Stem Cell Markets

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Publication Date: 2007-01-01

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A stem cell is an extraordinary type of cell that has the ability to self-renew for long periods of time and to differentiate into specialized cells under appropriate physiological or experimental conditions. Traditionally, stem cells have been classified as either embryonic, adult (tissue-specific or cord blood) stem cells. Recent understanding of stem cell biology may provide new approaches for the treatment of a number of diseases as well as tissue/organ injuries, including cardiovascular disease, neurological disease, musculoskeletal disease, diabetes and hematopoietic disorders. Stem cell fate is determined by both intrinsic regulators and the extra-cellular environment (niche), and their expansion and differentiation ex vivo are generally controlled by growing them in a specific configuration (monolayer or three-dimensional culture). This process, which is vital to enable stem cells to be used for therapeutic purposes, is called differentiation. Differentiation is a process involving unspecialized cells progressing to become specialized cells with restricted developmental potential.The purpose of this TriMark Publications report is to describe the specific market segments of the medical research space using stem cells for research and development (R&D) purposes. This study reviews all of the generally accepted analytical methods that are currently in use today for preparing and using stem cells. It examines the use of stem cells in developing new therapies for disease.

Table of Contents

  • Appendix 1.Glossary of Terms in Stem Cell Biology97


  • INDEX OF FIGURES

  • Figure 2.1: Derivation of Embryonic Stem Cells (ESCs) from the Inner Cell Mass of Blastocysts7
  • Figure 2.2: Classification of Stem Cells: Embryonic Stem Cells versus Adult Stem Cells8
  • Figure 2.3: Somatic Cell Nuclear Transfer (SCNT)11
  • Figure 3.1: Segmentation of the Stem Cells Marketplace Based Upon Commercial Offerings-Products and Services16
  • Figure 3.2: Geographical Breakout of Stem Cell End-User Survey Respondents20
  • Figure 3.3: Affiliation (Pharma, Biotech, Academic/University) of Stem Cell End-user Survey Respondents20
  • Figure 3.4: Most of the Survey Respondents are Studying Stem Cells or Using Stem Cells in their Research21
  • Figure 3.5: Length of Time our Survey Respondent Pool has been Studying Stem Cells or Using Stem Cells in their Research Activities21
  • Figure 3.6: Utilization/Research with Different Stem Cell types22
  • Figure 3.7: Range of Number of Experiments Involving Stem Cells Conducted Per Week23
  • Figure 3.8: Differences with Respect to Usage of Stem Cell Types24
  • Figure 3.9: How Much Research Dollars are Spent Monthly on Research/Studies with Different Stem Cell Types25
  • Figure 3.10: Growth of Research Spending in Various Segments of the Stem Cells Space (Defined by Stem Cell Type)26
  • Figure 3.11: Growth in End-User Utilization of the Various Different Stem Cell Types26
  • Figure 3.12: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells28
  • Figure 3.13: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months28
  • Figure 3.14: Broad Classification of Research Activities Being Performed with Stem Cells by Researchers29
  • Figure 3.15: Current End-User Utilization Category of Adult Stem Cells (ASCs)30
  • Figure 3.16: Current End-User Utilization Category of Human Embryonic Stem Cells (hESCs)30
  • Figure 3.17: Current End-User Utilization Category of Human Cord Blood Stem Cells30
  • Figure 3.18: Current End-User Utilization Category of Animal Stem Cells31
  • Figure 3.19: Current End-User Utilization Category of Cancer Stem Cells31
  • Figure 3.20: Challenges in the Study or Utilization of Adult Stem Cells (ASCs)33
  • Figure 3.21: Challenges in the Study or Utilization of Human Embryonic Stem Cells (hESCs)33
  • Figure 3.22: Challenges in the Study or Utilization of Human Cord Blood Stem Cells34
  • Figure 3.23: Challenges in the Study or Utilization of Animal Stem Cells34
  • Figure 3.24: Challenges in the Study or Utilization of Cancer Stem Cells35
  • Figure 3.25: Top Unmet Needs in Commercial Products in the Stem Cells Research Space38
  • Figure 3.26: Stem Cells Research Market, 2006-201151
  • Figure 4.1: Stem Cell Research Worldwide55


  • INDEX OF TABLES

  • Table 2.1: The Different Types of Stem Cells and their Properties8
  • Table 2.2: Adult Stem Cell (ASC) Differentiation Properties9
  • Table 3.1: Characteristics of Different Stem Cell Types and Associated Market Opportunity15
  • Table 3.2: Segmentation of the Stem Cell Market by Type/Lineage of Stem Cell16
  • Table 3.3: Selected Cord Blood Banks in the U.S.18
  • Table 3.4: Selected Companies in the Cord Blood Stem Cell Technology and Therapeutics Development Space19
  • Table 3.5: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells27
  • Table 3.6: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months27
  • Table 3.7: Market Shares of Companies/Institutions Offering Different Stem Cells to Researchers41
  • Table 3.8: Market Shares of Companies/Institutions Offering Reagents for Stem Cell Research42
  • Table 3.9: The Stem Cells Research Market Forecast, 2006-201150
  • Table 3.10: The World Market for Stem Cell Products and Services, 2005-201252
  • Table 4.1: Major Milestones in Stem Cell Research and Associated Timeline, 1981-200654
  • Table 4.2: Selected Stem Cell Hot Spots Worldwide Administering Non-FDA Approved Stem Cell Therapeutic Regimens56
  • Table 4.3: NIH Funding of Stem Cell Research in the U.S., 2002-200657
  • Table 4.4: Snapshot of the Current Key Stem Cell Patents59
  • Table 4.5: Stem Cell Derivations68
  • Table 5.1: Estimate of Potential Market Opportunity for Stem Cell-based Therapeutics74
  • Table 5.2: Autologous Versus Allogeneic Cell Therapy75
  • Table 5.3: Diseases Treated with HSC Transplantation Today76
  • Table 5.4: HSC Sources and their Properties77
  • Table 5.5: Stem Cell Therapeutics for Hematological Diseases in Development78
  • Table 5.6: Stem Cell-based Therapeutics for Cardiac and Ischemic Diseases in Development79
  • Table 5.7: Stem Cell-based Therapeutics for Vascular Diseases in Development80
  • Table 5.8: Stem Cell Therapeutics for Type I Diabetes in Development80
  • Table 5.9: Stem Cell Therapeutics for Orthopedic Disease in Development81
  • Table 5.10: Stem Cell Therapeutics for Neurological Disease in Development82
  • Table 5.11: Segmentation of the Allogeneic Cell Therapy Market84
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