Monoclonal Antibodies: Financial and strategic analysis of the mAb market
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- About the PharmaVitae team - page 3
- Scope of the report - page 4
- CHAPTER 1 EXECUTIVE SUMMARY - page 5
- Key findings - page 5
- Total market outlook - page 5
- Monoclonal antibody market outlook - page 6
- Introduction to the PharmaVitae universe - page 7
- The prescription pharmaceutical market to 2012 - page 9
- Prescription pharmaceutical market performance, 2006-12 - page 9
- Balance of launches and expiries in the prescription pharmaceutical market, 2006-12 - page 10
- The majority of expiry-driven sales occurs between 2011 and 2012 - page 11
- Forecast sales performance by molecule type - page 14
- Molecule type definitions - page 15
- Industry consequences of molecule type - page 17
- Prescription pharmaceutical sales by molecule type, 2006-12 - page 18
- Change in annual sales by molecule type - page 20
- Sales growth rate by molecule type, 2006-12 - page 21
- The 2011-12 'patent cliff' - insight from molecule type analysis - page 22
- The lack of a biosimilar/generic protein product threat for mAbs - page 24
- Introduction to the issues - page 24
- FDA view on generic protein products - page 26
- Consequences for mAb market performance - page 29
- Regulatory environment - page 30
- Intellectual property- timing and complexity barrier - page 32
- Technology barrier - page 33
- Biosimilars - conclusion - page 34
- Average revenue analysis - page 35
- Monoclonal antibodies address disease areas of high unmet need - page 38
- Monoclonal antibodies access 'novel target space' - page 41
- ECS targets account for the majority of mAb sales - page 44
- Novel target space reduces competitive pressures - page 45
- Monoclonal antibodies are the most attractive product segment in the prescription pharmaceutical market out to 2012 - page 47
- mAb market performance, 2006-12 - page 49
- mAb market growth - page 49
- Product-level sales growth - page 51
- Company level sales growth - page 52
- Therapy level sales growth - page 55
- mAb technology level sales growth - page 57
- mAb target level sales growth - page 59
- The recurring mAb market theme: dominance of 'the big 5' - page 61
- 'Big 5' revenue preeminence to 2012 - page 63
- 'Big 5' contribute majority of sales growth to 2012 - page 63
- 'Big 5' command highest revenues per product in segment - page 64
- Are mAbs always commercially more attractive than small molecules? - page 65
- Factors determining evolution of a mAb market dominated by 'big 5' - page 67
- Why do the Big 5 dominate the mAb market? - page 67
- Factors driving oncology product dominance - page 67
- Factors Driving AIID product dominance - page 72
- mAb market growth - page 49
- Key findings - page 5
- CHAPTER 2 MAB TECHNOLOGY OVERVIEW - page 80
- Key findings - page 80
- Introduction - page 81
- The immune system - page 81
- B lymphocytes and antibodies - page 81
- Antibody structure - page 81
- Hybridoma technique - the production of mAbs - page 83
- Monoclonal antibodies as therapeutic agents - page 83
- Targets - page 84
- Target selection - the importance of an accessible epitope - page 84
- Production of mAbs - page 85
- Transgenic mice - page 85
- Phage display - page 86
- Future focus - page 86
- Mode of action - page 87
- mAb focused oncology - page 87
- The effect of the effector region - page 88
- Blockade - page 88
- mAbs as a delivery vehicle - page 88
- Evolution of mAbs - page 89
- Limitations associated with immunization - page 89
- Murine - page 94
- Chimeric and humanized antibodies - page 95
- Chimeric - page 95
- Humanized - page 96
- Fully human - page 97
- Fragments - page 97
- Conjugated - page 101
- Radiolabeled conjugated mAbs - page 102
- Focus for antibody R&D - oncology immunotoxin drug conjugates - page 102
- Naked mAbs still dominate - page 104
- Systematic naming of monoclonal antibodies - page 105
- The mAb timeline - technology evolution - page 106
- Manufacturing - page 112
- Time to market and manufacturing of monoclonal antibodies - page 112
- Mammalian cell culture - still the most widely-used system - page 113
- The immune system - page 81
- CHAPTER 3 MARKET ANALYSIS - page 116
- Key findings - page 116
- Introduction - page 117
- mAb market: historical performance, 2003-06 - page 117
- mAb market: forecast performance, 2006-12 - page 120
- Historical product analysis, 2003-06 - page 125
- Avastin (bevacizumab) - page 125
- Herceptin (trastuzumab) - page 126
- Remicade (infliximab) - page 127
- MabThera/Rituxan (rituximab) - page 127
- Humira (adalimumab) - page 128
- Erbitux (cetuximab) - page 128
- Forecast product analysis, 2006-12 - page 129
- Growth drivers - page 135
- Avastin - page 135
- MabThera/Rituxan - page 137
- Humira - page 138
- Herceptin - page 139
- Lucentis (ranibizumab) - page 140
- Numax - page 141
- Growth resistors - page 142
- Synagis - page 142
- Growth drivers - page 135
- Historical company analysis, 2003-06 - page 144
- Genentech and Roche - page 144
- Abbott - page 148
- Johnson & Johnson - page 148
- Forecast company analysis, 2006-12 - page 149
- Growth drivers - page 153
- Genentech & Roche - page 153
- Abbott - page 154
- Amgen - page 154
- Biogen IDEC - page 156
- UCB Schwarz - page 156
- Johnson & Johnson - page 157
- Novartis - page 157
- Growth drivers - page 153
- Historical therapy area analysis, 2003-06 - page 159
- Oncology - page 159
- AIID - page 160
- Other therapy areas - page 160
- Forecast therapy area analysis, 2006-12 - page 161
- Growth drivers - page 163
- Oncology - page 163
- AIID - page 165
- Ophthalmology - page 165
- Others - page 166
- Growth drivers - page 163
- Historical technology analysis, 2003-06 - page 167
- Humanized - page 168
- Chimeric - page 168
- Human - page 168
- Others - page 169
- Forecast technology analysis, 2006-12 - page 169
- Growth drivers - page 171
- Humanized - page 171
- Human - page 172
- Chimeric - page 172
- Antibody fragment - page 173
- Growth drivers - page 171
- Historical target analysis, 2003-06 - page 174
- TNF alpha - page 174
- VEGF - page 175
- Her2 - page 176
- CD20 - page 176
- EGFR - page 176
- Forecast target analysis, 2006-12 - page 178
- Growth drivers - page 181
- VEGF - page 181
- TNF alpha - page 181
- CD20 - page 181
- EGFR - page 182
- Her2 - page 183
- Integrin alpha-4/beta-1 - page 183
- Growth drivers - page 181
- CHAPTER 4 PIPELINE ANALYSIS - page 185
- Key findings - page 185
- Introduction - page 186
- mAb pipeline overview - page 187
- Company pipeline analysis - page 195
- Emerging mAb players - page 204
- Technology pipeline analysis - page 205
- Human content of mAbs, the future focus - page 211
- Therapy area pipeline analysis - page 212
- Oncology focus remains - page 216
- Target pipeline analysis - page 217
- Target crowding evident with late-stage mAbs - page 219
- Novel late-stage targets - page 220
- Novel target early-stage candidates - page 224
- TNF alpha and CD20 - target crowding from further pipeline launches? - page 230
- CHAPTER 5 PRODUCT OVERVIEW - page 235
- Key findings - page 235
- Oncology - page 236
- Avastin - page 236
- Overview - page 236
- Sales forecast - page 237
- News flow - page 237
- Rituxan/MabThera - page 240
- Overview - page 240
- Sales forecast - page 240
- News flow - page 241
- Herceptin - page 243
- Overview - page 243
- Sales forecast - page 243
- News flow - page 244
- Erbitux - page 247
- Overview - page 247
- Sales forecast - page 247
- News flow - page 248
- Vectibix - page 251
- Overview - page 251
- Sales forecast - page 251
- News flow - page 252
- Pertuzumab - page 254
- Overview - page 254
- Sales forecast - page 255
- News flow - page 255
- Ticilimumab - page 256
- Overview - page 256
- Sales forecast - page 256
- News flow - page 257
- Ipilimumab - page 258
- Overview - page 258
- Sales forecast - page 259
- News flow - page 259
- Humax CD20 - page 261
- Overview - page 261
- Sales forecast - page 261
- News flow - page 262
- Lumiliximab - page 264
- Overview - page 264
- Sales forecast - page 264
- News flow - page 265
- Rencarex - page 267
- Overview - page 267
- Sales forecast - page 267
- News flow - page 268
- Mylotarg - page 270
- Overview - page 270
- Sales forecast - page 270
- News flow - page 271
- Campath/MAB Campath - page 272
- Overview - page 272
- Sales forecast - page 272
- News flow - page 273
- Zevalin - page 274
- Overview - page 274
- Sales forecast - page 275
- News flow - page 275
- Bexxar - page 277
- Overview - page 277
- Sales forecast - page 277
- News flow - page 278
- Zalutumumab - page 279
- Overview - page 279
- Sales forecast - page 279
- News flow - page 280
- Zanolimumab - page 281
- Overview - page 281
- Sales forecast - page 281
- News flow - page 282
- Proxinium/Vicinium - page 283
- Overview - page 283
- Sales forecast - page 283
- News flow - page 284
- Catumaxomab - page 285
- Overview - page 285
- Sales forecast - page 285
- News flow - page 286
- Avastin - page 236
- AIID - page 287
- Humira - page 287
- Overview - page 287
- Sales forecast - page 287
- News flow - page 288
- Remicade - page 291
- Overview - page 291
- Sales forecast - page 291
- News flow - page 292
- Cimzia - page 295
- Overview - page 295
- Sales forecast - page 295
- News flow - page 296
- Rituxan/MabThera RA - page 298
- Overview - page 298
- Sales forecast - page 299
- News flow - page 299
- Actemra - page 302
- Overview - page 302
- Sales forecast - page 302
- News flow - page 303
- Golimumab - page 305
- Overview - page 305
- Sales forecast - page 305
- News flow - page 306
- Raptiva - page 308
- Overview - page 308
- Sales forecast - page 308
- News flow - page 309
- CNTO-1275 - page 310
- Overview - page 310
- Sales forecast - page 310
- News flow - page 311
- Mepolizumab - page 312
- Overview - page 312
- Sales forecast - page 312
- News flow - page 313
- Simulect - page 314
- Overview - page 314
- Sales Forecast - page 314
- News flow - page 315
- Lymphocide - page 316
- Overview - page 316
- Sales forecast - page 316
- News flow - page 317
- Zenapax - page 318
- Overview - page 318
- Sales forecast - page 318
- News flow - page 319
- Nuvion - page 320
- Overview - page 320
- Sales forecast - page 320
- News flow - page 321
- Leukotac - page 322
- Overview - page 322
- Sales forecast - page 322
- News flow - page 323
- Humira - page 287
- CNS - page 324
- Tysabri - page 324
- Overview - page 324
- Sales forecast - page 324
- News flow - page 325
- Tysabri - page 324
- Cardiovascular - page 328
- ReoPro - page 328
- Overview - page 328
- Sales forecast - page 328
- News flow - page 329
- ReoPro - page 328
- Respiratory - page 330
- Xolair - page 330
- Overview - page 330
- Sales forecast - page 330
- News flow - page 331
- Xolair - page 330
- Ophthalmology - page 333
- Lucentis - page 333
- Overview - page 333
- Sales forecast - page 334
- News flow - page 334
- Lucentis - page 333
- Hematology - page 336
- Soliris - page 336
- Overview - page 336
- Sales forecast - page 336
- News flow - page 337
- AMG-531 - page 338
- Overview - page 338
- Sales forecast - page 338
- News flow - page 339
- Soliris - page 336
- Women's health - page 340
- Denosumab - page 340
- Overview - page 340
- Sales forecast - page 340
- News flow - page 341
- Denosumab - page 340
- Infectious disease - page 343
- Numax - page 343
- Overview - page 343
- Sales forecast - page 343
- News flow - page 344
- Mycograb - page 346
- Overview - page 346
- Sales forecast - page 346
- News flow - page 347
- Aurograb - page 348
- Overview - page 348
- Sales forecast - page 348
- News flow - page 349
- Synagis - page 350
- Overview - page 350
- Sales forecast - page 350
- News flow - page 351
- Numax - page 343
- CHAPTER 6 APPENDIX - page 352
- References - page 352
- Datamonitor reports - page 352
- References - page 352
- List of Tables
- Table 1: PharmaVitae company coverage by peer set - page 7
- Table 2: Molecule type definitions - page 15
- Table 3: General characteristics of small molecule drugs vs. biologics - page 17
- Table 4: Forecast sales by molecule type ($m), 2006-12 - page 18
- Table 5: Top 25 sales growth resistors ($m), 2011-12 - page 23
- Table 6: Average revenues, 2006 - page 35
- Table 7: Average operating cost ratios and operating profit margin for small molecule, therapeutic protein and mAb specialists (%), 2002-06 - page 37
- Table 8: Target family classification - page 43
- Table 9: mAb 'big 5' in 2003, 2006 and 2012 - page 61
- Table 10: Overview of a selection of marketed mAbs: technology type and immunogenicity - page 91
- Table 11: Infix nomenclature for mAbs - page 105
- Table 12: Manufacturing cell lines for marketed mAbs - page 114
- Table 13: Forecast product sales ($m), 2006-12 - page 129
- Table 14: Forecast mAb sales by company ($m), 2006-12 - page 149
- Table 15: Forecast sales by therapy area ($m), 2006-12 - page 161
- Table 16: Forecast sales by mAb technology type ($m), 2006-12 - page 169
- Table 17: Forecast sales by target ($m), 2006-12 - page 178
- Table 18: mAb pipeline Phase I-pre-registration overview - page 187
- Table 19: Count of marketed mAbs - page 195
- Table 20: Count of Phase III mAb players - page 198
- Table 21: Count of companies with more than one Phase I-II pipeline candidates - page 201
- Table 22: mAb count split by technology type - page 206
- Table 23: Count of mAb candidates by therapy area - page 213
- Table 24: Detailed product/target analysis - page 217
- Table 25: Novel late-stage targets - page 220
- Table 26: Novel early-stage candidates - page 224
- Table 27: Companies with multiple novel early-stage targets - page 228
- Table 28: TNF alpha-targeting mAbs - page 231
- Table 29: CD20-targeting mAbs - page 233
- Table 30: Avastin: overview - page 236
- Table 31: Avastin global sales ($m), 2006-12 - page 237
- Table 32: Avastin: news flow - page 237
- Table 33: Rituxan/MabThera: overview - page 240
- Table 34: Rituxan/MabThera global sales ($m), 2006-12 - page 240
- Table 35: Rituxan/MabThera: news flow - page 241
- Table 36: Herceptin: overview - page 243
- Table 37: Herceptin global sales ($m), 2006-12 - page 243
- Table 38: Herceptin: news flow - page 244
- Table 39: Erbitux: overview - page 247
- Table 40: Erbitux global sales ($m), 2006-12 - page 247
- Table 41: Erbitux: news flow - page 248
- Table 42: Vectibix: overview - page 251
- Table 43: Vectibix global sales ($m), 2006-12 - page 251
- Table 44: Vectibix: news flow - page 252
- Table 45: Pertuzumab: overview - page 254
- Table 46: Pertuzumab global sales ($m), 2006-12 - page 255
- Table 47: Pertuzumab: news flow - page 255
- Table 48: Ticilimumab: overview - page 256
- Table 49: Ticilimumab global sales forecast ($m), 2006-12 - page 256
- Table 50: Ticilimumab: news flow - page 257
- Table 51: Ipilimumab: overview - page 258
- Table 52: Ipilimumab global sales ($m), 2006-12 - page 259
- Table 53: Ipilimumab: news flow - page 259
- Table 54: Humax CD20: overview - page 261
- Table 55: Humax CD20 global sales ($m), 2006-12 - page 261
- Table 56: HuMax CD20: news flow - page 262
- Table 57: Lumiliximab: overview - page 264
- Table 58: Lumiliximab global sales ($m), 2006-12 - page 264
- Table 59: Lumiliximab: news flow - page 265
- Table 60: Rencarex: overview - page 267
- Table 61: Rencarex global sales ($m), 2006-12 - page 267
- Table 62: Rencarex: news flow - page 268
- Table 63: Mylotarg: overview - page 270
- Table 64: Mylotarg global sales ($m), 2006-12 - page 270
- Table 65: Mylotarg: news flow - page 271
- Table 66: MAB Campath: overview - page 272
- Table 67: MAB Campath global sales ($m), 2006-12 - page 272
- Table 68: MAB Campath: news flow - page 273
- Table 69: Zevalin: overview - page 274
- Table 70: Zevalin global sales ($m), 2006-12 - page 275
- Table 71: Zevalin: news flow - page 275
- Table 72: Bexxar: overview - page 277
- Table 73: Bexxar global sales ($m), 2006-12 - page 277
- Table 74: Bexxar: news flow - page 278
- Table 75: Zalutumumab: overview - page 279
- Table 76: Zalutumumab global sales ($m), 2006-12 - page 279
- Table 77: Zalutumumab: news flow - page 280
- Table 78: Zanolimumab: overview - page 281
- Table 79: Zanolimumab global sales ($m), 2006-12 - page 281
- Table 80: Zanolimumab: news flow - page 282
- Table 81: Proxinium/Vicinium: overview - page 283
- Table 82: Proxinium/Vicinium: news flow - page 284
- Table 83: Catumaxomab: overview - page 285
- Table 84: Catumaxomab: news flow - page 286
- Table 85: Humira: overview - page 287
- Table 86: Humira global sales ($m), 2006-12 - page 287
- Table 87: Humira: news flow - page 288
- Table 88: Remicade: overview - page 291
- Table 89: Remicade global sales ($m), 2006-12 - page 291
- Table 90: Remicade: news flow - page 292
- Table 91: Product: overview - page 295
- Table 92: Cimzia global sales ($m), 2006-12 - page 295
- Table 93: Product: news flow - page 296
- Table 94: Rituxan/MabThera RA: overview - page 298
- Table 95: Rituxan/MabThera global sales ($m), 2006-12 - page 299
- Table 96: Rituxan/MabThera RA: news flow - page 299
- Table 97: Actemra: overview - page 302
- Table 98: Actemra global sales ($m), 2006-12 - page 302
- Table 99: Actemra: news flow - page 303
- Table 100: Golimumab: overview - page 305
- Table 101: Golimumab global sales ($m), 2006-12 - page 305
- Table 102: Golimumab: news flow - page 306
- Table 103: Raptiva: overview - page 308
- Table 104: Raptiva global sales ($m), 2006-12 - page 308
- Table 105: Raptiva: news flow - page 309
- Table 106: CNTO-1275: overview - page 310
- Table 107: CNTO-1275 global sales ($m), 2006-12 - page 310
- Table 108: CNTO-1275: news flow - page 311
- Table 109: Mepolizumab: overview - page 312
- Table 110: Mepolizumab global sales ($m), 2006-12 - page 312
- Table 111: Product: news flow - page 313
- Table 112: Simulect: overview - page 314
- Table 113: Simulect global sales ($m), 2006-12 - page 314
- Table 114: Simulect: news flow - page 315
- Table 115: Lymphocide: overview - page 316
- Table 116: Lymphocide global sales ($m), 2006-12 - page 316
- Table 117: Lymphocide: news flow - page 317
- Table 118: Zenapax: overview - page 318
- Table 119: Zenapax global sales ($m), 2006-12 - page 318
- Table 120: Zenapax: news flow - page 319
- Table 121: Nuvion: overview - page 320
- Table 122: Nuvion global sales ($m), 2006-12 - page 320
- Table 123: Nuvion: news flow - page 321
- Table 124: Leukotac: overview - page 322
- Table 125: Leukotac: news flow - page 323
- Table 126: Tysabri: overview - page 324
- Table 127: Tysabri global sales ($m), 2006-12 - page 324
- Table 128: Tysabri: news flow - page 325
- Table 129: ReoPro: overview - page 328
- Table 130: ReoPro global sales ($m), 2006-12 - page 328
- Table 131: ReoPro: news flow - page 329
- Table 132: Xolair: overview - page 330
- Table 133: Xolair global sales ($m), 2006-12 - page 330
- Table 134: Xolair: news flow - page 331
- Table 135: Lucentis: overview - page 333
- Table 136: Lucentis global sales ($m), 2006-12 - page 334
- Table 137: Lucentis: news flow - page 334
- Table 138: Soliris: overview - page 336
- Table 139: Soliris global sales ($m), 2006-12 - page 336
- Table 140: Soliris: news flow - page 337
- Table 141: AMG-531: overview - page 338
- Table 142: AMG-531 global sales ($m), 2006-12 - page 338
- Table 143: AMG-531: news flow - page 339
- Table 144: Denosumab: overview - page 340
- Table 145: Denosumab global sales ($m), 2006-12 - page 340
- Table 146: Denosumab: news flow - page 341
- Table 147: Numax: overview - page 343
- Table 148: Numax global sales ($m), 2006-12 - page 343
- Table 149: Numax: news flow - page 344
- Table 150: Mycograb: overview - page 346
- Table 151: Mycograb global sales ($m), 2006-12 - page 346
- Table 152: Mycograb: news flow - page 347
- Table 153: Aurograb: overview - page 348
- Table 154: Aurograb global sales ($m), 2006-12 - page 348
- Table 155: Aurograb: news flow - page 349
- Table 156: Synagis: overview - page 350
- Table 157: Synagis global sales ($m), 2006-12 - page 350
- Table 158: Synagis: news flow - page 351
- List of Figures
- Figure 1: Pharmaceutical market performance, sales ($m) and year-on-year growth (%), 2006-12 - page 9
- Figure 2: Sales growth by launch, core & expiry (ethical sales $m), 2006-12 - page 11
- Figure 3: Expiry portfolio, year-on-year change in annual sales ($m), 2006-12 - page 12
- Figure 4: Launch, core and expiry portfolio year-on-year change in annual sales ($m), 2006-12 - page 13
- Figure 5: Forecast sales by molecule type ($m), 2006-12 - page 19
- Figure 6: Change in annual sales ($m) by molecule type, 2006-12 - page 20
- Figure 7: Sales compound annual growth rate (CAGR) by molecule type, 2006-12 - page 21
- Figure 8: Levels of structural similarity by drug type - page 26
- Figure 9: Average revenues per product ($m), 2006 - page 36
- Figure 10: Percentage of oncology and AIID sales by molecule type, 2006 - page 39
- Figure 11: Percentage of oncology and AIID sales by molecule type, 2012 - page 40
- Figure 12: The role of drug targets in disease treatment - page 41
- Figure 13: Molecule type sales by target family, 2006 - page 44
- Figure 14: Total market sales growth (CAGR %) by target family, 2006-12 - page 46
- Figure 15: Sales growth drivers and resistors for mAbs, therapeutic proteins and small molecules - page 48
- Figure 16: mAb market outlook, sales ($m) and year-on-year growth (%), 2006-12 - page 49
- Figure 17: Product analysis, historical and forecast sales growth ($m), 2006-12 - page 51
- Figure 18: Product growth drivers and resistors ($m), 2006-12 - page 52
- Figure 19: Company analysis, historical and forecast sales growth ($m), 2006-12 - page 53
- Figure 20: Company growth drivers and resistors ($m), 2006-12 - page 54
- Figure 21: Therapy analysis, historical and forecast sales growth ($m), 2006-12 - page 55
- Figure 22: Therapy area growth drivers and resistors ($m), 2006-12 - page 56
- Figure 23: Technology analysis, historical and forecast sales growth ($m), 2006-12 - page 57
- Figure 24: Technology growth drivers and resistors ($m), 2006-12 - page 58
- Figure 25: Target analysis, historical and forecast sales growth ($m), 2006-12 - page 59
- Figure 26: Target growth drivers and resistors ($m), 2006-12 - page 60
- Figure 27: The 'big 5' mAbs have held over 70% of mAb sales since 2003 and are forecast to retain this market dominance until 2012 - page 62
- Figure 28: Total mAb sales ($m) of the 'big 5' vs. 'the rest' - page 63
- Figure 29: Absolute growth of the 'big 5' mAbs vs. 'the rest' - page 64
- Figure 30: Average revenues per product in 2006 of the 'big 5' mAbs and 'the rest' - page 65
- Figure 31: Quartile analysis, average 2006 revenues per product ($m) - page 66
- Figure 32: Dominance of the oncology mAb segment by Avastin, Rituxan and Herceptin - page 70
- Figure 33: Dominance of AIID biologic market by Remicade, Humira and Enbrel - page 76
- Figure 34: The structure of an antibody - page 82
- Figure 35: Types of antibodies - page 90
- Figure 36: Immunogenicity ranges - page 92
- Figure 37: Number of marketed mAb technologies - page 93
- Figure 38: Schematic illustration of antibody fragments - page 99
- Figure 39: Number of marketed full length mAbs versus fragments - page 100
- Figure 40: Number of Phase I-marketed mAb fragments - page 101
- Figure 41: Number of marketed naked and conjugated mAbs - page 104
- Figure 42: mAb timeline - technology shift - page 107
- Figure 43: Ethical sales ($m) and year-on-year growth rate (%), 2003-06 - page 119
- Figure 44: Ethical sales ($m) and year-on-year growth rate (%), 2006-12 - page 120
- Figure 45: Absolute sales growth rate (ethical sales) ($m), 2003-12 - page 121
- Figure 46: mAb CAGRs (%), 2003-12 - page 124
- Figure 47: Growth drivers/resistor products of historical revenue performance ($m), 2003-06 - page 125
- Figure 48: Product analysis, historical and forecast sales growth ($m), 2003-12 - page 131
- Figure 49: mAb count and average mAb sales per mAb, 2003-12 - page 134
- Figure 50: Product growth drivers and resistors ($m), 2006-12 - page 135
- Figure 51: Key growth driver companies by historical revenue performance ($m), 2003-06 - page 144
- Figure 52: Company analysis, historical and forecast sales growth ($m), 2003-12 - page 150
- Figure 53: Company growth drivers and resistors ($m), 2006-12 - page 153
- Figure 54: Growth drivers/resistor therapy areas of historical revenue performance ($m), 2003-06 - page 159
- Figure 55: Therapy analysis, historical and forecast sales growth ($m), 2003-12 - page 162
- Figure 56: Therapy area growth drivers and resistors ($m), 2006-12 - page 163
- Figure 57: Growth drivers/resistor technologies of historical revenue performance ($m), 2003-06 - page 167
- Figure 58: Technology analysis, historical and forecast sales growth ($m), 2003-12 - page 170
- Figure 59: Technology growth drivers and resistors ($m), 2006-12 - page 171
- Figure 60: Growth drivers/resistor targets of historical revenue performance ($m), 2003-06 - page 174
- Figure 61: Target analysis, historical and forecast sales growth ($m), 2003-12 - page 179
- Figure 62: Target growth drivers and resistors ($m), 2006-12 - page 180
- Figure 63: Count of marketed mAb players - page 196
- Figure 64: Count of Phase III pipeline mAb players - page 199
- Figure 65: Count of companies with more than one Phase I-II pipeline candidates - page 202
- Figure 66: Emerging mAb players - page 204
- Figure 67: Phase I-III pipeline count split by technology - page 207
- Figure 68: The stepwise evolution of naked mAb technology - page 208
- Figure 69: Overview of pipeline technology type Phase I-pre-reg - page 209
- Figure 70: Emerging mAb technologies (% mAb candidates) - page 211
- Figure 71: Phase I-pre-reg mAb count split by therapy area - page 214
- Figure 72: Percentage contribution from mAb candidates, 2006 - page 216
- Figure 73: Phase III and pre-registration target count - page 218
- Figure 74: Count of targets with more than one Phase I-II pipeline candidates - page 222
- Figure 75: Count of the most popular targets in early-stage development - page 227
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