Medical Nanotechnology Markets
Nanotechnology has reached critical mass. Nowhere is this more evident than in medicine.
Rising medical costs, demands for less-invasive procedures and pressures for immediate feedback of medical conditions, all point to nanotechnology as offering a new approach in healthcare. According to U.S. National Science Foundation estimates, by 2015 the annual global market for nano-related goods and services will top $1 trillion, thus making it one of the fastest-growing industries in history. Assuming that these figures prove to be accurate, nanotechnology will emerge as a larger economic force than the combined telecommunications and information technology industries at the beginning of the technology boom of the late 1990s.
This report covers the specific segments of the medical nanotechnology markets, with particular emphasis on those segments where this emerging technology is or shows the potential to be most impactful.
Nanotechnology, a field of science and technology that aims to control matter at the atomic, molecular and macromolecular level, potentially has far-reaching and paradigm-shifting implications for biology, drug discovery and medical technologies. The discipline has already yielded healthcare discoveries that have been used for drug delivery and diagnostic purposes.
This report describes various nanotechnologies under development for biological and medical purposes and assess their potential. Moreover, this analysis is arranged to provide an overview of the regulatory issues faced by the medical nanotechnology industry and focuses on how specific segments within the industry are poised for high future growth.
Table of Contents
- 1Overview6
- 1.1Statement of Report6
- 1.2About This Report6
- 1.3Scope of the Report8
- 1.4Methodology8
- 1.5Executive Summary10
- 2Medical Products (Drugs, Devices and Nutraceuticals) Nanotechnology Markets13
- 2.1Background13
- 2.2Market Calculations13
- 2.3Market Demands14
- 2.4Market Overview18
- 2.4.1The Role of Nanotechnologies in Medicine18
- 2.4.2Nanotechnology Sector Challenges21
- 2.4.3Nanotechnology Sector Drivers21
- 2.4.4Nanotechnology Sector Restraints21
- 2.5Nanotechnology Medical Product Market Segments21
- 2.5.1Overview21
- 2.5.2World Markets22
- 2.5.3U.S. Market24
- 2.5.4European Market25
- 2.5.5Japanese Market26
- 2.5.6Asian Market27
- 2.5.7Middle East29
- 2.5.8ROW30
- 3Medical and Life Science Nanotechnology Markets32
- 3.1Nano-Particles33
- 3.2Market for Nano-Particles in Life Sciences and Medicine34
- 3.2.1Key Players34
- 3.2.2Application Manufacturers36
- 3.3Dendrimers36
- 3.3.1PAMAM Dendrimers36
- 3.3.2Market for Nanocapsules in Life Sciences and Healthcare37
- 3.3.3Key Players37
- 3.4Market for Nanoporous and Nanostructured Materials in Life Sciences and Healthcare37
- 3.4.1Key Players37
- 3.4.2Nanofiltration38
- 3.5Nanodevices, Nanosensors and Quantum Dots38
- 3.5.1Sector Overview38
- 3.5.2Market for Quantum Dots in Life Sciences and Medicine39
- 3.5.3Commercial Applications for Quantum Dots39
- 3.5.4Key Players40
- 3.5.5Nanomaterials Suppliers41
- 3.5.6Application Manufacturers41
- 3.6Nanocoatings42
- 3.7Nanocomposites42
- 3.8Nanoarrays42
- 3.8.1Bead NanoArrays: A High-Sensitivity Detection System43
- 3.9Fullerenes43
- 3.9.1Key Applications and Market Opportunities44
- 3.9.2Medical Market Uses for Carbon Nanotubes44
- 3.9.3Key Players, Including Application Manufacturers, End Users and Nanomaterials Suppliers45
- 3.10Liposome-like Nano-Particles45
- 3.10.1Nanostructured Lipid Carriers46
- 3.10.2DauxoXome® Liposomal Formulation46
- 3.11Nanosensors46
- 3.11.1Microcantilever Sensors and Photonic Sensors46
- 3.11.2Field-Effect Nanoplate Devices46
- 3.11.3Electrochemical-Transducing Electrode Systems47
- 4Technology Issues48
- 4.1Nanotechnology in Drug Delivery and Development48
- 4.1.1Drug Delivery Using Nanotechnology50
- 4.1.2Design of Nanotechnology-Based Drug Delivery Systems52
- 4.1.3Using Magnetic Nano-Particles in Targeted Drug Delivery53
- 4.1.4Cancer Drug Delivery53
- 4.1.5Nano-Particle-Mediated Delivery of siRNA55
- 4.1.6Targeting Angiogenesis with Nano-Particles55
- 4.1.7Nanosystems and Inflammation56
- 4.1.8The Chiral Drug Development Process56
- 4.1.9Reasons Why the Drug Delivery Market is Rapidly Expanding57
- 4.2Categories of Medical Nanotechnology Products57
- 4.2.1Surgical Steel Devices58
- 4.2.2Contrast-Enhancing Agents for MRI (Magnetic Resonance Imaging)58
- 4.2.3Wound Dressings / Anti-Microbial Textiles59
- 4.2.4Nanocoated Surgical Blades59
- 4.2.5Suture Needles and Microneedles59
- 4.2.6Catheters for Minimally-Invasive Surgery59
- 4.2.7Optical Nanosurgery59
- 4.2.8Nanocoated or Nanocontoured Implant Surfaces60
- 4.3Biosensors and Biodetection60
- 4.3.1Cantilever Arrays60
- 4.3.2Nanosensors60
- 4.3.3Optical Sensors60
- 4.3.4Nano-Particle Sensors and Detectors61
- 4.3.5In Vitro Diagnostics61
- 4.3.6Imaging, In Vivo Diagnosis and Theranostics64
- 4.4Vaccines-Virus-Like Particles (VLPs)65
- 4.5Transdermal Drug Delivery65
- 4.6Phage Microarrays65
- 4.7Neuroscience66
- 4.8Nanotechnology Materials for Medical Products67
- 4.8.1Dental Materials67
- 4.8.2Bone Replacement68
- 4.8.3Contact Lenses68
- 4.9New Drug Development68
- 4.10Future Directions69
- 4.10.1Sources of Nano Development69
- 4.10.2Commercialization70
- 4.10.3Current/Pending Clinical Trials on New Products and Emerging Technologies70
- 4.10.4Future Directions72
- 4.11Key Technology Findings for Medical Uses of Nanotechnology72
- 4.1Nanotechnology in Drug Delivery and Development48
- 5Business Trends74
- 5.1Market Forces74
- 5.1.1Market Drivers74
- 5.1.2Market Restraints74
- 5.1.3Medical / Clinical Studies74
- 5.1.4Demographics75
- 5.2Market Prospects75
- 5.3Marketing and Distribution75
- 5.4Competitive Landscape76
- 5.5Business Developments76
- 5.5.1Drug Pedigrees76
- 5.6Acquisitions and Partnerships77
- 5.7Key Players77
- 5.8Patent Climate77
- 5.9Investment Climate78
- 5.9.1U.S. Government79
- 5.9.2Europe80
- 5.10Venture Capital Environment80
- 5.10.1Medical and Health Nanotech Venture Companies81
- 5.10.2Pharma and Biotech Nanotech Venture Companies83
- 5.11Business Strategies for Medical Nanotechnology88
- 5.12Nanotechnology Questions90
- 5.12.1What Are the Near-Term Business Opportunities in the Medical Nanotechnology Markets?90
- 5.12.2What Are the Business Models Currently Used by Companies in the Medical Nanotechnology Markets?90
- 5.12.3How Will Manufacturers, Researchers, Physicians, Patients and Payers Influence the Medical Nanotechnology Markets?91
- 5.12.4What Are the Drivers and Bottlenecks Influencing the Medical Nanotechnology Markets?91
- 5.12.5What Are the Current and Emerging Technologies used in the Medical Nanotechnology Markets?91
- 5.12.6Who Holds the Proprietary Rights to the Medical Nanotechnology Markets, Especially in such a Multidisciplinary Environment?92
- 5.12.7What Are Current Applications of These Technologies?92
- 5.12.8What Regulatory Processes Must Medical Nanotechnology Undergo in the U.S., Japan and Europe?92
- 5.12.9How Will New or Emerging Medical Nanotechnologies Change Treatment and Payment Paradigms?92
- 5.12.10How Will Medical Nanotechnologies Reduce Adverse Clinical Reactions and Decrease Total Patient Care Cost?93
- 5.12.11How Will Medical Nanotechnology Reduce Healthcare Expenditures?93
- 5.12.12How Will Medical Nanotechnology Decrease Patient Diagnostic Testing Costs?93
- 5.12.13What is the Role of Nanotechnology in Drug Development?93
- 5.12.14Which Medical Nanotechnology Product Categories Are Driving Growth?94
- 5.12.15How Are Biomarkers Being Developed Using Nanotechnology?94
- 5.12.16What Companies Are Developing Nanotechnology Drug Delivery Systems?94
- 5.12.17How Are Nano-Optical Tagging Technologies Used in Animal Drug Safety Assessment Studies?94
- 5.12.18What Nanotechnology Platforms Are Being Used in Point of Care Diagnostic Testing?95
- 5.1Market Forces74
- 6Technology Assessment96
- 6.1Current Technologies for Nano96
- 6.1.1Nanodiagnostics96
- 6.1.2Competitive Analysis of Nano-Particle Assays99
- 6.1.3In Vivo Imaging99
- 6.1.4In Vitro Clinical Diagnostics99
- 6.2Future Technologies101
- 6.3Technology Accelerators, Roadblocks and Challenges103
- 6.3.1Technology Accelerators103
- 6.3.2Technology Roadblocks and Challenges103
- 6.3.3Public Awareness104
- 6.4Nanotechnology Product Trends and New Concepts for Medical Applications106
- 6.4.1Market Trends-Diagnostics106
- 6.4.2Market Trends-Therapies115
- 6.4.3Market Trends-Preventive and Other120
- 6.4.4Nanofibers in Medical Applications124
- 6.4.5Dental Applications125
- 6.4.6Optical Applications126
- 6.5Production Methods126
- 6.1Current Technologies for Nano96
- 7Medical Nanotechnology Market Regulation and Reimbursement128
- 7.1Market Segments128
- 7.1.1Diagnostics128
- 7.1.2Therapies128
- 7.1.3Preventive128
- 7.2Customer Needs128
- 7.3Competitor Analysis128
- 7.4Pricing Pressures129
- 7.5U.S. Medicare and Other Government Agency Issues129
- 7.6Third-Party Reimbursement129
- 7.7Regulatory Trends129
- 7.7.1Regulatory Policy for Nanotechnology Drugs and Medical Devices130
- 7.7.2Current Good Manufacturing Practices (cGMPs)133
- 7.7.3Current Progress134
- 7.7.4Future Regulatory Trends134
- 7.7.5Key Issues136
- 7.7.6Labeling Requirements136
- 7.8Government Initiatives136
- 7.8.1NNI Research Centers137
- 7.8.2NNI Centers and Networks of Excellence137
- 7.8.3FDA's Nanotechnology Task Force137
- 7.8.4Dutch Government Nano Action Plan138
- 7.8.5Other Research Centers138
- 7.9Medical Regulatory and cGMPs Issues139
- 7.10New Technology Concerns140
- 7.11Use Environment141
- 7.11.1Cancer141
- 7.11.2Medical Review141
- 7.12Risk Assessment141
- 7.12.1Risk Management (ISO 14971:2007)141
- 7.12.2Toxicology Assessment141
- 7.12.3Safety Evaluation142
- 7.13Cautions for Medical Nanotechnology Platforms144
- 7.13.1ETUC Precautionary Principle Applied to Nanotechnologies145
- 7.13.2Possible Risks to Human Health from Nanotechnology Products145
- 7.1Market Segments128
- 8Corporate Profiles146
- 8.1Abbott Laboratories146
- 8.2Abraxis Biosciences146
- 8.2.1NDA Pipeline147
- 8.3Aduro BioTech148
- 8.4Advanced Magnetics (AMAG Pharmaceuticals)148
- 8.5Alnis BioSciences149
- 8.6APP Pharmaceuticals149
- 8.7Arrowhead Research Corporation150
- 8.8Baxter International151
- 8.9Bristol-Myers Squibb151
- 8.10Caliper151
- 8.11Capsulution NanoScience AG152
- 8.12CytRx Corporation152
- 8.13Dendritech, Inc.152
- 8.14Dendritic Nanotechnologies, Inc.152
- 8.15Dow Chemical153
- 8.16DuPont153
- 8.16.1The Framework155
- 8.17Elan Drug Delivery (see also Bristol-Myers Squibb)156
- 8.18Evident Technologies157
- 8.19Evolved Nanomaterial Sciences (ENS)157
- 8.20Flamel Technologies157
- 8.21General Electric160
- 8.22GlaxoSmithKline160
- 8.23Honeywell International160
- 8.24Invitrogen161
- 8.25Nano-C162
- 8.26Nanocyl SA163
- 8.27Nanogen, Inc.163
- 8.28Nanolab Systems164
- 8.29NanoPass Technologies, Ltd.164
- 8.30Nanophase Technologies Corporation164
- 8.31Nanospectra Biosciences165
- 8.32Nanosphere, Inc.165
- 8.33Nanosys166
- 8.34New England Precision Grinding (NEPG)166
- 8.35Novartis167
- 8.36Novavax167
- 8.37Nucryst (Westaim) Pharmaceuticals168
- 8.38Orthovita168
- 8.39Phillips168
- 8.40pSivida Corporation169
- 8.41Quantum Dot Corporation169
- 8.42Roche170
- 8.43Sandvik Bioline170
- 8.44Starpharma Holdings, Limited171
- 8.45Sigma Aldrich172
- 8.46Wyeth Pharmaceuticals173
- 9Appendix: Nanotechnology References174
- 10Appendix: Glossary of Terms in Nanotechnology175
- 10.1Bionanotechnology175
- 10.1.1Nanopore Sequencing175
- 10.1.2Cantilevers with Functionalized Tips175
- 10.1.3Microneedles175
- 10.1.4Microchips for Drug Delivery175
- 10.1.5Nucleic Acid Lattices and Scaffolds176
- 10.1.6Nanofibers as Biomaterials176
- 10.1.7Carbon Nanotubes177
- 10.2Definition of Nano-Particles with Biological and Medical Applications177
- 10.2.1Superparamagnetic Iron Oxide Crystals177
- 10.2.2Quantum Dots178
- 10.2.3Dendrimers178
- 10.2.4Polymeric Micelles178
- 10.2.5Liposomes178
- 10.2.6Nanospheres179
- 10.2.7Aquasomes (Carbohydrate-Ceramic Nano-Particles)179
- 10.2.8Polyplexes/Lipopolyplexes179
- 10.1Bionanotechnology175
- 11Appendix: NNI Centers and Networks of Excellence180
- 11.1National Science Foundation180
- 11.2Department of Energy181
- 11.3Department of Defense181
- 11.4National Aeronautics and Space Administration (NASA)182
- 11.5National Institute for Occupational Safety and Health182
- 11.6National Institute of Standards and Technology182
- 11.7National Institutes of Health182
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