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Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands.

Bioorganic & medicinal chemistry letters 2005 Aug 15; 15(16):3753-7

Link to PubMed abstract

Paillet-Loilier M M, Fabis F F, Lepailleur A A, Bureau R R, Butt-Gueulle S S, Dauphin F F, Delarue C C, Vaudry H H, Rault S S

Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, UFR des Sciences Pharmaceutiques, 5, rue Vaubénard 14032 Caen Cedex, France.

Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT7 receptor ligands. The synthesis and the affinity for the 5-HT7 receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT7 receptors.