Commercial Insight Top 20 Cancer Therapeutics
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Oncology pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Scope of the analysis - page 3
- Datamonitor insight into the cancer market - page 4
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 15
- Market definition for this report - page 15
- Cytotoxics - page 15
- L1A - Alkylating agents - page 15
- L1B - Antimetabolites - page 16
- L1C - Vinca alkaloids and other plant-derived products - page 16
- L1D - Antineoplastic antibiotics - page 16
- L1X2 - Platinum compounds - page 17
- Antihormonal therapies - page 17
- L2A3 - Luteinizing hormone-releasing hormone analogs - page 17
- L2B1 - Anti-estrogens - page 17
- L2B2 - Anti-androgens - page 17
- L2B3 - Aromatase inhibitors - page 18
- Targeted therapies - page 18
- L1X3 - Antineoplastic monoclonal antibodies - page 18
- L1X9 - All other antineoplastics - page 18
- Cytotoxics - page 15
- The Top 20 cancer therapeutics - page 19
- Current market situation - page 22
- Market definition for this report - page 15
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 26
- Current and future opportunities and threats in the cancer market - page 26
- Global opportunities and threats - page 26
- Opportunities - page 26
- Threats - page 31
- US: opportunities and threats - page 36
- Opportunities - page 36
- Threats - page 38
- Japan: opportunities and threats - page 40
- Opportunities - page 40
- Threats - page 41
- EU5: opportunities and threats - page 43
- Opportunities - page 43
- Threats - page 45
- France: opportunities and threats - page 47
- Opportunities - page 47
- Threats - page 48
- Germany: opportunities and threats - page 49
- Opportunities - page 49
- Threats - page 50
- Italy: opportunities and threats - page 51
- Opportunities - page 51
- Threats - page 52
- Spain: opportunities and threats - page 54
- Opportunities - page 54
- Threats - page 55
- UK: opportunities and threats - page 56
- Opportunities - page 56
- Threats - page 56
- Global opportunities and threats - page 26
- Summary of environmental issues affecting the cancer market size - page 59
- Current and future opportunities and threats in the cancer market - page 26
- CHAPTER 4 FORECAST ANALYSIS - page 61
- Country-specific assumptions and events - page 61
- Effect of Medicare Modernization Act in the US - page 61
- Biennial price cuts in Japan - page 61
- Generic erosion assumptions - page 61
- Product-specific assumptions and events - page 62
- Cytotoxics - page 62
- Schering-Plough's Temodar/Temodal (temozolomide) - page 62
- Eli Lilly's Alimta (pemetrexed) - page 63
- Eli Lilly's Gemzar (gemcitabine) - page 64
- Taiho Pharmaceuticals' TS-1 (tegafur, gimeracil & oteracil) - page 66
- Taiho Pharmaceuticals' UFT (tegafur & uracil) - page 67
- Pharmion Corp's Vidaza (5-azacitidine) - page 68
- Roche's Xeloda (capecitabine) - page 69
- Pfizer/Yakult/Daiichi's Camptosar/Campto (irinotecan) - page 70
- Pierre Fabre/GlaxoSmithKline's Navelbine (vinorelbine) - page 71
- Bristol-Myers Squibb's Taxol (paclitaxel) - page 72
- Sanofi-Aventis's Taxotere (docetaxel) - page 74
- Johnson & Johnson/Schering-Plough's Doxil/Caelyx (pegylated liposomal doxorubicin) - page 77
- Pfizer's Ellence/Farmorubicin (epirubicin) - page 78
- Sanofi-Aventis's Eloxatin (oxaliplatin) - page 79
- Bristol-Myers Squibb's Paraplatin (carboplatin) - page 82
- Antihormonal therapies - page 83
- Debiopharm's Decapeptyl (triptorelin) - page 83
- Takeda/TAP/Abbott/Wyeth's Lupron (leuprorelin) - page 84
- Sanofi-Aventis's Suprefact (buserelin) - page 84
- AstraZeneca's Zoladex (goserelin) - page 85
- AstraZeneca's Nolvadex (tamoxifen) - page 86
- AstraZeneca's Casodex (bicalutamide) - page 88
- AstraZeneca's Arimidex (anastrozole) - page 89
- Pfizer's Aromasin (exemestane) - page 91
- Novartis's Femara (letrozole) - page 92
- Targeted therapies - page 94
- Genentech/Roche's Avastin (bevacizumab) - page 94
- ImClone/Bristol-Myers Squibb/Merck KGaA's Erbitux (cetuximab) - page 96
- Genentech/Roche's Herceptin (trastuzumab) - page 99
- Genentech/Roche's Rituxan/MabThera (rituximab) - page 101
- Novartis's Gleevec/Glivec (imatinib) - page 103
- AstraZeneca's Iressa (gefitinib) - page 105
- OSI Pharmaceuticals/Genentech/Roche's Tarceva (erlotinib) - page 107
- Ortho Biotech/Millennium Pharmaceuticals' Velcade (bortezomib) - page 109
- Pipeline and newly marketed products - page 111
- Amgen's ABX-EGF (panitumumab) - page 111
- Onyx Pharmaceuticals/Bayer's Nexavar (sorafenib) - page 114
- Bristol-Myers Squibb's Sprycel (dasatinib) - page 117
- Pfizer's Sutent (sunitinib) - page 119
- GlaxoSmithKline's Tykerb (lapatinib) - page 121
- Cytotoxics - page 62
- Data definitions, limitations and assumptions - page 124
- Standard units - page 124
- Japanese market data - page 124
- Derivation of sales forecasts and pricing trends - page 124
- Forecasts - page 124
- Forecast methodology - page 125
- Country-specific assumptions and events - page 61
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 126
- Introduction - page 126
- Case study 1 - page 126
- Changes to the Top 20 cancer therapeutics between 2005 and 2015 - page 126
- The Top 20 cancer therapeutics in 2005 - cytotoxics have the largest share - page 126
- The Top 20 cancer therapeutics in 2015 - targeted therapies are key - page 129
- Product sales growth between 2005 and 2015 - page 131
- Individual country Top 20 cancer therapeutics - page 134
- Changes to the Top 20 cancer therapeutics between 2005 and 2015 - page 126
- Case study 2 - page 139
- Genentech/Roche's Avastin: increasing market penetration and line extensions expected to break all boundaries - page 139
- The first commercialized angiogenesis inhibitor - page 139
- The Genentech/Roche partnership: a key to success - page 140
- Expanding range of indications - page 141
- Despite formulation issues, the monoclonal antibodies generally confer greater clinical benefit than the small molecules - page 143
- Competitor threats to be heeded - page 144
- Biosimilars: should Genentech and Roche take note? - page 145
- A prime example of becoming the leader in a new drug class - page 146
- Genentech/Roche's Avastin: increasing market penetration and line extensions expected to break all boundaries - page 139
- Case study 3 - page 146
- The impact of targeted therapies in redefining cancer - page 146
- Greater understanding & new technologies have enabled the development of molecular targeted therapies - page 146
- Redefining classification of tumor types - page 147
- Genentech/Roche's Herceptin: using patient population subtypes to expedite regulatory approval - page 147
- Commercial potential for diagnostics and biomarkers - page 148
- The impact of targeted therapies in redefining cancer - page 146
- APPENDIX A - MARKET DATA AND MAJOR BRAND KEY FACTS - page 150
- Cytotoxics market data - page 150
- Antihormonal therapies market data - page 158
- Targeted therapies market data - page 163
- APPENDIX B - MARKET FORECAST DATA - page 168
- US forecasts - page 168
- Japan forecasts - page 170
- France forecasts - page 172
- Germany forecasts - page 174
- Italy forecasts - page 176
- Spain forecasts - page 178
- UK forecasts - page 180
- EU5 forecasts - page 182
- Seven major market forecasts - page 184
- APPENDIX C - page 186
- Bibliography - page 186
- Report methodology - page 194
- About Datamonitor - page 195
- About Datamonitor Healthcare - page 195
- About the Oncology analysis team - page 196
- Disclaimer - page 197
- List of Tables
- Table 1: Definition of the cancer market, 2006 - page 15
- Table 2: Top 20 cancer therapeutics in the US, Japan, France and Germany, 2005 - page 20
- Table 3: Top 20 cancer therapeutics in Italy, Spain, the UK and collective seven major markets, 2005 - page 21
- Table 4: Key pipeline/newly marketed drugs included in the Top 20 cancer therapeutics - page 22
- Table 5: Seven major market sales of Top 20 cancer therapeutics by drug class, 2005 - page 22
- Table 6: Key targeted therapies included in the Top 20 cancer therapeutics - page 23
- Table 7: Key cytotoxics included in the Top 20 cancer therapeutics - page 24
- Table 8: Key antihormonal therapies included in the Top 20 cancer therapeutics - page 25
- Table 9: Market share of Taxotere, 2005 - page 75
- Table 10: Market share of Eloxatin - page 80
- Table 11: Approved indications for Rituxan in the US and EU, 2006 - page 102
- Table 12: Clinical pipeline for ABX-EGF, 2006 - page 111
- Table 13: Clinical pipeline for Nexavar, 2006 - page 115
- Table 14: Clinical pipeline for Sprycel, 2006 - page 117
- Table 15: Summary of Phase II Sprycel clinical trial results - page 118
- Table 16: Clinical pipeline for Sutent, 2006 - page 120
- Table 17: Clinical pipeline for Tykerb, 2006 - page 122
- Table 18: Seven market forecast sales of the Top 20 cancer therapeutics, 2005 - page 127
- Table 19: Seven market forecast sales of the Top 20 cancer therapeutics, 2015 - page 129
- Table 20: Top 20 cancer therapeutics in the US, 2005-15 - page 135
- Table 21: Top 20 cancer therapeutics in Japan, 2005-15 - page 136
- Table 22: Top 20 cancer therapeutics in the five EU markets, 2005-15 - page 138
- Table 23: Key events in Avastin's lifecycle - page 139
- Table 24: Seven market forecast sales of Avastin, 2005-15 - page 141
- Table 25: Global forecast sales of Avastin based on company-reported data, 2005-15 - page 142
- Table 26: Alimta: key facts - page 150
- Table 27: Camptosar: key facts - page 151
- Table 28: Doxil: key facts - page 151
- Table 29: Ellence: key facts - page 152
- Table 30: Eloxatin: key facts - page 152
- Table 31: Gemzar: key facts - page 153
- Table 32: Navelbine: key facts - page 153
- Table 33: Paraplatin: key facts - page 154
- Table 34: Taxol: key facts - page 154
- Table 35: Taxotere: key facts - page 155
- Table 36: Temodar: key facts - page 155
- Table 37: TS-1: key facts - page 156
- Table 38: UFT: key facts - page 156
- Table 39: Vidaza: key facts - page 157
- Table 40: Xeloda: key facts - page 157
- Table 41: Arimidex: key facts - page 158
- Table 42: Aromasin: key facts - page 158
- Table 43: Casodex: key facts - page 159
- Table 44: Decapeptyl: key facts - page 159
- Table 45: Femara: key facts - page 160
- Table 46: Lupron: key facts - page 160
- Table 47: Nolvadex: key facts - page 161
- Table 48: Suprefact: key facts - page 161
- Table 49: Zoladex: key facts - page 162
- Table 50: Avastin: key facts - page 163
- Table 51: Erbitux: key facts - page 163
- Table 52: Gleevec: key facts - page 164
- Table 53: Herceptin: key facts - page 164
- Table 54: Iressa: key facts - page 165
- Table 55: Nexavar: key facts - page 165
- Table 56: Rituxan: key facts - page 166
- Table 57: Sutent: key facts - page 166
- Table 58: Tarceva: key facts - page 167
- Table 59: Velcade: key facts - page 167
- Table 60: Top 20 cancer therapeutics forecasts in the US, 2005-15 (1 of 2) - page 168
- Table 61: Top 20 cancer therapeutics forecasts in the US, 2005-15 (2 of 2) - page 169
- Table 62: Top 20 cancer therapeutics forecasts in Japan, 2005-15 (1 of 2) - page 170
- Table 63: Top 20 cancer therapeutics forecasts in Japan, 2005-15 (2 of 2) - page 171
- Table 64: Top 20 cancer therapeutics forecasts in France, 2005-15 (1 of 2) - page 172
- Table 65: Top 20 cancer therapeutics forecasts in France, 2005-15 (2 of 2) - page 173
- Table 66: Top 20 cancer therapeutics forecasts in Germany, 2005-15 (1 of 2) - page 174
- Table 67: Top 20 cancer therapeutics forecasts in Germany, 2005-15 (2 of 2) - page 175
- Table 68: Top 20 cancer therapeutics forecasts in Italy, 2005-15 (1 of 2) - page 176
- Table 69: Top 20 cancer therapeutics forecasts in Italy, 2005-15 (2 of 2) - page 177
- Table 70: Top 20 cancer therapeutics forecasts in Spain, 2005-15 (1 of 2) - page 178
- Table 71: Top 20 cancer therapeutics forecasts in Spain, 2005-15 (2 of 2) - page 179
- Table 72: Top 20 cancer therapeutics forecasts in the UK, 2005-15 (1 of 2) - page 180
- Table 73: Top 20 cancer therapeutics forecasts in the UK, 2005-15 (2 of 2) - page 181
- Table 74: Top 20 cancer therapeutics forecasts in the EU5, 2005-15 (1 of 2) - page 182
- Table 75: Top 20 cancer therapeutics forecasts in the EU5, 2005-15 (2 of 2) - page 183
- Table 76: Top 20 cancer therapeutics forecasts in the seven major markets, 2005-15 (1 of 2) - page 184
- Table 77: Top 20 cancer therapeutics forecasts in the seven major markets, 2005-15 (2 of 2) - page 185
- List of Figures
- Figure 1: Seven market population aged 60 and over, 2000-50 - page 26
- Figure 2: Increasing incidence of cancer with increasing age - page 27
- Figure 3: Seven major pharmaceutical market oncology sales, 2004-14 - page 28
- Figure 4: Summary of global opportunities and threats affecting the cancer market, 2006 - page 59
- Figure 5: Summary of regional opportunities and threats affecting the cancer market, 2006 - page 60
- Figure 6: Seven market sales of the Top 20 cancer therapeutics by drug class, 2005 - page 128
- Figure 7: Seven market sales of the Top 20 cancer therapeutics by drug class, 2015 - page 130
- Figure 8: Seven market cytotoxics sales growth, 2005-15 - page 131
- Figure 9: Seven market antihormonal therapies sales growth, 2005-15 - page 132
- Figure 10: Seven market targeted therapies sales growth, 2005-15 - page 133
- Figure 11: Forecast sales of Avastin, 2005-15 - page 142
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