Proteomics - Technologies, Markets and Companies
This report describes and evaluates the proteomic technologies that will play an important role in drug discovery, molecular diagnostics and practice of medicine in the post-genomic era - the first decade of the 21st century. Most commonly used technologies are 2D gel electrophoresis for protein separation and analysis of proteins by mass spectrometry. Microanalytical protein characterization with multidimentional liquid chromatography/mass spectrometry improves the throughput and reliability of peptide mapping. Matrix-Assisted Laser Desorption Mass Spectrometry (MALDI-MS) has become a widely used method for determination of biomolecules including peptides, proteins. Functional proteomics technologies include yeast two-hybrid system for studying protein- protein interactions. Establishing a proteomics platform in the industrial setting initially requires implementation of a series of robotic systems to allow a high-throughput approach for analysis and identification of differences observed on 2D electrophoresis gels. Protein chips are also proving to be useful. Proteomic technologies are now being integrated into the drug discovery process as complimentary to genomic approaches. Toxicoproteomics, i.e. the evaluation of protein expression for understanding of toxic events, is an important application of proteomics in preclincial drug safety. Use of bioinformatics is essential for analyzing the massive amount of data generated from both genomics and proteomics.
Proteomics is providing a better understanding of pathomechanisms of human diseases. Analysis of different levels of gene expression in healthy and diseased tissues by proteomic approaches is as important as the detection of mutations and polymorphisms at the genomic level and may be of more value in designing a rational therapy. Protein distribution / characterization in body tissues and fluids, in health as well as in disease, is the basis of the use of proteomic technologies for molecular diagnostics. Proteomics will play an important role in medicine of the future which will be personalized and will combine diagnostics with therapeutics.The text is supplemented with nearly 50 tables, 30 figures and over 500 selected references from the literature.
The number of companies involved in proteomics has increased remarkably during the past few years. More than 300 companies have been identified to be involved in proteomics and well over half are profiled in the report with nearly 500 collaborations.
The markets for proteomic technologies are difficult to estimate as they are not distinct but overlap with those of genomics, gene expression, high throughput screening, drug discovery and molecular diagnostics. Markets for proteomic technologies are analyzed for the year 2009 and are projected to years 2014 and 2019. The largest expansion will be in bioinformatics and protein biochip technologies. Important areas of application are cancer and neurological disorders
Table of Contents
Part I: Technologies and Markets
- Basics of Proteomics
- Proteomic Technologies
- Protein Biochip technology
- Bioinformatics in Relation to Proteomics
- Research in Proteomics
- Pharmaceutical Applications of Proteomics
- Application of Proteomics in Healthcare
- Commercial Aspects of Proteomics
- Future of Proteomics
- References
Part II: Companies
- Companies Involved in Developing Proteomics
Full table of contents: Part I, Part II
Download Table of Contents as a PDF
Other users found this report page using the following search terms: proteomics multidimentional liquid chromatography mass spectrometry Matrix-Assisted Laser Desorption Mass Spectrometry MALDI-MS robotic systems high-throughput 2D electrophoresis Protein chips bioinformatics genomics proteomics proteomics companies molecular diagnostics diagnostic proteomic markets technologies technologies market
If you can't find a report that meets your needs contact LeadDiscovery. We are one of the few report providers with extensive drug development experience and we frequently use this knowledge to help clients source the most appropriate reports or produce reports for them from scratch.
Refund and Cancellation Policy: The descriptions of the products and services sold on LeadDiscovery.co.uk are as complete and accurate as possible, and customers are encouraged to read all available information about a product before placing an order. Due to the nature of the information being sold, orders for reports cannot be canceled.