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Tissue Engineering and Stem Cell Technology Report 2007

The market potential of tissue engineering and stem cell technology is so huge that revenues may be in excess of $10 billion by 2013.

Tissue engineering, the manufacture of complete tissues outside of the body ready for future transplant use, is already with us, including several types of replacement skin and a cartilage substitute. The estimated market for future tissue engineered products including the regeneration of bone, cartilage, and other connective structural treatments is worth approximately $5 billion worldwide.

This report will analyse these two highly lucrative markets for you and will include:

1. An in-depth explanation of the physiology behind stem cell technology
2. A listing of over 100 companies involved and a survey of the principle companies in stem cell development
3. An examination of the products in development & the likely clinical areas for future treatments
4. An in-depth assessment of the future markets delivered to you today
5. A thorough examination of the ethical and regulatory aspects behind stem cell research
6. A detailed analysis of the financial position of the market as it stands and future projections of growth

Methodology

The information contained in this report is from primary industry sources. This includes one-on-one interviews with companies, with governmental bodies and academic insitutions. Analysis has also been drawn from company reports, whether annual financial returns or white papers. The author of this report has dealt with over 50+ companies and industry contacts to assist on the production of this report.

This market has grown rapidly since the isolation of embryonic stem cells in 1998. 
It is the multifaceted role of stem cells in a whole wide range of diseases that accounts for this huge potential. The diseases that stem cell technology may offer treatments for includes:

1. Parkinson's Disease
2. Diabetes
3. Chronic Heart Disease
4. Kidney Disease
5. Liver Failure
6. Cancer
7. Spinal Cord Injury
8. Multiple Sclerosis
9. Alzheimer's Disease
10. Gene Therapy

Why you must buy this report:

The pharmaceutical industry has been seeking the next blockbuster drug, yet it appears as though these might not be as profligate as they have been in the past. However, the tissue engineering & stem cell treatment hold promise. This report analyses the current situation in the market and assesses the potential of work that are currently in the pipeline.

Table of Contents

Chapter 1. Introduction

• 1.1 Introduction
• 1.2 Stem cells
  • 1.2.1 History
  • 1.2.2 Definitions
• 1.3 Embryonic stem (ES) cells
• 1.4 Embryonic germ (EG) cells
  • 1.4.1 Embryonic stem (ES) cells versus embryonic germ (EG) cells
• 1.5 Adult stem cells
  • 1.5.1 Advantages of adult stem cells
  • 1.5.2 Disadvantages of adult stem cells
  • 1.5.3 Adult stem cell plasticity and transdifferentiation
  • 1.5.4 Questions about adult stem cells
• 1.6 Cloning
  • 1.6.1 Therapeutic cloning
  • 1.6.2 Reproductive cloning
  • 1.6.3 Dolly the sheep
  • 1.6.4 Other cloning successes
• 1.7 Tissue engineering
  • 1.7.1 History
  • 1.7.2 Progress
• 1.8 Conclusions

 
Chapter 2. Key players

• 2.1 Introduction
  • 2.1.1 Novocell
  • 2.1.2 ES Cell International
  • 2.1.3 Reliance Life Sciences
  • 2.1.4 Cytori Therapeutics
  • 2.1.5 Intercytex
• 2.2 Companies that have stem cell lines currently stored at the NIH Human Embryonic Stem Cell Registry in the US
  • 2.2.1 BresaGen 
  • 2.2.2 Cellartis
  • 2.2.3 Cythera/ Novocell
  • 2.2.4 ES Cell International (ESI)
  • 2.2.5 Geron
  • 2.2.6 Reliance Life Sciences
• 2.3 Pharmaceutical industry
  • 2.3.1 Amersham
  • 2.3.2 Amgen
  • 2.3.3 AstraZeneca
  • 2.3.4 Johnson & Johnson
  • 2.3.5 Merck
  • 2.3.6 Novartis AG
  • 2.3.7 Schering AG
• 2.4 Key companies - US
  • 2.4.1 Aarstrom Biosciences Inc.
  • 2.4.2  Advanced Cell Technology Inc.
  • 2.4.3 BioE
  • 2.4.4 Cellerant
  • 2.4.5 Cytori Therapeutics
  • 2.4.6 Genentech
  • 2.4.7 Osiris 
  • 2.4.8 Stem Cells Inc.
  • 2.4.9 Stem Cell Therapeutics Corp
  • 2.4.10 Titan Pharmaceuticals Inc.
  • 2.4.11 Viacell
• 2.5  Key companies - UK
  • 2.5.1 Angel BioTechnology
  • 2.5.2 Axordia
  • 2.5.3 Epistem
  • 2.5.4 Intercytex
  • 2.5.5 Novathera 
  • 2.5.6 Odontis 
  • 2.5.7 RegenTec
  • 2.5.8 Reinnervate
  • 2.5.9 ReNeuron
  • 2.5.10 Renovo
  • 2.5.11 Stem Cell Sciences
• 2.6 Key companies - global
  • 2.6.1 Australia
    • 2.6.1.1 Mesoblast Limited
  • 2.6.2 Israel
    • 2.6.2.1 Pluristem
    • 2.6.2.2 BrainStorm Cell Therapeutics
    • 2.6.2.3 Gamida
  • 2.6.3 Thailand
    • 2.6.3.1 TheraVitae
  • 2.6.4 India
    • 2.6.4.1 Stempeutics
  • 2.6.5 Singapore
  • 2.6.6 Sweden
• 2.7  Other companies
  • 2.7.1 Bioheart, Inc.
  • 2.7.2  Aldagen
  • 2.7.3  Cellular Dynamics International
  • 2.7.4  RhinoCyte
  • 2.7.5  Stem Cell Innovations
  • 2.7.6  StemCell Technologies
  • 2.7.7  Vesta Therapeutics
  • 2.7.8  Vistagen Therapeutics 
• 2.8    Conclusions

 
Chapter 3. The Market

• 3.1 Introduction
• 3.2 The Global burden of disease
• 3.3 Numbers of patients
• 3.4 Cost of illness
• 3.5 Major clinical applications
  • 3.5.1 Cardiac applications
  • 3.5.2 Other circulatory applications
  • 3.5.3 Cosmetic applications
  • 3.5.4 Dermatological applications
  • 3.5.5 Endocrine applications
  • 3.5.6 Hepatic applications
  • 3.5.7 Neural applications
  • 3.5.8 Optical applications
  • 3.5.9 Orthodontic applications
  • 3.5.10 Orthopaedic applications
  • 3.5.11 Renal applications
  • 3.5.12 Other applications
• 3.6 Regenerative medicine market
  • 3.6.1 Stem cell market
  • 3.6.2 Media coverage
  • 3.6.3 Tissue engineering
• 3.7 Conclusions

 
Chapter 4. Issues

• 4.1 Introduction
• 4.2 Ethical Issues
  • 4.2.1 The Ethics of how life is defined
  • 4.2.2 The Ethics of using stem cells
• 4.3 Social Issues
  • 4.3.1 Tissue source
  • 4.3.2 Hybrids
  • 4.3.3 Long term implications of stem cell research
• 4.4 Moral issues
• 4.5 Religious issues
  • 4.5.1 Catholicism
  • 4.5.2 Protestantism
  • 4.5.3 Judaism
  • 4.5.4  Islam
  • 4.5.5 Hinduism
• 4.6 Political issues
  • 4.6.1 US
• 4.7 Conclusions

 
Chapter 5. Regulations and patents

• 5.1 Introduction
• 5.2 Regulatory issues
  • 5.2.1 UK Government initiatives
  • 5.2.2 UK Stem cell bank
  • 5.2.3 UK - Current regulations
  • 5.2.4 US Government initiatives
    • 5.2.4.1 History
    • 5.2.4.2 Appropriations Bill, HR 3061 (Sec. 510)
  • 5.2.5 US Current regulations
  • 5.2.6 Ongoing controversy
  • 5.2.7 Political landscape
  • 5.2.8 Cell line viability
  • 5.2.9 Xenotransplantation
  • 5.2.10 Rest of World
  • 5.2.11 Europe
  • 5.2.12 Asia
    • 5.2.12.1 Japan
    • 5.2.12.2 China
    • 5.2.12.3 Singapore
    • 5.2.12.4 India
    • 5.2.12.5 South Korea
  • 5.2.13 Australasia
  • 5.2.14 Canada and South America
  • 5.2.15 Middle East
  • 5.2.16 Africa
• 5.3 Conclusions
• 5.4 Patenting Issues
  • 5.4.1 Background
  • 5.4.2 Patenting - Europe
  • 5.4.3 Patenting - UK
    • 5.4.3.1 Processes for obtaining stem cells from   human embryos
    • 5.4.3.2 Human totipotent cells
    • 5.4.3.3 Human embryonic pluripotent cells
  • 5.4.4 Patenting - USA
    • 5.4.4.1  Wisconsin Alumni Research Foundation   (WARF)
    • 5.4.4.2. Geron
  • 5.4.5 Patenting controversy
  • 5.4.6 Patenting - global
• 5.5 Conclusions

 
Chapter 6. Trends, Drivers and Opportunities

• 6.1 Introduction
• 6.2 Stem Cell Research - SWOT analysis
  • 6.2.1 Strengths
  • 6.2.2 Weaknesses
  • 6.2.3 Opportunities
  • 6.2.4 Threats
• 6.3 Trends
  • 6.3.1 Portfolio diversification
  • 6.3.2 Strong proprietary rights
  • 6.3.3 Strategic partnerships
• 6.4 Drivers
  • 6.4.1 Funding
  • 6.4.2 Results
• 6.5 Opportunities
  • 6.5.1 Suppliers to the stem cell industry
  • 6.5.2 Cord blood banking
• 6.6 Conclusions

 
Chapter 7.  Stem cell research funding

• 7.1 Introduction
• 7.2 Charities and research councils
  • 7.2.1 Wellcome Trust/ Juvenile Diabetes Research Foundation
  • 7.2.2 Wellcome Trust/ Medical Research Council/ Wolfson Foundation
  • 7.2.3 Juvenile Diabetes Research Foundation (JDRF)
• 7.3 Private funds
  • 7.3.1 The Starr Foundation
  • 7.3.2 Ansary Center for Stem Cell Therapeutics
  • 7.3.3 Johns Hopkins.
  • 7.3.4 University of Texas Health Centre
  • 7.3.5 University of California, San Francisco (UCSF)
• 7.4 Public funds
  • 7.4.1 Venture Capital
  • 7.4.2 Other public funds
  • 7.4.3 California 
  • 7.4.4 New Jersey
  • 7.4.5 Massachusetts
  • 7.4.6 Connecticut
  • 7.4.7 Illinois
  • 7.4.8 Maryland
  • 7.4.9 Ohio
  • 7.4.10 Others
  • 7.4.11 European Union
• 7.5 Conclusions

 
Chapter 8. Conclusions - the future of the stem cell market

• 8.1 Introduction
• 8.2 Progress
  • 8.2.1 Science
  • 8.2.2 Media
  • 8.2.3 Geography
  • 8.2.4 Funding
  • 8.2.5 Patenting
  • 8.2.6 Politics
• 8.3 Recommendations

 
List of tables

• Table 1.1 Key achievements in stem cell research
• Table 1.2 Diseases and conditions treated with adult stem cell therapies
• Table 2.1 Organisations currently listed as the supplier of stem cell lines to the NIH Human Embryonic Stem Cell Registry
• Table 3.1 The world top 20 threats to health in 2002 and projected 2030
• Table 3.2 Number of potential patients in the US eligible for stem cell therapy 
• Table 3.3 Annual direct expenditure in the US for leading diseases and conditions
• Table 3.4 Top surgical and non-surgical cosmetic procedures for men and women (2005)
• Table 5.1 Representative state-wide initiatives regarding the application of stem cell research
• Table 5.2 EU member states legislation (2006)

 
List of figures

• Figure 1.1 Number of papers published per annum (1996-2006)
• Figure 1.2 Schematic of embryonic stem cell differentiation
• Figure 1.3 Lung cells derived from human embryonic stem cells
• Figure 1.4 Foetal neural stem cells
• Figure 1.5 Schematic of embryonic tissue differentiation
• Figure 5.1 Published patents (1997 - 2005), Title search: "Stem cell*", "Embryonic stem cell*" and "Human embryonic stem cell*"
• Figure 5.2 Number of key patent families (2000 - 2005)
• Figure 7.1 Current translation pathway for stem cell research to commercialisation

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