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1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.

Bioorganic & medicinal chemistry letters 2010 Apr 3; In press

Link to PubMed abstract

Tollefson M MB, Acker B BA, Jacobsen E EJ, Hughes R RO, Walker J JK, Fox D DN, Palmer M MJ, Freeman S SK, Yu Y, Bond B BR

Pfizer Global Research and Development, 700 Chesterfield Parkway, Chesterfield, MO 63017, United States.

1H-Pyrazolo[4,3-d]pyrimidines are a class of potent and selective second generation phosphodiesterase 5 (PDE5) inhibitors. This work explores the potency, selectivity and efficacy of 1-(2-ethoxyethyl)-1H-pyrazolo[4,5-d]pyrimidines as PDE5 inhibitors resulting in the advancement of a clinical candidate.

Keywords: PDE5 phosphodiesterase