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Oxime Carbamate-Discovery of a series of novel FAAH inhibitors.

Bioorganic & medicinal chemistry letters 2009 Nov 24; In press

Link to PubMed abstract

Sit S SY, Conway C CM, Xie K, Bertekap R, Bourin C, Burris K KD

Department of Chemistry, Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.

A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of selected targets are discussed, along with inhibition kinetics and molecular modeling studies.(1).

Keywords: FAAH