Cancer Cell Therapy Markets

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Publication Date: 2008-03-02

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Traditionally, treatment of disease is carried out by small molecules that target specific cell types. In diseases such as cancer, the treatment is meant to kill cancer cells, leading to the removal or at least the inhibition of cancer cell proliferation.

In other circumstances, a variety of therapeutic molecules have been utilized lead the disease cells to perform a specific function that they normally do not. These include small molecules, peptides, proteins, antibodies, anti-sense RNAs and ribozymes.

In the case of cell therapy, as the name indicates, treatment is carried out with cells instead of small molecules. In cell therapy, cells are given to the patient as the therapeutic delivery system for a specific disease to achieve therapeutic benefit.

The purpose of this report is to describe the cell therapy market.  A review of cellular agents is provided.

Table of Contents

 

  • Appendix I: List of Human Clusters of Differentiation (CD) Antigens268
  • Appendix II: Glossary of Terms in the Stem Cells Space274
  • Appendix III: Markers Commonly Used to Identify Stem Cells and to Characterize Differentiated Cell Types (Hematopoietic-focused)284


  • INDEX OF FIGURES

  • Figure 2.1: Autologous Process for Cancer Vaccination35
  • Figure 2.2: Patient Treatment Schedule for Second Line Caner Cell Therapy36
  • Figure 2.3: Cell Maturation Process37
  • Figure 2.4: CTL Cell Division37
  • Figure 2.5: Prostate Specific Membrane Antigen38
  • Figure 2.6: Exosomes39
  • Figure 2.7: Current End-user Utilization Category of CSCs59
  • Figure 2.8: Current End-user Utilization Category of Adult Stem Cells (ASCs)60
  • Figure 2.9: Current End-user Utilization Category of hESCs60
  • Figure 2.10: Current End-user Utilization Category of Human Cord Blood Stem Cells60
  • Figure 3.1: Cancer Vaccine Active Immune-Therapy Process73
  • Figure 3.2: Current End-user Utilization Category of CSCs178


  • INDEX OF TABLES

  • Table 2.1: TC Cell Activation13
  • Table 2.2: Innate Versus Adaptive Immunity15
  • Table 2.3: Proposed Cell-Surface Markers of Undifferentiated HSCs17
  • Table 3.1: Clinical Trials for Autologous Tumor Cell Vaccines78
  • Table 3.2: Pipeline of Cancer Vaccines86
  • Table 3.3: List of Cell Therapy Clinical Trials90
  • Table 3.4: Distribution of Adoptive Immunotherapy of Cancer Clinical Studies being Performed Worldwide104
  • Table 3.5: Clinical Studies Utilizing MSCs105
  • Table 3.6: Distribution of MSC-based Cancer Clinical Studies being Performed Worldwide107
  • Table 3.7: HSC-based Cancer Therapy108
  • Table 3.8: Distribution of HSC-based Cancer Clinical Studies Being Performed Worldwide177
  • Table 3.9: Characteristics of Different Stem Cell Types and Associated Market Opportunity185
  • Table 3.10: Segmentation of the Stem Cell Market by Type/Lineage of Stem Cell186
  • Table 4.1: Classes of Tumor Antigens187
  • Table 4.2: Cancer Vaccines in Phase III Clinical Trials190
  • Table 9.1: Cell Genesys Clinical Pipeline222
  • Table 9.2: Favrille Development Programs236

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