary outcome? - page 114
- Code of best practice - page 110
- Pipeline overview: limited pipeline dominated by existing market players - page 105
- CHAPTER 7 FOLLITROPIN LATE-STAGE DRUG ANALYSIS & FORECASTS - page 116
- Overview for the follitropin class - page 117
- Comparative forecasts - page 117
- Comparative Datamonitor drug assessment summary - page 118
- Definition of current comparator therapy: Puregon - page 119
- Puregon's key clinical trials - page 121
- Marketing and patient factors - page 123
- Org-36286 (extended-release corifollitropin alpha) - page 125
- Drug overview - page 125
- Datamonitor drug assessment summary - page 126
- Forecasts to 2016 - page 126
- Marketing factors - page 128
- Patient potential - page 128
- Clinical trial data - page 130
- Phase III - page 130
- Phase II - page 131
- Overview for the follitropin class - page 117
- CHAPTER 8 MENOTROPIN LATE-STAGE DRUG ANALYSIS & FORECASTS - page 133
- Overview for the menotropin class - page 134
- Comparative forecasts - page 134
- Comparative Datamonitor drug assessment summary - page 135
- Definition of current comparator therapy: Menopur - page 136
- Menopur's key clinical trials - page 137
- Marketing and patient factors - page 138
- Pergoveris (follitropin alpha and lutropin alpha) - page 140
- Drug overview - page 140
- Datamonitor drug assessment summary - page 140
- Forecasts to 2016 - page 141
- Marketing factors - page 143
- Patient potential - page 144
- Clinical trial data - page 145
- Primary Phase II/III bridging study - page 145
- Secondary Phase II/III bridging study - page 147
- Overview for the menotropin class - page 134
- CHAPTER 9 GLOBAL MARKET ISSUES - page 149
- Globalization of the infertility market - page 150
- E7 markets are a useful guide to worldwide market growth - page 150
- Despite growth, E7 markets will not rival 7MM in the short term - page 151
- Inter-market differences: the impact of legislation - page 151
- E7 markets are a useful guide to worldwide market growth - page 150
- Reproductive tourism - page 155
- A multitude of inter-related factors promote reproductive tourism - page 156
- Case study: Observing patient migration from Italy - page 157
- Responding to the impact of reproductive tourism - page 158
- Pharma must strengthen portfolios in stable or recipient markets - page 158
- Physician behavior is vital to maintain the respectability of reproductive travel - page 159
- Reproductive tourism is the best solution for patients in the absence of ethical agreement - page 161
- Globalization of the infertility market - page 150
- BIBLIOGRAPHY - page 163
- Journal papers and articles - page 163
- Websites - page 168
- APPENDIX A - page 173
- Forecasting methodology - page 173
- Datamonitor forecast methodology - page 173
- Epidemiological patient-based forecasts - page 173
- IMS forecasts - page 175
- Datamonitor forecast methodology - page 173
- Contributing experts - page 177
- Forecasting methodology - page 173
- APPENDIX B - page 178
- About Datamonitor - page 178
- About Datamonitor Healthcare - page 178
- Datamonitor Healthcare's therapy area capabilities - page 179
- About the Disease analysis team - page 180
- Disclaimer - page 181
- About Datamonitor - page 178
- List of Tables
- Table 1: Infertility market top down forecast across the seven major markets, 2006-2016 - page 8
- Table 2: Top down forecast of key pipeline infertility products in 2016 ($000s) - page 8
- Table 3: Infertility market bottom-up forecast based on patient numbers in the US, Japan and 5EU, 2006-2016 - page 9
- Table 4: Causes of female infertility - page 14
- Table 5: Causes of male infertility - page 19
- Table 6: Patient population of women receiving infertility treatment in the 7MM, 2006 - page 24
- Table 7: Infertility market value ($m) patient based forecasts, 2003-2009 - page 31
- Table 8: Infertility market value ($m) forecast derived from patient numbers, 2010-2016 - page 32
- Table 9: Patient numbers by female infertility etiology in the US and 5EU, 2006 - page 39
- Table 10: Classification of the infertility market according to Datamonitor's definition - page 45
- Table 11: Branded follitropins available in the 7MM, 2006 - page 47
- Table 12: Branded menotropins available in the 7MM, 2006 - page 48
- Table 13: Branded chorionic gonadotrophins available in the 7MM, 2006 - page 49
- Table 14: Branded GnRH agonists available in the 7MM, 2006 - page 50
- Table 15: Branded GnRH antagonists available in the 7MM, 2006 - page 50
- Table 16: Treatment cycles in the 7MM, 2000 and 2001 - page 52
- Table 17: Studies investigating the efficacy of GnRH analogs - page 56
- Table 18: ICD-10 codes used to define the infertility market - page 70
- Table 19: Country-specific ART practices, 2007 - page 75
- Table 20: Organon's infertility franchise, 2007 - page 83
- Table 21: Merck Serono's infertility franchise, 2007 - page 86
- Table 22: Ferring's infertility franchise, 2006 - page 88
- Table 23: IBSA's infertility franchise, 2007 - page 90
- Table 24: Infertility patient websites, 2007 - page 97
- Table 25: Legislation governing ART in the 7MM, 2007 - page 99
- Table 26: Infertility market pipeline, 2007 - page 105
- Table 27: Key companies involved in the infertility pipeline, 2007 - page 108
- Table 28: Methodological considerations of infertility trials - page 111
- Table 29: Key products in late-stage R&D pipeline for follitropins, 2007 - page 117
- Table 30: Puregon: key facts - page 121
- Table 31: Key products in late-stage R&D pipeline for menotropins, 2007 - page 134
- Table 32: Menopur: key facts - page 137
- Table 33: E7 infertility market sales, 2006 and CAGR, 2003-06 - page 151
- Table 34: E7 infertility markets: key facts, 2007 - page 153
- Table 35: Datamonitor drug assessment parameters - page 176
- List of Figures
- Figure 1: Datamonitor pipeline infertility drug assessment summary - page 10
- Figure 2: Algorithm for the treatment of male infertility - page 20
- Figure 3: Number of women aged between 20 and 45 years old in the seven major infertility markets, 2006-2021 - page 36
- Figure 4: Females patients willing and able to receive infertility treatment in the 7MM from 2006 to 2016 - page 37
- Figure 5: Causes of infertility for US couples undergoing ART using fresh, non-donor eggs or embryos, 2004 - page 38
- Figure 6: ART treatment options - page 41
- Figure 7: Infertility treatment pathway in the seven major markets - page 51
- Figure 8: Schematic overview of trends expected in infertility treatment, 2007-2016 - page 53
- Figure 9: Unmet need in the infertility market, 2007 - page 62
- Figure 10: Growth of the seven major infertility markets, 2003-06 - page 71
- Figure 11: Breakdown of the gonadotrophin class by molecule, 2006 - page 73
- Figure 12: Infertility market size by country, 2003-06 - page 76
- Figure 13: Sales performance of the top five infertility brands across the 7MM, 2005-06 - page 78
- Figure 14: Percentage breakdown of total brand sales by indication of the top five infertility products in the 7MM, 2006 - page 80
- Figure 15: Market share and growth of the top three companies in the infertility market, 2005-06 - page 81
- Figure 16: Organon's 7MM infertility franchise by brand, 2006 - page 84
- Figure 17: Merck Serono's 7MM infertility franchise by brand, 2006 - page 87
- Figure 18: Ferring's seven major market infertility franchise by brand, 2006 - page 89
- Figure 19: SWOT analysis of the infertility market across the seven major markets, 2007 - page 92
- Figure 20: Mother's age at first birth in France, Germany, Spain and Italy, 1985-2000 - page 93
- Figure 21: Ferring's fertility website - page 98
- Figure 22: Breakdown of fertility market pipeline by development status, 2007 - page 106
- Figure 23: Datamonitor's comparative forecast of sales for the follitropins across the IMS-derived, seven major markets ($m), 2007-2016 - page 117
- Figure 24: Datamonitor's competitive positioning analysis for Puregon and Org-36286 in the IMS derived, seven major markets, 2007-2016 - page 119
- Figure 25: Historical sales for the follitropins, Puregon and Gonal-F, 2003-06 - page 124
- Figure 26: Datamonitor's competitive positioning analysis for Org-36286 in the IMS-derived, seven major markets, 2007-2016 - page 126
- Figure 27: Datamonitor's forecast of sales for Org-36286 across the seven major markets ($m), 2007-2016 - page 127
- Figure 28: Datamonitor's comparative forecast of sales for the menotropins across the IMS-derived, seven major markets ($m), 2007-2016 - page 134
- Figure 29: Datamonitor's competitive positioning analysis for Menopur and Pergoveris in the IMS-derived, seven major markets, 2007-2016 - page 136
- Figure 30: Historical sales for the top three menotropins Menopur, Menogon and Humegon, 2003-06 - page 139
- Figure 31: Datamonitor's competitive positioning analysis for Pergoveris in the IMS derived, seven major markets, 2007-2016 - page 141
- Figure 32: Datamonitor's forecast of sales for Pergoveris across the IMS derived, seven major markets ($m), 2007-2016 - page 142
- Figure 33: Market share and growth of the E7 infertility markets, 2005-06 - page 152
- Figure 34: Reproductive migration of Italian couples in 2003 and 2005 - page 158
Other users found this report page using the following search terms: infertility fertilization market infertility fertility pergoveris menopur pipeline puregon serono merck ferring
If you can't find a report that meets your needs contact LeadDiscovery. We are one of the few report providers with extensive drug development experience and we frequently use this knowledge to help clients source the most appropriate reports or produce reports for them from scratch.
Refund and Cancellation Policy: The descriptions of the products and services sold on LeadDiscovery.co.uk are as complete and accurate as possible, and customers are encouraged to read all available information about a product before placing an order. Due to the nature of the information being sold, orders for reports cannot be canceled.