The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model.
Vaccine 2005 Sep 23; 23(40):4860-6
Fang J J, Wang G G, Yang Q Q, Song J J, Wang Y Y, Wang L L
School of Life Sciences, Northeast Normal University, 5268 Renmin Street, Nanguan District, Changchun 130024, PR China.
The tumor specific antigen epitope melanoma antigen A1(161--169) (MAGE-A1(161--169)) was displayed on the major protein (p VIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1(161--169) in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1(161--169) specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy.