Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake.
Peptides 2010 Jun 22; In press
Li J JB, Asakawa A, Terashi M, Cheng K, Chaolu H, Zoshiki T, Ushikai M, Sheriff S, Balasubramaniam A, Inui A
Division of Psychosomatic Internal Medicine, Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
The objective of this study was to clarify the role of a novel agonist with high selectivity and affinity for Y4 receptors in the regulation of food intake. The Y4 receptor agonist BVD-74D was administered to C57BL/6J mice that were fed with a normal or high-fat diet, and to fatty liver Shionogi (FLS)-ob/ob mice; the food intake, water intake, and body weight gain were measured in these mice. In the mice fed with a normal diet, the cumulative food intake significantly decreased at 20minutes and 1 hour after the administration of 1mg/kg of BVD-74D and at 1, 2, 4, 8, and 24hours after the administration of 10mg/kg of BVD-74D. Moreover, the cumulative water intake and body weight gain significantly decreased in these mice. Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, and 4hours after BVD-74D (10mg/kg) administration. Furthermore, the cumulative food intake significantly decreased 2 and 4hours after BVD-74D (10mg/kg) administration in the FLS-ob/ob mice. Thus, we propose that the novel Y4 receptor agonist BVD-74D has suppressive effects on food intake, water intake, and weight gain in normal mice fed with normal diets and on food intake in normal mice fed with high fat diets and in FLS-ob/ob mice. These findings indicate that the Y4 receptor and its agonist would be promising targets for obesity.
Keywords: obesity