SNP Genotyping and Analysis Markets
SNPs (single nucleotide polymorphisms), single base pair mutations that occur at a specific site in the DNA sequence, are the most common type of genetic variation between human beings. Because they are responsible for over 80% of the variation between two individuals, SNPs are ideal for the task of hunting for correlations between genotype and behavior or quality exhibited by a living organism.
The use of SNP analysis has spread into numerous areas in recent years. But diagnostics and pharmacogenomics are the most promising applications, and market watchers in diagnostics, pharmaceutical, biotechnology and related instrument industries will want to watch developments in SNP analysis closely.
SNP Genotyping and Analysis Markets looks at SNPs analysis instruments, reagents, software and services, providing information critical to having an understanding of the business behind this new technology:
- Overview of SNPs, their Applications and Key SNP Analysis Methods
- Current Market Size and Estimates of Future Growth
- Estimates of Revenues by Region (North America, Europe and ROW) and By Product Type (Consumable, Instruments, Software)
- Complete List of Over 180 SNP-Related Deals Made Between Companies Since 2002
- Exhaustive Review of Products on the Market
- Market Share of Major Companies in SNP Analysis
- Discussion of Government Involvement and Funding
- Corporate Profiles
- Regulatory, Technology and Industry Trends as well as;
- Eight Strategic Recommendations for Companies in the SNP Analysis Market
While the market is expected to create opportunities for growth, the SNP Genotyping and Analysis market is not without its challenges. The following will impact the market:
- Cheaper Sequencing Creates Competition
- Small Number of Suppliers
- Issues With Use of Public Databases
- Data Management Requirements
- Backlash Against Rush Into Genetic Testing, DTC Marketing
- Standard Processes for SNP Experiments Still Not Established
- Shortcomings in Sample Preparation and Handling Hinder Success
- Privacy Concerns Pose Threat to Broad Technology Adoption
SNP Genotyping and Analysis Markets is the result of a primary research effort. An analyst with experience following the biotech instrument industry researching all available sources and contacting industry experts and end users to obtain real market insights. Strategic Planners, Marketing Directors, Business Development Executives are among the individuals who will benefit from this resource.
Table of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
- What is a SNP?
- Applications
- The Market
- Competitive Analysis
- Challenges
- Scope and Methodology
CHAPTER TWO: INTRODUCTION
- Background
- SNP Analysis Methods
- Amplification
- Allele discrimination / assay reaction mechanism
- Single Nucleotide Addition; Pyrosequencing
- Assay Format
- Detection Method
- Scope and Methodology
- Definitions
- DNA Microarray
- Genome-Wide Association
- Linkage Analysis
- Mass Spectrometry
- Single-Nucleotide Polymorphism (SNP)
CHAPTER THREE: APPLICATIONS
- Life Science Research
- Pharmacogenetics / Pharmacogenomics
- Case Study #1 -- SNPs in Gene for P-glycoprotein Affect Antidepressant Response
- Case Study #2 - Celera Studying SNPs Associated With Heart Disease
- Case Study #3 - Synonymous SNPs Alter mRNA Splicing with Obesity
- Case Study #4 - University of Ottawa Heart Institute (UOHI) Coronary Artery
- Disease Research
CHAPTER FOUR: INDUSTRY AND REGULATORY TRENDS
- Industry Trends
- Consolidation Occurring in Array and Life Science Markets
- FDA Involvement Making Drug Industry More Comfortable
- Acceptance of SNP Analysis, Pharmacogenetics Reached Tipping Point
- Core Labs Becoming Established Paradigm
- Technology Trends
- Increased Multiplexing Expands Applications
- End-Users Attracted to Larger-Scale SNP Platforms
- Complexity of Biological Systems Requires Multiple Techniques
- Miniaturization of Equipment and Instruments
- Regulatory Trends
- Introduction
- Critical Path Initiative
- March 2005 - “Guidance for Industry - Pharmacogenomic Data Submissions”
- April 2005 - “Drug-Diagnostic Co-Development Concept Paper”
- March 2006 - Critical Path Opportunities List
- November 2006 - “Recommendations for the Generation and Submission of
- Genomic Data”
- August 2007 - “Pharmacogenomic Data Submissions — Companion Guidance”
- August 2007 - FDA Updates Labeling of Warfarin (Coumadin)
- December 2007 - EGAPP Reviews Use of CYP450 Genetic Testing For SSRIs
CHAPTER FIVE: PRODUCTS
- Affymetrix
- Overview of Affymetrix Products
- Hardware
- Applied Biosystems
- Overview of Applied Biosystems Products
- Assays and Reagent
- Instruments
- Beckman Coulter
- CombiMatrix
- febit
- GE Healthcare
- Illumina
- Hardware
- Microarrays
- LI-COR Biosciences (Lincoln, NE)
- Roche Applied Science
- Sequenom
- Services
- Agencourt Biosciences
- DNAPrint Genomics
- Polymorphic DNA Technologies
- Software
- Applied Biosystems
- Premier Biosoft
- Public Tools
CHAPTER SIX: CONSORTIA, GOVERNMENT INVOLVEMENT, DEALS
- Consortia, Collaborative Projects
- The Cancer Genome Atlas (TCGA) Pilot Project
- Cancer Sequencing Project
- Critical Path Institute
- DNA Polymorphism Discovery Resource
- Genetic Association Information Network (GAIN)
- Genotype-To-Phenotype Database (GEN2PHEN)
- International HapMap Project
- Introduction & Background
- Rationale for HapMap Approach
- Process for Producing HapMap
- Populations Included in HapMap
- Measures Taken to Protect Donors’ Privacy
- Laboratories and Technologies Involved in HapMap
- Practical Use of the HapMap Data
- MicroArray Quality Control (MAQC) Project
- NIH Roadmap
- NIH Roadmap for Medical Research
- Pharmacogenetics Research Network (PGRN)
- NIH Involvement, Funding for SNPs and Sequencing
- Funding for Sequencing Projects Affecting SNP Market
- Continued Rapid Growth in Sequence Production
- Funding and Consortia for Sequencing
- NHGRI Funds Large-Scale Sequencing Centers, 2006
- Competitive Activity
CHAPTER SEVEN: MARKET DATA AND COMPETITIVE ANALYSIS
- Historical
- Illumina as Bellwether for SNP Analysis Market
- Applied Biosystems as Bellwether for RT-PCR Products
- Forecast
- Assumptions
- SNP Revenues by Region
- SNP Revenues by Product
- Competitive Analysis
CHAPTER EIGHT: CORPORATE PROFILES
- Affymetrix
- Applied Biosystems
- Illumina
CHAPTER NINE: CHALLENGES AND STRATEGIC RECOMMENDATIONS
- Challenges
- Cheaper Sequencing Creates Competition for SNP Analysis Platforms
- Market Is Dominated by a Small Number of Suppliers
- Issues Arise With Use of Public Databases
- Data Management Requirements Limit Large-Scale Technologies
- Diagnostic Market Holds Obstacles For New Innovations
- Backlash Against Rush Into Genetic Testing, DTC Marketing
- Standard Processes for SNP Experiments Still Not Established
- Shortcomings in Sample Preparation and Handling Hinder Success
- Privacy Concerns Pose Threat to Broad Technology Adoption
- Strategic Recommendations
- Figure-1-1: SNP Analysis Market 2007-2013
- Figure 1-2: Growth Rate in SNP Analysis Revenues 2008-2013
CHAPTER TWO: INTRODUCTION
- Table 2-1 Adelle-Specific Invasive Cleavage
- Table 2-2 Adelle-Specific Ligation
- Table 2-1 Allele-Specific Primer Extension
- Table 2-4 Single Base Primer Extension
CHAPTER FOUR: INDUSTRY AND REGULATORY TRENDS
- Table 4-1: Critical Path Opportunities List
CHAPTER FIVE: PRODUCTS
- Figure 5-1: Taq Man Assay
- Figure 5-2: SOLID System Average Throughput Progress
- Figure 5-3: SNPstream Method
- Figure 5-4: Roche SimpleProbe System
- Figure 5-5: Roche HybProbe System
- Table 5-1 Products in the SNP Analysis Market
- Table 5-2 Public SNP Tools and Resources (Tool, Website)
CHAPTER SIX: CONSORTIA, GOVERNMENT INVOLVEMENT, DEALS
- Figure 6-1: Domains of Genomes Sequenced by Year (Archaea, Bacteria, Eukaryota)
- Major Sequencing Centers, Jan 2008
- Figure 6-5: Top Funding Agencies, DNA Sequencing, 2008
- Figure 6-4: Major Sequencing Centers and Percent of Sequencing Projects (WORLD, GENOSCOPE, BMC, Sanger, WashU, BROAD, JCVI, JGI), Jan 2008
- Figure 6-5: Top Funding Agencies, DNA Sequencing, 2008 ($M)
- Figure 6-6: Human Genome Project Funding, DOE& NIH ’90-‘03
- Figure 6-7: Areas Funding Genome Sequencing, Jan 2008 (Medical, Evolutionary, Agricultural, Environmental, Biotechnology)
- Table 6-5: Large-Scale Sequencing Centers, NHGRI Funding, 2004-2006
- Figure 6-8: Top Genome Sequencing Countries, Jan. 2008 (# projects)
- Figure 6-9: SNP Analysis Related Deals (Companies, Date, Details of Deal)
- Figure 6-10: SNP: NHGRI Funded Large-Scale Sequencing Ctrs, ‘07
- Table 6-6: SNP Analysis-Related Deals (Companies, Date, Details of Deal)
CHAPTER SEVEN: MARKET DATA AND COMPETITIVE ANALYSIS
- Figure 7-1: Illumina Quarterly Revenues, 2001-2007 ($M)
- Figure 7-2: Applied Biosystems Revenues in Real Time PCR/Applied Genomics
- Table-7-1: Forecasted Revenues in the SNP Analysis Market
- Figure-7-3: Forecasted Revenues in the SNP Analysis Market
- Table 7-2: Growth Rate in SNP Analysis Tools Market, 2008-2013
- Figure 7-4: Growth Rate in SNP Analysis Tools Market, 2008-2013
- Figure 7-5: SNP Analysis Revenues by Region (North America, Europe, Rest of World)
- Table 7-3: SNP Analysis Revenues by Region (North America, Europe, Rest of World)
- Figure 7-6 SNP Market by Product Segment (Instruments, Consumables, Software & Services)
- Table 7-4: SNP Market by Segment (Instruments, Consumables, Software & Services)
- Table 7-5: Revenues Among the Top Companies in SNP Analysis (Illumina, Affymetrix, Applied Biosystems, Other)
- Figure 7-7: SNP Analysis Market Share, 2007
CHAPTER EIGHT: CORPORATE PROFILES
- Figure 8-1: Affymetrix’ Revenues by Product Type, 2004 - 2007
- Figure 8-2: Illumina BeadStation Installed Base, 2004-2006
CHAPTER NINE: CHALLENGES AND STRATEGIC RECOMMENDATIONS
- Figure 9-1: Estimated Decrease in Screening Price
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