Angiogenesis in Oncology: Drug Pipeline Update 2007
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Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Investigators
Includes more than 125 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms
Lists commercial, generic and code names for drugs. In all more than 400 names
Developmental stage
This Drug Pipeline Update contains more than 180 drugs in active development and more than 420 developmental projects of VDA/VTA/Anti-angiogenic drugs for the treatment of cancer:
6 marketed drugs
> 20 projects in Phase III
> 160 projects in Phase II
> 105 projects in Phase I
> 110 projects in Preclinical
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications
Included VDA/VTA/Anti-angiogenic drugs are in development for 50 different cancer indications.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets
Identified drugs are linked to 100 different targets, divided into 32classifications of molecular function:
- Acyltransferase activity
- Carboxy-lyase activity
- Catalytic activity
- Cell adhesion molecule activity
- Cofactor binding
- Cysteine-type peptidase activity
- Cytokine activity
- DNA topoisomerase activity
- Extracellular matrix structural constituent
- Growth factor activity
- GTPase activity
- Hydrolase activity
- Kinase activity
- Lipid kinase activity
- Metallopeptidase activity
- Oxidoreductase activity
- Peptidase activity
- Phosphoric diester hydrolase activity
- Protease inhibitor activity
- Protein serine/threonine kinase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor binding
- Serine-type peptidase activity
- Structural constituent of cytoskeleton
- Superoxide dismutase activity
- Transcription factor activity
- Transcription regulator activity
- Translation regulator activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
- Unclassified
Identified targets are categorized into 17 different primary and alternate localizations:
- Clathrin-coated vesicle
- Cytoplasm
- Cytoplasmic vesicle
- Cytosol
- Endoplasmic reticulum
- Endosome
- Extracellular
- Golgi apparatus
- Lysosome
- Mitochondrion
- Nucleolus
- Nucleus
- Perinuclear vesicle
- Peroxisome
- Plasma membrane
- Secreted
- Secretory granule
Note: You are able to sort and find drugs according to target name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile
Direct links are provided from inside the application to protein expression profiles of 37 drug targets in various human tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Targeted Signaling Pathways
Identified targets have been cross referenced against 20 signaling pathways, and no less than 18 are currently being pursued in drug development:
- Alpha6 Beta4 Integrin Signaling Pathway
- Androgen Receptor Signaling Pathway
- B Cell Receptor Signaling Pathway
- EGFR1 Signaling Pathway
- IL-1 Signaling Pathway
- IL-2 Signaling Pathway
- IL-3 Signaling Pathway
- IL-4 Signaling Pathway
- IL-5 Signaling Pathway
- IL-6 Signaling Pathway
- IL-7 Signaling Pathway
- IL-9 Signaling Pathway
- Kit Receptor Signaling Pathway
- Notch Signaling Pathway
- T Cell Receptor Signaling Pathway
- TGF-beta Receptor Signaling Pathway
- TNF-alpha Signaling Pathway
- Wnt Signaling Pathway
Note: You are able to sort and find drugs according to targeted signaling pathway from drop-down menu in the application.
Mechanism
In total there are at least 107 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound
Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile
Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms (if any)
Principal Investigator & Partners
Presentation of principal investigator and partners (if any)
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Targeted Signaling Pathways
Described target(s) is/are matched for the involvement in 20 major signaling pathways.
MechanismDrug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Licensing Information
Availability for licensing
Application Features
Use 13 different parameters, available in drop-down menus, to find and sort among drugs
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Signaling Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Target data is linked directly to Human Protein Atlas
- Direct links to company web pages of principal investigators
Export and sharing of information
- Found information is easily shared with others over e-mail, file export (xls) or in print
System Requirements
- AMD-Athlon/Pentium II PC
- Windows 98/NT4/2000/ME/XP
- 8x-speed CD Rom drive
- SVGA 16 bit display. (32 bit recommended)
- 32 MB of available RAM (128 MB recommended)
- Internet access (for related internet resources)
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