Pipeline Insight: Anxiety Disorders - A decade of declining revenues
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the CNS pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Scope of the analysis - page 3
- Datamonitor insight into the anxiety market - page 5
- Key metrics - page 7
- CHAPTER 2 PATIENT POTENTIAL - page 24
- Etiology of anxiety disorders - page 24
- Generalized anxiety disorder - page 24
- Panic disorder - page 24
- Social anxiety disorder - page 25
- Obsessive-compulsive disorder - page 26
- Post-traumatic stress disorder - page 26
- Premenstrual dysphoric disorder - page 27
- Agoraphobia - page 27
- Specific phobias - page 28
- Classification of anxiety disorders - page 28
- ICD-10 classification - page 29
- DSM-IV classification - page 30
- Diagnosis algorithm - page 31
- Epidemiology of anxiety - page 32
- Prevalence of anxiety disorder types - page 32
- Generalized anxiety disorder - page 33
- Panic disorder - page 33
- Social anxiety disorder - page 34
- Obsessive-compulsive disorder - page 35
- Post-traumatic stress disorder - page 36
- Premenstrual dysphoric disorder - page 37
- Agoraphobia - page 37
- Specific phobias - page 38
- Other anxiety disorders - page 38
- Prevalence of anxiety disorder types - page 32
- Key patient segments - page 38
- Acute versus chronic anxiety - page 38
- Gender and age - page 39
- Comorbidities of anxiety disorders - page 40
- Unmet needs in anxiety disorders - page 42
- Improving patient compliance is key - page 42
- Improving the perceived therapeutic efficacy through patient education - page 43
- Patient education and public awareness - page 43
- Faster onset of action on the horizon - page 45
- Limiting side effects is essential - page 45
- Targeting comorbidity expands the prescribing potential of a drug - page 46
- Improving patient compliance is key - page 42
- Etiology of anxiety disorders - page 24
- CHAPTER 3 R&D APPROACH - page 48
- Classification of marketed and pipeline products - page 48
- Serotonergics - page 49
- Noradrenergics - page 49
- GABAergic drugs - page 50
- Novel therapies - page 51
- Clinical trials and drug development - page 52
- Clinical trial endpoints and anxiety rating scales - page 52
- Hamilton Anxiety (HAM-A) - page 52
- Hospital Anxiety and Depression scale (HADS) - page 52
- Liebowitz Social Anxiety Scale (LSAS) - page 53
- Patient Global Impression of Improvement Scale (PGI) - page 53
- Clinical Global Impression Improvement Scale (CGI-I) - page 53
- Social Phobia and Anxiety Inventory (SPAI) - page 53
- Social Phobia Inventory (SPIN) - page 54
- Clinician Administered PTSD Scale (CAPS) - page 54
- Treatment Outcome PTSD Scale - page 55
- Davidson Trauma Scale (DTS) - page 55
- Short PTSD Rating Interview (SPRINT) - page 55
- Brief Social Phobia Scale fear subscale - page 55
- Panic Disorder Severity Scale (PDSS) - page 55
- Panic and Agoraphobia Scale (PAS) - page 56
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS) - page 56
- The National Institute of Mental Health Obsessive Compulsive Scale (NIMH-OC) - page 56
- Daily Record of Severity of Problems (DRSP) - page 57
- Other scales - page 57
- Clinical trial design guidance - page 57
- Inclusion criteria - page 57
- Exclusion criteria - page 58
- Assessing efficacy - page 58
- Strategy and design of clinical trials - page 59
- Key research recommendations - page 61
- Clinical trial endpoints and anxiety rating scales - page 52
- Classification of marketed and pipeline products - page 48
- CHAPTER 4 MARKETED AND PIPELINE ANXIETY DRUG OVERVIEW - page 64
- Marketed anxiety drug overview - page 64
- The market value is calculated using IMS diagnosis value - page 65
- Forecast caveats - page 66
- Pipeline overview - page 67
- Anxiety drugs in Phase III and above - page 67
- Anxiety drugs in Phase II - page 69
- Anxiety drugs in Phase I - page 70
- Key companies involved in the anxiety pipeline - page 71
- GSK - page 71
- Wyeth - page 77
- Lilly - page 80
- Other key companies involved in the anxiety pipeline - page 84
- Sanofi-Aventis - page 84
- Fabre Kramer - page 85
- Methodology of SWOT analysis - page 86
- Gold standard anxiolytic - page 87
- Generalized Anxiety Disorder - page 88
- Obsessive Compulsive Disorder - page 89
- Panic Disorder - page 89
- Social Anxiety Disorder - page 90
- Premenstrual Dysphoric Disorder - page 90
- Post traumatic stress disorder - page 91
- Gold standard anxiolytic - page 87
- Marketed anxiety drug overview - page 64
- CHAPTER 5 GAD PIPELINE DRUG OVERVIEW - page 92
- Overview of GAD drugs - page 92
- Launched drugs - page 92
- Pipeline summary - page 93
- Lyrica (pregabalin) - page 94
- Clinical trial data - page 94
- Cymbalta (duloxetine) - page 102
- Clinical trial data - page 102
- Recently completed clinical trials - page 103
- Ongoing clinical trials - page 104
- PRX-00023 - page 105
- Clinical trial data - page 105
- Ongoing clinical trials - page 106
- SR-58611 - page 107
- Ongoing clinical trials - page 107
- Gabitril (tiagabine) - page 109
- Clinical trial data - page 109
- Ongoing clinical trials - page 114
- Seroquel SR (quetiapine sustained release) - page 114
- Clinical trial data - page 115
- AC-5216 - page 116
- Ongoing clinical trials - page 116
- MN-305 (osemozotan / MKC-242) - page 117
- Jazz Pharma - page 117
- Ongoing clinical trials - page 118
- Recently discontinued pipeline drugs - page 119
- Lyrica (pregabalin) - page 94
- CHAPTER 6 OCD PIPELINE DRUG OVERVIEW - page 120
- Overview of OCD drugs - page 120
- Launched drugs - page 120
- Pipeline summary - page 121
- Lexapro (escitalopram) - page 122
- Clinical trial data - page 122
- Ongoing clinical trials - page 123
- Luvox CR (fluvoxamine controlled release) - page 124
- Clinical trial data - page 124
- Lexapro (escitalopram) - page 122
- CHAPTER 7 SAD PIPELINE DRUG OVERVIEW - page 126
- Overview of SAD drugs - page 126
- Launched drugs - page 126
- Pipeline summary - page 127
- Luvox CR (fluvoxamine controlled release) - page 128
- Clinical trial data - page 128
- Lexapro (escitalopram) - page 130
- Clinical trial data - page 130
- Cymbalta (duloxetine) - page 136
- Ongoing clinical trials - page 136
- TGWOOAD/AA - page 137
- LY686017 - page 137
- Ongoing clinical trials - page 137
- Gabitril (tiagabine) - page 138
- Clinical trial data - page 138
- Completed clinical trials - page 140
- casopitant (GW679769) - page 141
- Ongoing clinical trials - page 141
- Luvox CR (fluvoxamine controlled release) - page 128
- CHAPTER 8 PD PIPELINE DRUG OVERVIEW - page 142
- Overview of PD drugs - page 142
- Launched drugs - page 142
- Pipeline summary - page 143
- Lexapro (escitalopram) - page 144
- Clinical trial data - page 145
- TGAR01P - page 145
- Lexapro (escitalopram) - page 144
- CHAPTER 9 PTSD PIPELINE DRUG OVERVIEW - page 146
- Overview of PTSD drugs - page 146
- Launched drugs - page 146
- Pipeline summary - page 147
- Risperdal (risperidone) - page 148
- Clinical trial data - page 148
- Ongoing clinical trials - page 150
- Paxil CR (paroxetine controlled release) - page 150
- Ongoing clinical trials - page 150
- Gabitril (tiagabine) - page 152
- Clinical trial data - page 152
- Effexor XR (venlafaxine extended release) - page 154
- Clinical trial data - page 155
- Risperdal (risperidone) - page 148
- CHAPTER 10 PMDD PIPELINE DRUG OVERVIEW - page 157
- Overview of PMDD drugs - page 157
- Launched drugs - page 157
- Pipeline summary - page 158
- YAZ (drospirenone and ethinyl estradiol) - page 159
- Clinical trial data - page 159
- Librel (levonorgestrel / ethinyl estradiol) - page 160
- Ongoing clinical trials - page 160
- YAZ (drospirenone and ethinyl estradiol) - page 159
- CHAPTER 11 NON-SPECIFIED ANXIETY DISORDERS DRUG OVERVIEW - page 162
- Non-specified anxiety disorders drug overview - page 162
- Launched drugs - page 162
- Pipeline summary - page 163
- alprazolam - page 163
- AP-521 - page 163
- ELB139 - page 163
- Clinical trial data - page 164
- vestipitant (GW597599) + paroxetine - page 165
- Recently suspended pipeline drugs - page 165
- CHAPTER 12 ANALYSIS AND FORECASTS OF PIPELINE ANXIETY DRUGS - page 166
- Analysis and forecasts of pipeline anxiety drugs - page 166
- Lyrica (pregabalin) - page 166
- Lyrica demonstrates a strong safety and efficacy profile, with a fast onset - page 167
- Schedule V may limit patient uptake in the US - page 170
- Lyica will become a first-line treatment for pure GAD - page 171
- Lyrica's anxiety revenues will slow the decline of Pfizer's anxiety franchise - page 172
- Threat from generic gabapentin? - page 174
- Lyrica will be the next new anxiety drug to reach the market - page 175
- Cymbalta (duloxetine) - page 178
- Cymbalta's side effects will limit uptake in anxiety - page 178
- Lack of clear differentiation from venlafaxine in anxiety - page 181
- Global partnerships enhance commercial prospects of Cymbalta - page 183
- Cymbalta's revenue growth in the anxiety market will be short lived - page 183
- PRX-00023 - page 185
- Physicians are unconvinced with the therapeutic potential of PRX-00023 - page 185
- PRX-00023 will be used to augment SSRI therapy - page 187
- PRX-00023 is unlikely to compete on the same therapeutic plain as the SSRIs - page 189
- SR-58611 - page 190
- Efficacy in severe depression may carry over into anxiety - page 190
- Initial off-label usage will support growth in GAD once approved - page 193
- Gabitril (tiagabine) - page 193
- Physicians unimpressed by Gabitril's efficacy in anxiety - page 194
- FDA seizure warning severely threatens Gabitril's patient potential - page 195
- Treatment of comorbid pain in GAD - page 197
- Gabitril's commercial potential is limited - page 198
- Gabitril is unlikey to receive FDA approval for GAD - page 200
- Seroquel SR (quetiapine sustained release) - page 201
- A strong safety and efficacy profile in schizophrenia and BD bodes well for use in anxiety - page 201
- Seroquel will retain patent protection until 2011, protecting the initial uptake of Seroquel SR - page 202
- Targeting community based psychiatric disorders will favor Seroquel SR's growth - page 203
- AC-5216 - page 204
- Physicians are skeptical of the therapeutic potential of AC-5216 - page 204
- MN-305 (Osemozotan / MKC-242) - page 205
- The record for the 5-HT1A partial agonists has been appallingly bad - page 206
- MediciNova will need to find a marketing partner - page 207
- Jazz Pharma - page 208
- Lexapro (escitalopram) - page 208
- US non-approvals for SAD and PD will limit future revenues - page 211
- Lack of pipeline compounds will limit long-term anxiety revenues for Lundbeck and Forest - page 212
- Lexapro will retain patent protection until 2011 - page 214
- Lexapro's anxiety specific revenues will continue to grow through 2009 - page 215
- Luvox CR (fluvoxamine controlled release) - page 216
- Luvox will continue to grow in Japan, despite genericization - page 217
- Luvox CR is commercial suicide - page 218
- TGWOOAD/AA - page 220
- TGWOOAD/AA's mode of action is not particularly unique - page 220
- Fabre Kramer will need to find a marketing partner - page 222
- TGAR01P - page 223
- Physicians have serious concerns regarding TGAR01P - page 224
- Datamonitor does not expect that TGAR01P will receive FDA approval - page 225
- LY686017 - page 226
- Risperdal (risperidone) - page 226
- Risperdal demonstrates efficacy in reducing the symptoms of PTSD - page 227
- J&J has limited time to gain FDA approval for Risperdal for PTSD before the availability of generic risperidone - page 227
- Paxil CR (paroxetine controlled release) - page 228
- GSK faces several hurdles in terms of establishing Paxil CR as a first-line treatment for PTSD - page 228
- GSK's NK1 antagonists - casopitant (GW679769) and vestipitant (GW597599) - page 231
- Combination of an NK1 antagonist and SSRI shows potential - page 231
- Effexor XR (venlafaxine extended release) - page 234
- Effexor XR's recent approval for PD will certainly boost revenues - page 234
- US and EU patent expiries lead to erosion of Effexor XR revenues from 2008 onwards - page 236
- YAZ (drospirenone and ethinyl estradiol) - page 238
- YAZ will provide an alternative treatment to women who feel that there is a stigma attached to taking an SSRI - page 239
- No PMDD market in the EU limits revenue potential - page 242
- YAZ is expected to continue to grow Schering AG/Berlex's flagship women's health franchise - page 243
- Librel (levonorgestrel / ethinyl estradiol) - page 246
- Librel's continuous regimen may provide a competitive advantage - page 246
- Librel's uptake will be limited by YAZ's first to market status - page 247
- NovaDel's alprazolam oral spray - page 250
- Improved therapeutic potential remains uncertain despite a head-to-head trial with alprazolam tablets - page 250
- NovaDel will have difficulty in gaining FDA approval for the formulation - page 252
- Datamonitor does not expect oral spray alprazolam will receive FDA approval - page 254
- AP-521 - page 255
- ELB139 - page 256
- Lyrica (pregabalin) - page 166
- Analysis and forecasts of pipeline anxiety drugs - page 166
- CHAPTER 13 INNOVATIVE EARLY-STAGE PROJECTS - page 257
- Overview of innovative early-stage projects - page 257
- NK receptor antagonists - page 258
- ALXZ-002 - page 259
- Synthetic human secretin - page 259
- The subcutaneous formulation is unlikely be received well by patients - page 261
- CRF antagonists - page 262
- 5-HT agonists - page 263
- Metabotropic glutamate receptor 5 modulators - page 264
- MAO inhibitors - page 264
- CCK antagonists - page 265
- PDE 2 inhibitor - page 265
- Vasopressin - page 265
- Future treatment of anxiety disorder - page 266
- Overview of innovative early-stage projects - page 257
- APPENDIX A - page 268
- Forecast revenues - page 268
- Anxiety market data - page 269
- Competitive positioning analysis of pipeline anxiety drugs - page 284
- Bibliography - page 286
- Journal articles and conference abstracts - page 294
- APPENDIX B - page 305
- Report methodology - page 305
- Datamonitor forecast methodology - page 305
- Sales calculations - page 305
- Datamonitor forecast methodology - page 305
- About Datamonitor - page 307
- About Datamonitor Healthcare - page 307
- Datamonitor Healthcare's therapy area capabilities - page 308
- Report methodology - page 305
- List of Tables
- Table 1: Forecast revenues ($m) of marketed and pipeline anxiety drugs across the seven major markets, 2006-15 - page 8
- Table 2: ICD-10 classification codes for anxiety disorders - page 29
- Table 3: DSM-IV classification codes for anxiety disorders - page 30
- Table 4: Prevalence rate of sub-categories of anxiety disorder in the general population across the seven major markets - page 32
- Table 5: Prevalence of GAD - page 33
- Table 6: Prevalence of panic disorder - page 34
- Table 7: Prevalence of SAD in four of the major markets - page 34
- Table 8: Prevalence of OCD - page 35
- Table 9: Prevalence of a comorbid psychiatric condition with anxiety disorders across the seven major markets - page 40
- Table 10: Marketed anxiety drugs approved for specific anxiety disorders, in the US, EU and Japan. - page 64
- Table 11: Percentage of total molecule volume (accounted for by anxiety, diagnosis value, 2005 (MAT Q4 2004 to Q3 2005) - page 65
- Table 12: Drugs seeking approval for anxiety indications, 2006 - page 67
- Table 13: Drugs in Phase III development for anxiety disorders, 2006 - page 68
- Table 14: Drugs in Phase II development for anxiety disorders, 2006 - page 69
- Table 15: Drugs in Phase I development for anxiety disorders, 2006 - page 70
- Table 16: GSK's global CNS franchise, 2005 - page 71
- Table 17: GSK's marketed and pipeline anxiety drugs, 2006 - page 72
- Table 18: Wyeth's global CNS portfolio, 2004-05 - page 77
- Table 19: Wyeth's marketed and pipeline anxiety drugs, 2006 - page 77
- Table 20: Lilly's global CNS portfolio, 2005 - page 81
- Table 21: GSK's marketed and pipeline anxiety drugs, 2005 - page 82
- Table 22: Commercial strength / weakness factors - weightings and scoring definitions - page 86
- Table 23: Product specific strength / weakness factors - weightings and scoring definitions - page 87
- Table 24: Drugs approved for GAD - page 92
- Table 25: Drugs in Phase II development or above for GAD - page 93
- Table 26: Pipeline drugs recently discontinued from development for GAD - page 119
- Table 27: Drugs approved for OCD - page 120
- Table 28: Drugs in Phase II development or above for OCD - page 121
- Table 29: Drugs approved for SAD - page 126
- Table 30: Drugs in Phase II development or above for SAD - page 127
- Table 31: Drugs approved for PD - page 142
- Table 32: Drugs in Phase II development or above for PD - page 143
- Table 33: Drugs approved for PTSD - page 146
- Table 34: Drugs in Phase II development or above for PTSD - page 147
- Table 35: Drugs approved for PMDD - page 157
- Table 36: Drugs in Phase II development or above for PMDD - page 158
- Table 37: Drugs approved for non-specified anxiety disorders - page 162
- Table 38: Drugs in late-stage development for non-specified anxiety disorders - page 163
- Table 39: Pipeline drugs recently suspended from development for non-specified anxiety disorders - page 165
- Table 40: Proportion (%) of drug revenues attributed to anxiety disorders for Gabitril and approved anxiety drugs - page 201
- Table 41: Estimated patient and revenue potential of YAZ in PMDD - page 244
- Table 42: Estimated patient and revenue potential of Librel in PMDD - page 248
- Table 43: Drugs in Phase I clinical development for anxiety disorders, 2006 - page 257
- Table 44: Forecast revenues ($m) of marketed and pipeline anxiety drugs across the seven major markets, 2006-15 - page 268
- Table 45: Prozac key facts - page 269
- Table 46: Key Prozac events, 2005-2006 - page 269
- Table 47: Prozac key facts - page 270
- Table 48: Paxil key facts - page 271
- Table 49: Key Paxil events, 2005-2006 - page 271
- Table 50: Zoloft: key facts - page 272
- Table 51: Key Zoloft events, 2005-2006 - page 272
- Table 52: Celexa: key facts - page 273
- Table 53: Lexapro: key facts - page 274
- Table 54: Key Lexapro/Cipralex events, 2005-2006 - page 275
- Table 55: Luvox: key facts - page 276
- Table 56: Key Luvox events, 2005-2006 - page 276
- Table 57: Effexor: key facts - page 277
- Table 58: Key Effexor events, 2005-2006 - page 277
- Table 59: Xanax: key facts - page 278
- Table 60: Buspar: key facts - page 279
- Table 61: Cymbalta: key facts - page 280
- Table 62: Key Cymbalta events, 2005-2006 - page 281
- Table 63: Lyrica: key facts - page 282
- Table 64: Key Lyrica events, 2005-2006 - page 282
- Table 65: Gabitril: key facts - page 283
- Table 66: Key Gabitril events, 2005-2006 - page 283
- Table 67: Datamonitor's competitive positioning analysis of pipeline anxiety drugs compared to existing market players (1 of 2) - page 284
- Table 68: Datamonitor's competitive positioning analysis of pipeline anxiety drugs compared to existing market players (2 of 2) - page 285
- Table 69: Anxiety disorders market definition by ICD10 code - page 305
- List of Figures
- Figure 1: Datamonitor's forecast for anxiety specific revenues of pipeline and marketed anxiety drugs across the seven major markets, 2006-15 - page 7
- Figure 2: Datamonitor's SWOT analysis of pipeline drugs. - page 9
- Figure 3: Anxiety disorders diagnostic decision tree (DSM-IV) - page 31
- Figure 4: Patient distribution: acute versus chronic anxiety - page 39
- Figure 5: Reasons why patients receiving antidepressant therapy are non-compliant - page 42
- Figure 6: Drug classes in development for the treatment of anxiety disorders. - page 48
- Figure 7: NICE measurement of cost-effectiveness of drug treatment - page 62
- Figure 8: Revenues of the Paxil franchise after generic incursion - page 73
- Figure 9: US Drugstore Paxil prescriptions for anxiety disorders, 2003-05 - page 74
- Figure 10: US revenue split of Paxil and Paxil CR between anxiety disorders and alternative indications, 2002-05 - page 74
- Figure 11: Forecast revenues of the Paxil franchise across the seven major markets, 2006-15 - page 75
- Figure 12: US revenue split of the Effexor franchise XR between anxiety disorders and alternative indications, 2002-05 - page 78
- Figure 13: Forecast revenues of the Wyeth's anxiety franchise across the seven major markets, 2006-15 - page 80
- Figure 14: US revenue split of Prozac between anxiety disorders and alternative indications, 2002-05 - page 82
- Figure 15: Forecast revenues of Lilly's anxiety franchise across the seven major markets, 2006-15 - page 83
- Figure 16: Physician rated performance of main drugs used in the treatment of anxiety disorders - page 88
- Figure 17: Datamonitor's SWOT analysis of GAD pipeline drugs - page 94
- Figure 18: Datamonitor's SWOT analysis of OCD pipeline drugs - page 121
- Figure 19: Datamonitor's SWOT analysis of SAD pipeline drugs - page 128
- Figure 20: Datamonitor's SWOT analysis of PD pipeline drugs - page 144
- Figure 21: Datamonitor's SWOT analysis of PTSD pipeline drugs - page 148
- Figure 22: Datamonitor's SWOT analysis of PMDD pipeline drugs - page 158
- Figure 23: The pharmacologic profile of Lyrica compared to paroxetine - page 172
- Figure 24: Forecast revenues of Pfizer's anxiety franchise across the seven major markets, 2006-15 - page 173
- Figure 25: Anxiety specific revenue forecast for Lyrica across the seven major markets, 2006-15 - page 177
- Figure 26: The pharmacologic profile of Cymbalta compared to paroxetine - page 182
- Figure 27: Anxiety specific revenue forecast for Cymbalta across the seven major markets, 2006-15 - page 184
- Figure 28: The pharmacologic profile of PRX-00023 compared to paroxetine - page 188
- Figure 29: Anxiety specific revenue forecast for PRX-00023 across the seven major markets, 2006-15 - page 190
- Figure 30: The pharmacologic profile of SR5-8611 compared to paroxetine - page 192
- Figure 31: Quarterly revenues of Gabitril (2004-05) - page 196
- Figure 32: The pharmacologic profile of Gabitril compared to paroxetine - page 197
- Figure 33: US revenue split of Gabitril between anxiety disorders and alternative indications, 2002-05 - page 199
- Figure 34: The pharmacologic profile of Seroquel SR compared to paroxetine - page 202
- Figure 35: US revenue split of Lexapro between anxiety disorders and alternative indications, 2002-05 - page 210
- Figure 36: The pharmacologic profile of Lexapro compared to paroxetine - page 211
- Figure 37: US cash market share of Forest/Lundbeck's antidepressant franchise from 2002-05 - page 213
- Figure 38: Anxiety specific revenue forecast for Lexapro across the seven major markets, 2006-15 - page 216
- Figure 39: The pharmacologic profile of Luvox CR compared to paroxetine - page 220
- Figure 40: The pharmacologic profile of TGWOOAD/AA compared to paroxetine - page 222
- Figure 41: The pharmacologic profile of Risperdal compared to paroxetine - page 227
- Figure 42: The pharmacologic profile of Paxil CR compared to paroxetine - page 230
- Figure 43: Anxiety specific revenue forecast for Paxil CR across the seven major markets, 2006-15 - page 231
- Figure 44: The pharmacologic profile of Effexor XR compared to paroxetine - page 236
- Figure 45: Anxiety specific revenue forecast for Effexor XR across the seven major markets, 2006-15 - page 238
- Figure 46: The pharmacologic profile of YAZ compared to paroxetine - page 242
- Figure 47: Anxiety specific revenue forecast for YAZ across the seven major markets, 2006-15 - page 245
- Figure 48: The pharmacologic profile of Librel compared to paroxetine - page 247
- Figure 49: Anxiety specific revenue forecast for Librel across the seven major markets, 2006-15 - page 249
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