Commercial Insight: Antidiabetics
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Cardiovascular pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the antidiabetics market - page 4
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 11
- Market definition for this report - page 11
- Current market situation - page 12
- National markets - page 14
- The insulin market - page 15
- Humalog - page 16
- NovoLin - page 16
- Lantus - page 17
- Humulin - page 18
- NovoRapid/NovoLog - page 18
- Outlook - page 19
- Thiazolidinediones - page 19
- Actos - page 20
- Avandia - page 21
- Sulfonylureas - page 22
- Amaryl - page 23
- Glucotrol XL - page 24
- Biguanides - page 24
- Glucophage - page 25
- Strategic scoping and focus - page 25
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 28
- Current and future opportunities and threats in the antidiabetics market - page 28
- Global opportunities and threats - page 28
- Opportunities - page 28
- Threats - page 35
- US: current market assessment - page 36
- Overview - page 36
- US market issues - page 37
- Japan: current market assessment - page 42
- Overview - page 42
- Japan market issues - page 43
- Europe: current market assessment - page 47
- Overview - page 47
- Europe market issues - page 48
- Global opportunities and threats - page 28
- Summary of environmental issues affecting the antidiabetic market size - page 52
- Current and future opportunities and threats in the antidiabetics market - page 28
- CHAPTER 4 FORECAST ANALYSIS - page 54
- Assumptions and events - page 54
- Ongoing trends - page 54
- Increasing market size - page 54
- Trial results - page 54
- PROACTIVE - page 54
- CHICAGO and PERISCOPE - page 54
- DREAM - page 55
- ACCORD - page 56
- ADOPT - page 56
- ORIGIN - page 56
- NAVIGATOR - page 56
- New product launches - page 57
- Byetta and Exenatide LAR - page 57
- Symlin - page 59
- Pargluva - page 60
- Vildagliptin - page 61
- Liraglutide - page 62
- Exubera - page 63
- AERx iDMS - page 65
- Patent expiries - page 66
- Ongoing trends - page 54
- Limitations of data - page 67
- Forecasts - page 67
- Assumptions and events - page 54
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 68
- Introduction - page 68
- Case study 1 - page 68
- Aventis: Building a successful insulin portfolio - page 68
- Competitive landscape - page 68
- Lantus - page 70
- Lantus strategic analysis - page 75
- Conclusion - page 78
- Apidra - page 79
- Exubera - page 79
- The basis of commercial success - page 80
- Aventis: Building a successful insulin portfolio - page 68
- Case study 2 - page 81
- BMS: Managing the lifecycle of Glucophage - page 81
- Patent protection strategies - page 81
- DepoMed announces lawsuit against BMS for Glucophage XR patent infringement - page 82
- Study published in JAMA reveals Glucophage is prescribed to patients with heart and kidney disorders, despite black box warning of lactic acidosis side-effect - page 83
- Merck Sante announces a trademark and patent-licensing agreement with Sumitomo Pharmaceuticals for the development and commercialization of Glucophage and Glucophage XR in Japan - page 83
- BMS announces FDA approval of 750mg dose of Glucophage XR - page 84
- Strategic analysis - page 85
- BMS: Managing the lifecycle of Glucophage - page 81
- APPENDIX A - MAJOR BRAND KEY FACTS - page 87
- Insulin market data - page 87
- Humulin - page 87
- Humalog - page 88
- NovoLin - page 89
- NovoRapid/NovoLog - page 90
- Lantus - page 91
- TZDs market data - page 92
- Actos - page 92
- Avandia - page 93
- Sulfonylureas market data - page 94
- Amaryl - page 94
- Glucotrol XL - page 95
- Biguanide market data - page 96
- Glucophage and Glucophage XR - page 96
- Insulin market data - page 87
- APPENDIX B - page 97
- Bibliography - page 97
- Epidemiology - page 97
- Clinical trial data - page 98
- Report methodology - page 103
- Standard units - page 103
- Japanese market data - page 104
- About Datamonitor - page 105
- About Datamonitor Healthcare - page 105
- About the Cardiovascular Disease analysis team - page 106
- Disclaimer - page 107
- Bibliography - page 97
- List of Tables
- Table 1: Global sales in the antidiabetic market by drug class, 2004 - page 12
- Table 2: Global sales of the leading branded insulin families, 2003-04 - page 15
- Table 3: Global sales of the leading branded TZDs, 2003-04 - page 20
- Table 4: Global sales of the leading branded sulfonylureas, 2003-04 - page 23
- Table 5: Global sales of the leading branded biguanide compared to generics, 2003-04 - page 25
- Table 6: Future prevalence of type 1 and type 2 diabetes in the seven major markets, 2004-12 - page 27
- Table 7: Prevalence of obesity in the seven major markets by age (000s), 2003 - page 32
- Table 8: US sales and growth of drug classes - page 36
- Table 9: Japan sales and growth of drug classes - page 42
- Table 10: EU5 sales and growth of drug classes - page 47
- Table 11: Patent expiry dates used in forecasting antidiabetics market - page 67
- Table 12: Key Lantus events - page 70
- Table 13: Key Glucophage and Glucophage XR events - page 82
- Table 14: Annual cost of therapy for Glucophage brands versus generics - page 86
- Table 15: Humulin: key facts - page 87
- Table 16: Humalog: key facts - page 88
- Table 17: NovoLin: key facts - page 89
- Table 18: NovoLog: key facts - page 90
- Table 19: Lantus: key facts - page 91
- Table 20: Actos: key facts - page 92
- Table 21: Avandia: key facts - page 93
- Table 22: Amaryl: key facts - page 94
- Table 23: Glucotrol XL: key facts - page 95
- Table 24: Glucophage and Glucophage XR: key facts - page 96
- List of Figures
- Figure 1: Sales and growth for antidiabetic drug classes in the seven major markets, 2003-04 - page 13
- Figure 2: Share of antidiabetics market represented by each of the seven major markets in 2004 - page 14
- Figure 3: Pioglitazone's effects on triglyceride and HDL cholesterol levels - page 21
- Figure 4: Proportion of population 20-39 years of age, 2003 and 2015 and prevalence of diabetes in this age group, 2003 - page 29
- Figure 5: Proportion of population 40-59 years of age, 2003 and 2015 and prevalence of diabetes in this age group, 2003 - page 30
- Figure 6: Proportion of population 60-79 years of age, 2003 and 2015 and prevalence of diabetes in this age group, 2003 - page 31
- Figure 7: Annual US sales of the antidiabetic drug classes, 2001-04 - page 37
- Figure 8: Annual Japan sales of the antidiabetic drug classes, 2001-04 - page 43
- Figure 9: Annual EU5 sales of the antidiabetic drug classes, 2001-04 - page 48
- Figure 10: Summary of environmental issues - page 53
- Figure 11: SWOT analysis for Lantus - page 76
- Figure 12: SWOT analysis for the Glucophage franchise - page 85
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