Genomics World Markets
Genomics is transforming the pharmaceutical industry. Companies are moving from drug discovery and development based on medicinal chemistry to the design of drugs based on information provided by genomics. Virtually all of the major pharmaceutical houses have either formed partnerships with genomics firms that began to emerge in the early 1990s or have created in house genomics divisions.
The aim of this study is to provide in depth information on the developing market for genomics products and services.
The report includes detailed market analyses and discussions of industry trends in order to assess the impact of genomics on the current and emerging pharmaceutical and diagnostic markets. Forecasts and trends were developed from interviews with industry sources, as well as from an assessment of available and emerging technologies.
The report focuses on how researchers are applying new genomic approaches to drug discovery and development, and on how these technologies can be used most effectively and in a high throughput capacity.
Case studies analyzing particular applications of genomic technologies to specific disease related research are provided, and future trends and developments are forecasted.
Information to prepare this study was derived from interviews with product managers, marketing strategists, research executives and others. These individuals are employed at leading genomics firms or in pharmaceutical and biotechnology companies that either contract with these firms or have developed in house genomics capabilities.
Table of Contents
- 1.Introduction6
- 1.1Statement of Report6
- 1.2Objectives and Goals of Study6
- 1.3Methodology6
- 1.4Executive Summary8
- 1.4.1Market Drivers8
- 1.4.2Market Restraints8
- 1.4.3Market Size and Growth Projections8
- 1.5What Is a Gene?9
- 1.6Gene Expression10
- 1.7Genetic Variability10
- 1.8The Human Genome Project (HGP)11
- 1.9Gene Databases12
- 1.10Sequencing and Resequencing12
- 1.11RNA Interference (RNAi)13
- 1.12DNA Tags15
- 2.Genomics Technology and Industry16
- 2.1The Development of a Genomics Market16
- 2.1.1Market Size and Growth Projections16
- 2.1.2The U.S. Genomics Market16
- 2.2DNA Microarray Technology17
- 2.2.1Biochips17
- 2.2.2Photolithography17
- 2.2.3Instrumentation for DNA Microarray Analysis18
- 2.2.4Lab-on-a-Chip19
- 2.2.5DNA Microarrays20
- 2.3Applications of DNA Microarrays21
- 2.3.1DNA Sequence Analysis21
- 2.3.2Gene Expression Analysis28
- 2.3.3Effect of DNA Sequence and Gene Expression Monitoring on the Genomics Market31
- 2.4Bioinformatics32
- 2.5Functional Genomics34
- 2.5.1Gene Knockdown35
- 2.5.2Protein-Protein Interactions36
- 2.5.3Bioinformatics36
- 2.5.4Strategies of Functional Genomics Companies37
- 2.5.5Frontiers in Functional Genomics38
- 2.6Comparative Genomics39
- 2.7Pharmacogenomics39
- 2.8Proteomics40
- 2.9Structural Genomics40
- 2.10Disease Targets41
- 2.10.1Paradigm Shift in Drug Development: The Evolution of Targeted Therapies41
- 2.10.2Personalized Warfarin Therapy41
- 2.1The Development of a Genomics Market16
- 3.How Genomics Is Revolutionizing Healthcare44
- 3.1Pharmaceutical Applications44
- 3.2Diagnostics46
- 3.3Toxicogenomics50
- 3.4The Market for DNA Microarrays50
- 3.5DNA Chip Technology Competition50
- 3.6Expression Profiling51
- 3.7Gene Sequencing-Advantages of Chip Array Technology51
- 3.8Applied Markets for Genomics52
- 3.9Genomics and the Pharmaceutical Companies53
- 3.10Cancer Markets54
- 3.11Agricultural Markets55
- 3.11.1Plant Genomics56
- 3.11.2Food Processing57
- 3.11.3Animal Husbandry57
- 4.Proprietary Applications and Patents59
- 4.1What is Patentable?59
- 4.2Patents and Litigation61
- 5.Business Analysis64
- 5.1Facilitation and Capitalization of the Convergence of Gene Expression Analysis and Proteomics64
- 5.2Competition64
- 5.3Market Opportunities for Functional Genomics64
- 5.3.1Metabolic Profiling64
- 5.3.2Anti-Fungal Targets65
- 5.3.3Nutrition66
- 5.3.4Crop Production66
- 5.4The Highly-Competitive Nature of the Genomics Industry68
- 5.4.1First-Generation Biotech68
- 5.4.2Second-Generation Genomics Companies69
- 5.4.3Next-Generation DNA Sequencing Companies69
- 5.5Strategic Alliances69
- 6.Genomics Company Profiles71
- 6.1Affymetrix, Inc.71
- 6.2Agendia80
- 6.3Agilent Technologies, Inc.80
- 6.4Applied Biosystems Group81
- 6.5Bayer, AG85
- 6.6Biotage85
- 6.7Caliper Life Sciences85
- 6.8Celera Group88
- 6.9Cepheid88
- 6.10CLC bio89
- 6.11Clinical Data, Inc.89
- 6.12CuraGen Corporation90
- 6.13Cytocell Ltd.95
- 6.14diaDexus, Inc.95
- 6.15Enzo Biochem, Inc.97
- 6.16Exiqon A/S98
- 6.17GE Healthcare98
- 6.18Gene Link, Inc.98
- 6.19Gene Logic, Inc.98
- 6.20Genentech, Inc.100
- 6.21Genisphere, Inc.101
- 6.22Genomatix Software, Inc.102
- 6.23Genomic Solutions, Inc.102
- 6.24Gen-Probe, Inc.103
- 6.25Harvard Bioscience, Inc.105
- 6.26Helicos Biosciences Corporation105
- 6.27Human Genome Sciences, Inc.105
- 6.28Illumina, Inc.107
- 6.29Interleukin Genetics110
- 6.30LI-COR Biosciences111
- 6.31Luminex Corporation112
- 6.32Millennium Pharmaceuticals, Inc.112
- 6.33Monogram Biosciences, Inc.113
- 6.34Motorola, Inc.115
- 6.35MWG Biotech AG115
- 6.36Myriad Genetics, Inc.116
- 6.37Nanogen, Inc.117
- 6.38Nuvelo, Inc.120
- 6.39Orchid Cellmark121
- 6.40Pacific Biosciences, Inc.124
- 6.41QIAGEN, Inc.124
- 6.42Roche Diagnostics127
- 6.43Sequenom, Inc.129
- 6.44Third Wave Technologies, Inc.131
- 6.45Verenium Corporation133
- 6.46Visigen Technologies, Inc.133
- 6.47Brief Profiles of Companies Marketing Personalized Genomics Products134
- 6.47.123andMe, Inc.134
- 6.47.2deCODE Genetics, Inc.134
- 6.47.3Navigenics, Inc.134
- 6.48Brief Profiles of Other Selected Genomics Firms135
- 6.48.1Aber Genomic Computing135
- 6.48.2Spotfire, Inc.135
- 7.Genomics Challenges and Growth Factors136
- 7.1Market Drivers136
- 7.1.1Product Pipeline: Need for More Drug Candidates136
- 7.1.2Need for Increased Research and Development Productivity136
- 7.2A Genomics Market Bottleneck-Bioinformatics136
- 7.3Strategic Recommendations-Market Opportunities137
- 7.3.1More Comprehensive Tools Are Needed137
- 7.3.2Resolving Bottlenecks in Functional Genomics Market138
- 7.4Key Trends of Recent Mergers and Acquisition Deals139
- 7.5Chemogenomics139
- 7.6Pharmacogenomics140
- 7.7Biomarkers141
- 7.8Additional Genomics Market Opportunities142
- 7.1Market Drivers136
- 8.Bioinformatics146
- 8.1Types of Data and Bioinformatics Applications146
- 8.1.1Validated Core Modeling Technology147
- 8.1.2Broad Applicability147
- 8.1.3Data Management Compliant with Industry Standards148
- 8.1.4Open Architecture148
- 8.1.5Ease of Use148
- 8.1.6Increased Access148
- 8.2Functions of Informatics Software149
- 8.2.1Data Management149
- 8.2.2Transformation of Data into Knowledge149
- 8.2.3Collaboration Among Researchers149
- 8.2.4Interface for Online Data Sources149
- 8.3Target Markets for Informatics Software149
- 8.3.1Pharmaceutical Companies149
- 8.3.2Biotechnology Companies150
- 8.3.3Academic and Government Research Institutions150
- 8.3.4Agricultural, Environmental and Industrial Biotechnology Companies150
- 8.4Products of Bioinformatics150
- 8.4.1Sequences and Structure of Genes and Proteins150
- 8.4.23-D Molecular Structures150
- 8.4.3Genome Structures and Functions150
- 8.4.4Bibliographic Data150
- 8.5Bioinformatics Processes151
- 8.6Informatics Tools and Functionalities151
- 8.6.1Sequence to Structure151
- 8.6.2Lead Identification and Optimization152
- 8.6.3Development and Formulation152
- 8.6.4Improving Materials and Processes in the Chemicals Industry152
- 8.6.5Other Materials-Based Industries153
- 8.7Role of Bioinformatics in the Value Chain154
- 8.8Bioinformatics Market Segments154
- 8.8.1Database154
- 8.8.2Hardware154
- 8.8.3Software155
- 8.8.4Bioinformatics Services155
- 8.9Bioinformatics Business Models155
- 8.9.1Changing Business Models156
- 8.9.2Selected Business Strategies157
- 8.1Types of Data and Bioinformatics Applications146
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