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New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.

Bioorganic & medicinal chemistry 2006 Mar 15; 14(6):1698-705

Link to PubMed abstract

Schenone S S, Brullo C C, Bruno O O, Bondavalli F F, Ranise A A, Filippelli W W, Rinaldi B B, Capuano A A, Falcone G G

Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3-16132 Genoa, Italy. schensil@unige.it

Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.