Molecular Diagnostics Markets

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Price: $3,400.00

Publication Date: 2008-03-01

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The technologies that constitute molecular diagnostics-first-generation amplification, DNA probes, fluorescent in situ hybridization (FISH), second-generation biochips and microfluidics, next-generation signal detection, biosensors, and molecular labels-are influencing the discovery of therapeutic molecules, the screening and diagnosis of patients, and the optimization of drug therapy. In the past few years, this rapidly evolving field has seen several fascinating developments. This TriMark Publications report describes the specific market segment of the in vitro diagnostics market known as molecular diagnostics and includes all of the generally accepted clinical analytical activities in use today. It examines the prevalent clinical-measurement devices, as well as their reagents and supplies as utilized in hospitals, clinics, large reference laboratories and doctor's offices. Diagnostic tests marketed primarily as over-the-counter are generally not included in this report, although there is inevitably some overlap. The main objectives of this analysis are:

1) identifying viable technology drivers through a comprehensive look at platform technologies for molecular diagnostics, including probe-based nucleic acid assays, microarrays and sequencing;

2) obtaining a complete understanding of the chief molecular diagnostics tests-i.e., predictive, screening, prognostic, monitoring, pharmacogenomic and theranostic-from their basic principles to their applications;

3) discovering feasible market opportunities by identifying high-growth applications in different clinical diagnostic areas and by focusing on expanding markets, such as communicable diseases, cardiology and oncology; and

4) focusing on global industry development through an in-depth analysis of the major world markets for molecular diagnostics, including growth forecasts.

By Purchasing This Report You Will Have:·

This Report Will Cover the Following Molecular Diagnostics Technologies:

Analysis includes the use of charts and graphs measuring product growth and trends within the marketplace. In addition, a discussion of research into the molecular diagnostics arena provides the reader with a deeper understanding of the possibilities for future treatment and avenues for possible research and development budgets. Company-specific information, including sales figures, product pipeline status and research and development trends is provided throughout the report.

The report will:

This report answers the following questions

Table of Contents

 

 

  • Appendix 1. Biowarfare Agents262
  • Anthrax262
  • Botulinum Toxins263
  • Brucellosis263
  • Cholera264
  • Clostridium Perfringens Toxins265
  • Congo-Crimean Hemorrhagic Fever265
  • Ebola Haemorrhagic Fever266
  • Melioidosis267
  • Plague267
  • Q Fever268
  • Ricin268
  • Rift Valley Fever269
  • Saxitoxin269
  • Smallpox270
  • Staphylococcal Enterotoxin B (SEB)271
  • Trichothecene Mycotoxins271
  • Tularemia272
  • Venezuelan Equine Encephalitis (VEE)273


  • LIST OF FIGURES

  • Figure 2.1: Segment of Double-Stranded DNA Showing the Base-Pair Relationship15
  • Figure 3.1: Applications of Molecular Diagnostics Technology Platforms23
  • Figure 3.2: Overall Structure of Nucleic Acid Testing Market25
  • Figure 3.3: Serologic and Clinical Course of Acute HBV Infection49
  • Figure 3.4: Primary Causes of Chronic Liver Disease52
  • Figure 3.5: Time Course of Markers in Typical HCV Infection54
  • Figure 3.6: Bacillus anthracis105


  • LIST OF TABLES

  • Table 3.1: Global Market for Molecular Diagnostics Testing26
  • Table 3.2: Global Market for Nucleic Acid Testing27
  • Table 3.3: Summary of Molecular Diagnostics Testing, 200428
  • Table 3.4: Annual U.S. Market for DNA Probe Diagnostics28
  • Table 3.5: Annual Global Market for DNA Probe Diagnostics28
  • Table 3.6: Estimated Market Share of Major Competitors in U.S. DNA/PCR Kit Research Market30
  • Table 3.7: Estimated Market Share of Major Competitors in U.S. DNA/PCR Kit Diagnostics Market30
  • Table 3.8: Roche PCR Licenses31
  • Table 3.9: DNA Probe Market Segments in the U.S.31
  • Table 3.10: Companies Marketing Products Using DNA Probes33
  • Table 3.11: Global Sales of DNA Probe Kits34
  • Table 3.12: Companies Marketing DNA Detection Platforms35
  • Table 3.13: Companies Marketing Genotyping Technologies38
  • Table 3.14: Companies Marketing Clinical Genotyping Technologies39
  • Table 3.15: Summary of Assays for HIV Viral Load Testing46
  • Table 3.16: Global Market for HIV Diagnostic Testing47
  • Table 3.17: U.S. Market for HIV Diagnostic Testing47
  • Table 3.18: Serologic Diagnosis of HBV Infections*50
  • Table 3.19: Unusual HBV Serologic Profiles Requiring Further Evaluation50
  • Table 3.20: Recommendations for HBV Diagnostic Testing50
  • Table 3.21: Lower Detection Limits of HBV DNA Assays50
  • Table 3.22: Recommendations for HBV Testing51
  • Table 3.23: Recommendations for HCV Diagnostic Testing55
  • Table 3.24: Important HCV Statistics55
  • Table 3.25: Gen-Probe Clinical Diagnostic Products for the Detection of Viral Microorganisms57
  • Table 3.26: Global Market for HAV Diagnostic Testing57
  • Table 3.27: U.S. Market for HAV Diagnostic Testing58
  • Table 3.28: Global Market for HBV Diagnostic Testing58
  • Table 3.29: U.S. Market for HBV Diagnostic Testing58
  • Table 3.30: Global Market for HCV Diagnostic Testing58
  • Table 3.31: U.S. Market for HCV Diagnostic Testing59
  • Table 3.32: Global Market for SARS Diagnostics Testing60
  • Table 3.33: U.S. Market for SARS Diagnostics Testing60
  • Table 3.34: Global Market for Molecular Diagnostics Cancer Testing64
  • Table 3.35: Annual Volume of Infectious Disease NAT Testing67
  • Table 3.36: Global Market Dollar Volume of NAT STD Testing67
  • Table 3.37: U.S. Market Dollar Volume of NAT STD Testing68
  • Table 3.38: U.S. Market Share of NAT STD Testing68
  • Table 3.39: Global Market for Chlamydia Diagnostic Testing68
  • Table 3.40: U.S. Market for Chlamydia Diagnostic Testing68
  • Table 3.41: Global Market for Gonorrhea Diagnostic Testing69
  • Table 3.42: Global Market for TB Diagnostic Testing69
  • Table 3.43: Global Market for DNA Group B Streptococcus Diagnostic Testing69
  • Table 3.44: U.S. Market for Group B Streptococcus Diagnostic Testing69
  • Table 3.45: Gen-Probe Clinical Diagnostic Products for the Detection of Non-Viral Microorganisms71
  • Table 3.46: Global Market for Blood-Screening Diagnostic Testing75
  • Table 3.47: U.S. Market for Blood-Screening Diagnostic Testing75
  • Table 3.48: Gen-Probe Blood-Screening Products75
  • Table 3.49: Leading Players in SNP Genotyping80
  • Table 3.50: Global Market for SNP Genotyping80
  • Table 3.51: DNA-Analysis Market Competitors83
  • Table 3.52: Leading Companies in Medical Utility of SNPs83
  • Table 3.53: Competitors in the Field of Identity Genomics Testing84
  • Table 3.54: U.S. Market for Food-Screening Diagnostic Testing Using Molecular Diagnostics Techniques86
  • Table 3.55: Methods for Detection of Salmonella in Food Using Molecular Diagnostics Methods87
  • Table 3.56: U.S. Market for Forensic Analytical Testing Products, Instruments and Supplies, 2004, 2005 and 201089
  • Table 3.57: U.S. Market for Forensic Diagnostics Testing89
  • Table 3.58: U.S. Market for Biological Threat Detection Testing93
  • Table 3.59: Biotest Reagents97
  • Table 3.60: Variation of CF Carrier Risks by Ethnic Group108
  • Table 3.61: Reasons for CF Testing108
  • Table 3.62: Variation of CF Detection Rates by Ethnic Background108
  • Table 3.63: Global Market for CF Diagnostic Testing109
  • Table 3.64: U.S. Market for CF Diagnostic Testing109
  • Table 3.65: Commercial CF-Screening Products109
  • Table 3.66: Emerging CF-Screening Products109
  • Table 3.67: CF Screening Technology Summary110
  • Table 3.68: U.S. Market for HLA Type Testing111
  • Table 3.69: Competitors in HLA Testing111
  • Table 3.70: U.S. Market for NAT Genetic-Disease Testing112
  • Table 3.71: Non-U.S. Market for NAT Genetic-Disease Testing113
  • Table 3.72: U.S. Market for NAT Cytogenetic-Disease Testing113
  • Table 3.73: Non-U.S. Market for NAT Cytogenetic-Disease Testing113
  • Table 3.74: Carrier Rates of Common HFE Mutations in Caucasians114
  • Table 3.75: Results and Diagnosis for Fragile X Syndrome115
  • Table 3.76: Principal Competitors in Pharmacogenetics R&D for Personalized Medicine120
  • Table 3.77: Principal Competitors in Pharmacogenetics Patient Testing120
  • Table 4.1: DNA-Sequencing Market Players124
  • Table 4.2: Global Market for DNA Chips, 2000 to 2007124
  • Table 4.3: Top Ten Companies for Molecular Diagnostics Patents138
  • Table 6.1: Companies Licensed to Sell Custom Molecular Beacon Probes158
  • Table 7.1: Products Marketed by Abbott in the Diagnostics Market164
  • Table 7.2: Summary of Selected Affymetrix Expression-Profiling Customers169
  • Table 7.3: CuraGen Products and Applications192
  • Table 7.4: PACE Product Sales as a Percentage of Total Company Revenue, 2000 to 2003208
  • Table 7.5: Innogenetics HLA Products for Genetic Testing and Transplantation216
  • Table 7.6: Nanogen Product Sales228
  • Table 7.7: Rarely-Expressed Genes as Therapeutic Product Candidates231
  • Table 7.8: Roche Diagnostics Key Products245
  • Table 7.9: Sales by Region246
  • Table 7.10: Sales by Business Area246
  • Table 7.11: Product Line Sales 2005246
  • Table 7.12: Growth Drivers246
  • Table 8.1: Number of Molecular Diagnostics Tests in the U.S.254
  • Table 8.2: Ten Largest Diagnostics Companies Worldwide, 2004254
  • Table 8.3: Global Molecular Diagnostics Testing Revenues255
  • Table 8.4: Global Distribution of Molecular Diagnostics Testing, 2004255
  • Table 8.5: U.S. Molecular Diagnostics Testing Market256
  • Table 8.6: Japanese Molecular Diagnostics Testing Market256
  • Table 8.7: ROW Molecular Diagnostics Testing Market257
  • Table 8.8: Chinese Molecular Diagnostics Products Market Sales260

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