Head and Neck Cancer - Innovatives to Change the Face of Treatment
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Scope - page 3
- Datamonitor insight into the head and neck market - page 3
- CHAPTER 2 INTRODUCTION - page 11
- Head and neck cancer - page 11
- Epidemiology - page 12
- Incidence of head and neck cancer - page 14
- Forecast incidence of cancer of the oral cavity - page 14
- Forecast incidence of cancer of the larynx - page 14
- Total estimates of cancer of the oral cavity and larynx - page 15
- Head and neck cancer - page 11
- CHAPTER 3 CURRENT TREATMENT OPTIONS - page 17
- Staging of head and neck cancer - page 17
- Treatment of early-stage cancer - page 18
- Treatment of the oral cavity - page 18
- Oral cavity: lips - page 19
- Treatment for lip cancer - page 19
- Oral cavity: tongue - page 19
- Treatment - page 19
- Oral cavity: floor of the mouth - page 20
- Treatment for floor-of-the-mouth cancer - page 20
- Hypopharyngeal cancer - page 21
- Laryngeal cancer - page 21
- Paranasal sinus and nasal cavity cancer - page 22
- Stage I and II tumors - page 23
- Nasopharynx - page 23
- Treatment of early-stage cancer - page 18
- Current treament options for advanced stage head and neck cancer - page 24
- Concomitant chemotherapy with radiation - page 25
- Induction chemotherapy - only beneficial for a subset of patients - page 27
- Recurrent disease - page 28
- Stage at presentation - page 29
- Staging of head and neck cancer - page 17
- CHAPTER 4 CURRENT TREATMENT CONTROVERSIES - page 31
- Chemotherapy - can platinum-based chemotherapy be replaced - page 32
- Standard therapy for advanced stage III and IV head and neck cancer is changing - page 32
- Targeted therapy in head and neck cancer - identifying responder groups - page 32
- Combining two target agents - maximizing the chance of response - page 34
- COX-2 inhibition - new targets needed - page 35
- A need for increased public awareness - page 36
- Conclusions - page 36
- CHAPTER 5 PIPELINE DRUGS - page 37
- Tirazone (tirapazamine) - Sanofi-Aventis - page 37
- Erbitux (cetuximab) - Imclone/BMS/MerckKGaA - page 39
- Iressa (gefitinib) - AstraZeneca - page 40
- Advexin (INGN 201) - Introgen - page 41
- Forecasts to 2012 - page 43
- Phase II clinical trials - page 45
- CHAPTER 6 OPINION LEADER TRANSCRIPTS - page 49
- CHAPTER 7 APPENDIX - page 56
- References - page 56
- Methodology - epidemiology - page 59
- Integrity of incidence data - page 59
- Static incidence data - page 59
- The generation of incidence forecast - page 60
- List of tables - page 62
- List of figures - page 64
- About Datamonitor - page 65
- About Datamonitor Healthcare - page 65
- Datamonitor Healthcare's research and analysis methodologies - page 66
- Datamonitor Healthcare's therapy area capabilities - page 66
- About the Oncology analysis team - page 67
- Disclaimer - page 68
- List of Tables
- Table 1: Forecast incidence of cancer of the oral cavity in the seven major markets, 2003-12 - page 14
- Table 2: Forecast of incidence of cancer of the larynx in the seven major markets, 2003-12 - page 15
- Table 3: Total estimates of cancer of the oral cavity and larynx in the seven major markets, 2003-12 - page 16
- Table 4: Staging for head and neck cancer based on the American Joint Committee on Cancer Staging (AJCC) - page 18
- Table 5: T staging for oral cavity cancer - page 18
- Table 6: Five-year survival rates for cancer of the tongue by stage - page 20
- Table 7: Five-year survival rates for cancer of the floor of the mouth by stage - page 21
- Table 8: T staging for maxiallary sinus - page 22
- Table 9: WHO classification of nasopharyngeal carcinoma - page 24
- Table 10: Chemoradiation vs. radiation alone in patients with stage III and stage IV head and neck cancer - page 26
- Table 11: Concomitant chemotherapy with irradiation improves survival and locoregional control in advanced head and neck cancer - page 26
- Table 12: Neoadjuvant cisplatin confers a survival advantage in patients with inoperable stage III and IV head and neck cancer - page 28
- Table 13: Number of CA repeats in intron one of the EGFR gene correlates with response to Tarceva cell line data - page 33
- Table 14: Ongoing Phase III clinical trials for head and neck cancer - page 37
- Table 15: Assumptions influencing sales forecasts of head and neck cancer pipeline compounds - page 43
- Table 16: Sales forecasts for pipeline head and neck cancer drugs, 2004-12 - page 43
- Table 17: Ongoing Phase II clinical trials for head and neck cancer - page 45
- Table 18: Ongoing Phase I/II clinical trials for head and neck cancer - page 47
- Table 19: Ongoing Phase I clinical trials for head and neck cancer - page 48
- List of Figures
- Figure 1: Anatomical structure of head and neck cancer regions - page 12
- Figure 2: Datamonitor estimates of cancer to the oral cavity and larynx in the seven major markets, 2003-12 - page 16
- Figure 3: Break down of head and neck cancer by stage and treatment options - page 30
- Figure 4: Unmet needs in head and neck cancer - page 31
- Figure 5: Pipeline head and neck cancer drugs sales forecasts, 2004-12 - page 44
- Figure 6: Generation of incidence rate changes - page 61
Other users found this report page using the following search terms: head and neck neck cancer head innovatives face epidemiology treament chemo cancers joint
If you can't find a report that meets your needs contact LeadDiscovery. We are one of the few report providers with extensive drug development experience and we frequently use this knowledge to help clients source the most appropriate reports or produce reports for them from scratch.