RNA Interference Markets
Since its discovery, the naturally occurring RNA (ribonucleic acid) interference effect has been acclaimed as the most exciting technical breakthrough in biological research in the last decade. Some industry analysts predict that RNA interference (RNAi) may even surpass PCR as a top technology.
RNAi allows scientists to silence the expression or effect of a gene under study. This is known as gene knockdown. This field has rapidly emerged as a fast-growing new market.
The purpose of this report is to review the market for RNAi testing equipment and supplies. RNAi is a mechanism in molecular biology where the presence of certain fragments of double-stranded RNA (dsRNA) interferes with the expression of a particular gene which shares a similar sequence with the dsRNA. This study defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence market size and growth for RNAi testing.
The main objectives of this study are to:
1) understand the different sectors of RNAi testing market and to look at a description of the instruments, reagents and supplies marketed by major companies in each segment;
2) obtain a complete understanding of the individual RNAi-testing platforms-from basic principles to clinical applications;
3) discover feasible market opportunities by identifying high-growth applications in different analytical diagnostic areas, with a focus on the biggest and expanding markets;
4) focus on global industry developments and trends through an in-depth analysis of the major world markets for RNAi measurement technology, including growth forecasts; and
5) present market figures related to the current value of RNAi testing, market projections, market share, key players and sector growth rates.
Table of Contents
- 1Overview7
- 1.1Objectives7
- 1.2Scope7
- 1.3Methodology9
- 1.4Executive Summary10
- 2RNA Interference (RNAi)13
- 2.1Introduction13
- 2.2Overview of RNA Interference13
- 2.2.1Classes of Endogenous Small RNAs: siRNA, rasiRNA and miRNA14
- 2.2.2Mechanism of RNAi In Vivo15
- 2.3Glossary18
- 2.4What Areas of Research Does RNAi Impact?19
- 2.4.1RNAi Technology in Life Sciences Research, Drug Discovery and Development20
- 2.4.2RNAi Technology in Agriculture26
- 3Technology Trends in RNAi Space29
- 3.1Overview29
- 3.2End-User Segmentation29
- 3.3Technologies for Inducing RNAi30
- 3.3.1Methods for Detecting Gene Silencing31
- 3.3.2Comparison of Strategies for Target Validation32
- 3.3.3Libraries of siRNAs/shRNAs to Knock Down Genes En Masse32
- 3.4miRNA-Based RNAi: The Leading Edge of RNAi Space38
- 3.4.1Biological Function of miRNAs39
- 3.4.2Role of miRNAs in Disease40
- 3.4.3miRNA-based Diagnostics44
- 3.4.4miRNA-based Therapeutics46
- 3.5Market Shifts in RNAi Space: Where Is It Headed?47
- 3.5.1Intellectual Property and Patent Issues48
- 3.5.2Patents Covering the Molecular Characteristics of the RNAi Agent48
- 3.5.3Funding in RNAi Space: Grants, Venture Capital and IPOs50
- 3.5.4Partnerships, Alliances, Mergers and Acquisitions51
- 3.6SWOT Analysis of Technologies and Vendors in RNAi Space53
- 4RNAi Market Analysis56
- 4.1Overview56
- 4.2Market Data Collection and Respondent Pool56
- 4.2.1Respondent Pool Characteristics56
- 4.3RNAi Technologies / Products in Research Applications58
- 4.4RNAi Technologies/Products: Market Shares (Quantitative)59
- 4.5Quantitative Metrics of RNAi Usage: Market Opportunity and Growth62
- 4.5.1Growth of Various Segments in RNAi Space64
- 4.5.2Product Formats and Representation in RNAi Marketplace65
- 4.6RNAi Marketplace: Challenges, Unmet Needs and Drivers71
- 4.6.1Unmet Needs in RNAi Space72
- 4.6.2RNAi Market: Qualitative Growth Drivers74
- 5The RNAi Landscape75
- 5.1Overview75
- 5.2Market Segmentation of RNAi and Segment Characteristics75
- 5.3Quantitative Market Opportunities in RNAi Space77
- 5.3.1Opportunities in miRNA Space77
- 5.3.2Opportunities in siRNA/shRNA Space79
- 5.4RNAi Product Offerings and Associated Business Models80
- 5.5Challenges for RNAi Therapeutic Development82
- 6RNAi-Based Therapeutics: The Emerging Industry Landscape84
- 6.1Factors Contributing to the Success of RNAi Therapeutics84
- 6.2Advantages and Disadvantages of siRNA-based Drugs85
- 6.3Opportunities and Challenges with RNAi-based Therapeutics85
- 6.4The Gene Therapy Precedent86
- 6.5The Antisense Precedent87
- 6.6Interferon Response87
- 6.7Delivery of RNAi-based Therapeutics88
- 6.8Off-Target Effects90
- 6.9Overwhelming the Endogenous RNAi System-Affecting the microRNA Pathway90
- 6.10RNAi-based Therapeutics90
- 6.10.1Cancer91
- 6.10.2Cardiac Disease93
- 6.10.3Immunologic Disease94
- 6.10.4Infectious Disease94
- 6.10.5Inflammation97
- 6.10.6Lifestyle Therapeutics97
- 6.10.7Metabolic Disease97
- 6.10.8Neurologic Disease98
- 6.10.9Ophthalmic Disease98
- 6.10.10Renal Disease100
- 6.10.11Respiratory Disease100
- 7Company Profiles-U.S.101
- 7.1Alfacell Corporation102
- 7.2Allele Biotechnology and Pharmaceuticals, Inc.102
- 7.3Alnylam Pharmaceuticals102
- 7.4Ambion104
- 7.5Asuragen, Inc.105
- 7.6Avalon Pharmaceuticals, Inc.105
- 7.7B-Bridge International, Inc.106
- 7.8Bio-Rad Laboratories106
- 7.9Calando Pharmaceuticals, Inc.107
- 7.10Cepheid107
- 7.11Cequent107
- 7.12Clontech Laboratories, Inc.108
- 7.13CombiMatrix Corporation108
- 7.14Cyntellect, Inc.108
- 7.15CytRx Corp.109
- 7.16Dharmacon110
- 7.17Dicerna110
- 7.18Galenea Corporation110
- 7.19GeneCopoeia, Inc.111
- 7.20GeneThera, Inc.111
- 7.21Genlantis111
- 7.22GenoSensor111
- 7.23GRL, Inc.112
- 7.24IDT112
- 7.25Imgenex Corporation112
- 7.26Ingenuity Systems113
- 7.27Intradigm Corporation113
- 7.28Invitrogen113
- 7.29InvivoGen114
- 7.30Isis Pharmaceuticals, LLC114
- 7.31LC Sciences115
- 7.32Lentigen Corporation116
- 7.33Merck & Co., Inc.116
- 7.34Mirus Bio Corporation (Acquired by Roche)116
- 7.35Monsanto116
- 7.36Nastech Pharmaceutical Company, Inc.117
- 7.37New England BioLabs118
- 7.38Nucleonics, Inc.118
- 7.39Open Biosystems, Inc.119
- 7.40OPKO Health, Inc.119
- 7.41OriGene120
- 7.42Panomics, Inc.120
- 7.43PhaseRx120
- 7.44Promega Corp.120
- 7.45Quark Pharmaceuticals, Inc.121
- 7.46RXi Pharmaceuticals Corporation121
- 7.47Senetek PLC122
- 7.48Sigma-Aldrich122
- 7.49Sirna Therapeutics123
- 7.50Sirnaomics, Inc.124
- 7.51SomaGenics, Inc.125
- 7.52System Biosciences125
- 7.53Tacere Therapeutics125
- 7.54Targeted Genetics Corporation126
- 7.55Third Wave Technologies126
- 7.56Traversa126
- 8Company Profiles-Europe128
- 8.1Actigenics SA128
- 8.2Amaxa128
- 8.3AstraZeneca PLC129
- 8.4Cenix Bioscience GmbH129
- 8.5deVGen N.V.130
- 8.6DNAVision130
- 8.7Exiqon131
- 8.8Genovis131
- 8.9genOway131
- 8.10imaGenes GmbH132
- 8.11MWG Biotech AG132
- 8.12OZ Biosciences132
- 8.13Prosensa Holding133
- 8.14QIAGEN133
- 8.15RNAx GmbH (Germany)134
- 8.16Roche135
- 8.17Rosetta Genomics, Ltd.136
- 8.18Santaris Pharma A/S136
- 8.19Silence Therapeutics PLC137
- 8.20TaconicArtemis GmbH138
- 8.21TRANSAT138
- 9Company Profiles-Asia-Pacific140
- 9.1alphaGEN Co., Ltd.140
- 9.2Benitec, Ltd.140
- 9.3Bioneer140
- 9.4CytoPathfinder, Inc.141
- 9.5Genesis Research & Development Corp.141
- 9.6GeneDesign, Inc.142
- 9.7GNI Pharmaceutical Corporation142
- 9.8Koken Co., Ltd.142
- 9.9NanoCarrier Co., Ltd.142
- 9.10Oncolys Biopharma, Inc.143
- 9.11RealGene Bio-Technologies, Inc.143
- 9.12Samchully Pharmaceuticals143
- 9.13Samyang Corp.143
- 9.14Shanghai Biochip144
- 9.15Shanghai GenePharma Co.144
- 9.16Shanghai Genomics, Inc.144
- 9.17Transgene Biotek, Ltd.145
- 10Company Profiles-Rest of the World146
- 10.1Benitec, Ltd.146
- 10.2Tekmira147
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