The Pharmaceutical Industry: Key events and trends shaping its current status and future direction
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- REPORT SCOPE - page 3
- CHAPTER 1 THE CORPORATE LANDSCAPE: THE WINNERS AND LOSERS IN 2005 AND BEYOND - page 8
- Prescription sales growth - page 9
- Prescription sales growth, 2004-05 - page 9
- Forecast prescription sales growth, 2005-06 - page 12
- The best and worst performers, 2004-06 - page 14
- As the market sees it: the winners and losers in 2005 by share price - page 16
- Winner: Genentech tops the list - page 17
- Winner: 2005 signals a turn around in Schwarz Pharma's fortunes - page 17
- Winner: AstraZeneca's strong sales growth and new partnerships drive investor confidence - page 18
- Loser: Pfizer hit by poor results - page 18
- Mergers and acquisitions - page 19
- 2005 - page 19
- Mylan and King Pharmaceuticals merger deal fell apart in 2005 - page 21
- Shire Pharmaceuticals shifts its focus onto niche indications with its acquisition of Transkaryotic Therapies - page 21
- Japanese companies - a wave of consolidation - page 22
- Pfizer focuses on acquiring drug developers to boost pipeline - page 22
- M&A continues to be a integral part of Johnson & Johnson's growth strategy - page 23
- Five biotech acquisitions in 2005, all centered on antibody therapies - page 24
- Vaccines makers are a popular area for acquisitions in 2005 - page 25
- 2006 - page 26
- Elan's troubling affairs - page 26
- Japanese companies continue to consolidate - page 27
- Could Merck be a possible target for Pfizer? - page 27
- Companies up for sale - page 27
- Generics mergers and acquisitions - consolidation will be necessary to maintain growth - page 28
- Sandoz - seals global leadership through double acquisition in 2005 - page 29
- Teva - re-establishes itself in top spot after IVAX deal is completed - page 29
- 2006 - page 29
- 2005 - page 19
- Licensing - page 30
- 2005 - revenue generated by top companies from in-licensed products surpasses $100 billion for the first time - page 30
- 2006 - companies are expected to increasingly focus on licensing - page 32
- Prescription sales growth - page 9
- CHAPTER 2 PRODUCTS: THE BIG STORIES OF 2005 AND BEYOND - page 35
- Introduction - page 36
- Key products driving industry growth - page 37
- Top-selling products, 2005 - page 37
- Lipitor - record-breaking sales once again - page 38
- Plavix - second highest drug in terms of sales, but patent under threat - page 38
- Epoetin alfa - a year of decline but strong sales remain - page 39
- Seretide - safety issues can't blunt growth - page 40
- Norvasc - facing its final years of blockbuster sales before generic competition - page 41
- Nexium - benefiting from the Vioxx fall out - page 42
- Zocor - impact of generic competition in the EU is a preview of expected 2006 erosion - page 42
- Biggest dollar sales growth, 2004-2005 - page 43
- Tamiflu - sales boosted by bird flu fears - page 44
- Lipitor - actual sales increase by over $1 billion - page 45
- Roche - oncology products driving strong overall performance - page 45
- Biggest percentage sales growth, 2004-2005 - page 46
- Tarceva - initial market penetration is positive - page 48
- Lyrica - a worthy successor to Neurontin - page 48
- Truvada - redefining the HIV gold standard - page 49
- Major new launches - page 49
- 2005 - page 50
- 2006 - page 53
- Comparison of product launches by year - page 58
- Top-selling products, 2005 - page 37
- The key restraint on pharmaceutical market growth in 2006 will be generic competition - page 59
- A favorable environment for generics, but pressures mean the landscape is changing - page 59
- Significant patent expiries in 2005 have led to steep growth in generic competition - page 60
- 2006 - over $20 billion of sales at-risk for generic competition - page 61
- Major patent challenges dominated the headlines in 2005 - page 64
- Lipitor - Ranbaxy's patent challenge causes concern for Pfizer - page 64
- Lovenox (enoxaparin) - a loophole for biogeneric approval? - page 66
- Fosamax (alendronate sodium) - Merck's outlook takes a turn for the worse - page 67
- Toprol XL (metoprolol) - early generic competition is likely - page 68
- Pharmacovigilance will play an increasingly important role - post-Vioxx, safety is everything - page 68
- 2005 - significant new pharmacovigilance regulations introduced in the EU - page 69
- 2006 and beyond - major changes in the US expected - page 70
- Pharmacogenomics comes under the spotlight - page 71
- Landmark diagnostic approvals - page 71
- Disclosure of clinical trial results could become mandatory - page 72
- Product withdrawals due to safety continued in 2005 - page 72
- Bextra - review of COX-II's leads to drug withdrawal - page 73
- Palladone, Cylert and Adderall XR - CNS therapeutics increasingly examined - page 73
- Tysabri may be an exception - down but not out? - page 73
- Safety warnings abound in a period of intense scrutiny - page 74
- Several drugs failed in the final stages of approval in 2005 - page 75
- Iressa - withdrawal of EMAA ends commercial prospects - page 76
- Exanta - the second AstraZeneca failure of 2005 - page 76
- Pargluva - suspect safety profile leads to FDA request for more information - page 76
- Oporia - non-approvable for prevention of osteoporosis - page 77
- Zarnestra - additional data may lead to approval - page 77
- Dapoxetine - development to be continued - page 78
- Intrinsa - lack of long-term safety data leads to FDA rejection - page 78
- Xinlay - Abbott continuing developmemnt but stronger evidence required - page 78
- Pipeline setbacks also hit the headlines in 2005 - page 79
- PTK/ZK (PTK787) - page 79
- ReoPro (abciximab) - page 79
- CCR5 inhibitors for HIV - page 80
- Pharmaceutical marketing practices under the spotlight - page 80
- DTC advertising blamed for the COX-II disaster - changes now afoot - page 81
- Further reduction in sales forces expected - page 82
- Medicare Part D reforms will provide a short term boost, but longer term the impact is less certain - page 83
- CHAPTER 3 APPENDIX: SUPPORTING DATA - page 85
- Supporting Data - page 85
- Financial data - page 87
- Exchange rates - page 87
- List of Tables
- Table 1: The top 55 pharmaceutical companies' ethical sales between 2004 and 2005, ranked by sales growth: mid-cap and small players were the fastest growing companies - page 9
- Table 2: The top 55 pharmaceutical companies' ethical sales between 2004 and 2005, ranked by sales growth - page 12
- Table 3: Major healthcare-related merger and acquisition deals announced by the top 55 pharmaceutical companies worldwide during 2005 - page 20
- Table 4: Top 10 pharmaceutical companies with the highest licensing dependence in 2005: Forest Laboratories remains at the top - page 31
- Table 5: Top 10 companies that are forecast to have the highest licensing dependence in 2006: Roche makes an appearance - page 33
- Table 6: Top 20 pharmaceutical products worldwide, ranked by 2005 global sales - page 37
- Table 7: Roche products dominate in the list of the products which have demonstrated the highest absolute growth between 2004 and 2005 - page 43
- Table 8: Newly launched products have shown the greatest percentage sales growth between 2004 and 2005 - page 47
- Table 9: Top 20 new product launches in 2005, ranked by their forecast sales in 2009 - page 51
- Table 10: Top 20 new product launches in 2006, ranked by their forecast sales in 2010 - page 54
- Table 11: Despite a higher number of new product launches, 2005 was disappointing in terms of potential commercial success - page 58
- Table 12: 2004 was a much stronger year for blockbuster launches: six products launched in 2004 are forecast to surpass $1 billion in global sales within four years - page 58
- Table 13: Share price performance of top publicly-listed pharmaceutical companies during 2005 - page 85
- Table 14: Exchange rates*, 2004 - page 87
- List of Figures
- Figure 1: Fastest growing and slowest growing companies: Genentech is way ahead of the game - page 15
- Figure 2: Share price performance in 2005: overall, a positive year - page 16
- Figure 3: Growth from marketed products and new launches must offset negative factors to ensure continued market growth - page 36
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