Commercial Insight: Antihormonal Therapies Aromatase Inhibitors Reinvigorate a Mature Market
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Oncology pharmaceutical analysis team - page 2
- Richard Faint - Director of Oncology - page 2
- About the Oncology pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Datamonitor insight into the antihormonal therapies market - page 3
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 16
- Market definition for this report - page 16
- L2A - Cytostatic hormones - page 16
- L2A3 - Luteinizing hormone-releasing hormone (LHRH) analogs - page 16
- L2B - Cytostatic hormone antagonists - page 16
- L2B1 - Anti-estrogens - page 16
- L2B2 - Anti-androgens - page 17
- L2B3 - Aromatase inhibitors - page 17
- L2B9 - Other hormone antagonists - page 17
- L2A - Cytostatic hormones - page 16
- Excluded drug classes - page 18
- L2A1 - Cytostatic estrogens - page 18
- L2A2 - Cytostatic progestogens - page 18
- L2A9 - Other cytostatic hormones - page 19
- Current market situation - page 20
- Market definition for this report - page 16
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 22
- Current and future opportunities and threats in the antihormonal therapies market - page 22
- Global opportunities and threats - page 22
- Opportunities - page 22
- Threats - page 25
- US: opportunities and threats - page 28
- Opportunities - page 28
- Threats - page 29
- Japan: opportunities and threats - page 30
- Opportunities - page 30
- Threats - page 31
- EU5: opportunities and threats - page 32
- Opportunities - page 32
- Threats - page 33
- France: opportunities and threats - page 35
- Opportunities - page 35
- Threats - page 35
- Germany: opportunities and threats - page 37
- Opportunities - page 37
- Threats - page 37
- Italy: opportunities and threats - page 38
- Opportunities - page 38
- Threats - page 39
- Spain: opportunities and threats - page 41
- Opportunities - page 41
- Threats - page 41
- UK: opportunities and threats - page 42
- Opportunities - page 42
- Threats - page 42
- Global opportunities and threats - page 22
- Summary of environmental issues affecting the antihormonal therapies market size - page 45
- Current and future opportunities and threats in the antihormonal therapies market - page 22
- CHAPTER 4 FORECAST ANALYSIS - page 46
- Overriding assumptions and effects - page 46
- Effect of Medicare Modernization Act - page 46
- Biennial price cut in Japan - page 46
- LHRH analogs - page 46
- Lupron (leuprolide) - page 46
- Despite increasing competition from super generics, Lupron remains the LHRH analog leader - page 46
- Eligard (leuprolide) - page 47
- Eligard's super-generic status is expected to erode Lupron's sales - page 47
- Viadur (leuprolide) - page 47
- Yearly formulation for advanced disease is likely to limit Viadur's use - page 47
- Zoladex (goserelin) - page 48
- Despite clinical efficacy to Lupron, Zoladex's difficult and painful administration may deter patients - page 48
- Decapeptyl (triptorelin) - page 48
- Genericized status has eroded Decapeptyl's sales, as well as physician favor for Lupron - page 48
- Plenaxis (abarelix) - page 49
- Despite withdrawal from US market due to slow uptake, Plenaxis may realize success in Europe - page 49
- Suprefact (buserelin) - page 49
- Inconvenience of administration severely limits use of Suprefact - page 49
- Lupron (leuprolide) - page 46
- Anti-estrogens - page 50
- Nolvadex (tamoxifen) - page 50
- Although Nolvadex is set to lose its gold-standard status to an aromatase inhibitor, its presence will always be felt in the breast cancer market - page 50
- Fareston (toremifene) - page 51
- Fareston has always been in tamoxifen's shadow, although an approval for atamestane may increase its sales - page 51
- Nolvadex (tamoxifen) - page 50
- Anti-androgens - page 52
- Casodex (bicalutamide) - page 52
- Despite a heavily genericized market, the branded Casodex remains the clear leader - page 52
- Eulexin (flutamide) - page 53
- Inconvenience of dosing schedule compared to other anti-androgens has caused its use to decline - page 53
- Anandron (nilutamide) - page 53
- Compared to Casodex, Anandron has a less favorable toxicity profile, meaning that physicians favor the former drug - page 53
- Androcur (cyproterone) - page 53
- Androcur's association with potentially severe hepatotoxicity has severely restricted its use - page 53
- Casodex (bicalutamide) - page 52
- Aromatase inhibitors - page 54
- Arimidex (anastrozole) - page 54
- Arimidex's status as the leading aromatase inhibitor has been set in stone by recent ATAC results and ASCO recommendations - page 54
- Femara (letrozole) - page 55
- Recent ASCO recommendations and potential additional indications will serve to boost Femara's sales - page 55
- Aromasin (exemestane) - page 56
- Difference in mechanism of action may provide Aromasin with new opportunities - page 56
- Cytadren (aminoglutethimide) - page 57
- Age of product and advent of more effective products has left Cytadren redundant - page 57
- Arimidex (anastrozole) - page 54
- Other hormone antagonists - page 57
- Faslodex (fulvestrant) - page 57
- Additional indications and complexity of formulation will ensure that Faslodex's sales continue to rise - page 57
- Faslodex (fulvestrant) - page 57
- Pipeline products - page 58
- Vantas (histrelin) - page 58
- Yearly formulation is likely to limit Vantas's potential, particularly in the saturated LHRH analog market - page 58
- Atamestane (atamestane) - page 59
- Atamestane's development in combination with Orion Corp's Fareston may distinguish it from the other aromatase inhibitors - page 59
- Evista (raloxifene) - page 60
- Vantas (histrelin) - page 58
- Forecasts - page 61
- Overriding assumptions and effects - page 46
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 62
- Introduction - page 62
- Case study 1 - page 62
- The rising profile of the aromatase inhibitors - page 62
- Link between aromatase inhibitors and anti-estrogens - page 62
- Demise of tamoxifen - page 63
- Arrival of the aromatase inhibitors - page 63
- Clinical superiority in treatment of breast cancer? - page 63
- ASCO recommendations - page 64
- Clinical superiority in prevention? - page 65
- Opportunities for further growth - page 66
- The rising profile of the aromatase inhibitors - page 62
- Case study 2 - page 67
- Failure of Plenaxis to enter a mature market - page 67
- Saturation of the LHRH analogs market - page 67
- Initial high expectations - page 67
- Multiple drawbacks - page 67
- Different strategy may result in European success - page 68
- Physician prescribing patterns difficult to shift - page 68
- Potentially shifting paradigms in treatment of prostate cancer - page 68
- Superiority in all aspects - page 70
- Failure of Plenaxis to enter a mature market - page 67
- Case study 3 - page 70
- AstraZeneca's optimal strategy - page 70
- First-to-market status - page 70
- Effective lifecycle management diluted generic erosion of Nolvadex - page 70
- Arimidex as replacement for Nolvadex? - page 71
- Maintenance of lead position - page 71
- Future challenges to overcome - page 72
- AstraZeneca's optimal strategy - page 70
- APPENDIX A - MARKET DATA AND MAJOR BRAND KEY FACTS - page 73
- L2A3 (LHRH analogs) class market data - page 73
- L2B1 (anti-estrogens) class market data - page 77
- L2B2 (anti-androgens) class market data - page 78
- L2B3 (aromatase inhibitors) class market data - page 80
- L2B9 (other hormone antagonists) class market data - page 83
- Sales data and forecasts - page 83
- PowerPoint Executive Presentation - page 83
- APPENDIX B - SALES FORECASTS - page 84
- US forecasts - page 84
- Japan forecasts - page 87
- France forecasts - page 90
- Germany forecasts - page 94
- Italy forecasts - page 98
- Spain forecasts - page 101
- UK forecasts - page 104
- EU5 forecasts - page 108
- Global forecasts - page 112
- APPENDIX C - page 116
- Bibliography - page 116
- Report methodology - page 119
- About Datamonitor - page 120
- About Datamonitor Healthcare - page 120
- About the Oncology analysis team - page 121
- Disclaimer - page 122
- List of Tables
- Table 1: Key players in the antihormonal therapies market - page 20
- Table 2: Antihormonal therapy sales in the seven major markets by drug class, 2003-04 - page 21
- Table 3: Lupron: key facts - page 73
- Table 4: Eligard: key facts - page 74
- Table 5: Viadur: key facts - page 74
- Table 6: Zoladex: key facts - page 75
- Table 7: Decapeptyl: key facts - page 75
- Table 8: Plenaxis: key facts - page 76
- Table 9: Suprefact: key facts - page 76
- Table 10: Nolvadex: key facts - page 77
- Table 11: Fareston: key facts - page 77
- Table 12: Casodex: key facts - page 78
- Table 13: Eulexin: key facts - page 78
- Table 14: Anandron: key facts - page 79
- Table 15: Androcur: key facts - page 79
- Table 16: Arimidex: key facts - page 80
- Table 17: Femara: key facts - page 81
- Table 18: Aromasin: key facts - page 81
- Table 19: Lentaron: key facts - page 82
- Table 20: Cytadren: key facts - page 82
- Table 21: Faslodex: key facts - page 83
- Table 22: Forecasts for LHRH analogs in the US to 2014 - page 84
- Table 23: Forecasts for aromatase inhibitors in the US to 2014 - page 85
- Table 24: Forecasts for anti-androgens, anti-estrogens and other hormone antagonists in the US to 2014 - page 86
- Table 25: Forecasts for LHRH analogs in Japan to 2014 - page 87
- Table 26: Forecasts for aromatase inhibitors and anti-androgens in Japan to 2014 - page 88
- Table 27: Forecasts for anti-estrogens and other hormone antagonists in Japan to 2014 - page 89
- Table 28: Forecasts for LHRH analogs in France to 2014 - page 90
- Table 29: Forecasts for aromatase inhibitors in France to 2014 - page 91
- Table 30: Forecasts for anti-androgens in France to 2014 - page 92
- Table 31: Forecasts for anti-estrogens and other hormone antagonists in France to 2014 - page 93
- Table 32: Forecasts for LHRH analogs in Germany to 2014 - page 94
- Table 33: Forecasts for aromatase inhibitors in Germany to 2014 - page 95
- Table 34: Forecasts for anti-androgens in Germany to 2014 - page 96
- Table 35: Forecasts for anti-estrogens and other hormone antagonists in Germany to 2014 - page 97
- Table 36: Forecasts for LHRH analogs in Italy to 2014 - page 98
- Table 37: Forecasts for aromatase inhibitors in Italy to 2014 - page 99
- Table 38: Forecasts for anti-androgens, anti-estrogens and other hormone antagonists in Italy to 2014 - page 100
- Table 39: Forecasts for LHRH analogs in Spain to 2014 - page 101
- Table 40: Forecasts for aromatase inhibitors in Spain to 2014 - page 102
- Table 41: Forecasts for anti-androgens, anti-estrogens and other hormone antagonists in Spain to 2014 - page 103
- Table 42: Forecasts for LHRH analogs in the UK to 2014 - page 104
- Table 43: Forecasts for aromatase inhibitors in the UK to 2014 - page 105
- Table 44: Forecasts for anti-androgens in the UK to 2014 - page 106
- Table 45: Forecasts for anti-estrogens and other hormone antagonists in the UK to 2014 - page 107
- Table 46: EU5 forecasts for LHRH analogs to 2014 - page 108
- Table 47: EU5 forecasts for aromatase inhibitors to 2014 - page 109
- Table 48: EU5 forecasts for anti-androgens to 2014 - page 110
- Table 49: EU5 forecasts for anti-estrogens and other hormone antagonists to 2014 - page 111
- Table 50: Global forecasts for LHRH analogs to 2014 - page 112
- Table 51: Global forecasts for aromatase inhibitors to 2014 - page 113
- Table 52: Global forecasts for anti-androgens to 2014 - page 114
- Table 53: Global forecasts for anti-estrogens and other hormone antagonists to 2014 - page 115
- List of Figures
- Figure 1: Seven market population aged 60 and over, 1950-2050 - page 22
- Figure 2: Increasing incidence of breast and prostate cancer with increasing age - page 23
- Figure 3: Global oncology sales, 2003-09 - page 24
- Figure 4: Summary of regional opportunities and threats affecting the antihormonal therapies market - page 45
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