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Discovery of novel hydroxy pyrazole based factor IXa inhibitor.

Bioorganic & medicinal chemistry letters 2006 May 15; 16(10):2796-9

Link to PubMed abstract

Vijaykumar D, Sprengeler P PA, Shaghafi M, Spencer J JR, Katz B BA, Yu C, Rai R, Young W WB, Schultz B, Janc J

Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. dvijayku@hotmail.com

Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.