Erectile Dysfunction - Product differentiation and patient segmentation
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- Datamonitor's therapeutic area studies comprise the following features: - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the erectile dysfunction market - page 3
- CHAPTER 2 MARKET OVERVIEW - page 13
- Introduction and scope - page 13
- Market definition for this report - page 14
- Etiology - page 14
- Physiology of penile erection - page 14
- Pathophysiology of erectile dysfunction - page 15
- Psychogenic erectile dysfunction - page 17
- Neurogenic erectile dysfunction - page 18
- Endocrinologic erectile dysfunction - page 19
- Vasculogenic erectile dysfunction - page 19
- Confounds in identifying erectile dysfunction risk factors - page 21
- Treatment Overview - page 21
- Drug therapy - page 21
- PDE-5 inhibitors transformed the market - page 22
- PDE-5 inhibitors are not without drawbacks - page 23
- Alprostadil dogged by undesirable administration methods. - page 24
- Hormonal therapy is useful in combination - page 25
- Non-pharmacological therapy - page 25
- Sexual counseling for psychogenic and organic impotence - page 25
- Vacuum devices are efficacious for most - page 26
- Implants associated with high patient satisfaction - page 26
- The efficacy and acceptance of surgical procedures varies widely - page 27
- Drug therapy - page 21
- Epidemiology - page 28
- Wealth of studies show considerable variability - page 28
- Previously reported prevalence estimates - page 29
- Identifying the target population - page 30
- Data caveats - page 31
- Treated patient numbers may not grow as fast as erectile dysfunction prevalence - page 31
- Unmet need - page 34
- Need for treatment options for patients unresponsive to PDE-5 inhibitors - page 34
- Improved patient guidance is needed to control drug expectations - page 36
- Market dynamics - page 37
- Key players - page 37
- Regional analysis - page 38
- Seven major market total grew 3.5% to $1.95 billion in 2005 - US has over two-thirds share - page 38
- Strong growth in the European markets - page 39
- Brand analysis - page 40
- Blockbuster Viagra still market leader but sales hit by competition from Cialis and Levitra - page 41
- Pharmacological profile helps Cialis challenge Viagra - page 41
- Levitra continues to gain market share - page 42
- Delivery mode restricts sales of Caverject - page 42
- Growth for diagnostic Viridal - page 42
- Muse's market share diminishes - page 43
- Brand analysis by region - page 43
- Cialis overtakes Viagra in the French market - page 43
- Market expansion in Germany allows market growth of big three - page 44
- Growth of big three in the UK - page 45
- Levitra challenges Viagra in Japan - page 46
- Full-year 2006 forecasts - page 47
- Growth rates appear to stabilize across the market in 2006 - page 49
- Cialis and Levitra continued to capture Viagra's market share in 2006 - page 50
- CHAPTER 3 PIPELINE ANALYSIS - page 52
- Pipeline overview - page 52
- Varied pipeline looks to capitalize on gaps in the market - page 52
- Small companies look for opening in erectile dysfunction market - page 54
- PDE-5 inhibitors will remain the mainstay of treatment - page 54
- 'Me-too' PDE-5 inhibitors do not address major clinical needs - page 55
- Time of onset and action provide opportunity for differentiation - page 57
- Rush of generics from 2012 will massively increase competition - page 58
- Can other mechanisms of action challenge PDE-5 inhibitors? - page 58
- MSH/melanocortin agonists: a brand new class - page 60
- Dopamine agonists must hope for a better reception second time around - page 60
- PGE-1 agonist use is dependent on cream formulation - page 61
- Gaps in treatable patient population creates opportunity for new products - page 62
- The growing diabetic population is a commercially viable target - page 62
- Post surgery use is set to increase - page 63
- Non-erectile dysfunction indications for PDE-5 inhibitors: cardiovascular disorders - page 64
- Chronic versus immediate treatment - page 64
- New delivery modes will have mixed success in challenging oral formulations - page 65
- Injections will remain as last line drug treatment options - page 65
- Creams and gels avoid GI metabolism but may irritate partner - page 66
- Oral inhaled and intranasal therapies offer quick onset of action - page 66
- Eroxon creates speculation about over-the-counter erectile dysfunction products - page 67
- Topical drugs are well suited to the OTC market - page 67
- OTC expands the customer base to include sufferers that find it difficult approaching health professionals about their condition - page 67
- FDA requirements for OTC drug applications - page 68
- Key pipeline company analysis - page 68
- Pfizer has a speculative back-up plan - page 68
- UK-357903 may be a Viagra reformulation - page 69
- Pfizer is likely biding its time to assess other opportunities - page 69
- Pfizer has a speculative back-up plan - page 68
- Key pipeline product profiles - page 70
- Comparative drug (Viagra) - page 71
- Drug overview - page 71
- Clinical Trials - page 72
- Invicorp (aviptadil and phentolamine mesylate) - page 75
- Drug overview - page 75
- Clinical trial results - page 76
- Patient potential - page 79
- Marketing factors - page 81
- Udenafil/ DA-8159 - page 82
- Drug overview - page 82
- Clinical trial results - page 82
- Patient potential - page 84
- Marketing factors - page 85
- Apomorphine/VR-004 - page 86
- Drug Overview - page 86
- Clinical trial - page 86
- Patient potential - page 88
- Marketing factors - page 90
- Bremelanotide (PT-141) - page 91
- Drug Overview - page 91
- Clinical trial results: Part 1 - page 92
- Clinical trial results: Part 2 - page 94
- Patient potential - page 95
- Marketing factors - page 97
- Alprox-TD/Befar (alprostadil cream) - page 97
- Drug Overview - page 97
- Clinical trial results - page 98
- Patient potential - page 100
- Marketing factors - page 102
- GPI-1485 - page 102
- Drug Overview - page 102
- Clinical trial results - page 102
- Patient potential - page 104
- Marketing factors - page 104
- Eroxon/MED2002 - page 105
- Drug Overview - page 105
- Clinical trials - page 105
- Clinical trials - page 106
- Patient potential - page 107
- Marketing factors - page 108
- Comparative drug (Viagra) - page 71
- Pipeline overview - page 52
- CHAPTER 4 CASE STUDY ANALYSIS - page 109
- Introduction - page 109
- Creation of a super-brand - page 109
- Case Study: Viagra - page 109
- Direct-to-consumer marketing successfully quashes erectile dysfunction taboo - page 110
- Impact of safety fears minimized - page 111
- Pfizer's problem solving strategies - page 112
- Generating brand familiarity to rival Viagra - page 114
- Case study: Cialis (tadalafil) - page 114
- A two-stage marketing process - page 114
- Capitalizing on differentiating factors: 'the drug that allows spontaneity' - page 115
- Reformulations can expand the target patient population - page 116
- Case study: Cialis (tadalafil) - page 114
- Me-toos can compete based on a lower price point - page 117
- Case study: Levitra (vardenafil) - page 117
- Pricing helps Levitra in the US - page 118
- Forced to follow suit with marketing - page 119
- High risk head-to-head trials may pay off - page 120
- Case study: Levitra (vardenafil) - page 117
- Introduction - page 109
- BIBLIOGRAPHY - page 121
- References - page 121
- Websites - page 125
- APPENDIX - page 127
- Contributing experts - page 127
- Prevalence methodology - page 127
- About Datamonitor - page 129
- About Datamonitor Healthcare - page 129
- About the Women's Health and Urology analysis team - page 130
- Disclaimer - page 131
- List of Tables
- Table 1: Classification of Erectile Dysfunction - page 17
- Table 2: Comparison of the three market leading PDE-5 inhibitors, 2006 - page 22
- Table 3: Selected studies to obtain prevalence rates for combined moderate and severe ED in the seven major markets - page 29
- Table 4: Target population for erectile dysfunction therapy by region (000s) - page 30
- Table 5: Analysis of key brands for erectile dysfunction in the seven major markets, 2005-06 - page 37
- Table 6: Pipeline products for erectile dysfunction, 2006 - page 52
- Table 7: 2006 erectile dysfunction pipeline products chosen by Datamonitor for detailing - page 70
- Table 8: Incidence of adverse events in populations taking Viagra compared with placebo - page 75
- Table 9: PDE-5 inhibitor price per tab in the US and UK, 2006 - page 118
- Table 10: Segmentation of the male population suitable for ED therapy aged 25-54 years by age and region, 2005 (000s) - page 127
- Table 11: Segmentation of the male population suitable for ED therapy aged 55-74 years by age and region, 2005 (000s) - page 128
- List of Figures
- Figure 1: Total sales of the seven major erectile dysfunction markets by region, 2001-05 - page 38
- Figure 2: Total sales of the five European erectile dysfunction markets, by region, 2001-05 - page 39
- Figure 3: The top six selling products in the seven major markets, 2005 - page 41
- Figure 4: The top five brands in the French erectile dysfunction market with sales over $1m in 2005 - page 44
- Figure 5: The top five brands in the German erectile dysfunction market with sales over $1m in 2005 - page 45
- Figure 6: The top five brands in the UK erectile dysfunction market with sales over $1m in 2005 - page 46
- Figure 7: Total sales of the two products in the Japanese market, 2001-05 - page 47
- Figure 8: Datamonitor's predicted sales performance for the top six selling products in the seven major markets, 2006 - page 48
- Figure 9: Datamonitor's predicted change in market growth for the six leading products in the seven major markets for 2005-06 - page 49
- Figure 10: Datamonitor's predicted change in market share for the six leading products in the seven major markets for 2005-06 - page 50
- Figure 11: Active pipeline Erectile Dysfunction therapies by mechanism of action and development phase, 2006 - page 55
- Figure 12: Active pipeline Erectile Dysfunction therapies by mechanism of action, 2006 - page 59
- Figure 13: Frequency of reported erectile improvement in placebo-controlled trials of men taking Viagra, by treatment option. - page 74
- Figure 14: Sales of PDE-5 inhibitors in the 5EU and US markets, Q1 2001-Q2 2006 - page 112
Other users found this report page using the following search terms: erectile dysfunction dysfunction erectile market uk differentiation viagra segmentation cialis cream otc
If you can't find a report that meets your needs contact LeadDiscovery. We are one of the few report providers with extensive drug development experience and we frequently use this knowledge to help clients source the most appropriate reports or produce reports for them from scratch.