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Isoxazolone Based Inhibitors of p38 MAP Kinases.

Journal of medicinal chemistry 2008 Mar 29; In press

Link to PubMed abstract

Laufer S A, Margutti S S

stefan.laufer@uni-tuebingen.de.

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.

Keywords: p38 MAP Kinase MAPK