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Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy 2005 Oct 1; 49(10):4335-8

Link to PubMed abstract

Johnson C CM, Pandey R R, Sharma S S, Khuller G GK, Basaraba R RJ, Orme I IM, Lenaerts A AJ

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523-1682, USA. christine.johnson@colostate.edu

We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.