Cell Culture: The World Market for Media, Sera, and Reagents
As the biopharmaceutical market grows, so will the cell culture products market. Cell culture is a major foundation of biopharmaceutical development, bioprocessing and manufacturing. Biopharmaceutical products are developed from large, complex protein molecules, which require equally complex manufacturing methods and an array of analytical techniques. As growing cells for biopharmaceutical production is slow, expensive and complicated, optimizing cell culture development is of paramount concern to companies developing biopharmaceuticals.
This report is focused on cell culture used in the research and production of biopharmaceuticals, analyzing the world cell culture market and the major trends driving this market in three specific segments:
- Media,
- Sera, and
- Reagents
In addition to a thorough discussion of the technologies and techniques currently employed and emerging in the cell culture area, the Kalorama's exhaustive report provides specific information on:
- Market Size, growth, and forecasts of the segments through 2011
- Competitive Market Share by leading supplier as of 2005.
- Estimated Market Share by Media Type (this is not available in other reports)
- Key Market Drivers and Restraints for suppliers, including discussions of biopharmaceutical pipelines, seasonal vaccine production, biomedical R&D directions, and the future of transgenic plant and animal production.
- Review of the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems
- Discussion of the trends and preferences in media types vying for dominance in the market, including the following:
- ADCF - animal derived component free media
- CD - chemically defined media
- CSFM - complete serum free medium
- PF - protein free media
- SF - serum free media
- SFM - serum free medium
- Profiles of 28 leading suppliers and information about M&A activities since 2003.
The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company and cell culture supply company representatives included marketing directors, division managers, and product representatives.
Table of Contents
Chapter One: Executive Summary
- Scope and Methodology
- Cells for Biopharmaceutical Production
- Bacteria and Yeasts Systems
- Animal Cell Systems
- Insect Cell Systems
- Cell Lines and Cell Banks
- Fermentors and Bioreactors
- Stirred-Tank Reactors
- Airlift Fermentors
- Packed Bed Reactors
- Hollow-Fiber Reactor
- Disposable Systems
- Fermentation Processes
- Batch and Fed-Batch Fermentation
- Suspended vs. Anchored Cells
- Microencapsulation
- Cell Culture Environment: Functions and Components of Basal Media
- pH and Osmotic Pressure
- Energy Sources
- Nutrients
- Cell Culture Media
- Lysogeny broth (LB)
- Classical Media
- Serum-Free Media
- Protein-Free Media
- Chemically Defined Media
- Specialty Media
- Sera
- Reagents
- Shifting Towards Non-Animal Derived Reagents
- Addressing Reagent Safety Issues
- World Cell Culture Market
- Impact of Shift to Serum-free Products on Cell Culture Suppliers
- Impact of Shift to Serum-Free Products On Research
- Impact of Shift to Serum-Free Products on Biopharmaceutical Manufacturers
- Market Drivers
- Cell Culture Market Forecast
- Trends Impacting The Cell Culture Market
Chapter Two: Genetically Modified Cells for Biopharmaceutical Development
- Overview
- Growing Demand for Biopharmaceuticals
- Demand Increasing for Cell Culture Products
- A Brief History of Biotechnology
- Science of Genetic Manipulation
- From Petri Dish to Biopharmaceutical
- Upstream Bioprocessing: Cell Culture Expression Systems
- Cells for Biopharmaceutical Production
- Bacteria and Yeasts Systems
- Animal Cell Systems
- Insect Cell Systems
- Advantages/Disadvantages of Cell Culture Systems
- Cell Lines and Cell Banks
- Biopharmaceuticals Produced from Cell Culture
- Cell Culture Practices and Regulatory Guidelines
- Validation of Facilities
- Maintaining Sterilization Standards
Chapter Three: Cell Culture Technology
- Introduction and Overview
- Cell Lines for Bioproduction
- Predominant Cell Lines
- Chinese Hamster Ovary (CHO)
- SP2/0, and NS0
- HEK 293 and PER. C6
- Sources: Largest Collections of Cell Lines
- The European Collection of Cell Cultures (ECACC)
- The American Type Cell Culture (ATCC)
- Fermentors and Bioreactors
- Types of Bioreactors/Fermentors
- Stirred-Tank Reactors
- Airlift Fermentors
- Packed Bed Reactors
- Hollow-fiber Reactor
- Disposable Systems
- Fermentation Processes
- Batch and Fed-Batch Fermentation
- Suspended vs. Anchored Cells
- Microencapsulation
- Types of Bioreactors/Fermentors
- Cell Culture Environment:
- pH and Osmotic Pressure
- Energy Sources
- Nutrients
- Cell Culture Media
- Lysogeny Broth (LB)
- Classical Media
- Serum-Free Media
- Protein-Free Media
- Chemically Defined Media
- Specialty Media
- Sera
- Sources of Sera
- Bovine Serum Safety Issues and Regulations
- Shift to Serum-Free Media
- Reagents
- Major Types of Biologic Reagents
- Amino Acids
- Growth Factors and Cytokines
- Albumin
- Transferrin
- Thrombin
- Growth Supplements
- Protease Inhibitor
- Attachment Factors
- Shifting Towards Non-animal Derived Reagents
- Addressing Reagent Safety Issues
- Major Types of Biologic Reagents
- Predominant Cell Lines
Chapter Four: Trends and Market Analysis
- Shift Away From Serum-Based Cell Culture
- Impact of Shift to Serum-Free Products on Cell Culture Suppliers
- Impact of Shift to Serum-Free Products on Research
- Impact of Shift Serum-Free Products on Biopharmaceutical Manufacturers
- Cell Culture Market
- Market Drivers
- Cell Culture Market and Forecast
- Segment Analysis
- Media
- Sera
- Reagents
- Market Characteristics
- Major Acquisitions
- Competitive Market Share
- Trends Impacting The Cell Culture Market
- Stem Cell Research
- Invitrogen
- Sigma-Aldrich
- Millipore Corporation
- Cell Culture-Based Vaccine Production
- Transgenically Produced Biopharmaceuticals
- Stem Cell Research
Chapter Five: Company Profiles
- Advanced Biotechnologies, Inc.
- History and Lines of Business
- Cell Culture Products and Services
- AMRESCO, Inc.
- History and Lines of Business
- Cell Culture Products
- Analytical Biological Services Inc.
- History and Lines of Business
- Cell Culture Products
- Mammalian Cell Culture
- Cell in Microtiter Plates for HTS
- Primary Cultures
- Insect Cell Culture
- Atlanta Biologicals, Inc.
- History and Lines of Business
- Cell Culture Products
- Athena Enzyme Services
- History and Lines of Buiness
- Cell Culture Products
- Biochrom AG
- History and Lines of Business
- Cell Culture Products
- BD Biosciences
- History and Lines of Business
- Cell Culture Products
- Clinical and Clinical Research Reagents
- Financial Information
- Cambrex Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Cell Essentials, Inc.
- History and Lines of Business
- Cell Culture Products
- CellGenix Technologie Transfer GmbH
- History and Lines of Business
- Cell Culture Products and Services
- Fisher Scientific International, Inc.
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Invitrogen Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Irvine Scientific
- History and Lines of Business
- Cell Culture Products
- J R Scientific, Inc.
- History and Development
- Cell Culture Products
- Hyclone Laboratories
- History and Lines of Business
- Cell Culture Products
- Kemp Biotechnologies, Inc.
- History and Lines of Business
- Cell Culture Products
- Cell Culture - Fermentation
- Cell Culture - Stable Mammalian
- Cell Culture - Mammalian Transient Transfection
- Cell Culture - Baculovirus (Insect Cell)
- Mediatech, Inc.
- History and Lines of Business
- Cell Culture Products
- Millipore Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- PAA Laboratories, Inc.
- History and Lines of Business
- Cell Culture Products
- PromoCell GmbH
- History and Lines of Business
- Cell Culture Products
- Quality Biological, Inc.
- History and Lines of Business
- Cell Culture Products
- R&D Systems, Inc.
- History and Lines of Business
- Cell Culture Products
- SBH Sciences
- History and Lines of Business
- Cell Culture Products
- Selexis SA
- History and Lines of Business
- Cell Culture Products
- SeraCare Life Sciences, Inc.
- History and Lines of Business
- Cell Culture Products
- Sigma-Aldrich Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- USB Corporation
- History and Lines of Business
- Cell Culture Products
- Wisent, Inc.
- History and Lines of Business
- Cell Culture Products
List of Exhibits
Chapter One: Executive Summary
- Exhibit 1-1: Market Summary: World Cell Culture Market 2002-2011
Chapter Two: Genetically Modified Cells for Biopharmaceutical Development
- Exhibit 2-1: Biopharmaceuticals Appoved in the US or the EU in 2005 (Product, Expression, Indications, Company)
- Exhibit 2-2: Approximate Times from Introduced Gene to Protein Production at Useable Levels by Expression System (Bacteria, Yeast, Mammilian, Insect)
- Exhibit 2-3: Disadvantages/Advantages of Cell Culture Systems by Expression System (Bacteria, Yeast, Animal, Insect)
- Exhibit 2-4: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells (Expression System, Product, Manufacturer, Indication)
Chapter Three: Cell Culture Technology
- Exhibit 2-1: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma, and CHO cell lines (Company, Product, Type [ADCF, CD, CSFM, PF, SF, SFM], Cell Line)
Chapter Four: Trends and Market Analysis
- Exhibit 4-1: Selected Brand Name Serum-Free Formulations of Cell Culture Products Currently on the Market (Brand, Product, Manufactuer)
- Exhibit 4-2: World Cell Culture Market Revenues and Growth 2002-2011
- Exhibit 4-3: Cell Culture World Market Share by Geographical Region 2006
- Exhibit 4-4: Estimated Share of Cell Culture Media Market by Media Type (Animal Sourced vs Animal Free and Animal Free vs Chemically Defined)
- Exhibit 4-5: World Cell Culture Market Revenues by Segment (Media, Sera, Reagents) 2002-2011
- Table 4-6: Major Acquisitions in the Cell Culture Industry 2003-2006
- Exhibit 4-7: Cell Culture Revenues and Market Share by Leading Competitor 2005
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