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DNA Sequencing and PCR Markets

The focus of this report is to describe the DNA sequencing market. This analysis includes all of the generally-accepted DNA-oriented analytical activities that are currently used today, such as enabling technologies like polymerase chain reaction (PCR).  It examines these measurement technology platforms and their reagents and supplies as utilized in biotechnology research, pharmacology and healthcare. Generally, diagnostic tests which are marketed primarily as over-the-counter products directly to patients are not included in this study, although there is inevitably some overlap. This examination will:

1) Identify viable technology drivers through a comprehensive look at various platform technologies for molecular sequencing, including immunoassays electrophoretic methods, probe-based nucleic acid assays, microarrays and non-PCR sequencing

2) Obtain a complete understanding of the chief molecular sequencing tests for predictive, screening, prognostic, monitoring, pharmacogenomic and theranostic applications

3) Discover feasible market opportunities via an identification of high-growth applications in different therapeutic areas, with a focus on the biggest and expanding markets-communicable diseases, cardiology and oncology

4) Focus on global industry development through an in-depth analysis of the major world markets for molecular sequencing, including forecasts for growth.

Table of Contents

• 1.Overview6
  • 1.1Statement of Report6
  • 1.2About This Report6
  • 1.3Scope of the Report6
  • 1.4Methodology7
  • 1.5Executive Summary8
  
  
• 2.Introduction to DNA Sequencing and Amplification and PCR Technology10
  • 2.1Science Overview: Introduction to DNA10
    • 2.1.1DNA Sequencing and PCR Applications Space14
    • 2.1.2Proteomics15
    • 2.1.3Products for the Genomics Market15
  • 2.2The Impact of the Human Genome Project on Molecular Biology15
  • 2.3Impact of DNA Sequencing Techniques on Biotechnology, Pharmaceutical and Healthcare Industries15
  • 2.4Molecular Diagnostics in the Post-genomic Era-The Role of SNPs16
  • 2.5Advances in Molecular Diagnostic Technologies17
  • 2.6The Use of PCR Technology18
  • 2.7Genetic Variability and Disease19
  
  
• 3.Market Analysis of PCR and DNA Sequencing Product Market21
  • 3.1Overview of the Sequencing and Amplification Market21
    • 3.1.1 Highlights of DNA Sequencing Market23
    • 3.1.2 Genomic Analysis Market Development23
    • 3.1.3 Leading U.S. and Canadian Companies Offering Sequencing Technology Platforms24
    • 3.1.4 Competition27
    • 3.1.5 Markets for DNA Sequencing28
    • 3.1.6 Market Opportunity29
    • 3.1.7 Market Dynamics30
    • 3.1.8 Overview of Current DNA Sequencing Technology Platforms and Players31
    • 3.1.9 Limitations of Current Sequencing Technologies52
    • 3.1.10Overview of the Life Science Marketplace55
    • 3.1.11Research Laboratories58
      • 3.1.11.1Market Share59
  • 3.2Paradigm Shift in Drug Discovery and Development59
    • 3.2.1 Systems Biology and the Need for More Effective Tools60
    • 3.2.2Molecular Medicine and the New Therapeutics60
    • 3.2.3Pharmacogenomics Using Genotyping and Phenotyping Clinical Biomarkers60
    • 3.2.4The Market61
  • 3.3Detection of Amplified DNA61
    • 3.3.1 Nucleic Acid Amplification Methods62
    • 3.3.2Amplification of Refractory Mutation System (ARMS)64
  • 3.4DNA Reagent Applications Market Share and Key Players64
    • 3.4.1Product Description64
      • 3.4.1.1Pricing64
  • 3.5PCR/DNA Testing Market Analysis66
    • 3.5.1 Nucleic Acid-Amplification and Detection Systems: How Big a Market?66
    • 3.5.2Market Size 2004-2010 and Growth Projections in DNA Amplification Instrumentation66
      • 3.5.2.1U.S. Market66
      • 3.5.2.2European Market66
    • 3.5.3Market Share of Key Players in DNA Amplification67
  • 3.6The Drivers of the Biotech Industry67
    • 3.6.1Isolation of DNA for PCR Profiling68
    • 3.6.2Analysis by PCR-Based DNA Typing68
    • 3.6.3Rapid Isolation of DNA for RFLP and PCR68
    • 3.6.4DNA for PCR-STR Typing69
  • 3.7Biotechnology Instrumentation Outlook69
    • 3.7.1Products for the Genomics Market69
    • 3.7.2 Genetic Analysis Products70
    
    
• 4.Use of PCR and DNA Amplification Products72
  • 4.1 PCR Components72
    • 4.1.1Primers for PCR72
    • 4.1.2Equipment for PCR72
  • 4.2Sources of DNA for PCR75
  • 4.3PCR Primer Sequence75
  • 4.4Thermostable DNA Polymerases76
  • 4.5 PCR Protocols77
  • 4.6Microfluidic Automated DNA Analysis Using PCR78
  
  
• 5.Technical Trends in PCR79
  • 5.1 Practical Applications of PCR79
    • 5.1.1Overview79
  • 5.2Quality Control Issues in PCR79
  • 5.3Determining Length of cDNA Product79
    • 5.3.1Direct Signal Amplification Using the Invader Assay79
    • 5.3.2Biosensor Technologies81
      • 5.3.2.1DNA Hybridization Biosensor Chips81
      • 5.3.2.2PNA-Based Biosensors82
  • 5.4Novel Nucleic Acid Amplification Techniques82
  • 5.5 Microplate Readers83
  • 5.6Genotyping Methods83
    • 5.6.1Use of DNA Sequencers83
      • 5.6.1.1Capillary-Based Sequencers84
      • 5.6.1.2Pyrosequencing85
    • 5.6.2Use of Microarrays86
  • 5.7RiboMaker Detection System86
  • 5.8RNA Isolation Kits87
  • 5.9Nucleic Acid Sample Prep Platforms88
  • 5.10DNA Microarrays89
    • 5.10.1The Technique89
    • 5.10.2The Market89
    • 5.10.3Gene Expression Monitoring Arrays90
  • 5.11Emerging Markets of DNA Arrays90
  • 5.12Alternatives to PCR Amplification90
    • 5.12.1Locked Nucleic Acids (LNAs)90
    • 5.12.2Multiplexed Nuclease-Protection Assay and ArrayPlate91
    
    
• 6.Corporate Directory93
  • 6.1Abbott Laboratories93
  • 6.2Affymetrix94
  • 6.3Agilent Technologies101
  • 6.4AgriGen Biotech Pty 102
  • 6.5GE Healthcare102
  • 6.6Applera Applied Biosystems103
  • 6.7Avesthagen Gengraine Technologies, Pvt.106
  • 6.8Bayer Corporation106
  • 6.9BD Biosciences107
  • 6.10Beckman Coulter108
  • 6.11BGI Life Tech110
  • 6.12bioMérieux111
  • 6.13Bioneer112
  • 6.14Bio-Rad Laboratories112
  • 6.15BioTrove113
  • 6.16Caliper LifeSciences114
  • 6.17Cepheid117
  • 6.18Cogenics (A subsidiary of Clinical Data)118
  • 6.19CombiMatrix Corporation119
  • 6.20Commonwealth Biotechnologies121
  • 6.21Complete Genomics122
  • 6.22CuraGen Corporation122
  • 6.23Cytocell124
  • 6.24Dako A/S124
  • 6.25DiaDexus124
  • 6.26DNA LandMarks125
  • 6.27DNAVision126
  • 6.28Enzo Biochem126
  • 6.29Epicentre126
  • 6.30Eppendorf AG127
  • 6.31Eurofins Medigenomix127
  • 6.32Exiqon127
  • 6.33Febit Biomed128
  • 6.34Geneart AG128
  • 6.35GeneticTechnologies Limited128
  • 6.36GeneWorks129
  • 6.37Genisphere129
  • 6.38Genizon BioSciences129
  • 6.39Genovoxx130
  • 6.40Gen-Probe130
  • 6.41Genset134
  • 6.42Genta134
  • 6.43Genzyme135
  • 6.44GVK BIO 137
  • 6.45Hamilton Thorne Biosciences137
  • 6.46Helicos BioSciences Corporation137
  • 6.47High Throughput Genomics138
  • 6.48Hokkaido System Science138
  • 6.49Hy Laboratories138
  • 6.50Illumina138
  • 6.51Incyte Corporation143
  • 6.52Integrated DNA Technologies144
  • 6.53Invitrogen144
  • 6.54Inqaba Biotechnical Industries 146
  • 6.55Johnson & Johnson146
  • 6.56Kreatech Holding BV147
  • 6.57LI-COR148
  • 6.58Sygnis Pharma AG148
  • 6.59Lucigen149
  • 6.60Luminex Corporation149
  • 6.61Meridian Biosciences151
  • 6.62Microchip Biotechnologies153
  • 6.63Microsynth AG153
  • 6.64MilleGen SA154
  • 6.65Millennium Pharmaceuticals154
  • 6.66MWG Biotech AG154
  • 6.67Myriad Genetics154
  • 6.68Nanogen156
  • 6.69Nanosys158
  • 6.70Nymox159
  • 6.71Ocimum Biosolutions160
  • 6.72Orchid Cellmark161
  • 6.73Ostex161
  • 6.74Pacific Biosciences161
  • 6.75PamGene161
  • 6.76Perlegen Sciences162
  • 6.77PPD162
  • 6.78PPGx162
  • 6.79PrimmBiotech162
  • 6.80Promega162
  • 6.81Biotage163
  • 6.82QIAGEN163
  • 6.83Quidel165
  • 6.84Research Biolabs Pte 167
  • 6.85Roche Diagnostics167
  • 6.86Shanghai Sangon Biological Engineering Technology & Services Co.168
  • 6.87Saturn Biotech 168
  • 6.88Sequenom169
  • 6.89Sequetech170
  • 6.90Shimadzu Biotech170
  • 6.91Siemens AG170
  • 6.92Tepnel Life Sciences171
  • 6.93Third Wave Technologies171
  • 6.94Visible Genetics173
  • 6.95VisiGen Biotechnologies173
  • 6.96Vysis173
  • 6.97Wellcome Trust Sanger Institute 174
  • 6.98ZS Genetics174
  
  
• 7.Market Trends and Forecasts175
  • 7.1Market Dynamics175
  • 7.2Future Considerations for Molecular Diagnostics175
  • 7.3How Genomics is Transforming Pharmaceutical R&D175
  • 7.4Cancer Markers176
  • 7.5NAT and Personalized Medicine176
  • 7.6Three Growth Areas of Molecular Diagnostics176
  • 7.7RNA Detection177
  • 7.8Ramification Amplification Method177
  • 7.9Invader Assays/Third Wave Technologies178
  • 7.10Molecular Beacons179
  
  
• 8. Major Product Innovations/Launches in DNA Sequencing Industry181
  • 8.1 Major Product Innovations/Launches in DNA Sequencing Industry181
  • 8.2 Major Activities in DNA Sequencing Industry183
  
  
  

 

LIST OF FIGURES

Figure 2.1: Segment of Double-Stranded DNA Showing the Base-Pair Relationship11

Figure 3.1: Global Market for DNA Sequencing22

Figure 4.1: Cepheid\'s I-CORE Module78

LIST OF TABLES

Table 3.1: Global Market for DNA Sequencing21

Table 3.2: DNA Sequencing Market Players24

Table 3.3: Major DNA Product Companies in Europe25

Table 3.4: Major DNA Product Companies in Asia and Australia25

Table 3.5: Major DNA Product Companies in Japan25

Table 3.6: Major DNA Product Companies in Rest of the World25

Table 3.7: Market Revenue and Market Share of DNA Sequencing Market Players31

Table 3.8: Thermal Cyclers Marketed by Applied Biosystems46

Table 3.9: Applied Biosystems\' Real-Time PCR Systems46

Table 3.10: Applied Biosystems Genetic Analysis Instruments48

Table 3.11: Gene Expression Assays Offered by Applied Biosystems49

Table 3.12: SNP Genotyping Assays Offered by Applied Biosystems49

Table 3.13: Comparison of Established Genomic Analysis Technologies54

Table 3.14: Life Science Techniques Frequently Used55

Table 3.15: The Most Commonly Used Reagents Used by Life Science Researchers55

Table 3.16: The Most Commonly Used Instruments and Apparatus in Life Science Research56

Table 3.17: The Most Widely Reported Categories of Software in Life Science Research56

Table 3.18: Reagents and Equipment Sales for Use in DNA Sequencing Worldwide56

Table 3.19: Global Market for Tools and Consumables Used in Drug Discovery and Development, Clinical Diagnostics and Biomedical Research58

Table 3.20: Key Bioassay Technologies in the Life Sciences Industry59

Table 3.21: Nucleic Acid Amplification Methods62

Table 3.22: Properties of Various Acid Amplification Techniques63

Table 3.23: Amplification Reagent Product Description64

Table 3.24: Standard Prep Pricing65

Table 3.25: Small Target Prep Pricing65

Table 3.26: Hybridization Pricing65

Table 3.27: Analysis Pricing66

Table 3.28: U.S. Market Size 2004-2010 in DNA Amplification Instrumentation66

Table 3.29: Market Share of Key Players in DNA Amplification Thermostable Enzymes67

Table 3.30: Leading Manufacturers of Thermal Cyclers and Market Share67

Table 4.1: ThermoFisherMolecular Biology Thermal Cyclers73

Table 4.2: PCR Systems and Thermocyclers74

Table 5.1: RiboMaker™ Assays to be Introduced for Cancer and Pathogen Detection87

Table 8.1: The Key Bioassay Technologies in the Life Sciences Industry181

 

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