CNS Market Overview - neurology, pain and psychiatry
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the CNS pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Scope of the analysis - page 3
- Datamonitor insight into the CNS market - page 4
- Related reports - page 5
- CHAPTER 2 MARKET DEFINITION - page 9
- Introduction - page 9
- CNS sector sizing - page 9
- Neurology and Psychiatry sector sizing methodologies - page 10
- Pain - page 10
- Geographic coverage - page 11
- CHAPTER 3 BACKGROUND AND OVERVIEW - page 13
- CNS market performance - page 15
- Market comparison using the main CNS ATC1 class - page 15
- ATC N class is the largest in terms of both sales value and sales volume - page 15
- CNS market performance by sector - page 19
- The CNS market totaled $95.48 billion in 2007 - page 20
- CNS market performance by region - page 25
- High price points means US market dominates 7MM CNS market value - page 25
- 5EU sees greatest value growth over past 4 years - page 26
- Market comparison using the main CNS ATC1 class - page 15
- CNS disease sector comparison - page 27
- Commercial viability of CNS sectors in 2015 - page 28
- Market dynamics of key CNS indications through to 2015 - page 30
- Growth to arise from all three key pain disease markets - page 30
- Historical sector dynamics - page 31
- Top-line sector comparisons - page 31
- Brand dominance - page 33
- Company dominance - page 34
- Generic dominance - page 35
- CNS product analysis - page 38
- Leading brand analysis - page 38
- Psychiatric brands take up 6 of the top 10 CNS brand positions - page 38
- Case study analysis 1: versatile drug classes excel in the CNS market - page 40
- N3A - Anticonvulsants - page 42
- N5A - Antipsychotics - page 44
- N6A - Antidepressants - page 46
- Case study analysis 2: promotional spend in the CNS market - page 49
- Promotional spend by region - page 49
- Promotional spend by ATC4 class - page 50
- Promotional spend by brand - page 52
- Leading brand analysis - page 38
- Leading company involvement in the CNS market - page 54
- Sales performance of the top 10 CNS companies of 2007 - page 54
- J&J consolidates its market leading position as its nearest rivals experience a decline in their CNS portfolios - page 54
- Sector presence - page 56
- Market leading company assessment - page 59
- J&J -CNS franchise faces a challenging future following key patent expiries - page 59
- Pfizer - Lyrica lays the groundwork for a new generation of CNS offerings - page 61
- GSK - protecting its neurology portfolio remains the immediate focus - page 63
- Forecast performance of other key CNS companies through to 2012 - page 64
- Tactical acquisitions to provide greater CNS market presence for UCB and Schering Plough - page 65
- Sales performance of the top 10 CNS companies of 2007 - page 54
- CNS market performance - page 15
- CHAPTER 4 NEUROLOGY - page 68
- Market dynamics - page 69
- Neurology market size and structure - page 69
- US and EU are key neurology growth regions - page 69
- Key indication market dynamics - page 70
- Commercial viability of key neurological indications in 2015 - page 71
- Market dynamics and prevalence through to 2015 - page 73
- Historical sales dynamics of key neurological indications over the period 2004-07 - page 75
- Company analysis - page 81
- Neurological drugs definition - page 81
- Top five neurological drug companies' comparative marketed and pipeline portfolio potential - page 82
- Historical performance and top-line dynamics of the leading neurological drug companies in 2007 - page 84
- Analysis of the top five neurological drug companies of 2007 - page 87
- Star performers within the neurological drug market - Emergence of UCB, Forest and Sepracor - page 98
- Brand analysis - page 100
- Anticonvulsants dominate the top 10 selling neurological drug brands - page 100
- Neurology market size and structure - page 69
- Key disease-specific insight - page 103
- Alzheimer's disease - page 103
- Key market insights - page 103
- Market forecast summary - page 104
- Disease definition - page 105
- Epidemiology - page 106
- Current market dynamics - page 107
- Issues affecting the global Alzheimer's disease market - page 109
- Key product launches and patent expiries through to 2016 - page 113
- Epilepsy - page 115
- Key market insights - page 115
- Market forecast summary - page 116
- Disease definition - page 116
- Epidemiology - page 118
- Current market dynamics - page 120
- Key companies and leading brands in the epilepsy market - page 123
- Issues affecting the global epilepsy market - page 127
- Key product launches and patent expiries through to 2016 - page 131
- Insomnia - page 133
- Key market insights - page 133
- Market forecast summary - page 134
- Disease definition - page 135
- Epidemiology - page 136
- Current market dynamics - page 137
- Key companies and leading brands in the Insomnia market - page 138
- Issues affecting the global insomnia market - page 141
- Key product launches and patent expiries through to 2016 - page 143
- Migraine - page 146
- Key market insights - page 146
- Disease definition - page 148
- Epidemiology - page 149
- Current market dynamics - page 151
- Key companies and leading brands in the migraine market - page 154
- Issues affecting the global migraine market - page 157
- Key product launches and patent expiries through to 2016 - page 163
- Multiple Sclerosis - page 166
- Key market insights - page 166
- Market forecast summary - page 168
- Disease definition - page 168
- Epidemiology - page 169
- Current market dynamics - page 170
- Key companies and leading brands in the MS market - page 173
- Environmental issues affecting the seven major MS markets - page 174
- Key product launches and patent expiries through to 2016 - page 178
- Parkinson's disease - page 181
- Key market insights - page 181
- Market forecast summary - page 183
- Disease definition - page 183
- Epidemiology - page 184
- Current market dynamics - page 186
- Unmet needs in Parkinson's disease - page 187
- Key product launches and patent expiries through to 2016 - page 189
- Other orphan neurological disorders - page 191
- Amyotrophic lateral sclerosis (ALS/Motor neuron disease) - page 191
- Huntington's disease - page 195
- Alzheimer's disease - page 103
- Market dynamics - page 69
- CHAPTER 5 PAIN - page 200
- Market dynamics - page 202
- Pain market size and structure - page 202
- 5EU is the key historical pain sector growth market - page 202
- Key indication market dynamics - page 203
- Commercial viability of key pain indications in 2015 - page 204
- Market dynamics and prevalence through to 2015 - page 206
- Historical sales dynamics of the three key pain indications over the period 2003-06 - page 208
- Company analysis - page 211
- Pain drugs definition - page 211
- Top five pain drug companies' comparative marketed and pipeline portfolio potential - page 212
- Historical performance and top-line dynamics of the leading pain drug companies of 2007 - page 214
- Analysis of the top five pain drug companies of 2007 - page 217
- Star performer in the pain drug market - page 229
- Major sector loser in the pain drug market - page 229
- Brand analysis - page 230
- Generic nature of pain sector sees leading brands being less dominant over market - page 230
- Key non-traditional analgesics used in pain - page 231
- Anticonvulsants for pain - Pregabalin and gabapentin gain significant revenues from neuropathic pain - page 232
- Antidepressants for pain - Neuropathic pain an important revenue generator for Lilly's Cymbalta - page 233
- Pain market size and structure - page 202
- Key disease-specific insight - page 234
- Breakthrough pain - page 234
- Key market insights - page 234
- Market forecast summary - page 235
- Disease definition - page 235
- Epidemiology - page 236
- Unmet needs in breakthrough pain - page 237
- Fibromyalgia - page 237
- Key market insights - page 237
- Market forecast summary - page 238
- Disease definition - page 239
- Epidemiology - page 239
- Current treatment approaches for fibromyalgia - page 240
- Unmet needs in fibromyalgia - page 241
- Neuropathic pain - page 242
- Key market insights - page 242
- Market forecast summary - page 243
- Disease definition - page 243
- Epidemiology - page 244
- Current market dynamics - page 248
- Current treatment approaches for neuropathic pain - page 249
- Unmet needs in neuropathic pain - page 252
- Breakthrough pain - page 234
- Traditional analgesic class dynamics - page 252
- Opioids - page 252
- Key market insights - page 253
- Market forecast summary - page 253
- Current market dynamics - page 254
- Key product launches and patent expiries through to 2016 - page 255
- NSAIDs - page 258
- Current market dynamics - page 258
- Key brands in the NSAID market - page 262
- Opioids - page 252
- Market dynamics - page 202
- CHAPTER 6 PSYCHIATRY - page 264
- Market dynamics - page 266
- Psychiatry market size and structure - page 266
- US psychiatry sales dwarf that from the 5EU and Japan - page 266
- Key indication market dynamics - page 267
- Commercial viability of key psychiatric indications in 2015 - page 268
- Market dynamics and prevalence through to 2015 - page 270
- Historical sales dynamics of key psychiatric indications over the period 2003-06 - page 273
- Company analysis - page 276
- Psychiatric drugs definition - page 276
- Top five psychiatric drug companies' comparative marketed and pipeline portfolio potential - page 277
- Historical performance and top-line dynamics of the leading psychiatric drug companies of 2008 - page 279
- Analysis of the top five psychiatric drug companies of 2007 - page 282
- Star performers within the psychiatric drug market - Teva and Reckitt Benckiser - page 297
- Major psychiatric drug sector losers - Pfizer and GSK suffer after key antidepressants go generic - page 299
- Brand analysis - page 301
- Atypical antipsychotics and antidepressants fill nine of the top 10 places - page 301
- Key non-traditional psychiatric drugs used in psychiatry - page 302
- Anticonvulsants are regularly used to treat bipolar maintenance - page 303
- Psychiatry market size and structure - page 266
- Key disease-specific insight - page 304
- Anxiety - page 304
- Key market insights - page 304
- Market forecast summary - page 304
- Disease definition - page 305
- Epidemiology - page 307
- Current market dynamics - page 308
- Unmet needs in Anxiety - page 309
- ADHD - page 310
- Key market insights - page 310
- Market forecast summary - page 312
- Disease definition - page 312
- Epidemiology - page 313
- Current market dynamics - page 316
- Issues affecting the global ADHD market - page 318
- Key product launches and patent expiries through to 2017 - page 325
- Bipolar disorder - page 328
- Key market insights - page 328
- Market forecast summary - page 329
- Disease definition - page 330
- Epidemiology - page 335
- Current market dynamics - page 335
- Unmet needs in bipolar disorder - page 338
- Depression (Manic depressive disorder) - page 339
- Key market insights - page 339
- Market forecast summary - page 340
- Disease definition - page 341
- Epidemiology - page 342
- Current market dynamics - page 343
- Timeline of key events in the depression disease market - page 345
- Issues affecting the global depression market - page 347
- Key product launches and patent expiries through to 2016 - page 351
- Nicotine dependence - page 354
- Key market insights - page 354
- Market forecast summary - page 355
- Disease definition - page 355
- Epidemiology - page 357
- Current market dynamics - page 358
- Unmet needs in nicotine dependence - page 361
- Schizophrenia - page 362
- Key market insights - page 362
- Market forecast summary - page 362
- Disease definition - page 363
- Epidemiology - page 364
- Current market dynamics - page 364
- Unmet needs in schizophrenia - page 365
- Anxiety - page 304
- Market dynamics - page 266
- BIBLIOGRAPHY - page 367
- Literature - page 367
- Websites - page 381
- Datamonitor sources - page 389
- APPENDIX A - page 392
- International Classification of Diseases - page 392
- Disease of the nervous system (neurology) - page 392
- Mental and behavioral disorders (Psychiatry) - page 392
- Estimated 2007 sales revenue - page 393
- Top five sector drug companies' comparative marketed and pipeline portfolio potential methodology - page 393
- Marketed potential - page 393
- Pipeline potential - page 394
- ATC classes included in 'others' to define the migraine market - page 395
- ICD-10 codes used to define neuropathic pain market - page 396
- International Classification of Diseases - page 392
- APPENDIX B - page 398
- Report methodology - page 398
- About Datamonitor - page 398
- About Datamonitor Healthcare - page 398
- About the CNS analysis team - page 399
- Disclaimer - page 400
- List of Tables
- Table 1: Key dynamics - Nervous system versus other therapeutic sectors, 7MM, 2004-07 - page 17
- Table 2: Central nervous system sector dynamic comparison - key volume and value metrics, 7MM, 2004-07 - page 22
- Table 3: Central nervous system regional dynamic comparison - key volume and value metrics, 7MM, 2004-07 - page 27
- Table 4: Commercial viability of the three CNS market sectors in 2015 - page 29
- Table 5: Market attractiveness - brand, company and generic dominance of the three CNS sectors, 7MM, 2007 - page 32
- Table 6: Top 10 selling CNS brands across the 7MM, 2007 - page 38
- Table 7: Top 10 CNS companies by CNS drug revenues across the 7MM, 2007 - page 55
- Table 8: Sector rankings of the top 10 CNS companies in 2007 - page 56
- Table 9: Other leading CNS companies according to forecast revenues, 2006-2012 - page 65
- Table 10: Commercial viability of key neurological indications in 2015 - page 72
- Table 11: Top 20 neurological drug companies by 2007 seven major market revenues, 2004-07 - page 81
- Table 12: Top five neurological drug companies in the 7MM by revenue versus the rest of the market, 2004-07 - page 85
- Table 13: Top five neurological drug companies by 7MM revenue versus rest of market, 2004-07 - page 86
- Table 14: GSK's neurological drug portfolio overview, 2004-07 - page 88
- Table 15: GSK's late-stage neurology pipeline, 2004-07 - page 89
- Table 16: J&J's neurological drug portfolio overview, 2004-07 - page 91
- Table 17: J&J's late-stage neurology pipeline, 2008 - page 91
- Table 18: Pfizer's neurological drug portfolio overview, 2004-07 - page 92
- Table 19: Pfizer's late-stage neurology pipeline, 2008 - page 93
- Table 20: Eisai's neurological drug portfolio overview, 2004-07 - page 94
- Table 21: Eisai's late-stage neurology pipeline, 2008 - page 95
- Table 22: Sanofi-Aventis's neurological drug portfolio overview, 2004-07 - page 96
- Table 23: Sanofi-Aventis's late-stage neurology pipeline, 2008 - page 97
- Table 24: Star performing neurological drug companies in the 7MM, 2004-07 - page 98
- Table 25: Top 10 neurological brands in the 7MM by revenue, 2004-07 - page 101
- Table 26: Population size and prevalence rate of Alzheimer's disease across the 7MM, 2008 - page 106
- Table 27: Summary of key environmental issues in the AD market across the 7MM, 2008 - page 110
- Table 28: Estimated launch dates for new Alzheimer's disease drugs in the 7MM, 2008-2017 - page 114
- Table 29: Patent expiry dates for the key approved Alzheimer's disease brands in the 7MM, 2008-2017 - page 114
- Table 30: Prevalence of epilepsy across the 7MM, 2008 - page 118
- Table 31: Key players in the epilepsy market, 2007 - page 125
- Table 32: Summary of environmental issues in the epilepsy market across the 7MM, 2008 - page 128
- Table 33: Estimated launch dates for new epilepsy drugs in the 7MM, 2007-2016 - page 132
- Table 34: Patent expiry dates for the key approved epilepsy brands in the 7MM, 2007-2016 - page 133
- Table 35: Diagnosed prevalence of insomnia in the 7MM, 2008 - page 136
- Table 36: Performance of the US, 5EU and Japan insomnia markets, 2005-06 - page 137
- Table 37: Key players in the insomnia market, 2007 - page 139
- Table 38: Summary of environmental issues in the seven major insomnia markets, 2007 - page 141
- Table 39: Estimated launch dates for new insomnia drugs in the 7MM, 2008-2016 - page 145
- Table 40: Dates of key patent expiries in the insomnia market across the 7MM, 2007-2016 - page 145
- Table 41: Prevalence of migraine across the 7MM, 2008 - page 150
- Table 42: Migraine population across the 7MM, 2008 - page 151
- Table 43: Key players in the migraine market, 2007 - page 154
- Table 44: Summary of environmental issues in the migraine market across the 7MM, 2007 - page 157
- Table 45: Datamonitor's estimated launch dates for migraine products in the 7MM, 2008-2016 - page 165
- Table 46: Key patent expiries of migraine brands across the 7MM, 2008-2016 - page 166
- Table 47: Prevalence of multiple sclerosis across the 7MM, 2008 - page 170
- Table 48: Key players in the multiple sclerosis market, 2007 - page 174
- Table 49: Summary of environmental issues in the multiple sclerosis market across the 7MM, 2007 - page 175
- Table 50: Datamonitor's estimated launch dates for MS products in the 7MM, 2008-2016 - page 180
- Table 51: Patent expiry dates for the approved multiple sclerosis disease-modifiers in the 7MM, 2008-2016 - page 180
- Table 52: Prevalence of PD across the 7MM, 2008 - page 184
- Table 53: Datamonitor's estimated launch dates for Parkinson's disease products in the 7MM, 2008-2016 - page 190
- Table 54: Key patent expiries of Parkinson's disease brands across the 7MM, 2008-2016 - page 190
- Table 55: Prevalence estimates of ALS across the 7MM, 2008 - page 193
- Table 56: HD base scenario prevalence and patient population in the 6MM, 2008 - page 197
- Table 57: Commercial viability of key pain indications in 2015 - page 205
- Table 58: Top 20 pain drug companies by 7MM revenue, 2004-07 - page 211
- Table 59: Top five pain drug companies in the by revenues versus the rest of the market, 2004-07 - page 215
- Table 60: Top five pain drug companies by 7MM revenues versus rest of market, 2004-07 - page 215
- Table 61: Pfizer's pain drug portfolio overview, 2004-07 - page 217
- Table 62: Pfizer's late-stage pain pipeline, 2008 - page 219
- Table 63: J&J's pain drug portfolio overview, 2004-07 - page 220
- Table 64: J&J's late-stage pain pipeline, 2008 - page 221
- Table 65: Mundi's pain drug portfolio overview, 2004-07 - page 222
- Table 66: Mundi's late-stage pain pipeline, 2008 - page 223
- Table 67: Endo's pain drug portfolio overview, 2004-07 - page 225
- Table 68: Endo's late-stage pain pipeline, 2008 - page 226
- Table 69: Teva's pain drug portfolio overview, 2004-07 - page 227
- Table 70: Star performing pain drug company in the 7MM, 2004-07 - page 229
- Table 71: Major pain drug sector company loser in the 7MM, 2004-07 - page 230
- Table 72: Top 10 pain brands by 7MM revenues, 2004-07 - page 231
- Table 73: Prevalence of fibromyalgia across the 7MM, 2008 - page 240
- Table 74: The diabetic neuropathic pain patient populations across the 7MM, 2008 - page 246
- Table 75: The HIV neuropathic pain patient population across the 7MM, 2008 - page 247
- Table 76: The post herpetic neuralgia patient population across the 7MM, 2008 - page 248
- Table 77: Estimated launch dates for new opioid drugs in the US and 5EU, 2008-2012 - page 257
- Table 78: Estimated launch dates for new opioid drugs in the Japan, 2008-2012 - page 258
- Table 79: Pivotal patent expiries for key marketed opioid drugs in the US and 5EU, 2008-2017 - page 258
- Table 80: Commercial viability of key psychiatry indications, 2015 - page 268
- Table 81: Top 20 psychiatric drug companies by 2007 seven major market revenues - page 276
- Table 82: Top five psychiatric drug companies 7MM revenues versus the rest of the market, 2004-07 - page 280
- Table 83: Top five psychiatry drug companies by 2007 seven major market revenues versus rest of market - page 281
- Table 84: Lilly's psychiatric drug portfolio overview, 2004-07 - page 283
- Table 85: Lilly's late-stage psychiatry pipeline, 2008 - page 284
- Table 86: J&J's psychiatric drug portfolio overview, 2004-07 - page 286
- Table 87: J&J's late-stage psychiatry pipeline, 2008 - page 288
- Table 88: AstraZeneca's psychiatric drug portfolio overview, 2004-07 - page 290
- Table 89: AstraZeneca's late-stage psychiatry pipeline, 2008 - page 291
- Table 90: Wyeth's psychiatric drug portfolio overview, 2004-07 - page 293
- Table 91: Wyeth's late-stage psychiatry pipeline, 2008 - page 294
- Table 92: Forest's psychiatric drug portfolio overview, 2004-07 - page 296
- Table 93: Star performing psychiatric drug companies in the 7MM, 2004-07 - page 298
- Table 94: Top 10 psychiatric brands by 7MMrevenues, 2004-07 - page 301
- Table 95: ICD-10 classification codes for anxiety disorders - page 306
- Table 96: DSM-IV classification codes for anxiety disorders - page 307
- Table 97: Prevalence rate of subcategories of anxiety disorder in the general population across the 7MM - page 308
- Table 98: Results of epidemiology studies of ADHD across the 7MM - page 314
- Table 99: Prevalence of ADHD in the 7MM, 2008 - page 316
- Table 100: Performance of the seven major ADHD markets, 2006-07e - page 318
- Table 101: Summary of environmental issues in the ADHD market across the 7MM, 2008 - page 319
- Table 102: Datamonitor's forecast launch dates for key ADHD pipeline products in the 7MM, 2008-2017 - page 327
- Table 103: Key patent expiries for key marketed drugs in the US and 5EU, 2008-2017 - page 328
- Table 104: Diagnostic criteria for bipolar I disorders - page 333
- Table 105: Diagnostic criteria for other types of bipolar disorders - page 334
- Table 106: Prevalence data overview of bipolar disorder in the US, Canada and Switzerland, 2008 - page 335
- Table 107: Prevalence rate and population size for MDD across the 7MM, 2008 - page 343
- Table 108: Summary of environmental issues in the seven major MDD markets, 2007 - page 347
- Table 109: Datamonitor's forecast launch dates for key depression pipeline products in the US and 5EU, 2008-2016 - page 352
- Table 110: Datamonitor's forecast launch dates for key depression pipeline products in Japan, 2008-2016 - page 353
- Table 111: Key depression drugs forecast to face generic competition during the forecast period, 2007-2016 - page 353
- Table 112: DSM-IV criteria for nicotine dependence - page 356
- Table 113: Prevalence of nicotine dependence in the 7MM, 2008 - page 358
- Table 114: Sales, growth and market share of Zyban and Chantix, 2005-06 - page 360
- Table 115: Key OTC nicotine replacement products, 2008 - page 361
- Table 116: Other ATC classes included for migraine market definition - page 395
- Table 117: Neuropathic pain market definition by ICD-10 codes - page 396
- List of Figures
- Figure 1: Key dynamics - Nervous system versus other key therapeutic sectors, 7MM, 2004-07 - page 19
- Figure 2: Central nervous system market sales value split by sector, 2004-07 - page 21
- Figure 3: Central nervous system overview - key value and volume sales dynamics by sector, 7MM, 2004-07 - page 24
- Figure 4: Central nervous system market sales volume and sales value split by region, 2004-07 - page 26
- Figure 5: Market dynamics of key CNS indications, 2007-2015 - page 31
- Figure 6: CNS overview - market attractiveness by sector, 7MM, 2007 - page 33
- Figure 7: Comparative concentration of product sales in the neurology, pain and psychiatry markets - cumulative market share of top selling products in the 7MM, 2007 - page 34
- Figure 8: Comparative concentration of company sales in the neurology, pain and psychiatry markets - cumulative market share of top companies in the 7MM, 2007 - page 35
- Figure 9: CNS sector branded versus generic share as a proportion of 2007 sector sales revenues - page 36
- Figure 10: CNS sector branded share as a proportion of sector sales revenues, 2004-07 - page 37
- Figure 11: Leading brand sales versus rest of market, 7MM, 2007 - page 39
- Figure 12: Seven major market CNS market sales value comparison by ATC3 class, 2006-2007 - page 41
- Figure 13: N3A-anticonvulsant ATC3 class sales value split by diagnosis, 2004-2007 - page 42
- Figure 14: Sales split of key anticonvulsant brands by diagnosis, 2007 - page 43
- Figure 15: N5A-antipsychotic ATC3 class sales value split by diagnosis, 2004-2007 - page 44
- Figure 16: Sales split of key antipsychotic brands by diagnosis, 2007 - page 45
- Figure 17: N6A-antidepressant ATC3 class sales value split by diagnosis, 2004-2007 - page 47
- Figure 18: Sales split of key antidepressant brands by diagnosis, 2007 - page 48
- Figure 19: Promotional spend in the US and 5EU CNS markets, 2004-06 - page 50
- Figure 20: Key dynamics of the top 10 highest promotional spend CNS ATC4 classes in the US, 2005-2006 - page 51
- Figure 21: Key dynamics of the top 10 highest promotional spend CNS ATC4 classes in the 5EU, 2005-2006 - page 52
- Figure 22: Key dynamics of the top 10 highest promotional spend CNS brands in the US, 2005-2006 - page 53
- Figure 23: Key dynamics of the top 10 highest promotional spend CNS brands in the 5EU, 2005-2006 - page 54
- Figure 24: Top 10 CNS companies' portfolio sector bias across the seven major market neurological, pain and psychiatric drug sectors, 2007 - page 58
- Figure 25: Neurology market sales value split by region, 2004-07 - page 69
- Figure 26: Neurology market sales volume split by region, 2004-07 - page 70
- Figure 27: Market dynamics and prevalence of key neurological indications, 2007-2015 - page 74
- Figure 28: Seven major market sales volume dynamics of the key neurology indications, 2003-06 - page 76
- Figure 29: Seven major market sales value dynamics of the key neurology indications, 2003-06 - page 78
- Figure 30: Regional variations in volume and value sales of key neurology indications, 2006 - page 80
- Figure 31: Comparative potential of the top five neurological drug companies' marketed and late-stage pipeline portfolios, 2008 - page 83
- Figure 32: Top five neurological drug companies 7MM revenue versus rest of market, 2004-07 - page 87
- Figure 33: Top 10 neurological brands in the 7MM by sales revenue, 2007 - page 102
- Figure 34: Datamonitor's base scenario Alzheimer's disease market forecast across the 7MM, 2007-2017 - page 105
- Figure 35: Overview of Datamonitor's AD population size methodology, 2008 - page 107
- Figure 36: AD-specific sales revenue, 7MM, 2003-07 - page 108
- Figure 37: AD-specific sales revenue ($ billions) by region, 2004-07 - page 109
- Figure 38: Forecast AD population, 2005-2050 - page 110
- Figure 39: Ageing population across 7MM, 2005-2050 - page 111
- Figure 40: Impact of each key event on the AD market across the seven major markets, 2008-2017 - page 113
- Figure 41: Datamonitor's epilepsy market forecast across the 7MM, 2007-2016 - page 116
- Figure 42: Incidence of epilepsy in different age groups - page 119
- Figure 43: Epilepsy market value across the 7MM ($ billions), 2003-06 - page 120
- Figure 44: Sales volume (SUs billions) and value ($ billions) of first- versus second-generation anticonvulsants, 2003-06 - page 121
- Figure 45: Performance of the nine key epilepsy therapies ($m), 2005-06 - page 122
- Figure 46: Timeline: launch dates and patent expiries impacting the epilepsy market, 1995-2007 - page 124
- Figure 47: Impact of key events on the 7MM epilepsy market, 2007-2016 - page 131
- Figure 48: Datamonitor's insomnia market forecast across the 7MM, 2007-2016 - page 135
- Figure 49: Performance of the key insomnia therapies, 2005-06 - page 138
- Figure 50: Key drug launches and patent expiries in the insomnia market 1992-2006 - page 139
- Figure 51: Population aged over 65 years in the 7MM, 2007-2017 - page 142
- Figure 52: Key events impacting the insomnia market, 2007-2016 - page 144
- Figure 53: Datamonitor's migraine market forecast across the 7MM, 2007-2016 - page 148
- Figure 54: Migraine-specific sales revenue across the 7MM ($ billions), 2003-06 - page 152
- Figure 55: Performance of the nine key migraine therapies across the 7MM ($m), 2005-06 - page 153
- Figure 56: Migraine-specific sales in the 7MM for the four leading migraine prophylaxis drug classes ($m), 2003-06 - page 158
- Figure 57: Migraine-specific standard units prescribed in the 7MM for the four leading migraine prophylaxis drug classes, 2003-06 - page 159
- Figure 58: Total Topamax brand sales ($m) by indication in the US, 2003-06 - page 160
- Figure 59: Generic sumatriptan's impact in the German, Spanish and UK migraine markets ($m and SUs), 2006 - page 162
- Figure 60: Forecasted impact of Imitrex and Topamax patent expiry on the US migraine market ($ billion), 2006-2016 - page 163
- Figure 61: Key events impacting the migraine market, 2007-2016 - page 164
- Figure 62: Datamonitor's multiple sclerosis market forecast across the 7MM, 2007-2016 - page 168
- Figure 63: World distribution of multiple sclerosis - page 169
- Figure 64: Multiple sclerosis market value across the 7MM ($ billions), 2003-06 - page 171
- Figure 65: Performance of the six disease-modifying multiple sclerosis therapies , 2005-06 - page 172
- Figure 66: Timeline: launch dates of disease-modifying therapies for treatment of multiple sclerosis, 1993-2006 - page 173
- Figure 67: Key events impacting the multiple sclerosis market, 2007-2016 - page 179
- Figure 68: Datamonitor's Parkinson's disease market forecast across the 7MM, 2007-2016 - page 183
- Figure 69: Age at diagnosis for each stage of PD, 2007 - page 185
- Figure 70: Parkinson's disease-specific sales revenue across the 7MM ($ billions), 2003-06 - page 186
- Figure 71: Performance of the seven key Parkinson's disease therapies across the 7MM ($m), 2005-06 - page 187
- Figure 72: Key unmet needs in Parkinson's disease, 2007 - page 188
- Figure 73: Key events impacting the Parkinson's disease market 2007-2016 - page 189
- Figure 74: Total ALS market sales revenue ($m), 2003-06 - page 194
- Figure 75: Key unmet needs in ALS treatment - page 195
- Figure 76: Total sales revenue of the six major HD markets by drug class, 2003-06 - page 198
- Figure 77: Unmet needs in HD treatment, 2007 - page 199
- Figure 78: Pain market sales value split by region, 2004-07 - page 202
- Figure 79: Pain market sales volume split by region, 2004-07 - page 203
- Figure 80: Market dynamics and prevalence of key pain indications, 2007-2015 - page 207
- Figure 81: Seven major market sales volume dynamics of the key pain indications, 2003-06 - page 209
- Figure 82: Seven major market sales value dynamics of the key pain indications, 2003-06 - page 210
- Figure 83: Comparative potential of the top five pain drug companies' marketed and late-stage pipeline portfolios, 2008 - page 213
- Figure 84: Top five pain drug companies by 7MM revenues versus rest of market, 2004-07 - page 216
- Figure 85: Key neurological drugs used for pain indications, 2007 - page 232
- Figure 86: Cymbalta total brand sales breakdown by sector, 2007 - page 233
- Figure 87: Datamonitor's breakthrough pain market forecast across the 7MM, 2006-2016 - page 235
- Figure 88: US and 5EU fibromyalgia market ($m), 2006-2016 - page 238
- Figure 89: Datamonitor's neuropathic pain market forecast across the 7MM, 2007-2016 - page 243
- Figure 90: Neuropathic pain-specific sales revenue across the 7MM ($ billions), 2003-06 - page 249
- Figure 91: Key unmet needs in neuropathic pain, 2008 - page 252
- Figure 92: Datamonitor's opioid market forecast across the 7MM, 2007-2017 - page 254
- Figure 93: Opioid sales revenue (as a percentage of total 2004 sales) across the 7MM, 2004-07 - page 255
- Figure 94: Impact of each key event on the opioid market across the 7MM, 2007-12 - page 256
- Figure 95: NSAID sales revenue across the 7MM ($ billions), 2003-07 - page 259
- Figure 96: NSAID sales volume across the 7MM (SU billions), 2003-07 - page 260
- Figure 97: Sales revenues of the M1A1 and M1A3 ATC classes across the 7MM ($ billions), 2003-07 - page 261
- Figure 98: Sales volume of the M1A1 and M1A3 ATC classes across the 7MM (SU billions), 2003-07 - page 262
- Figure 99: Performance of the key NSAID brands across the 7MM ($m), 2006-07 - page 263
- Figure 100: Psychiatry market sales value split by region, 2004-07 - page 266
- Figure 101: Psychiatry market sales volume split by region, 2004-07 - page 267
- Figure 102: Market dynamics and prevalence of key psychiatric indications, 2007-2015 - page 271
- Figure 103: Seven major market sales volume dynamics of the key psychiatric indications, 2003-06 - page 273
- Figure 104: Seven major market sales value dynamics of the key psychiatry indications, 2003-06 - page 275
- Figure 105: Comparative potential of the top five psychiatric drug companies' marketed and late-stage pipeline portfolios, 2008 - page 278
- Figure 106: Top five psychiatry drug companies by 7MM revenues versus rest of market, 2004-07 - page 282
- Figure 107: Performance of Pfizer's and GSK's psychiatry portfolios by 7MM revenues versus the top five and the rest of the market, 2004-07 - page 299
- Figure 108: Key neurological drugs used for psychiatric indications, 2007 - page 303
- Figure 109: Datamonitor's anxiety disorders market forecast across the 7MM, 2006-2015 - page 305
- Figure 110: Anxiety-specific sales revenue across the 7MM ($ billions), 2002-05 - page 309
- Figure 111: Reasons why patients receiving antidepressant therapy are non-compliant - page 310
- Figure 112: Datamonitor's ADHD market forecast across the 7MM, 2007-2017 - page 312
- Figure 113: ADHD market value across the 7MM ($ billions), 2004-07 - page 317
- Figure 114: Sales revenue ($m) of ADHD drugs prescribed for pediatric, adolescent and adult patients, 2004-07 - page 320
- Figure 115: Growth of sales revenue ($m) of drugs prescribed for pediatric, adolescent and adult ADHD in the US, 2004-07 - page 322
- Figure 116: Impact of each key event on the ADHD market across the seven major markets, 2008-2017 - page 326
- Figure 117: Datamonitor's bipolar disorder market forecast across the 7MM, 2006-2015 - page 330
- Figure 118: Symptoms associated with the two primary phases of bipolar disorder - page 332
- Figure 119: Bipolar-specific sales revenue across the 7MM ($ billions), 2002-05 - page 336
- Figure 120: Key unmet needs in bipolar disorder, 2006 - page 339
- Figure 121: Datamonitor's MDD market forecast across the 7MM, 2007-2016 - page 341
- Figure 122: MDD market value across the 7MM ($ billions), 2003-06 - page 344
- Figure 123: MDD-specific sales revenues across the 7MM by drug class, 2006 - page 345
- Figure 124: Key events impacting the MDD market, 1950-2007 - page 346
- Figure 125: Generic incursion on branded MDD-specific antidepressant sales in the US (SUs), 2003-2016 - page 349
- Figure 126: Key events impacting the MDD market, 2007-2016 - page 351
- Figure 127: Datamonitor's nicotine dependence market forecast across the 7MM, 2007-2016 - page 355
- Figure 128: Total sales of the key prescription nicotine dependence products by region ($m), 2003-06 - page 359
- Figure 129: Datamonitor's schizophrenia market forecast across the 7MM, 2006-2015 - page 363
- Figure 130: Schizophrenia-specific sales revenue across the 7MM ($ billions), 2002-05 - page 365
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