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Antimicrobial activity of rationally designed amino terminal modified peptides.

Bioorganic & medicinal chemistry letters 2007 May 13; 17(15):4343-6

Link to PubMed abstract

Bisht G GS, Rawat D DS, Kumar A, Kumar R, Pasha S

Peptide Research Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007,

Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000mug/mL) in mammalian erythrocytes was observed.