Coenzyme Q9 Provides Cardioprotection after Converting into Coenzyme Q10.
Journal of agricultural and food chemistry 2008 Jun 11; In press
Lekli I I, Das S S, Das S S, Mukherjee S S, Bak I I, Juhasz B B, Bagchi D D, Trimurtulu G G, Krishnaraju A V, Sengupta K K, Tosaki A A, Das D K
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut, Department of Pharmacy, University of Debrecen, Debrecen, Hungary, InterHealth Nutraceuticals, Benicia, California, and Laila Impex R & D Center, Vi
Coenzyme Q 10 (CoQ 10) has been extensively studied as adjunctive therapy for ischemic heart disease, and its cardioprotective ability is well-established. The mitochondrial respiratory chain contains several coenzymes, including CoQ 1, CoQ 2, CoQ 4, CoQ 6, CoQ 7, CoQ 8, CoQ 9, and CoQ 10. It is not known whether other CoQs, especially CoQ 9, is equally cardioprotective as CoQ 10. The present study was designed to determine if CoQ 9 could protect guinea pig hearts from ischemia reperfusion injury. Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ 9 and CoQ 10, respectively, for 30 days while group III served as control. After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion. Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis. Samples of hearts were examined for the presence of CoQ 9 and CoQ 10. The results demonstrated that both CoQ 9 and CoQ 10 were equally cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis. High performance liquid chromatographic (HPLC) analysis revealed that a substantial portion of CoQ 9 had been converted into CoQ 10. The results indicate that CoQ 9 by itself, or after being converted into CoQ 10, reduced myocardial ischemia/reperfusion-induced injury.
Keywords: Coenzyme Q9 Cardioprotection Coenzyme Q10