RNA Interference Markets

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Publication Date: 2008-05-02

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Since its discovery, the naturally occurring RNA (ribonucleic acid) interference effect has been acclaimed as the most exciting technical breakthrough in biological research in the last decade. Some industry analysts predict that RNA interference (RNAi) may even surpass PCR as a top technology.

RNAi allows scientists to silence the expression or effect of a gene under study. This is known as gene knockdown. This field has rapidly emerged as a fast-growing new market.

The purpose of this report is to review the market for RNAi testing equipment and supplies.

RNAi is a mechanism in molecular biology where the presence of certain fragments of double-stranded RNA (dsRNA) interferes with the expression of a particular gene which shares a similar sequence with the dsRNA. This study defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence market size and growth for RNAi testing.

The main objectives of this study are to:

1) understand the different sectors of RNAi testing market and to look at a description of the instruments, reagents and supplies marketed by major companies in each segment;

2) obtain a complete understanding of the individual RNAi-testing platforms-from basic principles to clinical applications;

3) discover feasible market opportunities by identifying high-growth applications in different analytical diagnostic areas, with a focus on the biggest and expanding markets;

4) focus on global industry developments and trends through an in-depth analysis of the major world markets for RNAi measurement technology, including growth forecasts; and

5) present market figures related to the current value of RNAi testing, market projections, market share, key players and sector growth rates.

 

Table of Contents

 

  • INDEX OF TABLES

  • Table 2.1: Advantages/Disadvantages of siRNAs and shRNAs as Inducers of RNAi in Mammalian Cells18
  • Table 2.2: Prevalence of siRNA-mediated RNAi in Disease Models, as Reported in Scientific Literature20
  • Table 2.3: RNAi-based Therapeutics in Clinical Trials21
  • Table 2.4: Suppliers of Enabling Technologies and Tools in RNAi Space22
  • Table 2.5: Suppliers of siRNA/shRNA Products (by Product/Service Class)23
  • Table 3.1: Currently Utilized Technologies for Inducing RNAi-Mediated Knockdown29
  • Table 3.2: Comparison of mRNA Detection Technologies29
  • Table 3.3: Characteristics of Various Publicly available Mouse and Human RNAi Libraries31
  • Table 3.4: Comparison of Formats for Library-Based Gene Knockdown33
  • Table 3.5: Strategies for Target Validation by Pharma/Biotech: RNAi and Others36
  • Table 3.6: Seminal Patents in RNAi39
  • Table 3.7: Venture Capital Raised by Selected Companies in the RNAi Space40
  • Table 3.8: List of Public Biotech Companies in RNAi Space41
  • Table 3.9: Disease-Related miRNAs48
  • Table 3.10: Publicly Available Computational Programs for Identifying miRNA Sequences/Targets49
  • Table 3.11: SWOT Analysis of siRNA Oligonucleotides52
  • Table 3.12: Transfection Reagents (Lipid-Mediated Delivery)52
  • Table 3.13: shRNA Plasmid Constructs53
  • Table 3.14: shRNA Pooled Libraries or Arrayed Collections (Retroviral/Lentiviral Delivery)53
  • Table 5.1: RNAi Market Segmentation and Research Settings73
  • Table 5.2: Segment 1: Basic Life Science Research Utilizing RNAi Tools and Technologies73
  • Table 5.3: Segment 2: RNAi for Drug Discovery and Development74
  • Table 5.4: Segment 3: RNAi Research for Development of RNAi Therapeutics74
  • Table 5.5: Segment 4: RNAi Fee-for-Service Business75
  • Table 5.6: Grants Awarded and Research Spending in miRNA Space, 2005-200875
  • Table 5.7: RNAi Opportunity and Market Size: Quantitative Model, 2006-200977


  • INDEX OF FIGURES

  • Figure 2.1: The miRNA Processing Pathway14
  • Figure 2.2: Growth of Scientific Publications Addressing miRNAs, 2001-200815
  • Figure 2.3: Mechanisms of Small RNA-induced Gene Regulation16
  • Figure 2.4: Types of RNAi Compounds18
  • Figure 2.5: Breakdown of Scientific Publications Related to RNAi by Geographic Region, 2007-200819
  • Figure 3.1: End-User Segmentation of RNAi Space27
  • Figure 3.2: RNAi Patents Filed Globally, by Geographical Origin39
  • Figure 3.3: Selected Deals in RNAi Space42
  • Figure 4.1: Geographical Breakdown of RNAi End-User Survey Respondents55
  • Figure 4.2: Affiliation of RNAi End-User Survey Respondents55
  • Figure 4.3: Utilization of RNAi Technologies/Products by Respondent Pool56
  • Figure 4.4: RNAi Utilization Period: Breakdown of Respondent Pool56
  • Figure 4.5: Research Applications Using RNAi Technologies/Products57
  • Figure 4.6: Types of RNAi Technologies Currently Utilized58
  • Figure 4.7: RNAi Technologies Most Commonly Utilized Currently by End-Users58
  • Figure 4.8: Types of RNAi Technologies: Expected Use in Six to 18 Months59
  • Figure 4.9: Evolution of Market Shares of RNAi-Inducing Technologies60
  • Figure 4.10: Number of Experiments Involving RNAi Conducted per Week60
  • Figure 4.11: Range of Research Dollars Spent Monthly on RNAi Research61
  • Figure 4.12: RNAi Experiment Throughput Correlated with Type of RNAi Technology Used62
  • Figure 4.13: Current RNAi Market Share by Segments63
  • Figure 4.14: Growth/Decline Rate of RNAi Marketplace Segments (Six to 18 Months)64
  • Figure 4.15: Product Formats Utilization for RNAi Research (Current and Six to 18 Months)65
  • Figure 4.16: Companies Offering Product Formats for Currently Used RNAi Products67
  • Figure 4.17: RNAi Product Offerings/Formats Use (Projections-Six to 18 Months)68
  • Figure 4.18: Percentage Change of RNAi Product Offerings/Formats (Six to 18 Months)69
  • Figure 4.19: Key Challenges Faced by End-Users in RNAi Space70
  • Figure 4.20: Unmet Needs in RNAi Space Ranked by Importance to End-Users71
  • Figure 5.1: Growth and Evolution of miRNA Space76
  • Figure 5.2: Elements of RNAi Value Chain77
  • Figure 5.3: Growth and Evolution of RNAi (siRNA/shRNA) Space78
  • Figure 5.4: Market Revenues Based on Components of siRNA Experimental Paradigm80
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