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Interaction of chiral MS-245 analogs at h5-HT6 receptors.

Bioorganic & medicinal chemistry letters 2005 Aug 1; 15(15):3510-3

Link to PubMed abstract

Abate C C, Kolanos R R, Dukat M M, Setola V V, Roth B BL, Glennon R RA

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.

Optically active pyrrolidinylmethylindole analogs related in structure to the benzenesulfonyltryptamine 5-HT(6) receptor antagonist MS-245 were evaluated and their R-isomers were found to bind with affinity higher than their S-enantiomers.