Licencing Opportunity:
This work represents a licensing opportunity.
WO05/033079
Further Information:
If you want to know the mechanism of GWT1 in detail, please see the following papers. 1)Tsukahara et al., Mol. Microbiol. 2003, 48, 1029. 2) WO02/04626 3) Umemura et al., J. Biol. Chem. 2003, 278, 23639.
Related Industry Reports:
Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives.
Bioorganic & medicinal chemistry letters 2010 Jun 8; In press
Nakamoto K, Tsukada I, Tanaka K, Matsukura M, Haneda T, Inoue S, Murai N, Abe S, Ueda N, Miyazaki M, Watanabe N, Asada M, Yoshimatsu K, Hata K
Discovery Research Laboratories, Eisai Co., Ltd, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan.
Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.
Keywords: antifungal