See today's edition of
DailyUpdates in your
therapeutic area
Search all articles

Keywords:

Boolean terms AND, OR, NOT can be used. Phrases should be entered within quotes. For wildcards use an *

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives.

Organic & biomolecular chemistry 2010 Jul 8; In press

Link to PubMed abstract

Rogers S SA, Whitehead D DC, Mullikin T, Melander C

Department of Chemistry, North Carolina State University, 2620 Yarbrough Dr., Raleigh, NC 27695-8204, USA.. christian_melander@ncsu.edu.

An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC(50) values.