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Microscopy Markets

This report deals primarily with the analysis of market segments of microscopes used in clinical and research laboratories. Emphasis is on the U.S. markets; however, the worldwide markets are analyzed and discussed as well.

Specifically, this report examines those companies and products which are actively developing and marketing microscopy devices and supplies in market segments which have the potential for growth rates above 5% per year over the next five years. It continues to examine those microscopy devices operated as light, confocal, electron and scanning probe microscopes. Also analyzed are applications for certain microscope technology platforms such as semi-conductor processing systems and automated imaging systems.

Concentration is centered on an overview of individual microscopy markets, which are believed to possess the elements that will lead to sustained growth rates for the foreseeable future. This report assesses the current status of each market, makes projections for market size, discusses the market strategies of leading companies in each market segment, and evaluates the forces that underlie the high growth of each segment. Additionally, there\'s an overview of the instruments and supplies marketed by major companies in each market segment. Analysis of the market size, growth rates, and market components for instruments used for microscopy are also discussed.

Table of Contents

1. Overview 5

• 1.1 Statement of Report 5
• 1.2 Scope of This Report 5
• 1.3 Objectives 6
• 1.4 Methodology 6
• 1.5 Aims of This Report 7
• 1.6 Executive Summary 8

2. Introduction to Microscopy Markets 9

• 2.1 Overview of Microscopy Technologies 9
  • 2.1.1 Introduction 9
  • 2.1.2 Basic Optical Microscopy 9
  • 2.1.3 Electron Microscopy and Other Charged-Particle Technologies 10
  • 2.1.4 Advanced Optical Microscopy 11
  • 2.1.5 Scanning Probe Microscopy 12
  • 2.1.6 Fourier Transform Infrared Microscopy 12
  • 2.1.7 Ultraviolet Microscopy 12
  • 2.1.8 Scanning Acoustic Microscopy 12
  • 2.1.9 X-Ray Microscopy / Microtomography (MCT, XMT, Micro-CT) 12
• 2.2 Market Perspective 13
• 2.3 Market Analysis 13
  • 2.3.1 Market Size 14
  • 2.3.2 Market Share 15
  • 2.3.3 Key Players 15
  • 2.3.4 Competition 15
  • 2.3.5 Barriers to Growth 16
  • 2.3.6 Market Drivers 16
• 2.4 Purchasers' Perspectives 16

3. In-Depth Discussion of Optical (Light) Microscopy 19

• 3.1 Lens Systems 20
• 3.2 Resolution 21
• 3.3 Illumination Systems 21
• 3.4 Innovations 22
  • 3.4.1 Stereo Microscopes 22
• 3.5 Major Applications of Optical Microscopy 23
  • 3.5.1 Semiconductor Manufacturing 23
  • 3.5.2 Automated Medical Imaging 24
  • 3.5.3 Market Drivers for Automated Systems for Semiconductor and Medical Applications 26
  • 3.5.4 Real-Time Imaging 26

4. In-Depth Discussion of Light-Based Fluorescence, Multi-Photon and Confocal Microscopy 27

• 4.1 Fluorescence Microscopy 27
• 4.2 Total Internal Reflection Fluorescence Microscopy 28
• 4.3 Multi-Photon Microscopy 28
• 4.3.1 Basic Principles 28
  • 4.3.2 Lasers 28
  • 4.3.3 Fluorophores for Multi-Photon Work 29
  • 4.3.4 Uncaging 29
  • 4.3.5 Autofluorescence 29
• 4.4 Laser Scanning Confocal Microscopy 29
  • 4.4.1 Basic Principles 30
  • 4.4.2 Confocal System Types 31
  • 4.4.3 Photobleaching 31
• 4.5 High-Throughput Fluorescence and Confocal Imaging Systems 31
• 4.6 Major Players and Products in Optical, Fluorescence, Multi-Photon and Confocal Microscopy 32
  • 4.6.1 Becton, Dickinson and Company (BD) 32
  • 4.6.2 KLA-Tencor Corporation 32
  • 4.6.3 Korima, Inc. 33
  • 4.6.4 Leica Microsystems, Inc. 33
  • 4.6.5 Nikon Instruments, Inc. 35
  • 4.6.6 Nanomics Imaging, Ltd. 38
  • 4.6.7 Olympus Imaging America, Inc. 38
  • 4.6.8 Veeco Instruments, Inc. 40
  • 4.6.9 Carl Zeiss Microimaging, Inc. 40
  • 4.6.10 Modular Confocal Scanners 41

5. In-Depth Discussion of Scanning Probe Microscopy, Including Near-Field and Atomic Force Microscopy 43

• 5.1 Introduction 43
• 5.2 Near-Field Scanning Optical Microscopy 43
  • 5.2.1 Resonance Frequency 44
  • 5.2.2 Aperture 44
  • 5.2.3 Reflection Mode 44
• 5.3 Near-Field Scanning Thermal Microscopy (NThM) 44
• 5.4 Atomic Force Microscopy 44
  • 5.4.1 Semiconductor Applications 45
  • 5.4.2 Magnetic Material Applications 45
  • 5.4.3 Electrochemical Applications 45
  • 5.4.4 Life Sciences Applications 45
• 5.5 Major Players and Products in Scanning Probe Microscopy (Including Near-Field and Atomic Force) 46
  • 5.5.1 Agilent Technologies 46
  • 5.5.2 Asylum Research 46
  • 5.5.3 JEOL USA, Inc. 47
  • 5.5.4 KLA-Tencor Corporation 47
  • 5.5.5 Nanonics Imaging, Ltd. 48
  • 5.5.6 Omicron NanoTechnology GmbH 48
  • 5.5.7 Veeco Instruments, Inc. 49
  • 5.5.8 WITec Instruments Corp. 50

6. In-Depth Discussion of Infrared and Ultraviolet Microscopy 52

• 6.1 Fourier-Transfer Infrared Microscopy (FT-IR) 52
• 6.2 Ultraviolet Microscopy 52
• 6.3 Major Players and Products for Infrared and Ultraviolet Microscopy 53
  • 6.3.1 Bruker Optics, Inc. 53
  • 6.3.2 Craic Technologies 53
  • 6.3.3 KLA-Tencor Corporation 53
  • 6.3.4 Korima, Inc. 54
  • 6.3.5 Thermo Scientific 54

7. In-Depth Discussion of Scanning Acoustic Microscopy, X-Ray Microtomography and Raman Spectroscopic Microscopy 55

• 7.1 Scanning Acoustic Microscopy (SAM) 55
• 7.2 X-Ray Microtomography 56
• 7.3 Raman Spectroscopic Microscopy 56
• 7.4 Coherent Anti-Stokes Raman Scattering Microscopy 57
• 7.5 Major Players and Products in Acoustic Microscopy 57
  • 7.5.1 Sonix, Inc. Scanning Acoustic Microscopes for Industrial Applications 57
  • 7.5.2 Sonoscan, Inc., Scanning Acoustic Microscopes for Industrial Applications 58
• 7.6 Major Players in X-Ray Microtomography 58
  • 7.6.1 Cameca Instruments, Inc. 58
  • 7.6.2 SkyScan 58
• 7.7 Major Players in Raman Microscopy 59
  • 7.7.1 Bruker Optics, Inc. 59
  • 7.7.2 Horiba Jobin Yvon, Inc. (Raman Analytical Microscopes) 59
  • 7.7.3 Renishaw, Inc. 59
  • 7.7.4 Thermo Scientific 60

8. In-Depth Discussion of Electron Microscopy and Related Charged-Particle Systems 61

• 8.1 Transmission Electron Microscope 61
  • 8.1.1 Electron Sources 62
• 8.2 Scanning Electron Microscope 63
  • 8.2.1 Rastering 63
  • 8.2.2 Exploring the Sample 63
  • 8.2.3 Types of Images 64
  • 8.2.4 Environmental SEM and Variable-Pressure SEM (VPSEM) 65
  • 8.2.5 Low-Voltage Scanning Electron Microscopy 65
  • 8.2.6 Tabletop Models 66
  • 8.2.7 Applications 66
• 8.3 Scanning/Transmission Electron Microscope 66
• 8.4 Electron Probe Microanalyzer (Microprobe) 67
• 8.5 Auger Electron Microscopy/Spectroscopy (Auger) 68
• 8.6 Electron Beam (E-Beam) Lithography 68
• 8.7 Focused Ion Beam and Dual-Beam Microscopes 68
• 8.8 Secondary Ion Mass Spectrometry (SIMS) 69
• 8.9 X-Ray Photoelectron Spectroscopy / Electron Spectroscopy for Chemical Analysis 69
• 8.10 Scanning Helium Ion Beam Microscopy 70

9. Ancillary Analytical Attachments 71

• 9.1 Energy-Dispersive and Wavelength-Dispersive X-ray Microanalyzers 71
• 9.2 Electron Backscatter Diffraction 71
• 9.3 Cathodoluminescence 71
• 9.4 X-Ray Microtomography 71
• 9.5 Raman Spectroscopy 72

10. Major Players and Products in Electron Beam and Other Charged-Particle Beam Microscopes 73

• 10.1 Cameca Instruments, Inc. 73
• 10.2 FEI Company 74
• 10.3 Hitachi High Technologies America, Inc. 78
• 10.4 JEOL USA, Inc. 81
• 10.5 KLA-Tencor Corporation 85
• 10.6 Omicron NanoTechnology GmbH 86
• 10.7 Vistec Lithography, Inc. 87
• 10.8 Carl Zeiss SMT Corporation 87

11. Company Profiles 90

• 11.1 Applied Materials, Inc. 90
• 11.2 Applied Precision, Inc. 91
• 11.3 Becton, Dickinson and Company 91
• 11.4 Bruker Optics 92
• 11.5 Buehler 92
• 11.6 Cameca (Owned by AMETEK, Inc.) 93
• 11.7 Carl Zeiss, Inc. 93
• 11.8 Danish Micro Engineering A/S 94
• 11.9 FEI Company 95
• 11.10 Gatan 95
• 11.11 Genetix (Acquired by Leica) 96
• 11.12 Hitachi, Ltd. 96
• 11.13 IRIS International 97
• 11.14 JEOL 98
• 11.15 KLA-Tencor Corporation 99
• 11.16 Leica Microsystems (part of Danaher Corporation) 100
• 11.17 Medical Integrated Services (MIS) 101
• 11.18 Nanonics Imaging, Ltd. 102
• 11.19 Nikon, Inc. 102
• 11.20 NT-MDT 104
• 11.21 Obducat-CamScan 104
• 11.22 Olympus Corporation 105
• 11.23 Omicron Nanotechnology 106
• 11.24 PerkinElmer 107
• 11.25 Questar Corporation 108
• 11.26 Schott North America 109
• 11.27 Shimadzu Corporation 109
• 11.28 SII NanoTechnology 110
• 11.29 Thermo Fisher Scientific, Inc. 110
• 11.30 Unitron 114
• 11.31 Veeco Instruments 115
• 11.32 WITec (Wissenschaftliche Instrumente und Technologie) GmbH 116

12. Company Directory 118

13. Glossary 123


INDEX OF FIGURES

Figure 2.1: Global Market for Microscopes, Accessories and Supplies, 2009-2014 14
Figure 3.1: Basic Components of the Optical Microscope 19
Figure 3.2: Stereo Microscope 22


INDEX OF TABLES

Table 2.1: Global Market for Microscopes and Accessories, 2009-2014 14
Table 2.2: Global Market for Optical Microscopes and Accessories 15
Table 2.3: Global Market for Charged Particle Microscopes and Accessories 15
Table 2.4: Global Market for Scanning Probe Microscopes and Accessories 15
Table 3.1: Basic Components of the Optical Microscope 19
Table 5.1: Types of Scanning Probe Microscopes 43

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