Chinese Pharmaceutical Market Overview
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- CHAPTER 1 EXECUTIVE SUMMARY - page 4
- Scope of the report - page 4
- IMS caveat - page 5
- Datamonitor's insights into the Chinese pharmaceutical market, 2006 - page 5
- China - a place for drug discovery and clinical trial partnerships? - page 6
- A changing focus in the Chinese pharmaceutical market? - page 7
- China - a land of opportunity for Western pharmaceutical manufacturers - page 8
- CHAPTER 2 MACRO-ENVIRONMENTAL ISSUES AFFECTING THE CHINESE PHARMACEUTICAL INDUSTRY - page 23
- Key findings - page 23
- General country information - China - page 24
- A changing economy - page 25
- Shift from a centralized to a market economy - page 25
- Benefits from World Trade Organization (WTO) membership - page 27
- A changing economy - page 25
- An overview of China's healthcare system - page 30
- The current scenario - page 30
- Symptoms of an ailing healthcare system - page 33
- Discrimination in China's Healthcare system - page 34
- The current scenario - page 30
- Administrative and regulatory bodies of the healthcare system in China - page 35
- SFDA's increased focus on improving drug safety - page 37
- China's health reforms - hope for the future? - page 37
- Healthcare expenditure and funding in China - page 39
- Healthcare expenditure and financing set to improve - page 39
- Health insurance coverage - increasing, but still insufficient - page 41
- Urban health insurance reform - improved healthcare at a price - page 42
- Rural health insurance reform - limited impact on poverty reduction, but potentially a significant impact on primary care - page 44
- CHAPTER 3 REGULATORY ISSUES IN CHINA - page 46
- Key findings - page 46
- Reimbursement is negotiated with local authorities rather than at national level - page 47
- Pharmaceutical Catalog classification - page 48
- Continuing national price cuts pose significant dilemmas for manufacturers - page 49
- A complex pricing system exists in China - page 50
- The SFDA is counteracting the bribery and corruption fueled by ongoing price cuts - page 52
- A complex distribution system in China - page 52
- Despite ongoing IP improvements, counterfeiting provides a significant threat to public health and drug development - page 54
- Implications - China is too risky for the manufacturing of on-patent APIs - page 60
- GMP - improving but still some way to go before Western manufacturers and regulatory agencies are fully satisfied - page 60
- Drug approvals - page 62
- Priority review procedures - public health crises - page 65
- CHAPTER 4 CHINESE MARKET ASSESSMENT - PERFORMANCE BENCHMARKING - page 67
- Key findings - page 67
- The Chinese pharmaceutical market - page 68
- China compared to the seven major markets - page 70
- Other emerging countries - stressing China's advantages and challenges - page 73
- Which therapy classes are growing? - page 80
- Competitive positioning of the top Chinese pharmaceutical players - page 82
- Segmentation of Pharma players in China - page 85
- Western manufacturers in China - page 88
- Traditional Chinese Medicine (TCM) - a strong past and bright future - page 92
- Regulation and GMP - the way forward for TCMs - page 94
- Joint ventures are increasingly popular, driving TCM R&D - page 95
- Datamonitor opinion - page 96
- OTC in China set to increase further in the coming decades - page 98
- Bayer acquires OTC cough and cold portfolio from Topsun Science and Technology - page 101
- Internet pharmacy is playing an increasing role in the OTC market - page 102
- OTC market entry recommendations - page 102
- CHAPTER 5 CHINESE DOMESTIC PHARMACEUTICAL COMPANY OVERVIEW - page 103
- Key findings - page 103
- Chinese Pharma companies have traditionally driven growth through the API and generics business - page 104
- Bulk manufacturing continues to drive China's export industry - page 104
- Alpharma enters agreement with Hisun for vancomycin production - page 106
- Degussa expands its global API business - page 106
- Overview of China's R&D pipeline - page 107
- Bulk manufacturing continues to drive China's export industry - page 104
- Generics and biosimilars - page 108
- There is little incentive for MNCs to enter the generics market - page 108
- SFDA introduces stricter generic labelling - page 110
- Chinese biosimilars players - page 110
- Dragon Pharmaceutical - China's leading biosimilar company - page 112
- Overview - page 112
- Biosimilar product portfolio/pipeline - page 113
- Strategy - page 114
- Outlook - page 115
- There is little incentive for MNCs to enter the generics market - page 108
- CHAPTER 6 OPPORTUNITIES FOR WESTERN MANUFACTURERS IN CHINA - page 116
- China - a land of opportunity for Western pharmaceutical manufacturers - page 117
- China - a place for drug discovery and clinical trial partnerships? - page 119
- China's Key R&D attractions - page 121
- Large pool of research scientists - page 121
- A low cost environment for R&D and clinical trials - page 122
- Biotechs are forging relationships with the biomedical research industry - page 122
- China's advancements in genomics and gene therapy hold considerable potential for the future - page 123
- Government support and tax incentives help drive R&D - page 123
- Foreign companies' drug discovery outsourcing activity in China - page 127
- Case study: WuXi PharmaTech's growth in services exemplifies China's growing popularity as a outsourcing destination - page 130
- MNCs are increasingly entering clinical trial partnerships for drugs for domestic and worldwide use - page 131
- China's Key R&D attractions - page 121
- Key Western players in China - case studies - page 133
- Key differences between AstraZeneca, Novo Nordisk and GSK operations in China - page 134
- AstraZeneca - rejuvenated growth in recent years - page 137
- AstraZeneca has a strong history in China - page 137
- Therapy area focus in China - page 137
- Novo Nordisk - continued high growth rate - page 143
- Novo Nordisk - one of the fastest growing MNCs in China - page 143
- Therapy area focus in China - page 143
- GSK - flat revenues due to increased generic competition on old drugs - page 149
- GSKs revenues stalling in China - page 149
- Therapy area focus in China - page 152
- CHAPTER 7 CHINESE PHARMACEUTICAL COMPANY PROFILES - page 156
- Previously highly fragmented and regionalized - page 156
- Leading domestic manufacturers sales in China - page 157
- Yangtze River Pharmacy Group - page 158
- Overview - page 158
- Strategy - page 159
- Therapy area focus and revenue generation - page 159
- Partners - page 161
- The Harbin Pharmaceutical Group - page 162
- Overview - page 162
- Strategy - page 163
- Therapy area focus and revenue generation - page 164
- HRP in the news - page 166
- Jiangsu Hengrui Medicine Company - page 167
- Overview - page 167
- Strategy - page 168
- Therapy area focus and revenue generation - page 169
- R&D investment and pipeline focus - page 171
- Partners - page 172
- Shandong Qilu Medicines - page 173
- Shanghai Pharmaceutical Group - Asia Pioneer - page 174
- Shanxi Pude Pharmaceuticals - page 175
- JL Weiwei Pharmaceuticals - page 176
- Guangzhou Tian Xin - page 177
- TH James-Andy - page 178
- Shandong Lunan Better Pharmaceutical - page 179
- Chongqing Yaoyou Pharmaceutical Company - page 180
- Shandong Reyoung Pharmaceutical Company - page 181
- CHAPTER 8 BIBLIOGRAPHY - page 182
- Bibliography - page 182
- Websites - page 182
- Journals and press articles - page 195
- Scrip - page 196
- Bibliography - page 182
- APPENDIX - page 198
- IMS caveat - page 198
- Exchange rate - page 198
- List of Tables
- Table 1: Economic statistics - China, 2005 - page 25
- Table 2: Main economic indicators for seven of the world's largest economies (2003) - page 27
- Table 3: China, country-specific healthcare information of interest, 2005 - page 30
- Table 4: Selected Chinese national health accounts indicators, 2003 - page 31
- Table 5: Ministry level agencies with health authority in China, 2006 - page 36
- Table 6: Distribution of drug products in the 2004 Pharmaceutical Catalog - page 49
- Table 7: Chamber of Commerce's report recommendations, September 2006 - page 58
- Table 8: Prescription pharmaceutical sales per capita across the US, 5EU, Japan and China, 2005 - page 71
- Table 9: Top five ATC classes by revenue in China, the US and 5EU, 2005 - page 77
- Table 10: Top five ATC classes by volume in China, the US and 5EU, 2005 - page 78
- Table 11: Top domestic and Western pharmaceutical manufacturers in China, 2005 - page 84
- Table 12: Average (mean) sales characteristics of manufacturer groupings, 2004-05 - page 87
- Table 13: Top OTC players in China by value ($m), 2004 - page 102
- Table 14: Dragon Pharmaceutical's biosimilar product portfolio and pipeline, 2006 - page 113
- Table 15: Advantages and disadvantages of clinical trials and R&D in China, 2006 - page 120
- Table 16: Key R&D investments by the top global pharmaceutical companies in China, 2005-06 - page 121
- Table 17: State Governmental scientific support programs - page 125
- Table 18: Key drug discovery outsourcing deals involving Chinese service providers, 2005-2006 - page 128
- Table 19: Mean price comparison between domestically produced and imported products, 2005 - page 136
- Table 20: AstraZeneca's product portfolio in China, 2004-05 - page 139
- Table 21: Novo Nordisk's product portfolio in China, 2004-05 - page 144
- Table 22: GSK's therapy franchises in China, 2004-05 - page 150
- Table 23: GSK's product portfolio in China, 2004-05 - page 151
- Table 24: Leading domestic manufacturers in China ($m), 2004-05 - page 157
- Table 25: Yangtze River Pharmaceutical Group's Chinese revenue breakdown by therapy area, 2004-05 - page 158
- Table 26: Yangtze River Pharmaceutical Group's top 10 products in China, 2004-05 - page 160
- Table 27: Harbin Pharmaceutical Group's Chinese revenue breakdown by therapy area ($m), 2004-05 - page 162
- Table 28: Harbin Pharmaceutical Group's top 10 products in China, 2004-05 - page 164
- Table 29: Harbin Pharmaceutical Group news, 2005-06 - page 166
- Table 30: Jiangsu Hengrui Medicine Company's total Chinese revenue breakdown by therapy area, 2004-05 - page 167
- Table 31: Jiangsu Hengrui Medicine Company's top 10 products in China ($m), 2004-05 - page 169
- Table 32: Jiangsu Hengrui Medicine Company's patent list, 2004-06 - page 171
- Table 33: Shandong Qilu Medicines total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 173
- Table 34: Shanghai Pharmaceutical Group - Asia Pioneer total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 174
- Table 35: Shanxi Pude Pharmaceuticals total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 175
- Table 36: JL Weiwei Pharmaceuticals total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 176
- Table 37: Guangzhou Tian Xin Pharmaceuticals total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 177
- Table 38: TH James-Andy total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 178
- Table 39: Shandong Lunan Better Pharmaceutical total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 179
- Table 40: Chongqing Yaoyou Pharmaceutical Company total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 180
- Table 41: Shandong Reyoung Pharmaceutical Company total Chinese revenue breakdown by therapy area ($m), 2004-05 - page 181
- Table 42: Exchange rates - page 198
- List of Figures
- Figure 1: Pros and cons of drug discovery and clinical trials in China - page 6
- Figure 2: Marketed biosimilar products from Chinese manufacturers, 2006 - page 8
- Figure 3: Size and revenue growth by therapy in the Chinese pharmaceutical market, 2001-05 - page 9
- Figure 4: China's major trading partners - page 29
- Figure 5: Total expenditure on health as percentage of GDP, 2003 - page 32
- Figure 6: Rise in cost of healthcare versus income in China, 1989-2001 - page 34
- Figure 7: Proportion of healthcare expenditure versus GDP, 1978-2004 - page 39
- Figure 8: Drug reimbursement in China, 2005 - page 48
- Figure 9: Branded drug price breakdown in China, 2006 - page 51
- Figure 10: Drug distribution channels in China, 2006 - page 53
- Figure 11: WTO timeline for revamping of China's pharmaceutical distribution networks, 2001-07 - page 54
- Figure 13: Protection of pharmaceutical products in China with or without a patent, 2006 - page 59
- Figure 13: Key steps for drug approval in China, 2006 - page 62
- Figure 14: Comparison of Approvals of New Drug Applications (NDAs) in the US and China, 2004 - page 63
- Figure 15: Comparison of the number of BLA and NME submissions in the US and China, 2000-04 - page 64
- Figure 16: Manufacturing and distribution in China, 2005 - page 69
- Figure 17: The Chinese pharmaceutical market size in comparison with the seven major markets, 2005 - page 70
- Figure 18: Estimates of China's prescription pharmaceutical market, 2004 - page 71
- Figure 19: Growth of the Chinese pharmaceutical market, 2001-05 - page 72
- Figure 20: Comparison of the Chinese, major seven developed, and emerging pharmaceutical markets, 2001-05 - page 73
- Figure 21: Positioning of emerging countries compared to China, 2006 - page 74
- Figure 22: Distribution of therapy area (ATC class) by revenue in China, the US and EU, 2005 - page 76
- Figure 23: Positioning of therapy classes by revenue from the leading domestic and Western manufacturers in China, 2005 - page 79
- Figure 24: Domestic manufacturers only lead the Western players in anti-infectives, 2006 - page 80
- Figure 25: Distribution of revenues by therapy area (ATC code) for the top 10 domestic and Western manufacturers in China, 2005 - page 81
- Figure 26: Leading domestic manufacturers have outstripped Western players in terms of product launches during 2004-05 - page 82
- Figure 27: Revenue growth of the top 10 leading Western and domestic manufacturers in China, 2001-05 - page 85
- Figure 28: Competitive positioning of top domestic and Western pharmaceutical companies in China, 2005 - page 86
- Figure 29: Competitive positioning of top Western pharmaceutical companies in China and the rest of the world by revenue ($), 2005 - page 88
- Figure 30: Competitive positioning of top pharmaceutical companies in China and the rest of the world by revenue growth (%), 2004-05 - page 89
- Figure 31: Competitive positioning of top pharmaceutical companies in China and the rest of the world by CAGR, 2001-05 - page 90
- Figure 32: Number of new product launches in China by Western manufacturers, 2002-05 - page 91
- Figure 33: Number of new product launches in China by domestic manufacturers, 2002-05 - page 92
- Figure 34: R&D expenditure on Traditional Chinese Medicine, 2002-04 - page 94
- Figure 35: China OTC market value and growth ($), 2000-04 - page 98
- Figure 36: China OTC market by segmentation, 2004 - page 99
- Figure 37: Distribution of OTC medicines in China, 2004 - page 101
- Figure 38: China's pharmaceutical imports versus exports, 2004 - page 105
- Figure 39: Pipeline drug candidates in China by franchise, 2006 - page 107
- Figure 40: Segmentation of the Chinese pharmaceutical market revenues by license status, 2005 - page 109
- Figure 41: Marketed biosimilar products from Chinese manufacturers, 2006 - page 111
- Figure 42: Size and revenue growth by therapy in the Chinese pharmaceutical market, 2001-05 - page 118
- Figure 43: Competitive positioning of top domestic and Western pharmaceutical companies in China, 2005 - page 134
- Figure 44: Revenue growth of AstraZeneca's, GSK's and Novo Nordisk's imported and domestic products, 2001-05 - page 136
- Figure 45: Revenues and growth of AstraZeneca's lead franchises in China, 2001-05 - page 138
- Figure 46: Growth and share of revenues and SUs between AstraZeneca and AZ-Wuxi in China, 2001-05 - page 141
- Figure 47: Novo Nordisk - the largest and one of the fastest growing diabetes franchises in China, 2005 - page 145
- Figure 48: Growth and share of revenues and volume between Novo Nordisk and Novo Nordisk Tianjin in China, 2001-05 - page 146
- Figure 49: Revenues and growth of GSK's lead franchises in China, 2001-05 - page 153
- Figure 50: GSK China - declining revenues and volume, 2001-05 - page 154
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